Review
Pharmacology & Pharmacy
Yiwei Huang, Yuyun Song, Jichen Li, Changning Lv, Zhe-Sheng Chen, Zhijun Liu
Summary: Human herpes simplex viruses use cell surface receptors such as heparan sulfate, herpesvirus entry mediator, and nectin-1/-2, 3-O-sulfated heparan sulfate to enter host cells. No vaccine or curative treatment is currently available for HSV infections.
DRUG DISCOVERY TODAY
(2022)
Article
Biochemistry & Molecular Biology
Bishajit Sarkar, Md. Asad Ullah, Yusha Araf, Sowmen Das, Md. Hasanur Rahman, Abu Tayab Moin
Summary: HSV is a highly infectious virus with two types, HSV-1 and HSV-2, infecting millions worldwide. This study designed three polyvalent subunit vaccines targeting multiple strains of HSV, which showed stability and potential effectiveness through molecular docking and simulation studies. Validation of these vaccines in wet lab-based studies is still needed.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Biotechnology & Applied Microbiology
Christina Seisenberger, Tobias Graf, Markus Haindl, Harald Wegele, Michael Wiedmann, Stefanie Wohlrab
Summary: Through a study comparing ELISAs and 2D-WBs for HCP monitoring, it was found that ELISAs are better suited for accurate detection of HCPs, while 2D-WBs have some limitations.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Article
Virology
Qing Fan, Richard Longnecker, Sarah A. Connolly
Summary: The viral fusion protein glycoprotein B (gB) is essential for virus entry in all herpesviruses. By introducing structure-based mutations, researchers identified mutations that counteracted a slow-entry phenotype in the virus and found that these mutations were located in different regions of the gB protein.
JOURNAL OF VIROLOGY
(2021)
Article
Pathology
Melissa Krystel-Whittemore, May P. Chan, Sara C. Shalin, Kenan J. Sauder, Amy Hudson, Ruth K. Foreman, Mai P. Hoang, Jeoffry B. Brennick, Shaofeng Yan, Rosalynn M. Nazarian
Summary: This study presents the first known report of herpes virus infecting deep stromal cells of the dermis, highlighting the importance of considering cutaneous stromal herpes in patients with atypical clinical lesions, especially when immunocompromised. Establishing the correct diagnosis is crucial for initiating therapy.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Dermatology
Deepthi Konda, Laxmisha Chandrashekar, Rahul Dhodapkar, Rajesh Nachiappa Ganesh, Devinder Mohan Thappa
Summary: This study characterized the clinical markers of herpes simplex virus (HSV) infection among patients with pemphigus vulgaris. It was found that male sex, presence of fissures, hemorrhagic crusts, erosions with angulated margins, linear erosions, and raised erythrocyte sedimentation rate were significantly associated with HSV infection. Hemorrhagic crusts and linear erosions were identified as independent predictors of HSV infection.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zipora Tietel, Sarit Melamed, Noy Eretz-Kdosha, Ami Guetta, Raanan Gvirtz, Navit Ogen-Shtern, Arnon Dag, Guy Cohen
Summary: Jojoba wax does not affect the growth of Staphylococcus aureus, Staphylococcus epidermidis, and Malassezia furfur, but significantly attenuates HSV-1 plaque formation. Different varieties of Jojoba wax show a high potency anti-viral effect against HSV-1 infection.
Article
Immunology
Malgorzata Krzyzowska, Anders Jarneborn, Karolina Thorn, Kristina Eriksson, Tao Jin
Summary: This study provides evidence that treatment with tofacitinib may increase the risk of disease aggravation and severe encephalitis in primary herpes simplex infection by impairing antiviral response induced by monocytes and microglia.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Cooper K. Hayes, Christopher K. Villota, Fiona B. McEnany, Stacey Ceron, Sita Awasthi, Moriah L. Szpara, Harvey M. Friedman, David A. Leib, Richard Longnecker, Matthew D. Weitzman, Lisa N. Akhtar
Summary: Clinical HSV-2 isolates collected from neonates with encephalitis are more neurovirulent in human neuronal cell culture and murine models as compared to isolates from neonates with skin-limited disease, suggesting that viral factors contribute to neurologic outcome following human neonatal infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Virology
Bangxing Hong, Upasana Sahu, Matthew P. Mullarkey, Balveen Kaur
Summary: Oncolytic herpes simplex virus (oHSV) shows promise as a treatment for solid tumors, but there are still barriers that limit its efficacy. This review focuses on the essential viral genes that allow for virus replication and spread, with the aim of enhancing oHSV infection and replication among tumor cells.
