Review
Biochemistry & Molecular Biology
Imogen Morris, Cresci-Anne Croes, Marianne Boes, Eric Kalkhoven
Summary: Invariant natural killer T (iNKT) cells can be activated by binding antigenic lipid/CD1d complexes. Antigenic lipids are processed, loaded, and displayed by lipid antigen-presenting cells (LAPCs). Recent studies show that adipocytes, in addition to their role in lipid storage, can activate iNKT cells and play a role in metabolic disease. It is important to understand the parameters that determine cytokine output and how obesity-associated metabolic disease affects them.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Engineering, Environmental
Liang Zhang, Lilai Shen, Yizhou Huang, Shixuan Cui, Qiming Zhao, Chunlong Zhang, Shulin Zhuang, Guibin Jiang
Summary: This study identified the key signaling cascades involved in oxidative stress in zebrafish larvae and evaluated the cell cycle arrests and associated developmental alterations caused by UV-328 exposure. UV-328 inhibited the p38 MAPK/p53/Gadd45a regulatory circuit, leading to G1 phase cell cycle arrest and abnormal embryo hatching and heart rate.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ping Li, Yiting Yang, Zijin Lin, Shijin Hong, Ling Jiang, Han Zhou, Lu Yang, Liang Zhu, Xiaodong Liu, Li Liu
Summary: The study revealed that liver injury affects the function and expression of retinal Mrp1 in rats, activating the p38 MAPK pathway. These findings suggest that controlling liver function may help prevent the development of retinal diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Lea-Marie Jenster, Karl-Elmar Lange, Sabine Normann, Anja vom Hemdt, Jennifer D. Wuerth, Lisa D. J. Schiffelers, Yonas M. Tesfamariam, Florian N. Gohr, Laura Klein, Ines H. Kaltheuner, Stefan Ebner, Dorothee J. Lapp, Jacob Mayer, Jonas Moecking, Hidde L. Ploegh, Eicke Latz, Felix Meissner, Matthias Geyer, Beate M. Kuemmerer, Florian I. Schmidt
Summary: This study describes how p38 signaling activates human NLRP1 by direct phosphorylation, integrating various cellular stress signals relevant to the skin.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Quan Zhu, Kaixuan Li, Haozhen Li, Feng Han, Zhengyan Tang, Zhao Wang
Summary: This study investigated the molecular mechanism of ketamine-induced bladder fibrosis and found that ketamine abuse had fibrotic effects on both rat bladders and SV-HUC-1 cells. The study also revealed that Metadherin (MTDH) regulated the process of epithelial-mesenchymal transition (EMT) through the P38 mitogen-activated protein kinase (MAPK) pathway, contributing to bladder fibrosis progression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Ge Li, Lili Tang, Chunmei Hou, Zhiding Wang, Yang Gao, Shuaijie Dou, Rongliang Mo, Ying Hao, Zhenfang Gao, Yuxiang Li, Jie Dong, Jiyan Zhang, Beifen Shen, Renxi Wang, Gencheng Han
Summary: Viral encephalitis is a common and serious condition, with high morbidity and mortality rates. Research indicates that peripheral injection of Tim-3 antibody can attenuate vesicular stomatitis virus encephalitis by enhancing immune cell recruitment and promoting the activation of specific T cells, providing potential applications in combating viral encephalitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Jian Gao, Liancheng Zhu, Huiyu Zhuang, Bei Lin
Summary: High expression of HE4 and Lewis y antigen in ovarian cancer may serve as markers for chemotherapy resistance and poor prognosis. These expressions are correlated in various cancer tissues and may act by activating the p38 MAPK pathway and inducing VEGFA, PTGS2, EGR1, and HIFI1A, thereby promoting malignant biological behavior and resistance in ovarian cancer.
ADVANCES IN THERAPY
(2022)
Article
Chemistry, Medicinal
Guoqiang Li, Lei Duan, Fengbiao Yang, Liang Yang, Yajun Deng, Yue Yu, Yanlong Xu, Yinian Zhang
Summary: This study demonstrates the protective effect of curcumin on traumatic brain injury (TBI) and its molecular mechanisms involving the p38/MAPK signaling pathway. Curcumin ameliorates secondary brain injury and inflammation associated with TBI, indicating its potential as a therapeutic approach for TBI-related inflammation.
