Article
Virology
Yubao Zhao, Kun Chen, Hui Yang, Feng Zhang, Lu Ding, Yan Liu, Le Zhang, Yuchen Zhang, Huiliang Wang, Yang Deng
Summary: HLA-DR genetic polymorphisms may predispose the host to immunoselection of HCC-related HBV mutations and affect the risk of HCC possibly through interacting with HBV mutations.
Article
Biochemistry & Molecular Biology
Yu-De Chu, Kwong-Ming Kee, Wey-Ran Lin, Ming-Wei Lai, Sheng-Nan Lu, Wen-Hung Chung, See-Tong Pang, Chau-Ting Yeh
Summary: The SYNE1-rs9479297 genotypes were found to be associated with the co-occurrence of HCC/TCC DPC and correlated with SYNE1 expression, which in turn impacted the proliferation and migration of HCC/TCC cells, thus affecting clinical outcomes.
Article
Virology
Jiaxin Xie, Yibo Ding, Xiaopan Li, Rui Pu, Wenbin Liu, Peng Li, Jianhua Yin
Summary: Estrogen receptor alpha (ESR1) is involved in the pathological process of Hepatitis B virus (HBV) infection and may play a role in gender differences. This study investigated the correlation between ESR1 polymorphisms and the susceptibility to HBV persistence and clinical outcomes. The results suggest that combinations of ESR1 polymorphisms may be useful for predicting HBV persistence.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Marwa Hassan, Sami Mohamed Nasr, Mohamed Elzallat
Summary: CD133 polymorphisms are associated with susceptibility and prognosis of viral hepatitis-induced liver cirrhosis and hepatocellular carcinoma. These findings suggest that CD133(+) cells and CD133 polymorphisms may serve as potential predictors for these diseases.
Article
Oncology
Alan Ayoub, Chimaobi M. Anugwom, Jhon Prieto, Domingo Balderramo, Javier Diaz Ferrer, Angelo Z. Mattos, Marco Arrese, Enrique Carrera, Zwier M. A. Groothuismink, Jeffrey Oliveira, Andre Boonstra, Jose D. Debes
Summary: This study investigated the association between the STAT4 rs7574865 genetic variant and the risk of hepatocellular carcinoma (HCC) in Latin American and European populations. The results showed no significant association between the risk allele and HCC development in both populations, but Latin Americans of European ancestry were more likely to carry the risk allele.
Article
Oncology
Meng Xue, Xiaona Lin, Qiu-Xiong Lin, Xiaoyong Pu, Jiumin Liu, Xing-Fang Li, Jun Hou, Xudong Liu, Ren Chen
Summary: This study found that HBV infection was associated with an increased risk of HCC compared to HEV infection, and that HEV infection may mitigate the promoting impact of HBV on HCC development.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Oncology
Chen Shen, Xin Jiang, Mei Li, Yao Luo
Summary: Hepatocellular carcinoma (HCC) is a global health challenge caused by hepatitis virus infection. Hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis D virus (HDV) are major risk factors for HCC development. This review discusses the mechanisms by which these viruses induce HCC and presents new diagnostic and therapeutic approaches. The potential relationship between hepatitis E virus (HEV) and HCC is also considered.
Review
Biochemistry & Molecular Biology
Nicholas Noverati, Rukaiya Bashir-Hamidu, Dina Halegoua-DeMarzio, Hie-Won Hann
Summary: Hepatitis B virus is a significant cause of hepatocellular carcinoma globally. The complex mechanisms of this virus include interactions with the host's immune system. Factors such as stress can amplify these mechanisms. Chronic stress, harmful to health, can suppress or activate the host's defense system, leading to tumor initiation and progression in liver cancer. Chronic stress, often overlooked, should be recognized as a potential risk factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Trudy M. Wassenaar, Visanu Wanchai, David W. Ussery
Summary: This study compared the genome sequences of Monkeypox virus isolates from the current outbreak to those from previous outbreaks. It identified consistent differences in the 2022 isolates, including variations in repeat units and single nucleotide polymorphisms. Some of these polymorphisms caused amino acid substitutions that may affect the virus's virulence. This bioinformatic analysis provides guidance for further wet-lab research.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Oncology
Tarek Mohamed Kamal Motawi, Nermin Abdel Hamid Sadik, Dina Sabry, Sally Atef Fahim, Nancy Nabil Shahin
Summary: This study found a significant association between the rs62139665 polymorphism in the EpCAM gene and HCC risk, as well as EpCAM gene and protein expression levels in the Egyptian population. Serum levels of EpCAM may be promising for HCC diagnosis and improving the diagnostic accuracy of alpha-fetoprotein.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yulong Chen, Xunjun Yang, Yao Chen, Guorong Chen, Cheryl A. Winkler, Ping An, Jianxin Lyu
Summary: This study identified for the first time an association between genetic variations in SOAT1 and the occurrence of HCC, indicating a potential role of SOAT1 in the development of HCC that requires further investigation.