Article
Microbiology
Kevin Danastas, Gerry Guo, Jessica Merjane, Nathan Hong, Ava Larsen, Monica Miranda-Saksena, Anthony L. Cunningham
Summary: This study explores the effects of interferons (IFNs) on herpes simplex virus-1 (HSV-1) and reveals that IFNs have the potential to block virus release from nerve endings, thereby preventing transmission into the skin. The study also highlights the potential wider antiviral effects of IFN-γ in neurons, suggesting its role in HSV-1 reactivation. These findings identify new targets for the development of immunotherapies to impede HSV-1 spread from nerves to the skin.
Article
Medicine, Research & Experimental
Catielen Paula Pavi, Isabella Dai Pra, Rafael Dorighello Cadamuro, Isamu Kanzaki, Jhuly Wellen Ferreira Lacerda, Louis Pergaud Sandjo, Roberto Messias Bezerra, Jorge Federico Orellana Segovia, Gislaine Fongaro, Izabella Thais Silva
Summary: This study evaluated the activity of seventeen extracts derived from eight Amazonian medicinal plants against herpes simplex virus and chikungunya virus. Four extracts exhibited significant activity against both viruses, including the drug-resistant strains. Virucidal tests showed a higher level of virucidal activity compared to antiviral activity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Infectious Diseases
Kanyaluck Jantakee, Panchika Prangkio, Aussara Panya, Yingmanee Tragoolpua
Summary: HSV infections are common worldwide and can cause life-threatening diseases. Silk extracts from silkworm cocoons, particularly the non-sericin extract, show potential antiviral activity against HSV-1 and HSV-2, as well as virucidal effects. Treatment with non-sericin extract in HSV-2-infected cells can reduce cell death and inflammation.
Article
Virology
Mashidur Rana, Mizumi Setia, Pratima K. Suvas, Anish Chakraborty, Susmit Suvas
Summary: Reactive oxygen species (ROS) play a crucial role in herpes stromal keratitis (HSK), with neutrophils being the primary cells responsible for ROS generation. NOX2 is involved in ROS production in neutrophils. However, manipulating ROS levels in neutrophils may help alleviate the severity of HSK, and NOX2 is not the main contributor to ROS generation in neutrophils.
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Edward Trybala, Nadia Peerboom, Beata Adamiak, Malgorzata Krzyzowska, Jan-Ake Liljeqvist, Marta Bally, Tomas Bergstrom
Summary: The study shows that the HSV-2 mutant deficient in mgG expression has a defect in releasing progeny virions from infected cells. The mgG of HSV-2 plays a critical role in balancing virus interactions with GAG chains, preventing trapping of progeny virions on infected cell surfaces. This balance is necessary to ensure proper release of virions.
