Article
Biochemistry & Molecular Biology
Changshou Wang, Lin Xu, Chen Du, Hao Yun, Keyun Wang, Hui Liu, Mingliang Ye, Jing Fan, Yu Zhou, Hong Cheng
Summary: CDK11 is a potential druggable target for cancer therapy, as it plays important roles in phosphorylating transcription and splicing factors and facilitating cell cycle progression in cancer cells. This study reveals that CDK11 forms a tight complex with cyclins L1/L2 and SAP30BP, and that SAP30BP is a critical activator of CDK11, regulating global pre-mRNA splicing.
Article
Biochemistry & Molecular Biology
Kazuhiro Maeta, Manal Farea, Hisahide Nishio, Masafumi Matsuo
Summary: This study identified a novel antisense oligonucleotide called KMM001 that inhibits the maturation of myostatin mRNA, resulting in decreased myostatin protein levels. KMM001 also inhibits SMAD-mediated myostatin signaling and promotes human myoblast proliferation. These findings suggest that KMM001 has potential therapeutic applications for muscle-wasting conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Genetics & Heredity
Raymond Kaempfer
Summary: The activation of PKR by double-helical RNA, especially viral RNA during replication, inhibits translation. However, short intragenic elements in specific genes can strongly activate PKR and improve mRNA splicing efficiency without affecting translation. HIV is the first virus to use this mechanism to promote splicing.
Article
Cardiac & Cardiovascular Systems
Julie W. Doberne, Oliver K. Jawitz, Vignesh Raman, Benjamin S. Bryner, Jacob N. Schroder, Carmelo A. Milano
Summary: This study compared the survival outcomes of heart transplantation in HIV-positive recipients with those of HIV-negative recipients, finding no difference in survival rates at 30 days, 1 year, and 5 years. HIV-positive recipients had higher rates of acute rejection and administration of antirejection treatments, but showed no significant difference in long-term survival compared to HIV-negative recipients.
ANNALS OF THORACIC SURGERY
(2021)
Article
Developmental Biology
Ching-In Lau, Jasmine Rowell, Diana C. Yanez, Anisha Solanki, Susan Ross, Masahiro Ono, Tessa Crompton
Summary: Foxa1 and Foxa2 are required during positive selection to regulate alternative splicing of genes essential for T-cell development, and they exert widespread control of alternative splicing by also regulating splicing of splicing factors. Multiple differentially used exons were observed in genes important for T-cell development and splicing factors in the double Foxa1/Foxa2 conditional knockout.
Article
Biochemistry & Molecular Biology
Shune Wang, Mei Xue, Chan He, Danyu Shen, Chunhao Jiang, Hongwei Zhao, Dongdong Niu
Summary: The study reveals that AtMC1 regulates plant immunity to bacterial pathogens and is physically associated with LSM4. The protein levels of AtMC1 and LSM4 increase with coexpression in vivo. Additionally, AtMC1 modulates the splicing of pre-mRNAs, including 4CL3, which regulates plant immunity.
MOLECULAR PLANT-MICROBE INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Irfana Saleem, Sameer Mirza, Aniruddha Sarkar, Mohsin Raza, Bhopal Mohapatra, Insha Mushtaq, Jun Hyun Kim, Nitish K. Mishra, Mansour A. Alsaleem, Emad A. Rakha, Fang Qiu, Chittibabu Guda, Hamid Band, Vimla Band
Summary: The mammalian orthologue of ECD protein plays important roles in embryogenesis, cell cycle progression, and mitigating endoplasmic reticulum stress. ECD interacts with key components of mRNA export complexes and the DEAD BOX protein helicase DDX39A to facilitate RNA export, with its overexpression correlating with poor patient survival in ErbB2+ and triple-negative breast cancer.