PHYTOTHERAPY RESEARCH
(2022)
Article
Immunology
Tingting Tan, Tao Li, Cheng Xiang, Zhengxiao Ouyang
Summary: Disruption of osteoclasts and osteoblasts balance can lead to bone diseases like osteoporosis. The study showed that toosendanin (TSN) attenuated RANKL-induced osteoclastogenesis in vitro by inhibiting p38 signaling. In a mouse model, TSN effectively inhibited the formation of TRAP-positive osteoclasts and protected against bone loss. These findings suggest the potential therapeutic use of TSN in osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Jun Yu, Yibo Wu, Hong Li, Hui Zhou, Cong Shen, Tingting Gao, Meng Lin, Xiuliang Dai, Jian Ou, Meiling Liu, Xiaoyan Huang, Bo Zheng, Fei Sun
Summary: The study identified BMI1 as a positive regulator of testosterone production, with the mechanism involving BMI1-mediated gene silencing to inhibit the p38 MAPK pathway and promote steroidogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Ruijie Dong, Zhenyi Xue, Guangyue Fan, Na Zhang, Chengzhi Wang, Guangliang Li, Yurong Da
Summary: Pin1 regulates NLRP3 inflammasome activation through the p38 MAPK signaling pathway in mice, impacting shock mortality and organ damage. Lack of Pin1 reduces NLRP3 inflammasome activation and secretion of inflammatory cytokines, suggesting Pin1 as a potential target for treating inflammatory diseases such as septic shock.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Ying Wei, Sichen Ren, Jian Wang, Yanling Wang, Yanfei Cui, Miao Tian, Ruilin Wang, Honghong Liu, Yanling Zhao
Summary: DHE alleviated dyspepsia, inflammatory infiltration, and tissue damage induced by IDO through the ERK and p38 signaling pathways rather than the JNK pathway.
Review
Pharmacology & Pharmacy
Nathalia Grave, Thamiris Becker Scheffel, Fernanda Fernandes Cruz, Liliana Rockenbach, Marcia Ines Goettert, Stefan Laufer, Fernanda Bueno Morrone
Summary: Gliomas are debilitating malignant brain tumors with limited response to therapies, driven by molecular abnormalities like mutations in regulatory networks. The MAPK pathway, particularly p38 MAPK activation, plays a crucial role in glioma cell invasion and metastasis, and is associated with tumor grade and chemotherapy resistance, underlining its potential as a therapeutic target.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Takuya Nagai, Tomohisa Sekimoto, Syuji Kurogi, Tomomi Ohta, Shihoko Miyazaki, Yoichiro Yamaguchi, Takuya Tajima, Etsuo Chosa, Mai Imasaka, Kumiko Yoshinobu, Kimi Araki, Masatake Araki, Narantsog Choijookhuu, Katsuaki Sato, Yoshitaka Hishikawa, Taro Funamoto
Summary: This study reveals that Tmem161a is a crucial regulator in bone structure and function. Depletion of Tmem161a leads to thicker and stronger bones in mice.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Huang Rui, Fang Zhao, Lei Yuhua, Jiang Hong
Summary: Myocardial fibrosis is a main pathological change of adverse cardiac remodeling and is associated with poor outcomes in heart disease patients. This study found that SMOC2 plays an important role in the development of cardiac fibrosis and could be a potential therapeutic target. The experiments showed that silencing the SMOC2 gene can alleviate cardiac fibrosis by inhibiting the induction of the ILK/p38 signaling pathway. These findings provide a preventative and control strategy for managing cardiac remodeling.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Arif Khan, Ahmed N. Aljarbou, Shamshir Khan, Masood A. Khan
Summary: This study reports a novel lipid-based drug encapsulation technique for the treatment of HER2-positive breast cancer. The technique demonstrates superior growth inhibition and gene silencing effects, offering a promising targeted treatment approach.
JOURNAL OF DRUG TARGETING
(2022)
Article
Biochemistry & Molecular Biology
Masood Alam Khan, Ajamaluddin Malik, Mohammad A. Alzohairy, Abdulmohsen M. Alruwetei, Bader Y. Alhatlani, Osamah Al Rugaie, Arif Khan
Summary: Advancements in nanotechnology have opened up possibilities for effective antiviral vaccines. Liposome-mediated delivery of antigens has shown promise in stimulating immune responses. In this study, dried, reconstituted vesicles were used as a vaccine carrier for the Middle East respiratory syndrome coronavirus 's papain-like protease. Immunization with these vesicles induced a higher immune response compared to traditional adjuvants. The results suggest that these vesicles may be an effective prophylactic formulation to prevent MERS-CoV infection.