Article
Infectious Diseases
K. Steinhagen, C. Probst, C. Radzimski, J. Schmidt-Chanasit, P. Emmerich, M. van Esbroeck, J. Schinkel, M. P. Grobusch, A. Goorhuls, J. M. Warnecke, E. Lattwein, L. Komorowski, A. Deerberg, S. Saschenbrecker, W. Stoecker, W. Schlumberger
Article
Clinical Neurology
Patrick Waters, Markus Reindl, Albert Saiz, Kathrin Schanda, Friederike Tuller, Vlastimil Kral, Petra Nytrova, Ondrej Sobek, Helle Hvilsted Nielsen, Torben Barington, Soren T. Lillevang, Zsolt Illes, Kristin Rentzsch, Achim Berthele, Timea Berki, Letizia Granieri, Antonio Bertolotto, Bruno Giometto, Luigi Zuliani, Dorte Hamann, E. Danielle van Pelt, Rogier Hintzen, Romana Hoeftberger, Carme Costa, Manuel Comabella, Xavier Montalban, Mar Tintore, Aksel Siva, Ayse Altintas, Gunnur Deniz, Mark Woodhall, Jacqueline Palace, Friedemann Paul, Hans-Peter Hartung, Orhan Aktas, Sven Jarius, Brigitte Wildemann, Christian Vedeler, Anne Ruiz, M. Isabel Leite, Peter Trillenberg, Monika Probst, Sandra Saschenbrecker, Angela Vincent, Romain Marignier
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2016)
Article
Clinical Neurology
Liane Dahm, Christoph Ott, Johann Steiner, Beata Stepniak, Bianca Teegen, Sandra Saschenbrecker, Christian Hammer, Kathrin Borowski, Martin Begemann, Sandra Lemke, Kristin Rentzsch, Christian Probst, Henrik Martens, Juergen Wienands, Gianfranco Spalletta, Karin Weissenborn, Winfried Stoecker, Hannelore Ehrenreich
ANNALS OF NEUROLOGY
(2014)
Article
Dermatology
Jana Langenhan, Jenny Dworschak, Sandra Saschenbrecker, Lars Komorowski, Wolfgang Schlumberger, Winfried Stoecker, Juergen Westermann, Andreas Recke, Detlef Zillikens, Enno Schmidt, Christian Probst
EXPERIMENTAL DERMATOLOGY
(2014)
Article
Medical Laboratory Technology
Jing Li, Ying Shen, Jing He, Rulin Jia, Xiujie Wang, Xiaosan Chen, Dahai Wang, Lei Han, Lei Zhu, Xiaofeng Chi, Sandra Saschenbrecker, Cornelia Daehnrich, Winfried Stoecker, Wolfgang Schlumberger, Zhan-Guo Li
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2013)
Article
Clinical Neurology
W. Stoecker, S. Saschenbrecker, K. Rentzsch, L. Komorowski, C. Probst
Editorial Material
Clinical Neurology
Harald Pruess, Marcus Rothkirch, Ute Kopp, Hajo M. Hamer, Mareike Hagge, Phillipp Sterzer, Sandra Saschenbrecker, Winfried Stoecker, Lutz Harms, Matthias Endres
Review
Clinical Neurology
Christian Probst, Sandra Saschenbrecker, Winfried Stoecker, Lars Komorowski
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2014)
Article
Virology
Ramona Dolscheid-Pommerich, Eva Bartok, Marcel Renn, Beate M. Kuemmerer, Bianca Schulte, Ricarda M. Schmithausen, Birgit Stoffel-Wagner, Hendrik Streeck, Sandra Saschenbrecker, Katja Steinhagen, Gunther Hartmann
Summary: This study analyzed the correlation between binding IgG and neutralizing antibodies in COVID-19 patients, revealing a strong positive relationship and supporting the use of QuantiVac ELISA to assess protective immunity post-infection or vaccination.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Yasemin Cosgun, Ahmet Aydemir, Hakan Hedef, Ayten Oz Kamiloglu, Oliver Klemens, Erik Lattwein, Julia Maria Klemens, Sandra Saschenbrecker, Katja Steinhagen, Gulay Korukluoglu
Summary: This study evaluated the performance of the new EUROIMMUN anti-CCHFV IgM and IgG enzyme-linked immunosorbent assays (ELISAs). The results showed that these ELISAs have high sensitivity and specificity, with strong concordance and correlation with other reference methods. Therefore, these new ELISAs can be used for reliable identification of acute CCHF cases in on-site outbreak support situations.
VECTOR-BORNE AND ZOONOTIC DISEASES
(2023)
Article
Immunology
Yasemin Cosgun, Nergis Emanet, Ayten Oz Kamiloglu, Evelin Grage-Griebenow, Susann Hohensee, Sandra Saschenbrecker, Katja Steinhagen, Gulay Korukluoglu
Summary: This study analyzes the short-term humoral responses against the SARS-CoV-2 spike and nucleocapsid protein in 50 Turkish adults after CoronaVac immunization. The results showed that two doses of CoronaVac vaccine significantly increased antibodies against the spike protein and nucleocapsid. The responses to the spike protein were stronger than those to the nucleocapsid.
