Review
Medicine, General & Internal
Mohamed Salaheldin, Heba Aly, Louis Lau, Shimaa Afify, Mohamed El-Kassas
Summary: Over the years, the complications of viral hepatitis and alcohol-related liver diseases have been a major concern in hepatology. However, recent advancements in the field have revealed a paradigm shift towards nonalcoholic fatty liver disease (NAFLD) as the leading cause of liver cirrhosis and cancer. This review focuses on updating knowledge about the pathogenesis of NAFLD-induced hepatocellular carcinoma (HCC), surveillance challenges, and potential disease markers, such as molecular biomarkers, which may revolutionize risk stratification, early detection, and treatment selection for NAFLD-related HCC.
Article
Gastroenterology & Hepatology
Won-Mook Choi, Gi-Ae Kim, Jonggi Choi, Gwang Hyeon Choi, Yun Bin Lee, Dong Hyun Sinn, Young-Suk Lim
Summary: This study aimed to investigate the association between baseline HBV viral load and on-treatment HCC risk in patients with CHB without cirrhosis. The study found that patients with moderate baseline viral load had the highest HCC risk.
Review
Biochemistry & Molecular Biology
Francesco Paolo Russo, Alberto Zanetto, Elisa Pinto, Sara Battistella, Barbara Penzo, Patrizia Burra, Fabio Farinati
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer-related death, with chronic viral hepatitis being a significant contributing factor. The pathophysiology of viral-related HCC involves liver inflammation, oxidative stress, and deregulation of cell signaling pathways. Regular ultrasound surveillance is recommended for patients with cirrhosis and high-risk individuals with chronic HBV infection. Antiviral therapy reduces the risks of HCC development and recurrence. Various scoring systems have been developed to predict the risk of HCC development in patients with chronic hepatitis B.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Anxin Chen, Shijie Li, Zhiyuan Yao, Jiahao Hu, Jiasheng Cao, Win Topatana, Sarun Juengpanich, Hong Yu, Jiliang Shen, Mingyu Chen
Summary: The meta-analysis showed that TACE plus sorafenib combination therapy is superior to sorafenib monotherapy in unresectable HCC patients, significantly improving overall survival, time to progression, and objective response rate. Combination therapy was particularly effective for patients with macrovascular invasion.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Virology
Kuo-Chin Chang, Ming-Tsung Lin, Jing-Houng Wang, Chao-Hung Hung, Chien-Hung Chen, Sherry Yueh-Hsia Chiu, Tsung-Hui Hu
Summary: This study found that in chronic hepatitis B-related liver cirrhosis (LC) patients undergoing long-term antiviral therapy, patients with higher levels of HBV core-related antigen (HBcrAg) are at a significantly increased risk for hepatocellular carcinoma (HCC) development. Especially for patients with lower levels of HBsAg quantification (HBsAg-HQ), HBcrAg level is an independent risk factor for HCC development.
Review
Chemistry, Multidisciplinary
Huimin Kong, Enguo Ju, Ke Yi, Weiguo Xu, Yeh-Hsing Lao, Du Cheng, Qi Zhang, Yu Tao, Mingqiang Li, Jianxun Ding
Summary: Liver disease, particularly viral hepatitis and hepatocellular carcinoma, remains a global healthcare burden with over 2 million deaths per year. The CRISPR/Cas technology shows promise in tackling these diseases at the genetic level. This review focuses on the development of CRISPR editors and the integration of gene editing and nanotheranostics for liver diseases.
Review
Cell Biology
Saleh A. Alqahtani, Massimo Colombo
Summary: Chronic infections with hepatitis B or C virus are common risk factors for hepatocellular carcinoma. Effective antiviral therapies can reduce the risk of developing HCC, but do not eliminate it completely. More strategies are needed to further improve outcomes in preventing HCC in patients with chronic viral hepatitis.
