Article
Veterinary Sciences
Florence Wootton, Barbara Glanemann, Sorrel Langley-Hobbs, Craig Breheny, Samuel Fowlie, Fiona Whitworth, Paolo Silvestrini, Anna Threlfall, Stephanie Sorrell, Vicki Black
Summary: This case series summary identified cats with non-erosive immune-mediated polyarthritis from seven referral hospitals between 2009 and 2020. The study found that prognosis for feline IMPA can be good with multimodal immunosuppression often required. Differentiating between associative and non-associative IMPA and choosing appropriate treatment strategies are crucial for the outcome of the disease.
JOURNAL OF FELINE MEDICINE AND SURGERY
(2022)
Article
Virology
Giovana Biezus, Thierry Grima de Cristo, Gabriela Bassi das Neves, Mariana da Silva Casa, Paula Barros Brizola, Marina Silvestre Sombrio, Luiz Claudio Miletti, Renata Assis Casagrande
Summary: Only a few studies have investigated the impact of FeLV subgroups on disease development in spontaneously infected cats. This study identified FeLV-A and FeLV-B subgroups in cats with lymphoma and leukemia and examined the phylogenetic relationships of env sequences. The prevalence of FeLV-AB in cats with lymphoma and leukemia in Brazil highlights the genetic diversity involved in the pathogenesis of these neoplasms.
Article
Multidisciplinary Sciences
Wei-Yu Lin, Sarah E. Fordham, Nicola Sunter, Claire Elstob, Thahira Rahman, Elaine Willmore, Colin Shepherd, Gordon Strathdee, Tryfonia Mainou-Fowler, Rachel Piddock, Hannah Mearns, Timothy Barrow, Richard S. Houlston, Helen Marr, Jonathan Wallis, Geoffrey Summerfield, Scott Marshall, Andrew Pettitt, Christopher Pepper, Christopher Fegan, Francesco Forconi, Martin J. S. Dyer, Sandrine Jayne, April Sellors, Anna Schuh, Pauline Robbe, David Oscier, James Bailey, Syed Rais, Alison Bentley, Lynn Cawkwell, Paul Evans, Peter Hillmen, Guy Pratt, David J. Allsup, James M. Allan
Summary: Prognostication in CLL patients is challenging due to its heterogeneous clinical course. This study identifies two genomic locations associated with disease progression, highlighting the impact of constitutional genetic variation on CLL prognosis. Additionally, functional genes implicated in modulating key pathways in CLL pathogenesis are identified.
NATURE COMMUNICATIONS
(2021)
Article
Veterinary Sciences
Kathryn A. LaQuaglia, James B. Robertson, Katharine F. Lunn
Summary: In dogs receiving vincristine for immune-mediated thrombocytopenia, administration of cyclosporine was significantly associated with the development of neutropenia. Neutropenic dogs had a significantly longer duration of hospitalization compared to non-neutropenic dogs, but there was no difference in survival rate.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Veterinary Sciences
Ninja Kolb, Kaspar Matiasek, Jana van Renen, Andrea Fischer, Yury Zablotski, Franziska Wielaender, Jasmin Nessler, Andrea Tipold, Rodolfo Cappello, Thomas Flegel, Shenja Loderstedt, Josephine Dietzel, Kirsten Gnirs, Kai Rentmeister, Stephan Rupp, Thilo von Klopmann, Frank Steffen, Konrad Jurina, Omar V. Del Vecchio, Martin Deutschland, Florian Koenig, Gualtiero Gandini, Tom Harcourt-Brown, Marion Kornberg, Ezio Bianchi, Teresa Gagliardo, Marika Menchetti, Henning Schenk, Joana Tabanez, Marco Rosati
Summary: The study investigates the prognostic biopsy findings in cats with inflammatory polyradiculoneuropathy, aiming to identify histologic features that are correlated with outcome. Hierarchical k-means clustering was performed to classify tissue samples into different categories, and the impact of histological parameters on outcome was evaluated. The study provides valuable insights into the prognosis of feline IMPN.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Hematology
Frank Akwaa, Ana Antun, Spero R. Cataland
Summary: This article reviews the main risk factors for relapse, exacerbation, and long-term complications of immune-mediated thrombocytopenic purpura (iTTP), as well as discusses the approach to observing patients with iTTP and providing long-term follow-up in the outpatient setting.