Article
Medicine, General & Internal
John B. Carter, Sara Carter, Sandra Saschenbrecker, Bruce E. Goeckeritz
FRONTIERS IN MEDICINE
(2018)
Article
Health Care Sciences & Services
Barbara Strobino, Katja Steinhagen, Wolfgang Meyer, Thomas Scheper, Sandra Saschenbrecker, Wolfgang Schlumberger, Winfried Stoecker, Andrea Gaito, Brian A. Fallon
Article
Immunology
Sabine L. Kramp, Dmitry Karayev, Guo Shen, Allan L. Metzger, Robert I. Morris, Eugene Karayev, Yvonne Lam, Richard M. Kazdan, Ger J. M. Pruijn, Sandra Saschenbrecker, Cornelia Daehnrich, Wolfgang Schlumberger
AUTOIMMUNITY HIGHLIGHTS
(2016)
Article
Clinical Neurology
Harald Pruess, Christian Hoffmann, Werner Stenzel, Sandra Saschenbrecker, Martin Ebinger
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2014)
Article
Biochemical Research Methods
Atif Khurshid Wani, Chirag Chopra, Daljeet Singh Dhanjal, Nahid Akhtar, Himanshu Singh, Poorvi Bhau, Anjuvan Singh, Varun Sharma, Rafael Silvio Bonilha Pinheiro, Juliana Heloisa Pine Americo-Pinheiro, Reena Singh
Summary: Zoonotic viral infections pose significant threats to global public health. Understanding the origins and dynamics of these infections is crucial for prevention and management of future outbreaks. Metagenomics is a powerful tool for studying the diversity of viral populations and potential zoonotic events.
JOURNAL OF VIROLOGICAL METHODS
(2024)
Article
Biochemical Research Methods
Michel V. F. Sucupira, Ana P. C. Argondizzo, Mariana Miguez, Anna E. de Araujo, Leila B. R. Silva, Marcelle B. Mello, Christiane F. S. Marques, Danielle Brito Cunha, Renata C. Bastos, Vanessa S. de Paula, Luciane A. Amado Leon
Summary: This study focuses on improving the purification, solubility, and protein expression levels of recombinant VP1-2A, a hepatitis A virus (HAV) structural protein with immunogenic activity. The results show that the modified approach successfully produces biologically active HAV VP1-2A, which can be used as a diagnostic tool for HAV infection.
JOURNAL OF VIROLOGICAL METHODS
(2024)
Article
Biochemical Research Methods
Arun K. Dhar, Roberto Cruz-Flores, Hung N. Mai, Janet Warg
Summary: A sensitive and robust TaqMan PCR method for detecting IHHNV in three commercially important shrimp species was developed and compared with other published methods. Multiple primer/probe sets, including qIH-Fw/qIH-Rv and 3144F/3232R, are recommended for the detection of IHHNV. These findings are valuable for large-scale screening of shrimp using a TaqMan real-time PCR assay.
JOURNAL OF VIROLOGICAL METHODS
(2024)
Article
Biochemical Research Methods
Kemal Mehinagic, Matthias Liniger, Maksym Samoilenko, Nick Soltermann, Markus Gerber, Nicolas Ruggli
Summary: A plasmid-based reporter assay has been developed for sensitive detection and titration of infectious African swine fever virus (ASFV). This novel method allows accurate measurement of ASFV titers and is applicable to ASFV of different genotypes, virulence, and sources.
JOURNAL OF VIROLOGICAL METHODS
(2024)
Article
Biochemical Research Methods
Jan Van Slambrouck, Charlotte Schoenaers, Lies Laenen, Xin Jin, Kurt Beuselinck, Ann Verdonck, Joost Wauters, Geert Molenberghs, Bart M. Vanaudenaerde, Robin Vos, Peter Mombaerts, Katrien Lagrou, Laurens J. Ceulemans
Summary: The ability to detect SARS-CoV-2 RNA or antigen in BAL fluid samples using point-of-care tests (POCTs) can reduce the risk of developing severe COVID-19 after lung transplantation.
JOURNAL OF VIROLOGICAL METHODS
(2024)