Review
Gastroenterology & Hepatology
Angelo Zambam de Mattos, Jose D. Debes, Andre Boonstra, Ju-Dong Yang, Domingo C. Balderramo, Giovana D. P. Sartori, Angelo Alves de Mattos
Summary: Chronic infections caused by hepatitis B and hepatitis C viruses are major contributors to hepatocellular carcinoma (HCC) worldwide. Effective measures to reduce the burden of viral hepatitis-related HCC include universal vaccination against hepatitis B, identification and treatment of infected individuals, and surveillance of high-risk groups for early detection of tumors.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Oncology
Xinhe Zhang, Lin Guan, Haoyu Tian, Zilu Zeng, Jiayu Chen, Die Huang, Ji Sun, Jiaqi Guo, Huipeng Cui, Yiling Li
Summary: HCC is a common cancer with increasing incidence caused by HBV and HCV infections, liver cirrhosis, and metabolic risk factors. Predictive factors can assess the risk of HCC, and prevention strategies include vaccination, antiviral treatment, and HCC management to reduce recurrence.
FRONTIERS IN ONCOLOGY
(2021)
Review
Microbiology
Toofan Datfar, Michael Doulberis, Apostolis Papaefthymiou, Ian N. Hines, Giulia Manzini
Summary: Viral hepatitis, especially hepatitis B and C, are closely associated with hepatocellular carcinoma development. Different genotypes of hepatitis B virus show varied disease progression, and mutations in viral genomes can predict HCC development. HCV infection leads to hepatocellular lipid accumulation associated with oncogenesis.
Article
Multidisciplinary Sciences
Masato, Yoshiya Yamamoto, Masaru Baba, Goki, Akinori, Yoshimasa Tokuchi, Takashi Kitagataya, Ren Yamada, Taku Shigesawa, Kazuharu Suzuki, Akihisa Nakamura, Takuya Sho, Kenichi Morikawa, Koji Ogawa, Ken Furuya, Naoya Sakamoto
Summary: Liver stiffness measurement is a useful tool in assessing liver fibrosis. This study identifies age and liver stiffness as important risk factors for hepatocellular carcinoma (HCC) following hepatitis C (HCV) eradication. Low-risk individuals have a lower incidence of HCC.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Hou-Ying Cheng, Rey-Heng Hu, Chih-Yang Hsiao, Ming-Chih Ho, Yao-Ming Wu, Po-Huang Lee, Cheng-Maw Ho
Summary: This study aimed to investigate the survival outcomes of antiviral agents in patients with hepatitis C virus who underwent liver resection for primary hepatocellular carcinoma. The results showed that antiviral treatment can prolong overall survival, and DAAs may have a protective effect against hepatic decompensation.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Lingbo Hu, Yu Zheng, Jiangyin Lin, Xingpeng Shi, Aidong Wang
Summary: This meta-analysis showed that postoperative adjuvant hepatic artery infusion chemotherapy (HAIC) is beneficial to HCC patients with portal vein invasion (PVI) and microvascular invasion (MVI). However, it remains uncertain whether HAIC can improve the survival outcome in all HCC patients after hepatic resection.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Microbiology
Yuanyuan Liu, Vaishnavi Veeraraghavan, Monica Pinkerton, Jianjun Fu, Mark W. Douglas, Jacob George, Thomas Tu
Summary: Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide, with chronic HBV infection being a major risk factor. Current early diagnosis methods have low sensitivity, leading to higher rates of late-stage diagnosis and treatment challenges. Combining viral biomarkers with existing screening methods can improve the accuracy of early diagnosis and patient survival rates.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Surgery
Kate Minoux, Guillaume Lassailly, Massih Ningarhari, Henri Lubret, Medhi El Amrani, Valerie Canva, Stephanie Truant, Philippe Mathurin, Alexandre Louvet, Gilles Lebuffe, Odile Goria, Eric Nguyen-Khac, Emmanuel Boleslawski, Sebastien Dharancy
Summary: This study investigated the trajectory of HCC patients awaiting liver transplantation who were treated with sorafenib. The results suggest that patients treated for HCC progression have high dropout rates and low survival rates, while patients treated for impossibility of loco-regional therapy have acceptable survival rates.