Article
Medicine, General & Internal
Mengying Wang, Ruoyu Meng, Yan Gao, Junxia Huang, Tianlan Li, Chunxia Mao, Shanshan Liu, Yujie Xu, Han Xu, Xianqi Feng
Summary: This article reports a case of chronic lymphocytic leukemia with secondary pancytopenia and reviews relevant literature to summarize its clinical characteristics, diagnosis, and treatment experience. Treatment with cyclosporine A had a positive effect on improving patient outcomes, but the mechanism of action still requires further study.
CLINICAL CASE REPORTS
(2022)
Review
Oncology
Candida Vitale, Elia Boccellato, Lorenzo Comba, Rebecca Jones, Francesca Perutelli, Valentina Griggio, Marta Coscia
Summary: In patients with chronic lymphocytic leukemia (CLL), immune alterations affecting both the innate and adaptive immunity are common, leading to autoimmune phenomena, increased infection risk, and secondary malignancies. These immune dysfunctions play a significant role in disease progression and clinical outcomes.
Review
Immunology
Marzia Palma, Tom A. Mulder, Anders Osterborg
Summary: BTK inhibitors have revolutionized the treatment of B-cell malignancies, especially chronic lymphocytic leukemia, with three FDA-approved inhibitors and many more in development. While these inhibitors have shown promising anti-tumor effects, their off-target effects on other kinases and impact on the immune system need to be further investigated for potential clinical implications.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Bihui Pan, Yue Li, Zhangdi Xu, Yi Miao, Hua Yin, Yilin Kong, Xinyu Zhang, Jinhua Liang, Yi Xia, Li Wang, Jianyong Li, Jiazhu Wu, Wei Xu
Summary: A novel prognostic model related to ferroptosis was established for CLL, which can be used for prognostic prediction. The model may also facilitate the development of new clinical ferroptosis-targeted therapies in patients with CLL.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Zong-Han Wang, Wei Li, Hao Dong, Fujun Han
Summary: Chronic lymphocytic leukemia (CLL) is a common hematological disease with a high incidence in western countries. Conventional chemotherapy and targeted therapeutic drugs have limitations in high-risk patients. Immunotherapy, particularly using natural killer (NK) cells, has shown potential for improved prognosis. NK cells enhance immune response through various mechanisms, including antibody-dependent cytotoxicity (ADCC), allogeneic NK cell therapy, and CAR-NK cell therapy. This article reviews the characteristics of NK cells, their receptors, and the advantages and disadvantages of NK cell-based immunotherapies for CLL.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Yucai Wang, Sutapa Sinha, Linda E. Wellik, Charla R. Secreto, Karen L. Rech, Timothy G. Call, Sameer A. Parikh, Saad S. Kenderian, Eli Muchtar, Suzanne R. Hayman, Amber B. Koehler, Daniel L. Van Dyke, Jose F. Leis, Susan L. Slager, Haidong Dong, Neil E. Kay, Rong He, Wei Ding
Summary: Compared to CLL patients, RS patients showed higher expression of PD-L1 in histiocytes and dendritic cells, as well as PD1 in neoplastic B cells in nodal tissue, along with increased infiltration of FOXP3-positive T cells and CD163-positive macrophages. Additionally, peripheral blood T-cell receptor clonality was significantly lower in RS patients, indicating a more diverse T-cell population in RS compared to CLL. These findings suggest that CLL and RS have distinct immune signatures that may impact immunotherapy efficacy.
BLOOD CANCER JOURNAL
(2021)
Article
Oncology
Isabel Jimenez, Barbara Tazon-Vega, Pau Abrisqueta, Juan C. Nieto, Sabela Bobillo, Carles Palacio-Garcia, Julia Carabia, Rafael Valdes-Mas, Magdalena Munuera, Lluis Puigdefabregas, Genis Parra, Anna Esteve-Codina, Clara Franco-Jarava, Gloria Iacoboni, Maria Jose Terol, Jose Antonio Garcia-Marco, Marta Crespo, Francesc Bosch
Summary: The study found limited and non-recurrent molecular changes at the time of progression in patients with CLL, indicating that clonal evolution may not be the main driver of clinical progression. Patients with progressing CLL showed increased dysfunction in the CD8(+) T cell compartment, while patients with stable disease did not exhibit this dysfunction.
