Journal
APPLIED RADIATION AND ISOTOPES
Volume 106, Issue -, Pages 22-28Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2015.06.016
Keywords
Sodium borocaptate (BSH); Boronophenylalanine (BPA); Melanomas and brain tumors; Optimization of delivery of BSH and BPA
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In this report five examples have been selected to illustrate how studies in experimental animals have lead directly to clinical implementation. These include (1) the use of BSH as a boron delivery agent for BNCT of patients with brain tumors, and more specifically gliomas; (2) the use of BPA as a delivery agent for BNCT for patients with melanomas and (3) its subsequent use for BNCT of patients with gliomas; (4) optimization of the delivery of BPA in patients with gliomas; and finally (5) the combination of BSH and BPA with BNCT alone or together with X-irradiation to treat patients with gliomas. (C) 2015 Elsevier Ltd. All rights reserved.
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