TRANSPLANT INTERNATIONAL
(2022)
Article
Immunology
Chi-Chang Sung, Jau-Hau Horng, Shih-Hong Siao, I-Tsu Chyuan, Hwei-Fang Tsai, Pei-Jer Chen, Ping-Ning Hsu
Summary: This study identified ASGM1-positive liver-resident CD8 T cells as the major effector immune cells that mediate anti-HBV immunity, working in coordination with TRM cells and other immune cells to clear HBV.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Chih-Ying Chien, Jiun-Lin Yan, Shih Tsung Han, Jin-Tang Chen, Ting-Shuo Huang, Yu-Hsien Chen, Chih-Yuan Wang, Yueh-Lin Lee, Kuan-Fu Chen
Summary: IVC volume and RTS are independent predictors of massive transfusion in trauma patients in the emergency department, with larger IVC volume associated with lower likelihood of massive transfusion.
JOURNAL OF INTENSIVE CARE MEDICINE
(2021)
Article
Cell Biology
Tung Chao, Hsueh-Tzu Shih, Shih-Chin Hsu, Pei-Jer Chen, Yu-Shan Fan, Yung-Ming Jeng, Zhao-Qing Shen, Ting-Fen Tsai, Zee-Fen Chang
Summary: Genotoxic insult leads to damages in nuclear and mitochondrial DNA with autophagy induction. The study reveals that specific nuclear DNA damage alone does not require autophagy for repair, unless there is mitochondrial DNA damage present. Furthermore, autophagy suppression causes increased mitochondrial permeability, releasing mitochondrial ENDOG to the nuclei and sustaining nuclear DNA damage.
Article
Health Care Sciences & Services
Jessica Qiuhua Sheng, Paul Jen-Hwa Hu, Xiao Liu, Ting-Shuo Huang, Yu Hsien Chen
Summary: The proposed deep learning-based method shows superior predictive performance for predicting complication phenotypes in patients with acute diseases compared to traditional techniques in the presence of insufficient patient data, temporal heterogeneities, and imbalanced outcome distributions.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Virology
Li-Ling Wu, Ting-Shuo Huang, Yu-Chiau Shyu, Chih-Lin Wang, Hurng-Yi Wang, Pei-Jer Chen
Summary: Hepatitis B virus takes advantage of immature innate immunity and not-yet stabilized gut microbiota in early life to establish chronic infection in humans. Both resident and infiltrating myeloid cells in the liver play crucial roles in immune responses to pathogens, and understanding their interactions with HBV is key. Research on the interactions between gut microbiota and hepatic macrophages is crucial for understanding the outcomes of HBV infection.
CURRENT OPINION IN VIROLOGY
(2021)
Article
Computer Science, Information Systems
Da Xu, Jessica Qiuhua Sheng, Paul Jen-Hwa Hu, Ting-Shuo Huang, Chih-Chin Hsu
Summary: Physicians rely on electronic health records to manage patients, but missing values pose a challenge. A deep learning-based method is proposed to impute missing values, showing more effective predictive efficacy.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2021)
Article
Biochemistry & Molecular Biology
Chih-Lang Lin, Rong-Nan Chien, Li-Wei Chen, Ting-Shuo Huang, Yu-Chiau Shyu, Chau-Ting Yeh, Kung-Hao Liang
Summary: Human alcohol consumption behavior is genetically encoded, with the rs671 G > A variant in the ALDH2 gene showing the strongest association with drinking behavior. The ALDH2*2 allele has been present in Asian populations for over 7,000 years, as evidenced by a study in Keelung, Taiwan, and a dataset from Guangzhou, China.
Article
Endocrinology & Metabolism
Tsai-Sheng Fu, Ting-Shuo Huang, Chi-Chin Sun, Yu-Chiau Shyu, Fang-Ping Chen
Summary: The study demonstrates that bisphosphonate treatment significantly reduces the risk of second hip fracture and mortality in patients with initial hip fracture. Factors such as gender, comorbidities, and complications also play a significant role in determining the prognosis.
