Journal
JOURNAL OF VIROLOGY
Volume 83, Issue 17, Pages 9013-9017Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00906-09
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Funding
- National Institutes of Health [AI57761, RR11069]
- Mayo Foundation for Medical Education and Research
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI057761] Funding Source: NIH RePORTER
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The widely used hepatitis B virus (HBV) vaccine is based on three doses of hepatitis B surface antigen (HBsAg) protein. We previously showed that vectored measles viruses (MV) expressing HBsAg retain measles vaccine function in monkeys but do not induce a protective anti-HBs response in all animals. We show here that a single dose of HBsAg protein following a three-dose vaccination regimen with an optimized HBsAg-expressing MV elicits protective anti-HBs responses in all four vaccinated Rhesus monkeys. Vaccination strategies coupling the effective, long-term immunity elicited by the high-coverage MV vaccine to prophylactic HBV immunity are discussed.
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