Review
Virology
Giacomo Emanuele Maria Rizzo, Giuseppe Cabibbo, Antonio Craxi
Summary: Hepatitis B virus (HBV) infection is associated with the risk of developing hepatocellular carcinoma (HCC), with or without liver cirrhosis, through various mechanisms. The molecular profile of HBV-HCC is constantly being studied, and it is the result of altered molecular pathways, changes in the microenvironment, and DNA damage. Proper management of HBV-related liver disease is crucial for prevention and treatment of HCC.
Review
Oncology
Xinhe Zhang, Lin Guan, Haoyu Tian, Zilu Zeng, Jiayu Chen, Die Huang, Ji Sun, Jiaqi Guo, Huipeng Cui, Yiling Li
Summary: HCC is a common cancer with increasing incidence caused by HBV and HCV infections, liver cirrhosis, and metabolic risk factors. Predictive factors can assess the risk of HCC, and prevention strategies include vaccination, antiviral treatment, and HCC management to reduce recurrence.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Shun Kaneko, Masayuki Kurosaki, Kento Inada, Sakura Kirino, Yuka Hayakawa, Koji Yamashita, Leona Osawa, Shuhei Sekiguchi, Mayu Higuchi, Kenta Takaura, Chiaki Maeyashiki, Nobuharu Tamaki, Yutaka Yasui, Jun Itakura, Yuka Takahashi, Kaoru Tsuchiya, Hiroyuki Nakanishi, Namiki Izumi
Summary: This study investigated the virological characteristics of HBcrAg in CHB patients and the factors associated with HCC risk in HBeAg-negative patients. Results showed that higher levels of HBcrAg in HBeAg-negative patients were associated with cirrhosis and higher HBV DNA levels, and were an independent predictive factor for HCC development in patients receiving NA therapy.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Medicine, General & Internal
Mirjam B. Zeisel, Francesca Guerrieri, Massimo Levrero
Summary: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is largely caused by chronic hepatitis B virus (HBV) infection. While antiviral therapies can suppress viral replication, there is currently no cure for chronic HBV infection. HBV contributes to liver carcinogenesis through direct and indirect effects on host epigenetic alterations, modulating gene expression.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Infectious Diseases
Jabar Babatunde Pacome Achimi Agbo Abdul, Bayode Romeo Adegbite, Micheska Epola Dibamba Ndanga, Jean Ronald Edoa, Rhett Chester Mevyann, Guy Rogue Arnault Ibinda Mfoumbi, Tshisekedi Jean de Dieu, Jocelyn Mahoumbou, Christopher Mebiame Biyogho, Sankarganesh Jeyaraj, Stefan Niemann, Bertrand Lell, Peter Gottfried Kremsner, Abraham Sunday Alabi, Ayola Akim Adegnika, Martin Peter Grobusch
Summary: The increasing incidence of MDR-TB infection in Gabon is alarming, especially among individuals aged 25-35. There is a need for improvement in case finding and contact tracing strategies for treatment-naive MDR-TB patients.
Article
Medicine, Research & Experimental
Oriol Mitja, Gilmar Reis, David R. Boulware, Adam M. Spivak, Ammar Sarwar, Christine Johnston, Brandon Webb, Michael D. Hill, Davey Smith, Peter Kremsner, Marla Curran, David Carter, Jim Alexander, Marc Corbacho, Todd C. Lee, Katherine Huppler Hullsiek, Emily G. McDonald, Rachel Hess, Michael Hughes, Jared M. Baeten, Ilan Schwartz, Luanne Metz, Lawrence Richer, Kara W. Chew, Eric Daar, David Wohl, Michael Dunne
Summary: This study conducted a pooled analysis of individual participant data from 11 randomized controlled trials to evaluate the efficacy of hydroxychloroquine (HCQ) in outpatients with mild COVID-19. The results suggest that HCQ does not show significant effects on viral clearance and hospitalization rate, and therefore, the use of HCQ in mild COVID-19 outpatients should be discontinued to reduce the risk of disease progression.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Respiratory System
Hien Thi Thu Nguyen, Vang Le-Quy, Son Van Ho, Jakob Holm Dalsgaard Thomsen, Malene Pontoppidan Stoico, Hoang Van Tong, Nhat-Linh Nguyen, Henrik Bygum Krarup, Son Hong Nguyen, Viet Quoc Tran, Linh Toan Nguyen, Anh Tuan Dinh-Xuan
Summary: This study aims to predict the severity of COVID-19 based on clinical and biological indicators, and identify biomarkers for prognostic assessment. The most important indicators were IL-6, ferritin, and D-dimer. Two different sets of biomarkers can be used for disease severity assessment and prognosis.