BIOMARKER RESEARCH
(2021)
Review
Oncology
Maiko Matsushita
Summary: Although TKIs are effective in treating CML patients, LSCs are resistant to them. Immunotherapies targeting LSCs may be crucial in curing CML.
Article
Oncology
Nancy D. Ebelt, Edwin R. Manuel
Summary: Cancer cells can escape surveillance through epigenetic modifications, while hypomethylating agents (HMAs) have shown promise as a milder treatment option for leukemia patients. In this study, HMAs were tested on murine leukemias and found to re-establish immune-related gene expression, reduce leukemic burden, and improve survival. However, resistance and immune checkpoint protein expression were observed.
Article
Veterinary Sciences
Reiichiro Sato, Kazutaka Yamada, Taiki Yokoyama, Koki Tanimoto, Shoko Takeuchi, Natsumi Tatsuzawa, Shiho Nakui, Hiroyuki Satoh, Mahmoud Fadul, Adrian Steiner
Summary: This case report suggests that the combination of partial hepatectomy and long-term administration of antibacterial drugs may restore the health of calves with multiple liver abscesses.
BMC VETERINARY RESEARCH
(2021)
Article
Veterinary Sciences
Naoyuki Aihara, Anna Momoki, Nanase Hattori, Hironobu Murakami, Motoharu Oishi, Yoshiaki Goto, Reiichiro Sato, Makoto Nagai, Kazutaka Yamada, Junichi Kamiie
Summary: This is a case of congenital malformations of the external and middle ear accompanied by temporal bone anomaly, characterized by bilateral microtia and absent external acoustic meatus.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Article
Veterinary Sciences
Naoya Matsumoto, Nanako Sawayama, Megumi Itoh, Takahito Toyotome, Kazutaka Yamada
Summary: This study used computed tomography (CT) to measure air sac volume and evaluate the respiratory condition of penguins. It was found that there was no correlation between air sac volume and body weight, but changes in air sac volume within the same individual could be useful for assessing the respiratory condition of penguins.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Article
Veterinary Sciences
Kei Kazama, Ken Onda, Sachiko Arai, Yasunori Shinozuka, Kazuhiro Kawai, Kazuyuki Kaneko, Taro Kondo, Kazutaka Yamada
Summary: A 9-month-old Holstein heifer presented with poor growth and diarrhea. The radiographic findings of a displaced abomasum were identified, suggesting that abdominal radiography could be used as an auxiliary diagnostic approach.
VETERINARNI MEDICINA
(2022)
Article
Veterinary Sciences
Taro Kondo, Fumio Sato, Nao Tsuzuki, Chun-Jen Chen, Kazutaka Yamada
Summary: This study aimed to establish an index for spinal cord compression using computed tomography (CT) in Thoroughbred horses. It was found that a cut-off value of 7.06 mm for spinal cord height can serve as an index for spinal cord compression. The study highlights the potential of CT in evaluating vertebral canal stenosis in horses.
