Review
Biochemistry & Molecular Biology
Samiksha Kukal, Debleena Guin, Chitra Rawat, Shivangi Bora, Manish Kumar Mishra, Priya Sharma, Priyanka Rani Paul, Neha Kanojia, Gurpreet Kaur Grewal, Shrikant Kukreti, Luciano Saso, Ritushree Kukreti
Summary: ABCG2 is a widely distributed protein in different cell types that plays a crucial role in maintaining cellular homeostasis and protecting tissues against xenobiotic insults, but its expression is influenced by various pathophysiological conditions. Therapeutic interventions should focus on regulating levels of ABCG2 rather than directly inhibiting its function to avoid serious side effects.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
B. Dudas, X. Decleves, S. Cisternino, D. Perahia, M. A. Miteva
Summary: This study simulated the transport process of ABCG2 by studying connecting pathways. An additional pocket between the two substrate-binding cavities was discovered, and the role of substrates in the transport process was revealed. The study is of great significance for understanding the complex efflux mechanism of ABCG2.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Agriculture, Dairy & Animal Science
Enoch B. de S. Jr Jr Meira, Emily E. Wiloch, Emma Nixon, James L. Yeatts, Farha Ferdous Sheela, Geof W. Smith, Ronald E. Baynes
Summary: The study evaluated the pharmacokinetics of transdermal flunixin in dairy goats and established milk withdrawal intervals of 60 hours and 96 hours to prevent residue contamination in the food supply.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Chemistry, Medicinal
Frauke Antoni, David Wifling, Guenther Bernhardt
Summary: This study focused on improving the solubility of ABCG2 inhibitors through a fragment-based approach, resulting in the discovery of novel inhibitors with improved solubility. These inhibitors exhibited good resistance in experiments, were non-toxic, and remained stable under various conditions.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
Paula C. C. Molinari, Brittney D. Davidson, Jimena Laporta, Geoffrey E. Dahl, I. Martin Sheldon, John J. Bromfield
Summary: Heat stress increases susceptibility to uterine diseases in dairy cows. This study shows that implementing evaporative cooling to alleviate heat stress during late pregnancy can have carry-over effects on postpartum innate immunity, potentially reducing the incidence of uterine disease.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Robert Wijma, Daniel J. Weigel, Natascha Vukasinovic, Dianelys Gonzalez-Pena, Shaileen P. McGovern, Brenda C. Fessenden, Anthony K. McNeel, Fernando A. Di Croce
Summary: Pregnancy losses in dairy cattle can have negative impacts on both animal health and economic outcomes. This study developed a genomic prediction model to identify high-risk cows and aid in the selection of more profitable and productive animals. The results showed that the model effectively predicted the risk of abortion in lactating Holstein dairy cows, providing valuable information for genetic selection towards healthier cows.
Article
Chemistry, Medicinal
Wei Shi, Ping Zhang, Feng Zou, Jiaqi Zhou, Ziyu Yin, Zilong Cai, Hesham Ghaleb, Yuxuan Jiang, Wenlong Huang, Yan Liu, Qianqian Qiu, Hai Qian
Summary: Chemotherapy is a crucial treatment for cancer, but resistance can occur. Researchers developed and synthesized compounds with dual inhibition to overcome resistance and improve the bioavailability of oral chemotherapy drugs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Orsolya Mozner, Boglarka Zambo, Zsuzsa Bartos, Anna Gergely, Kata Sara Szabo, Balint Jezso, Agnes Telbisz, Gyoergy Varady, Laszlo Homolya, Tamas Hegedus, Balazs Sarkadi
Summary: This study analyzed the effects of variants in the unresolved cytoplasmic region of the ABCG2 multidrug transporter on protein function and trafficking. It was found that the K360del variant increased membrane expression and cellular trafficking of ABCG2, while alanine replacements of neighboring lysines had no significant effect on transport function.