Review
Medicine, General & Internal
Yolanda Augustin, Henry M. Staines, Thirumalaisamy P. Velavan, Adeeba Kamarulzaman, Peter G. Kremsner, Sanjeev Krishna
Summary: The COVID-19 pandemic has led to global research on drug repurposing, focusing on antiviral therapies, anti-inflammatory agents, antithrombotic agents, and immune modulators. Corticosteroids and immunomodulators targeting IL-6 receptors have been shown to be effective in improving clinical outcomes. Other drugs under investigation include antidiabetic, antimalarial, tyrosine kinase inhibitors, antiviral, antiparasitic, and antidepressant drugs.
BRITISH MEDICAL BULLETIN
(2023)
Editorial Material
Infectious Diseases
Thirumalaisamy P. Velavan, Francine Ntoumi, Peter G. Kremsner, Shui Shan Lee, Christian G. Meyer
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Esam I. Azhar, Thirumalaisamy P. Velavan, Ikrormi Rungsung, Tieble Traore, David S. Hui, Brian McCloskey, Sherif A. El-Kafrawy, Alimuddin Zumla
Summary: This study analyzed the infection and epidemiological characteristics of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans and camels from January 1, 2012 to August 3, 2022. It found that MERS-CoV remains a threat to global health security, with ongoing infections in humans and camels. Proactive surveillance of MERS-CoV infections and variants in camels and humans, as well as the development of a MERS vaccine, are essential for epidemic preparedness.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Virology
Gedeon Prince Manouana, Paul Alvyn Nguema-Moure, Alexandru Tomazatos, Moustapha Nzamba Maloum, C. -Thomas Bock, Peter G. G. Kremsner, Thirumalaisamy P. P. Velavan, Akim Ayola Adegnika, Sandra Niendorf
Summary: This study aimed to evaluate the performance of the rapid rotavirus test compared to the one-step RT-qPCR method. The results showed that the rapid test had high sensitivity and was suitable for detecting rotavirus A in patients with gastroenteritis, especially in low-income countries.
Letter
Pediatrics
Constanze Heinzel, Yudi T. Pinilla, Ayla Binder, Peter G. Kremsner, Jana Held, Rolf Fendel, Andrea Kreidenweiss
Article
Microbiology
Tina Krueger, Moses Ikegbunam, Abel Lissom, Thaisa Lucas Sandri, Jacques Dollon Mbama Ntabi, Jean Claude Djontu, Marcel Tapsou Baina, Romeo Aime Laclong Lontchi, Moustapha Maloum, Givina Zang Ella, Romuald Agonhossou, Romaric Akoton, Luc Djogbenou, Steffen Borrmann, Jana Held, Francine Ntoumi, Ayola Akim Adegnika, Peter Gottfried Kremsner, Andrea Kreidenweiss
Summary: The frequency of pfhrp2 and pfhrp3 deleted strains in Central and West Africa was assessed and found to be low, indicating a low risk of false-negative results in HRP2-based rapid diagnostic tests. However, continuous monitoring is crucial due to the potential for rapid changes in this scenario to ensure the suitability of RDTs for malaria diagnostics.
