Review
Pharmacology & Pharmacy
Peter Lees, Pierre-Louis Toutain, Jonathan Elliott, Jerome M. Giraudel, Ludovic Pelligand, Jonathan N. King
Summary: Robenacoxib is a veterinary-approved NSAID used in orthopaedic and soft tissue surgery, as well as musculoskeletal disorders in dogs and cats. It has a wide safety margin and significant clinical efficacy.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Alison Jeffrey, Sara Gardhouse, Michael Kleinhenz, Samuel E. E. Hocker, Mikaela Weeder, Shawnee R. R. Montgomery, Yuntao Zhang, Anna Porting, Tess Rooney
Summary: This study aimed to investigate the pharmacokinetics and inhibitory actions of robenacoxib in rabbits and develop dosing guidelines. The results showed varying plasma concentrations of robenacoxib after oral and subcutaneous administration. Despite exceeding therapeutic levels, there was little significance in the differences associated with COX-1 and COX-2 inhibition.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Josep Sola, Angel Menargues, Josep Homedes, Marta Salichs, Ines Alvarez, Luz Romero, Jose Miguel Vela
Summary: This study assessed the mechanistic basis of Enflicoxib therapy and investigated its COX inhibitory activity. The metabolite exhibited the highest COX-2 inhibition and selectivity.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2022)
Article
Ecology
Daniel Garrido-Sanz, Pilar Vesga, Clara M. Heiman, Aline Altenried, Christoph Keel, Jordan Vacheron
Summary: In this study, all available Pseudomonas genomes were used to reassess the phylogeny of the Pseudomonas protegens subgroup, revealing the presence of 12 distinct species. These species showed differences at the phenotypic level, and most were able to antagonize soilborne phytopathogens and kill the plant pest insect Pieris brassicae. However, some strains failed to do so, possibly due to adaptation to particular niches. This research expands our understanding of the Pseudomonas protegens subgroup and highlights the importance of species diversification processes in shaping the ecological consequences of pathogenic host interactions in environmental bacteria.
Article
Chemistry, Physical
Khaled R. A. Abdellatif, Eman K. A. Abdelall, Phoebe F. Lamie, Madlen B. Labib, Marwa M. Abdelhakeem, Maha M. Abdel-Fattah, El-Shaymaa El-Nahaas
Summary: Novel pyrazole-oxadiazole hydrides were designed and synthesized as selective COX-2 inhibitors. Their COX-2 inhibition and anti-inflammatory activities were evaluated, and several compounds showed high potency and good gastric safety.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Medicinal
Amany M. Ghanim, Samar Rezq, Tarek S. Ibrahim, Damian G. Romero, Hend Kothayer
Summary: Novel 1,2,4-triazine-quinoline hybrids were designed and synthesized as dual COX/15-LOX inhibitors, with hybrid 8e exhibiting the most potent and selective inhibitory activity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Yevgeniya E. Koshman, Aimee L. Bielinski, Brandan M. Bird, Jonathon R. Green, Kenneth L. Kowalkowski, Jie Lai-Zhang, Prathap Kumar Mahalingaiah, James W. Sawicki, Nari N. Talaty, Amanda S. Wilsey, Mark T. Zafiratos, Terry R. Van Vleet
Summary: Secondary pharmacology profiling is important in drug discovery to investigate the off-target effects of a drug. The study focused on the potential effects of COX-2 inhibitors on platelet stickiness/aggregation, vasal tone and blood pressure, and endothelial cell activation using various in vitro and in vivo models. The results suggest that cardiovascular events associated with rofecoxib are not solely caused by COX-2 inhibition alone.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2023)
Article
Plant Sciences
Martin Zabka, Roman Pavela, Katerina Kovarikova, Jan Triska, Nadezda Vrchotova, Jan Bednar
Summary: The study assessed the antifungal and insecticidal effects of the essential oil from Ocimum sanctum L. against harmful organisms, confirming its efficacy against different fungi and insects as well as environmental safety.
