Journal
JOURNAL OF VIROLOGY
Volume 84, Issue 9, Pages 4860-4863Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00047-10
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- Loyola University Chicago
- Loyola University Chicago Biology department
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The ability for a virus to expand its host range is dependent upon a successful mode of viral entry. As such, the host range of the well-studied Phi X174 bacteriophage is dictated by the presence of a particular lipopolysaccharide (LPS) on the bacterial surface. The mutant Phi X174 strain JACS-K, unlike its ancestor, is capable of infecting both its native host Escherichia coli C and E. coli K-12, which does not have the necessary LPS. The conversion of an alanine to a very reactive threonine on its virion surface was found to be responsible for the strain's expanded host range.
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