Article
Medicine, General & Internal
Ling Tong, Cuilin Yan, Minjie Wang, Jiajia Yang, Hongmei Wang, Ying Wang
Summary: The study revealed that serum exosomal AHCY expression is significantly elevated in HBV-LC patients and has a significant positive correlation with the MELD score. It serves as a novel potential prognostic biomarker with great significance for the prognosis of HBV-LC patients.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Kai Yang, Ying Pan, Lei Jin, Furong Yu, Fasu Zhang
Summary: Iron metabolism disorder is closely related to acute-on-chronic liver failure (ACLF). This study aimed to analyze the levels of soluble transferrin receptor (sTfR) in hepatitis B virus (HBV)-related ACLF and evaluate its predictive value for short-term prognosis. The results showed that decreased sTfR levels were independently associated with 30-day mortality in HBV-ACLF patients, suggesting its potential as a predictor.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Immunology
Cheng-Xi Sun, Li-Yan Han, Kai Wang, Shuai Gao
Summary: This study found that serum exosomal lncRNA GAS5 may play a potential role in acute-on-chronic hepatitis B liver failure (ACHBLF) and has predictive value for 3-month mortality.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Jian Zhang, Yu Chen, Zhongping Duan
Summary: This study aimed to develop a prediction model for the prognosis of patients with Hepatitis B virus-related acute-on-chronic liver failure. The results showed that FT3 and Na were protective factors for the prognosis of patients, while age, TBil, INR, HE grading, and Cr were risk factors. The FT3-related prediction model had good predictive value for the 90-day prognosis.
Article
Biochemistry & Molecular Biology
Meera Shanmuganathan, Mohammad Omair Sarfaraz, Zachary Kroezen, Holly Philbrick, Richel Poon, Andrew Don-Wauchope, Marco Puglia, David Wishart, Philip Britz-McKibbin
Summary: Metabolomics using MSI-CE-MS and NMR techniques compared serum metabolome of HCV patients with liver fibrosis and non-HCV controls, revealing elevated serum choline and histidine in late-stage liver fibrosis. Serum choline to uric acid ratio provided optimal differentiation of liver disease severity.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Gastroenterology & Hepatology
Jun-feng Chen, Wei-zhen Weng, Miao Huang, Xiao-hua Peng, Jing Zhang, Jing Xiong, Jian-rong He, Shao-quan Zhang, Hui-juan Cao, Bin Gao, Deng-na Lin, Juan Gao, Zhi-liang Gao, Bing-liang Lin
Summary: This study analyzed the impact of serum TSH levels on the prognosis of patients with HBV-related ACLF. The results showed that higher TSH levels were associated with higher 30-day and 90-day survival rates. The findings suggest that serum TSH levels may be useful for predicting the survival of patients with HBV-related ACLF.
BMC GASTROENTEROLOGY
(2022)
Article
Immunology
Sylvia M. Brakenhoff, Robert J. de Knegt, Jeffrey Oliveira, Annemiek A. van der Eijk, Anneke J. van Vuuren, Bettina E. Hansen, Harry L. A. Janssen, Robert A. de Man, Andre Boonstra, Milan J. Sonneveld
Summary: In patients with chronic hepatitis B treated with peginterferon, higher levels of antibodies to hepatitis B core antigen were associated with more intrahepatic inflammatory activity and favorable treatment responses, highlighting the importance of B-cell activation in controlling hepatitis B virus replication.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Iva Klobucar, Luka Vidovic, Ilona Arih, Margarete Lechleitner, Gudrun Pregartner, Andrea Berghold, Hansjorg Habisch, Tobias Madl, Sasa Frank, Vesna Degoricija
Summary: Using NMR spectroscopy to measure serum metabolite levels, it was found that valine serum levels might have prognostic value for 1-year mortality in patients with acute heart failure.
Article
Biochemistry & Molecular Biology
Tong Yue, Huiling Tan, Yu Shi, Mengyun Xu, Sihui Luo, Jianping Weng, Suowen Xu
Summary: This study investigated the changes in metabolism during aging using machine learning and identified biomarkers associated with aging. The findings provide insights into potential therapeutic targets for delaying the effects of aging.
Review
Immunology
Jiajia Yang, Dawei Wang, Yuancheng Li, Hongmei Wang, Qiang Hu, Ying Wang
Summary: Viral hepatitis is a global public health issue, causing significant morbidity and mortality. The burden of viral hepatitis is mainly caused by five unrelated hepatotropic viruses: HAV, HBV, HCV, HDV, and HEV. Metabolomics, an emerging technology, can provide information about metabolic levels and changes in metabolic pathways. Changes in glucose, lipid, and amino acid levels are associated with the pathogenesis and medication mechanism of viral hepatitis. Differential metabolites can be used as biomarkers for diagnosis, prognosis, and therapeutic responses. This review provides a comprehensive overview of metabolomics in viral hepatitis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Oncology
Feng Li, Ying Zhang, Zhao-Hui Wang, Shuai Gao, Yu-Chen Fan, Kai Wang
Summary: Glucocorticoid treatment can reduce mortality in patients with acute-on-chronic hepatitis B liver failure (ACHBLF). The methylation of suppressor of cytokine signaling (SOCS) 1 is associated with mortality in ACHBLF patients.
CLINICAL EPIGENETICS
(2023)
Article
Medicine, General & Internal
Na Hu, Xian-Ci Xie, Lin-Lin Liu, Wei-Dong Lai
Summary: The study identified UBE2Q1 gene promoter methylation as a potential biomarker for predicting and diagnosing ACHBLF, with hypomethylation associated with the severity of the condition. The UBE2Q1 promoter methylation status combined with the model for end-stage liver disease score showed high sensitivity and specificity for early diagnosis of ACHBLF.
Article
Biochemistry & Molecular Biology
Ruben Araujo, Luis F. N. Bento, Tiago A. H. Fonseca, Cristiana P. P. Von Rekowski, Bernardo Ribeiro da Cunha, Cecilia R. C. Calado
Summary: Current infection biomarkers have limitations in predicting infection and disease outcomes, and have limited applications. Therefore, it is crucial to discover new and effective clinical infection biomarkers that can help physicians better manage patients, reduce severe outcomes, personalize therapies, minimize antibiotics overuse and hospitalization time, and significantly improve patient survival. Metabolomics provides a promising strategy to discover these biomarkers by directly examining the functional metabolic outcomes.
Article
Immunology
Wenqian Zhang, Hongjun Zhao, Pei Du, Haobo Cui, Shuang Lu, Zhongyuan Xiang, Qianjin Lu, Sujie Jia, Ming Zhao
Summary: This study identified biomarkers associated with different clinical phenotypes in SLE patients, which could facilitate a more precise diagnosis and assessment of disease progression in SLE.
CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Dakai Gan, Yuyu Zeng, Kaige Zhang, Yang He, Jiao Wan, Xiaoqing Zhang, Zhen Zhang, Longchuan Zhu, Tao Long, Nengwen Xie, Bo Zou, Xuezhen Zhang, Yunfeng Xiong, Guoliang Feng, Daya Luo, Molong Xiong
Summary: This study aims to establish a more efficient prognostic assessment system for hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). By analyzing data from 623 patients, a new scoring system was developed using results from the first reexamination, first examination, mean daily change, and other first examination results. The final prognostic scoring system accurately predicted 90-day mortality and patients with lower scores had longer survival times.