Article
Health Care Sciences & Services
Nithya Babu Rajendran, Fabiana Arieti, Carla Alejandra Mena-Benitez, Liliana Galia, Maela Tebon, Julio Alvarez, Beryl Primrose Gladstone, Lucie Collineau, Giulia De Angelis, Raquel Duro, William Gaze, Siri Goepel, Souha S. Kanj, Annemarie Kaesbohrer, Direk Limmathurotsakul, Estibaliz Lopez de Abechuco, Elena Mazzolini, Nico T. Mutters, Maria Diletta Pezzani, Elisabeth Presterl, Hanna Renk, Jesus Rodriguez-Bano, Oana Sandulescu, Federico Scali, Robert Skov, Thirumalaisamy P. Velavan, Cuong Vuong, Evelina Tacconelli
Summary: Strategic and standardised approaches are crucial for analyzing and reporting surveillance data on antimicrobial resistance (AMR) and informing antibiotic policies. This paper describes a multidisciplinary initiative involving experts from the human, animal, and environmental sectors to develop proposals for structuring and reporting full-scale AMR and antimicrobial consumption/antimicrobial residue surveillance data. The recommendations from this study can support national and regional plans to reduce resistance rates and promote a One Health approach to antimicrobial policy.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Parasitology
Aleksey V. Katokhin, Irina V. Saltykova, Claudio De Liberato, Rolf Schuster, Thirumalaisamy P. Velavan
Summary: Opisthorchis felineus is a trematode that mainly affects the liver and bile ducts, causing opisthorchiosis and potentially leading to cholangiocarcinoma. Little is known about the genetic structure of this parasite, but this study used microsatellite loci to investigate its genetic diversity and population structure. Analysis revealed at least three distinct populations and proposed a hypothesis about the formation of the present habitat of O. felineus.
PARASITOLOGY RESEARCH
(2023)
Article
Virology
Le Chi Cao, Vanessa Martin, Le Thi Kieu Linh, Tran Thi Giang, Ngo Thi Minh Chau, Ton Nu Phuong Anh, Vu Xuan Nghia, Nguyen Trong The, Truong Nhat My, Bui Tien Sy, Nguyen Linh Toan, Le Huu Song, C. -Thomas Bock, Thirumalaisamy P. Velavan
Summary: The prevalence of hepatitis E virus (HEV) in the Vietnamese population is underestimated. A study was conducted to investigate the seroprevalence of HEV antibodies and the presence of HEV RNA in blood donors. The results showed a high prevalence of HEV antibodies, with a higher risk in older individuals. Although HEV viraemia was not found in blood donors from Northern Vietnam, further surveillance is needed in other regions.
Letter
Pediatrics
Constanze Heinzel, Yudi T. Pinilla, Ayla Binder, Peter G. Kremsner, Jana Held, Rolf Fendel, Andrea Kreidenweiss
Summary: This cross-sectional study examines IgG antibody levels in children and adolescents in Germany after SARS-CoV-2 infection.
Article
Public, Environmental & Occupational Health
Hamada S. Badr, Josh M. Colston, Nhat-Lan H. Nguyen, Yen Ting Chen, Eleanor Burnett, Syed Asad Ali, Ajit Rayamajhi, Syed M. Satter, Nguyen Van Trang, Daniel Eibach, Ralf Krumkamp, Juergen May, Ayola Akim Adegnika, Gedeon Prince Manouana, Peter Gottfried Kremsner, Roma Chilengi, Luiza Hatyoka, Amanda K. Debes, Jerome Ateudjieu, Abu S. G. Faruque, M. Jahangir Hossain, Suman Kanungo, Karen L. Kotloff, Inacio Mandomando, M. Imran Nisar, Richard Omore, Samba O. Sow, Anita K. M. Zaidi, Nathalie Lambrecht, Bright Adu, Nicola Page, James A. Platts-Mills, Cesar Mavacala Freitas, Tuula Pelkonen, Per Ashorn, Kenneth Maleta, Tahmeed Ahmed, Pascal Bessong, Zulfiqar A. Bhutta, Carl Mason, Estomih Mduma, Maribel P. Olortegui, Pablo Penataro Yori, Aldo A. M. Lima, Gagandeep Kang, Jean Humphrey, Robert Ntozini, Andrew J. Prendergast, Kazuhisa Okada, Warawan Wongboot, Nina Langeland, Sabrina J. Moyo, James Gaensbauer, Mario Melgar, Matthew Freeman, Anna N. Chard, Vonethalom Thongpaseuth, Eric Houpt, Benjamin F. Zaitchik, Margaret N. Kosek
Summary: This study aimed to model the spatiotemporal variation in paediatric Shigella infection and predict its prevalence across low-income and middle-income countries. The findings revealed the association between Shigella and climatological factors, with sub-Saharan Africa being a high-risk region for transmission. These findings can guide prioritization of populations for future vaccine trials and campaigns.
LANCET GLOBAL HEALTH
(2023)