Article
Infectious Diseases
Kyran M. Staunton, Donovan Leiva, Alvaro Cruz, Joelyn Goi, Carlos Arisqueta, Jianyi Liu, Mark Desnoyer, Paul Howell, Francia Espinosa, Azael Che Mendoza, Stephan Karl, Jacob E. Crawford, Wei Xiang, Pablo Manrique-Saide, Nicole L. Achee, John P. Grieco, Scott A. Ritchie, Thomas R. Burkot, Nigel Snoad
Summary: Sound traps that attract male mosquitoes by mimicking female wingbeat frequencies have shown high species specificity in capturing Aedes aegypti and Aedes albopictus. Trials in dengue endemic environments demonstrated positive responses from male mosquitoes to frequencies between 450 and 600 Hz, with traps set at 550 Hz effectively capturing male Ae. aegypti and Ae. albopictus while reducing bycatch, particularly male Culex mosquitoes. This species-specificity could pave the way for more accurate smart-trap systems and reduced surveillance costs in public health programs.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Pharmacology & Pharmacy
Steven Sun, Yazdi K. Pithavala, Jean-Francois Martini, Joseph Chen
Summary: Lorlatinib is a highly effective treatment for ALK- or ROS1-positive non-small cell lung cancer, with strong intracranial activity. This study investigated the brain penetration of lorlatinib in patients with metastatic ALK- or ROS1-positive NSCLC. The results showed that lorlatinib concentrations in the cerebrospinal fluid exceeded the minimum effective concentrations for ALK mutations, indicating potent central nervous system penetration. These findings are consistent with the high intracranial response rates observed in clinical trials.
JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Horticulture
Martin Zabka, Roman Pavela
Summary: The growing pressure to reduce the environmental pesticide burden has led to increased demand for research on new, effective, naturally based agents. Chitosan has been shown to be highly effective and safe in controlling Phytophthora infestans, with a protective effect of 99.3% in natural conditions and equivalent direct activity to synthetic fungicides. Promoting further expansion of chitosan within legislation could reduce the pesticide burden and enhance eco-friendly plant protection.
Article
Pharmacology & Pharmacy
Margaret Gamalo, Yihua Zhao, Aijun Gao, Jingjing Ye, Junjing Lin, Eiji Eshida, YounJeong Choi, Robert Nelson
Summary: Pediatric patients should have access to appropriately evaluated medicines through revised labelling. The adequacy of the pediatric clinical development plan and safety database is critical for informed benefit-risk assessment. Although extrapolation from adults can support efficacy, reluctance to use the same approach in safety assessments may decrease trial efficiency. Safety review, specific assessments, and a unified approach using Bayesian methodology are explored to address this issue.
JOURNAL OF BIOPHARMACEUTICAL STATISTICS
(2023)
Article
Medicine, General & Internal
Yi Zhou, Wei Wu, Yuanjie Zhu, Xin Lv, Jianming Liu
Summary: This study aimed to determine the effective concentration of remifentanil used during the treatment of severe tracheal stenosis with fibreoptic bronchoscopy and evaluate its efficacy. The results showed that using remifentanil and dexmedetomidine can effectively inhibit stress response and maintain spontaneous breathing in patients. The satisfaction scores of the operator, anesthesiologist, and patients were high.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Andrea Greiter-Wilke, Sonia Roberts, Katja Heinig, David Waiz, Roland Jenni, Henry Holzgrefe
Summary: This study retrospectively analyzed the effects of thioridazine on heart rate, blood pressure, body temperature, and QT interval in dogs, cynomolgus monkeys, and Goettingen minipigs. The results showed significant species-specific differences in the response to thioridazine, highlighting the importance of considering potential impact of temperature and autonomic nervous system effects in nonclinical safety studies.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2022)
Article