Article
Agriculture, Dairy & Animal Science
Thidarat Gunha, Kanokwan Kongphitee, Bhoowadol Binsulong, Kritapon Sommart
Summary: This study aimed to evaluate the net energy for lactation of broken rice in dairy cows and the effects of broken rice substitution in diets on feed intake, nutrient energy utilization, and milk production. The findings showed that increasing the proportion of broken rice in the diet had no adverse effects on feed intake, milk yield and composition, and energy balance, but linearly increased the digestibility of dry matter, organic matter, and neutral detergent fiber. The estimated net energy for lactation of broken rice was 8.68 MJ/kg.
Article
Reproductive Biology
Ranran Zhang, Lauren Walker, Xia Wen, Cathleen Doherty, Ludwik Gorczyca, Brian Buckley, Emily S. Barrett, Lauren M. Aleksunes
Summary: The study found that the BCRP transporter reduces the accumulation of cadmium in syncytiotrophoblasts, which may be one mechanism to reduce subsequent toxicity to the placenta and developing fetus.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Microbiology
Jenna R. Williamson, Todd R. Callaway, Jeferson M. Lourenco, Valerie E. Ryman
Summary: This study aimed to characterize similarities between rumen, fecal, and milk microbiota simultaneously and investigate their associations with milk somatic cell count (SCC) and milk yield. The results demonstrated that rumen, fecal, and milk microbiota populations were distinct, with milk microbiota being the least diverse. Milk microbial populations from cows with low SCC showed a more evenly distributed microbiome compared to cows with high SCC values.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Rafael Mora-Medina, Antonio Jesus Lora-Benitez, Ana Maria Molina-Lopez, Nahum Ayala-Soldado, Rosario Moyano-Salvago
Summary: In recent years, there has been a growing concern about milk pollution by aflatoxin M1 due to the increasing prevalence of aflatoxins in animal feeding and dairy product consumption. A study was conducted to determine the transfer of aflatoxin B1 into milk and its effects on production and serological parameters in goats. Goats were exposed to different doses of aflatoxin B1 for 31 days and the concentration of aflatoxin M1 in milk was found to significantly increase with the amount of aflatoxin B1 ingested. However, the ingested amount did not affect the aflatoxin M1 carryover, indicating a certain resistance of goats to the effects of aflatoxin B1.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
C. Delavaud, H. Fougere, J. Bertrand-Michel, L. Bernard
Summary: This study examines the effects of diets supplemented with different lipids on plasma lipid composition in dairy cows and goats. The results indicate species-specific and diet-dependent variations in plasma lipid fractions, which in turn affect milk fat synthesis.
Article
Biotechnology & Applied Microbiology
Guangsheng Li, Xingtan Yu, Ananda B. Portela Fontoura, Awais Javaid, Victor Sainz de la Maza-Escola, Nia S. Salandy, Susan L. Fubini, Ester Grilli, Joseph. W. McFadden, Jingyue Ellie Duan
Summary: Through liver transcriptome analysis, we found 483 differentially expressed genes in her heat-stressed cows, especially significant downregulation of protein encoded genes in mitochondria. Furthermore, gene ontology enrichment analysis revealed an upregulation of protein folding pathway and a downregulation of oxidative phosphorylation pathway. This study provides important insights into the impact of heat stress on dairy cow health and productivity.
Article
Environmental Sciences
Emily S. Barrett, Zorimar Rivera-Nunez, Kylie Getz, Pamela Ohman-Strickland, Ranran Zhang, Danielle Kozlosky, Cathleen L. Doherty, Brian T. Buckley, Jessica Brunner, Richard K. Miller, Thomas G. O'Connor, Lauren M. Aleksunes
Summary: This study assessed the protective role of the BCRP gene in prenatal cadmium exposure. It was found that individuals with a reduced function polymorphism in the BCRP gene were more vulnerable to higher cadmium exposure in the placenta, which adversely affected fetal growth. This suggests that reduced function of the BCRP gene may increase the risk of smaller placental and fetal size associated with maternal cadmium exposure.
ENVIRONMENTAL RESEARCH
(2023)