The presence of resistance mutations to protease and polymerase inhibitors in Hepatitis C virus sequences from theLos Alamosdatabank

HCV Genotypes Are Differently Prone to the Development of Resistance to Linear and Macrocyclic Protease Inhibitors

(2012) Valeria Cento et al.   PLoS One

Highly Sensitive and Specific Detection of Rare Variants in Mixed Viral Populations from Massively Parallel Sequence Data

(2012) Alexander R. Macalalad et al.   PLoS Computational Biology

Hepatitis C viral kinetics with the nucleoside polymerase inhibitor mericitabine (RG7128)

(2011) Jeremie Guedj et al.   HEPATOLOGY

Combined X-ray, NMR, and Kinetic Analyses Reveal Uncommon Binding Characteristics of the Hepatitis C Virus NS3-NS4A Protease Inhibitor BI 201335

(2011) Christopher T. Lemke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations selected in the hepatitis C virus NS3 protease domain during sequential treatment with boceprevir with and without pegylated interferon alfa-2b

(2011) J. Vermehren et al.   JOURNAL OF VIRAL HEPATITIS

MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods

(2011) K. Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

Boceprevir for Untreated Chronic HCV Genotype 1 Infection

(2011) Fred Poordad et al.   NEW ENGLAND JOURNAL OF MEDICINE

Boceprevir for Previously Treated Chronic HCV Genotype 1 Infection

(2011) Bruce R. Bacon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Telaprevir for Retreatment of HCV Infection

(2011) Stefan Zeuzem et al.   NEW ENGLAND JOURNAL OF MEDICINE

Telaprevir for Previously Untreated Chronic Hepatitis C Virus Infection

(2011) Ira M. Jacobson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ultra-deep sequencing for the analysis of viral populations

(2011) Niko Beerenwinkel et al.   Current Opinion in Virology

Resistance Analysis of the Hepatitis C Virus NS5A Inhibitor BMS-790052 in an In Vitro Replicon System

(2010) R. A. Fridell et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435

(2010) O. Lenz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Susceptibility of Treatment-Naive Hepatitis C Virus (HCV) Clinical Isolates to HCV Protease Inhibitors

(2010) A. Bae et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The resistance mutation R155K in the NS3/4A protease of hepatitis C virus also leads the virus to escape from HLA-A*68-restricted CD8 T cells

(2010) Shadi Salloum et al.   ANTIVIRAL RESEARCH

New HCV therapies on the horizon

(2010) J. Vermehren et al.   CLINICAL MICROBIOLOGY AND INFECTION

Evolving epidemiology of hepatitis C virus

(2010) D. Lavanchy   CLINICAL MICROBIOLOGY AND INFECTION

New NS5B polymerase inhibitors for hepatitis C

(2010) Florence Legrand-Abravanel et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Protease Inhibitor–Resistant Hepatitis C Virus Mutants With Reduced Fitness From Impaired Production of Infectious Virus

(2010) Tetsuro Shimakami et al.   GASTROENTEROLOGY

Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice

(2010) Eiji Ohara et al.   JOURNAL OF HEPATOLOGY

Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial

(2010) Edward J Gane et al.   LANCET

Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients

(2009) Simone Susser et al.   HEPATOLOGY

Conservation of hepatitis C virus nonstructural protein 3 amino acid sequence in viral isolates during liver transplantation

(2009) I. M. V. G. C. Mello et al.   JOURNAL OF VIRAL HEPATITIS

Review: Hepatitis C Protease and Polymerase Inhibitors in Development

(2008) Gustine Liu-Young et al.   AIDS PATIENT CARE AND STDS

Selection of Replicon Variants Resistant to ACH-806, a Novel Hepatitis C Virus Inhibitor with No Cross-Resistance to NS3 Protease and NS5B Polymerase Inhibitors

(2008) W. Yang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Selection and Characterization of Hepatitis C Virus Replicons Dually Resistant to the Polymerase and Protease Inhibitors HCV-796 and Boceprevir (SCH 503034)

(2008) M. Flint et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization of resistance mutations against HCV ketoamide protease inhibitors

(2008) X TONG et al.   ANTIVIRAL RESEARCH

Resistance mechanisms in HCV: from evolution to intervention

(2008) Arthur Y Kim et al.   Expert Review of Anti-Infective Therapy

Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: Role of CD81 and scavenger receptor class B type I and effect of antiviral drugs

(2008) Judith M. Gottwein et al.   HEPATOLOGY

Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus

(2008) Christoph Welsch et al.   GENOME BIOLOGY

Naturally occurring NS3-protease-inhibitor resistant mutant A156T in the liver of an untreated chronic hepatitis C patient

(2007) Maria Cubero et al.   VIROLOGY