VETERINARY MEDICINE AND SCIENCE
(2022)
Article
Veterinary Sciences
Taro Kondo, Yamato Mashimo, Fumio Sato, Nao Tsuzuki, Kazutaka Yamada
Summary: This study found that variations in cranial cervical vertebral volume may be an important contributing factor in the development of CVSM in Thoroughbred horses. C3 demonstrated significantly smaller cervical vertebral volume, and there were significant differences in the variation of cervical vertebral volumes among C2 to C4 and C3 to C5 in the CVSM group.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Article
Veterinary Sciences
Taro Kondo, Fumio Sato, Nao Tsuzuki, Kazutaka Yamada
Summary: Cervical vertebral stenotic myelopathy (CVSM) is a common neurological disease in young adult Thoroughbred horses, characterized by ataxia and hindlimb weakness. This study evaluated sex differences in the development of cervical spinal cord and spinal canal in Thoroughbred horses. It found that male horses had larger cervical spinal cord volume and cervical spinal cord-to-spinal canal volume ratio compared to female horses, suggesting an imbalanced growth of the cervical spinal cord and spinal canal may be a cause of CVSM.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Article
Veterinary Sciences
Taro Kondo, Fumio Sato, Nao Tsuzuki, Kenichi Watanabe, Noriyuki Horiuchi, Yoshiyasu Kobayashi, Kazutaka Yamada
Summary: This study aimed to determine the characteristic CT myelography findings of CVSM lesions in Thoroughbred horses. Cervical vertebral malalignment and osseous lesions were observed. Ventral compressions were frequently seen in the cranial cervical vertebrae, while dorsal compressions were frequently seen in the caudal cervical vertebrae. CT myelography is a useful method for detecting CVSM changes.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Review
Mycology
Takahito Toyotome, Naoya Matsumoto, Megumi Itoh, Kazutaka Yamada
Summary: Aspergillosis is a significant fungal infection in both humans and animals. Penguins, in particular, are highly susceptible to aspergillosis, making it a major issue in captive penguins. To combat this, a multidisciplinary control team, which included a mycologist, was formed. Preventive measures such as minimizing contact between captive penguins and soil, washing the penguins' feet after outdoor marches, and sanitizing the rearing facility were implemented. These measures have successfully prevented aspergillosis in captive penguins since 2016. This case highlights the importance of a multidisciplinary team and the role of mycologists in aspergillosis control.
MEDICAL MYCOLOGY JOURNAL
(2022)
Article
Veterinary Sciences
Kikumi Ogihara, Akikazu Ishihara, Makoto Nagai, Kazutaka Yamada, Testuya Mizutani, Mei Harafuji, Hisanari Nishio, Hiroo Madarame
Summary: A case report of a horse with a recurrent mass of the glans penis undergoing partial phallectomy, euthanized due to suspected regrowth causing urinary retention. Histopathology and molecular analysis confirmed the mass as equine sarcoid, with a high sequence homology to BPV-1 from Hokkaido, Japan, indicating a geographical relationship for BPV-1.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)
Article
Veterinary Sciences
Hayato Amaike, Motoki Sasaki, Nao Tsuzuki, Mitsunori Kayano, Motoharu Oishi, Kazutaka Yamada, Hideki Endo, Tomoko Anezaki, Naoya Matsumoto, Rumiko Nakashita, Misako Kuroe, Hajime Taru, Gen Bando, Yuko Iketani, Ryohei Nakamura, Nobutaka Sato, Daisuke Fukui, Nobuo Kitamura
Summary: In this study, the pronation/supination angles of the forearm skeleton in Asiatic black, brown, and polar bears were examined nondestructively. The results showed that adult brown and polar bears had smaller angles compared to Asiatic black and non-adult brown bears. This suggests a relationship between pronation/supination angles and arboreal activity in Ursidae.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)
Article
Veterinary Sciences
Kazutaka Yamada, Taiki Yokoyama, Naoyuki Aihara, Yumi Une, Reiichiro Sato
Summary: Autopsy imaging (Ai) has been shown to be beneficial in veterinary medicine for farm animals, providing pre-dissection information on specific findings, facilitating pathological dissection, reducing lesion oversight, and aiding in educational purposes for students and farmers.
VETERINARY RECORD OPEN
(2021)
Article
Veterinary Sciences
Megumi Itoh, Miyuki Furuoka, Yukihiro Baba, Tetsu Saitoh, Eiji Hata, Yuki Hirano, Kazuhiro Senna, Kazutaka Yamada
Summary: The study found Mycoplasma bovigenitalium isolated from the vagina and farm environment of postpartum primiparous cows, with various genotypes detected in both. Some of the strains from the vagina and environment matched those previously found in positive milk, indicating a potential source of udder infection. It is important to manage postpartum cows to prevent udder infection with M.bg.
JAPANESE JOURNAL OF VETERINARY RESEARCH
(2021)
Article
Veterinary Sciences
Reiichiro Sato, Christoph Koch Mercier, Naoyuki Aihara, Kazuhiro Kawai, Hironobu Murakami, Rie Yasuda, Hiroyuki Satoh, Taiki Yokoyama, Kazutaka Yamada
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2020)
Article
Veterinary Sciences
Megumi Itoh, Takahito Toyotome, Naoya Matsumoto, Minoru Okamoto, Ken-ichi Watanabe, Kazutaka Yamada
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2020)