Article
Virology
Chun-Ming Hong, You-Yu Lin, Chun-Jen Liu, Ya-Yun Lai, Shiou-Hwei Yeh, Hung-Chih Yang, Jia-Horng Kao, Shih-Jer Hsu, Yi-Hsiang Huang, Sheng-Shun Yang, Hsing-Tao Kuo, Pin-Nan Cheng, Ming-Lung Yu, Pei-Jer Chen
Summary: About 4% of population in Taiwan are seropositive for anti-HCV Ab and 70% with HCV RNA. Taiwan National Health Insurance reimburses genotype-specific and pangenotype DAAs for chronic hepatitis C disease. Adherence is an important cause of failure clinically, while common resistance-associated substitutions include NS5A-L31, NS5A-Y93, NS5BC316 for genotype-specific DAAs and NS5A-L31, NS5A-A/Q/R30, NS5A-Y93 for pangenotype DAAs.
Review
Virology
Yi-Wen Huang, Albert Qin, Chan-Yen Tsai, Pei-Jer Chen
Summary: Ropeginterferon alfa-2b is a promising treatment option for MPN and chronic viral hepatitis due to its favorable pharmacokinetic profile and demonstrated efficacy in clinical studies. Administered once every two weeks, it has shown to be well-tolerated and effective in treating chronic hepatitis B, C, and D.
Review
Oncology
Chiao-Ling Li, Shiou-Hwei Yeh, Pei-Jer Chen
Summary: Cell-free tumor DNA (ctDNA) is a promising tumor marker that can reflect tumor burden, behavior, and prognosis. However, there are still challenges to be addressed before ctDNA can be used as a tumor marker. We propose using exogenous viral DNA integration to generate virus-host chimera DNA (vh-DNA) as a potential new biomarker. vh-DNA may overcome detection problems and serve as a universal marker for monitoring tumor expansion or burden related to oncogenic viruses.
Article
Medicine, General & Internal
Chen-Hua Liu, Chun-Jen Liu, Tung-Hung Su, Shang-Chin Huang, Tai-Chung Tseng, Jo-Hsuan Wu, Pei-Jer Chen, Jia-Horng Kao
Summary: This study found a strong correlation between serum M2BPGi levels and the severity of hepatic fibrosis in patients with HCV infection, and identified specific cutoff values that can be used for accurate diagnosis.
Article
Health Care Sciences & Services
Chun-Yu Chen, Jung- Ye, Ting-Shuo Huang, Chin-Chan Lee, Yih-Ting Chen, Cheng-Kai Hsu, Heng-Jung Hsu, Chiao-Yin Sun, Heng-Chih Pan, Kuo-Su Chen, Hao-Hsi Kao, Chia-Chun Ko, Yun-Hsuan She, Chun-Ying Wu, Chi-Chun Lai, Shang-Jyh Hwang, I-Wen Wu
Summary: Effective preventive measures against COVID-19 were implemented in an HD center in Taiwan, resulting in lower incidence rate compared to national and local estimates, with Keelung having the highest incidence among HD patients. Only one patient in the center got infected with COVID-19 and secondary transmission was contained successfully under the implemented measures.
Article
Gastroenterology & Hepatology
Tai-Chung Tseng, Chun-Jen Liu, Wan-Ting Yang, Chen-Yang Hsu, Chun-Ming Hong, Tung-Hung Su, Cheng-Hsueh Tsai, Chi-Ling Chen, Hung-Chih Yang, Chen-Hua Liu, Hsiu-Hsi Chen, Pei-Jer Chen, Jia-Horng Kao
Summary: In patients with chronic hepatitis B virus infection, higher levels of HBcrAg are associated with increased risk of cirrhosis. Among patients with intermediate viral load, HBcrAg <10 KU/mL defines a low-risk group for disease progression.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Surgery
Yu-Hsien Chen, Hoon-Yub Kim, Angkoon Anuwong, Ting-Shuo Huang, Quan-Yang Duh
Summary: The study compared the safety and outcomes of transoral robotic thyroidectomy (TORT) with transoral endoscopic thyroidectomy vestibular approach (TOETVA), finding that TORT requires a longer operative time but is as safe as TOETVA and may be useful for more complex thyroid operations.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