Article
Pharmacology & Pharmacy
Faris Alrumaihi, Masood Alam Khan, Ali Yousif Babiker, Mohammed Alsaweed, Faizul Azam, Khaled S. Allemailem, Ahmad A. Almatroudi, Syed Rizwan Ahamad, Naif AlSuhaymi, Mahdi H. Alsugoor, Ahmed N. Algefary, Arif Khan
Summary: This study aimed to develop a novel formulation of DADS to enhance its therapeutic potential in treating colorectal cancer. The results showed that the formulated DADS significantly increased the sensitivity of colon cancer cells and induced apoptosis when combined with oxaliplatin. Molecular docking analysis identified potential targets of DADS and oxaliplatin.
Article
Pharmacology & Pharmacy
Arif Khan, Mohammed A. Alsahli, Mohammad A. Aljasir, Hamzah Maswadeh, Mugahid A. Mobark, Faizul Azam, Khaled S. Allemailem, Faris Alrumaihi, Fahad A. Alhumaydhi, Ameen S. S. Alwashmi, Ahmed A. Almatroudi, Mahdi H. Alsugoor, Masood A. Khan
Summary: A novel formulation of Thymoquinone (TQ), called PEG-coated DSPC/cholesterol comprising TQ liposomes (PEG-Lip-TQ), has been developed and shown to have high anticancer activity and low toxicity in lung cancer cells. This study suggests that PEG-Lip-TQ could be a potential treatment for lung cancer in clinical settings.
Article
Integrative & Complementary Medicine
Ayman M. Mousa, Khaled S. Allemailem, Fahad A. Alhumaydhi, Faris Alrumaihi, Ahmad Almatroudi, Mohammad Aljasir, Ameen S. S. Alwashmi, Osamah Al Rugaie, Khaled E. A. Soliman, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Ahmed A. Ahmed, Arif Khan, Masood A. Khan, Naif AlSuhaymi, Mahdi H. Alsugoor, Wafa Abdullah Al-Megrin, Abulmaaty M. Elsayed
Summary: This study investigated the effects of mesna + celery seed oil or mesna + manuka honey cotherapy against cyclophosphamide-induced hemorrhagic cystitis (HC). The results showed that the combination of mesna and manuka honey provided complete protection against HC and exhibited antioxidant, anti-inflammatory, and antifibrotic properties.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Faizul Azam, Masood Alam Khan, Arif Khan, Shifa Ahmad, Syeda Fauzia Farheen Zofair, Hina Younus
Summary: In this study, ellagic acid (EA) was found to inhibit the activity of Cryptococcus neoformans laccase and the proliferation of the yeast cells. The molecular basis of the interaction between laccase and EA was unveiled, providing insights for the development of laccase inhibitors as potential anti-cryptococcal agents.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Masood Alam Khan, Ajamaluddin Malik, Abdulmohsen M. Alruwetei, Mohammad A. Alzohairy, Bader Y. Alhatlani, Osamah Al Rugaie, Fahad A. Alhumaydhi, Arif Khan
Summary: In this study, the immune response of α-GalCer-Lip-MERS-CoV PLpro as a vaccine formulation was investigated using mouse models. The results showed that this formulation induced higher levels of antigen-specific antibodies, switching to a more antiviral IgG2a subclass, and increased lymphocyte proliferation. In addition, splenocytes from immunized mice secreted more cytokines. These findings suggest that α-GalCer-Lip-MERS-CoV PLpro may be a promising vaccine formulation for protecting against MERS-CoV infection.
JOURNAL OF DRUG TARGETING
(2022)
Article
Environmental Sciences
Syeda Fauzia Farheen Zofair, Sumbul Ahmad, Md. Amiruddin Hashmi, Shaheer Hasan Khan, Masood Alam Khan, Hina Younus
Summary: With the growth of industries, there is a high risk of exposure to emerging contaminants and increasing environmental pollution. Laccases, known as green catalysts, provide an eco-friendly solution for the degradation of these hazardous pollutants and have a wide range of applications in various industries. This review summarizes the catalytic behavior of laccases, immobilization strategies, and their potential applications in bioremediation.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Biochemistry & Molecular Biology
Faris Alrumaihi, Masood Alam Khan, Ali Yousif Babiker, Mohammed Alsaweed, Faizul Azam, Khaled S. Allemailem, Ahmad A. Almatroudi, Syed Rizwan Ahamad, Mahdi H. Alsugoor, Khloud Nawaf Alharbi, Nahlah Makki Almansour, Arif Khan
Summary: This study aimed to improve the bioavailability of diallyl trisulfide (DATS) and evaluate its chemopreventive and chemosensitizing properties in colorectal cancer. The research demonstrated that DATS can significantly lower the dosage of chemotherapy drugs in colon cancer cells and effectively inhibit AOM-induced colon cancer promotion. The combination of DATSL and DOXL showed promise as a treatment for colorectal cancer.
