Article
Immunology
Cooper K. Hayes, Christopher K. Villota, Fiona B. McEnany, Stacey Ceron, Sita Awasthi, Moriah L. Szpara, Harvey M. Friedman, David A. Leib, Richard Longnecker, Matthew D. Weitzman, Lisa N. Akhtar
Summary: Clinical HSV-2 isolates collected from neonates with encephalitis are more neurovirulent in human neuronal cell culture and murine models as compared to isolates from neonates with skin-limited disease, suggesting that viral factors contribute to neurologic outcome following human neonatal infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Chandrashekhar D. Patil, Rahul K. Suryawanshi, Divya Kapoor, Deepak Shukla
Summary: HSV-1 infection induces significant alterations in host metabolism, limiting the energy and macromolecular precursors required for viral replication. This study is of great importance for understanding the pathogenesis of HSV-1 infection.
Review
Biochemistry & Molecular Biology
Ines Ripa, Sabina Andreu, Jose Antonio Lopez-Guerrero, Raquel Bello-Morales
Summary: The article discusses the role of the HSV-1 viral protein ICP34.5 in controlling cellular antiviral responses and debates its controversial functions such as autophagy inhibition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Michiel van Gent, Werner J. D. Ouwendijk, Victoria L. Campbell, Kerry J. Laing, Georges M. G. M. Verjans, David M. Koelle
Summary: This study suggests that VZV-specific CD8 T-cells play a limited role in maintaining latent infection of varicella-zoster virus in human trigeminal ganglia.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Microbiology
Chenchen Wang, Qi Liang, Dong Sun, Yun He, Jiaxuan Jiang, Rongjie Guo, Tejsu Malla, Pedram Hamrah, Xun Liu, Zhenping Huang, Kai Hu
Summary: In HSV-1 infection, nectin-1 acts as the primary gD receptor, while NMHC-IIB acts as the primary gB receptor, playing crucial roles in mediating HSV-1 entry into corneal nerves and replication. These receptors hold promise as therapeutic targets for resolving HSV-1 latency and HSK recurrence.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Clinical Neurology
Oliver Goldhardt, Robert Freiberger, Tobias Dreyer, Luisa Willner, Igor Yakushev, Marion Ortner, Hans Foerstl, Janine Diehl-Schmid, Esther Milz, Josef Priller, Alfredo Ramirez, Viktor Magdolen, Markus Thaler, Timo Grimmer
Summary: This study investigated the association between HSV infection and AD biomarkers. The results suggest that in HSV1-seropositive AD patients, there is a significant predictive effect of AI-IgG(HSV1/2) and Aβ(42)/Aβ(40) ratio on pTau.
ALZHEIMERS & DEMENTIA
(2023)
Article
Immunology
Peter-Paul A. Unger, Anna E. Oja, Tamana Khemai-Mehraban, Werner J. D. Ouwendijk, Pleun Hombrink, Georges M. G. M. Verjans
Summary: This study revealed that the human trigeminal ganglia (TG) is an immunocompetent environment where both CD4 and CD8 tissue-resident memory T-cells (T-RM) are established and retained. These findings provide support for T-RM-targeted vaccine strategies.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Microbiology
Qing Fan, Daniel P. Hippler, Yueqi Yang, Richard Longnecker, Sarah A. A. Connolly
Summary: This study reveals that two mutations in gH (H789Y and S830N) contribute to the activation of gB during herpes simplex virus 1 (HSV-1) entry into cells. These findings provide valuable insights into the functional interactions between gH/gL and gB.
Review
Virology
Nithya Jambunathan, Carolyn M. Clark, Farhana Musarrat, Vladimir N. Chouljenko, Jared Rudd, Konstantin G. Kousoulas
Summary: HSV-1 and HSV-2 are prototypical alphaherpesviruses that infect neurons and establish lifelong latent infections. They cause orofacial and ocular infections, genital and neonatal infections respectively. The viral glycoproteins bind to cellular receptors to enter cells and mediate cell-to-cell fusion for virus spread. The complex of viral glycoproteins and cellular receptors play a critical role in virus entry and spread.
Review
Biochemistry & Molecular Biology
Nancy M. Sawtell, Richard L. Thompson
Summary: This review focuses on the role of tegument protein and viral transactivator VP16 in the transition from latency to the lytic cycle of alpha herpesvirus. Reactivation is dependent on VP16 to drive entry into the lytic cycle, and in vivo expression is mediated by specific sequences in the viral genome. Challenges lie in reconciling these data into a unified model of virus reactivation.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
Article
Medicine, General & Internal
Yoshifumi Ashikawa, Fumiko Kusunoki Nakamoto, Tatsuya Sato, Junko Katsumata, Taro Bannai, Tomonari Seki, Masako Takeda, Yasushi Shiio
Summary: A 56-year-old man with herpes zoster ophthalmicus (HZO) experienced worsening ocular symptoms despite acyclovir and steroid therapy. MRI revealed severe orbital inflammation and abnormal lesions in the trigeminal nucleus and tract. Laser irradiation of the stellate ganglion and high-dose oral prednisolone therapy were effective in treating the symptoms associated with HZO.