Pharmacology & Pharmacy
Andrew Mead, Peter Lees, John Mitchell, Andrew Rycroft, Joseph F. Standing, Pierre-Louis Toutain, Ludovic Pelligand
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2019)
Article
Pharmacology & Pharmacy
Didier Concordet, Peggy Gandia, Jean-Louis Montastruc, Alain Bousquet-Melou, Peter Lees, Aude Ferran, Pierre-Louis Toutain
CLINICAL PHARMACOKINETICS
(2019)
Letter
Pharmacology & Pharmacy
Didier Concordet, Peggy Gandia, Jean-Louis Montastruc, Alain Bousquet-Melou, Peter Lees, Aude A. Ferran, Pierre-Louis Toutain
CLINICAL PHARMACOKINETICS
(2019)
Letter
Pharmacology & Pharmacy
Didier Concordet, Peggy Gandia, Jean-Louis Montastruc, Alain Bousquet-Melou, Peter Lees, Aude A. Ferran, Pierre-Louis Toutain
CLINICAL PHARMACOKINETICS
(2019)
Letter
Pharmacology & Pharmacy
Didier Concordet, Peggy Gandia, Jean-Louis Montastruc, Alain Bousquet-Melou, Peter Lees, Aude A. Ferran, Pierre-Louis Toutain
CLINICAL PHARMACOKINETICS
(2019)
Article
Microbiology
Pierre-Louis Toutain, Pritam Kaur Sidhu, Peter Lees, Ali Rassouli, Ludovic Pelligand
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Microbiology
Ludovic Pelliganch, Peter Lees, Pritam Kaur Sidhu, Pierre-Louis Toutain
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Pharmacology & Pharmacy
Didier Concordet, Peggy Gandia, Jean-Louis Montastruc, Alain Bousquet-Melou, Peter Lees, Aude A. Ferran, Pierre-Louis Toutain
CLINICAL PHARMACOKINETICS
(2020)
Letter
Pharmacology & Pharmacy
Didier Concordet, Peggy Gandia, Jean-Louis Montastruc, Alain Bousquet-Melou, Peter Lees, Aude A. Ferran, Pierre-Louis Toutain
CLINICAL PHARMACOKINETICS
(2019)
Letter
Pharmacology & Pharmacy
D. Concordet, P. Gandia, J. L. Montastruc, A. Bousquet-Melou, P. Lees, A. A. Ferran, P. L. Toutain
CLINICAL PHARMACOKINETICS
(2020)
Letter
Pharmacology & Pharmacy
Didier Concordet, Peggy Gandia, Jean-Louis Montastruc, Alain Bousquet-Melou, Peter Lees, Aude A. Ferran, Pierre-Louis Toutain
CLINICAL PHARMACOKINETICS
(2020)
Letter
Pharmacology & Pharmacy
Didier Concordet, Peggy Gandia, Jean-Louis Montastruc, Alain Bousquet-Melou, Peter Lees, Aude A. Ferran, Pierre-Louis Toutain
CLINICAL PHARMACOKINETICS
(2020)
Review
Pharmacology & Pharmacy
Peter Lees, Ludovic Pelligand, Etienne Giraud, Pierre-Louis Toutain
Summary: The evolution of antimicrobial drug (AMD) use in animals over the past eight decades has brought about revolutionary outcomes, with reports on various uses, misuses, and abuses increasing exponentially. While the treatment of animal diseases using AMDs will continue, it is crucial for it to be sustainable within the One Health paradigm and evolve towards more prudent, rational therapeutic uses. This review not only acknowledges concerns about antimicrobial resistance but also highlights the positive aspects and research-based advances resulting from the use of AMDs.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2021)
Review
Pharmacology & Pharmacy
Pierre-Louis Toutain, Ludovic Pelligand, Peter Lees, Alain Bousquet-Melou, Aude A. Ferran, John D. Turnidge
Summary: Pharmacokinetic/pharmacodynamic (PK/PD) modelling plays a crucial role in optimizing dosage regimens for systemically acting antimicrobial drugs (AMDs), with PK/PD indices being universally applicable across animal species. Two commonly used PK/PD indices in veterinary medicine are fAUC/MIC and fT > MIC. This review discusses more advanced PK/PD approaches and their applications in veterinary medicine, highlighting the importance of these indices in dose determination and establishing clinical breakpoints for antimicrobial susceptibility testing.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2021)
Review
Pharmacology & Pharmacy
Peter Lees, Pierre-Louis Toutain, Jonathan Elliott, Jerome M. Giraudel, Ludovic Pelligand, Jonathan N. King
Summary: Robenacoxib is a veterinary-approved NSAID used in orthopaedic and soft tissue surgery, as well as musculoskeletal disorders in dogs and cats. It has a wide safety margin and significant clinical efficacy.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2022)