Article
Chemistry, Multidisciplinary
Khaled S. Allemailem, Habeeb Khadri, Mohd Azam, Masood Alam Khan, Arshad Husain Rahmani, Faris Alrumaihi, Riazunnisa Khateef, Mohammad Azam Ansari, Eid A. Alatawi, Mahdi H. Alsugoor, Nahlah Makki Almansour, Bader Y. Alhatlani, Ahmad Almatroudi
Summary: This study successfully biosynthesized and characterized silver nanoparticles using the seed extract of Ajwa dates, and found that they exhibited anti-bacterial and anti-cancer potential against bacterial strains and breast cancer cells.
APPLIED SCIENCES-BASEL
(2022)
Article
Immunology
Arif Khan, Mohammed A. Alsahli, Mohammad A. Aljasir, Hamzah Maswadeh, Mugahid A. Mobark, Faizul Azam, Khaled S. Allemailem, Faris Alrumaihi, Fahad A. Alhumaydhi, Ahmad A. Almatroudi, Naif AlSuhaymi, Masood A. Khan
Summary: This study successfully prepared a novel formulation of TQ and evaluated its potential in chemoprevention in a chemically induced lung cancer animal model. The results showed that TQPSL could restore lung organ weight, cancer marker enzyme levels, and serum antioxidant enzyme levels, reduce malignancy in the lungs, induce apoptosis, and decrease intracellular ROS levels. Furthermore, molecular docking results suggested that TQ may have a strong affinity for the BRAF target.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Masood Alam Khan, Khaled S. Allemailem, Hamzah Maswadeh, Hina Younus
Summary: This study aimed to develop a safe and effective vaccine formulation against Acinetobacter baumannii infection. Immunization with liposomes-encapsulated whole cell antigens induced higher levels of specific antibodies, lymphocyte proliferation, and Th1 cytokine secretion. Vaccinated mice showed the highest resistance to A. baumannii infection and lower levels of inflammatory markers. The findings suggest that liposomes-encapsulated whole cell antigens may be a potential vaccine formulation for protecting individuals against A. baumannii infection.
Article
Biochemistry & Molecular Biology
Masood Alam Khan, Khaled S. Allemailem, Hamzah Maswadeh, Hina Younus
Summary: It is incredibly important to develop an effective vaccine formulation against drug-resistant Acinetobacter baumannii. In this study, a liposomal vaccine formulation loaded with glycosphingolipids (GSLs) and whole cell antigen (WCAgs) of A. baumannii was prepared. The results showed that this vaccine formulation stimulated a greater immune response, reduced biofilm formation, and improved survival rate in immunized mice, suggesting its potential as a prophylactic vaccine against A. baumannii infection.
Article
Multidisciplinary Sciences
Ping Li, Julia R. Walsh, Kevin Lopez, Abdulkadir Isidan, Wenjun Zhang, Angela M. Chen, William C. Goggins, Nancy G. Higgins, Jianyun Liu, Randy R. Brutkiewicz, Lester J. Smith, Hidetaka Hara, David K. C. Cooper, Burcin Ekser
Summary: In vitro evaluation of human immune responses to genetically modified porcine cells provides an efficient method to identify ideal combinations of genetic modifications for improving pig-to-human compatibility, which should accelerate the application of xenotransplantation to humans.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Uzma Saqib, Masood A. Khan, Manikandan Alagumuthu, Suraj P. Parihar, Mirza S. Baig
Summary: Atherosclerosis, a widespread pathological coronary heart disease, is primarily caused by the accumulation of cholesterol-laden macrophages in the artery wall, leading to the formation of foam-cells. Increased influx of oxidized LDL and decreased efflux of free cholesterol from macrophages are major factors in the progression of the disease. Studies on natural compounds effective for AS have increased, with an emphasis on plant-based compounds with potential therapeutic implications.
CELLULAR AND MOLECULAR BIOLOGY
(2021)