MOLECULAR AND CELLULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Evan P. Booy, Daniel Gussakovsky, Taegi Choi, Sean A. McKenna
Summary: BC200 is a noncoding RNA that plays a critical role in cell viability, invasion, and migration in tumor cells, acting as a negative regulator of translation. Overexpression studies have shown that BC200 is associated with increased translation levels and binds to ribosomal subunits and polysomal RNA. These findings suggest a novel understanding of BC200 function and have implications for the study of noncoding RNAs and translational regulatory mechanisms.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Zhihao Chen, Yangke Cun, Shilei Yan, Yingzhu Zi, Bokun Zhu, Keliang Ruan, Bojie Ding, Zhengmeng Yang, Asif Ali Haider, Imran Khan, Cherkasova Tatiana, Jianbei Qiu, Anjun Huang, Yue Liu, Zhengwen Yang
Summary: In this study, Yb2W3O12:Er negative thermal expansion (NTE) materials were prepared to achieve thermal enhancement of upconversion and NIR downshift luminescence. Additionally, a mixed phosphor was developed to address the limitations of thermal quenching and thermal coupling energy in temperature sensors using non-contact fluorescence intensity ratio (FIR) measurements.
SCIENCE CHINA-MATERIALS
(2023)
Article
Medicine, General & Internal
Hailu Tilahun, Sarah J. Masyuko, Jerusha N. Mogaka, Tecla Temu, John Kinuthia, Alfred O. Osoti, Damalie Nakanjako, Carey Farquhar, Stephanie T. Page
Summary: The prevalence of dyslipidemia is high in Western Kenya, but not significantly associated with HIV status or HIV-specific factors. Older age, being overweight, abdominal obesity, and low fruit and vegetable intake are associated with dyslipidemia.
Article
Forestry
Florian Hartsch, Felix A. Dreger, Martin Englund, Even Hoffart, Gerhard Rinkenauer, Thilo Wagner, Dirk Jaeger
Summary: The variance in productivity of fully mechanized timber harvesting can be attributed to different work practices of machine operators. Identifying positive and negative work practices is crucial for improving forest work efficiency. Interviews with forest machine operator instructors and a literature review showed that positive work practices include using optimal working ranges, frequent machine repositioning, matching operator skill and crane speed, and using appropriate pile sizes. However, there is a knowledge gap related to quantifying work practices.
Article
Pediatrics
Candice W. Ramsammy, Lisa Galvin, Celeste Joyce, Given Leshabane, Janice Buckley, Kennedy Otwombe, Afaaf Liberty, Avy Violari
Summary: This study describes the responses of children during a longitudinal disclosure study conducted in South Africa. The findings show that children who received full disclosure had mixed responses, with many experiencing strong negative emotions. However, through reassurance and subsequent counseling sessions, some children showed emotional improvement. The study also observed improvements in the communication and relationship between caregivers and children. Nevertheless, some children were avoidant of the topic of HIV.
FRONTIERS IN PEDIATRICS
(2022)
Article
Virology
Ongeziwe Taku, Zizipho Z. A. Mbulawa, Keletso Phohlo, Mirta Garcia-Jardon, Charles B. Businge, Anna-Lise Williamson
Summary: South African women in the Eastern Cape province have a high prevalence of HPV infection in CIN, especially in HIV-positive individuals. The study found a higher rate of multiple HPV types in HIV-positive women and identified common HPV genotypes in CIN2 and CIN3 cases. The nonavalent HPV vaccine could offer some benefits in preventing CIN2 and CIN3 in both HIV-negative and HIV-positive women, although complete protection may not be guaranteed.
Article
Virology
Sizhu Duan, Xin Yu, Chu Wang, Lina Meng, Yanxin Gai, Yan Zhou, Tiejun Gu, Bin Yu, Jiaxin Wu, Xianghui Yu
Summary: This study identified Vif mutants with high affinity for CBF beta, which could rescue APOBEC3s and restrict HIV-1 replication. Among them, Vif-6M showed cross-protection effect towards multiple APOBEC3s and inhibited viral replication in T lymphocytes. These findings suggest that Vif mutants targeting the Vif-CBF beta interaction hold promise as a new therapeutic strategy for HIV/AIDS.
JOURNAL OF VIROLOGY
(2022)
Article
Behavioral Sciences
Yu-Ming Chen, Chieh-Hsin Lin, Hsien-Yuan Lane
Summary: The study found that patients with schizophrenia had lower levels of DISC1 mRNA compared to healthy individuals, and that patients with lower DISC1 mRNA levels were more likely to exhibit more severe symptoms, including positive, negative, and depressive symptoms.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)