Article
Neurosciences
Liza Lind, Alexandra Svensson, Karolina Thorn, Malgorzata Krzyzowska, Kristina Eriksson
Summary: The study revealed that during herpesvirus neuroinflammation, anti-viral CD8(+) T cells accumulate in the central nervous system, particularly in the spinal cord, displaying high activation levels and expressing chemotactic receptors corresponding to chemotactic gradients present in the tissue.
JOURNAL OF NEUROVIROLOGY
(2021)
Review
Anesthesiology
Nicholas I. Koenig, Joseph A. Mcguire, Violet P. Shackleford, Kelsey Bauer
Summary: This article describes a case in which a woman with refractory migraine underwent a sphenopalatine ganglion block, but experienced recurrence of headache and herpes simplex virus infection following the procedure. The patient achieved headache resolution through treatment with valacyclovir. The study suggests that underlying HSV-1 infection may cause intractable migraine headache, and nerve blocks may potentiate reactivation of latent HSV infection.
Article
Pharmacology & Pharmacy
Lora McClain, Yun Zhi, Hoyee Cheng, Ayantika Ghosh, Paolo Piazza, Michael B. Yee, Santosh Kumar, Jadranka Milosevic, David C. Bloom, Ravit Arav-Boger, Paul R. Kinchington, Robert Yolken, Vishwajit Nimgaonkar, Leonardo D'Aiuto
ANTIVIRAL RESEARCH
(2015)
Article
Virology
Jean-Marc G. Guedon, Michael B. Yee, Mingdi Zhang, Stephen A. K. Harvey, William F. Goins, Paul R. Kinchington
Article
Chemistry, Medicinal
James McNulty, Leonardo D'Aiuto, Yun Zhi, Lora McClain, Carlos Zeieda-Velazquez, Spencer Ler, Hilary A. Jenkins, Michael B. Yee, Paolo Piazza, Robert H. Yolken, Paul R. Kinchington, Vishwajit L. Nimgaonkar
ACS MEDICINAL CHEMISTRY LETTERS
(2016)
Article
Neurosciences
Phillip R. Kramer, Crystal Stinson, Mikhail Umorin, Mohong Deng, Mahesh Rao, Larry L. Bellinger, Michael B. Yee, Paul R. Kinchington
Article
Neurosciences
Sergei Grigoryan, Paul R. Kinchington, In Hong Yang, Anca Selariu, Hua Zhu, Michael Yee, Ronald S. Goldstein
JOURNAL OF NEUROVIROLOGY
(2012)
Article
Multidisciplinary Sciences
Audrey A. Chan, Andrew J. Hertsenberg, Martha L. Funderburgh, Mary M. Mann, Yiqin Du, Katherine A. Davoli, Jocelyn Danielle Mich-Basso, Lei Yang, James L. Funderburgh
Article
Multidisciplinary Sciences
Sergei Grigoryan, Michael B. Yee, Yair Glick, Doron Gerber, Eldad Kepten, Yuval Garini, In Hong Yang, Paul R. Kinchington, Ronald S. Goldstein
Article
Microbiology
Meleri Jones, Inga R. Dry, Dan Frampton, Manuraj Singh, Ravinder K. Kanda, Michael B. Yee, Paul Kellam, Michael Hollinshead, Paul R. Kinchington, Edel A. O'Toole, Judith Breuer
Article
Cell Biology
Brian P. McSharry, Carolyn Samer, Hamish E. G. McWilliam, Caroline L. Ashley, Michael B. Yee, Megan Steain, Ligong Liu, David P. Fairlie, Paul R. Kinchington, James McCluskey, Allison Abendroth, Jose A. Villadangos, Jamie Rossjohn, Barry Slobedman
Article
Microbiology
Benjamin E. Warner, Michael B. Yee, Mingdi Zhang, Rebecca S. Hornung, Benedikt B. Kaufer, Robert J. Visalli, Phillip R. Kramer, William F. Goins, Paul R. Kinchington
Summary: Studies using a rat model of VZV inoculation show that viral gene expression is necessary for the development of pain behaviors.
Article
Virology
Betty W. Wu, Michael B. Yee, Ronald S. Goldstein, Paul R. Kinchington
Summary: In this study, the potential of using genome editors delivered by adeno-associated virus (AAV) vectors to treat Varicella Zoster Virus (VZV) was evaluated. The results showed that treatment with AAV2-expressing Staphylococcus aureus CRISPR/Cas9 greatly reduced VZV replication and cell-to-cell spread in epithelial cells and lytically infected human neurons. This approach has the potential to be a strategy for the treatment of VZV disease and virus spread in Herpes Zoster (HZ).
Correction
Behavioral Sciences
Phillip R. Kramer, Mahesh Rao, Crystal Stinson, Larry L. Bellinger, Paul R. Kinchington, Michael B. Yee
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2019)
Article
Behavioral Sciences
Phillip Kramer, Mahesh Rao, Crystal Stinson, Larry L. Bellinger, Paul R. Kinchington, Michael B. Yee
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2018)
Article
Behavioral Sciences
Phillip R. Kramer, Jennifer Strand, Crystal Stinson, Larry L. Bellinger, Paul R. Kinchington, Michael B. Yee, Mikhail Umorin, Yuan B. Peng
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2017)
Article
Clinical Neurology
Crystal Stinson, Mohong Deng, Michael B. Yee, Larry L. Bellinger, Paul R. Kinchington, Phillip R. Kramer