Article
Gastroenterology & Hepatology
Christophe Corpechot, Fabrice Carrat, Farid Gaouar, Frederic Chau, Gideon Hirschfield, Aliya Gulamhusein, Aldo J. Montano-Loza, Ellina Lytvyak, Christoph Schramm, Albert Pares, Ignasi Olivas, John E. Eaton, Karim T. Osman, George Dalekos, Nikolaos Gatselis, Frederik Nevens, Nora Cazzagon, Alessandra Zago, Francesco Paolo Russo, Nadir Abbas, Palak Trivedi, Douglas Thorburn, Francesca Saffioti, Laszlo Barkai, Davide Roccarina, Vicenza Calvaruso, Anna Fichera, Adele Delamarre, Esli Medina-Morales, Alan Bonder, Vilas Patwardhan, Cristina Rigamonti, Marco Carbone, Pietro Invernizzi, Laura Cristoferi, Adriaan van der Meer, Rozanne de Veer, Ehud Zigmond, Eyal Yehezkel, Andreas E. Kremer, Ansgar Deibel, Jerome Dumortier, Tony Bruns, Karsten Grosse, Georges-Philippe Pageaux, Aaron Wetten, Jessica Dyson, David Jones, Olivier Chazouilleres, Bettina Hansen, Victor de Ledinghen
Summary: In the largest ever study of LSM in patients with PBC, LSM assessed by VCTE improves prediction of survival beyond biochemical response, established prognostic scores, and age categories, independent of time. LSM can reasonably be regarded as a useful prognostic marker and a potential surrogate endpoint in PBC clinical trials.
JOURNAL OF HEPATOLOGY
(2022)
Article
Veterinary Sciences
Jason P. Bestwick, Barbara J. Skelly, James W. Swann, Barbara Glanemann, Nick Bexfield, Zeta Gkoka, David J. Walker, Paolo Silvestrini, Sophie Adamantos, Mayank Seth, James Warland
Summary: This study retrospectively describes the use of splenectomy in the management of immune-mediated hemolytic anemia and thrombocytopenia in dogs. The results suggest that splenectomy is successful in isolated cases of immune-mediated thrombocytopenia, but its effectiveness in immune-mediated hemolytic anemia and concurrent immune-mediated hemolytic anemia and severe thrombocytopenia remains uncertain.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Veterinary Sciences
Luca Aresu, Chiara Agnoli, Arturo Nicoletti, Antonella Fanelli, Valeria Martini, Francesco Bertoni, Laura Marconato
Summary: Canine Burkitt-like lymphoma (B-LL) is a rare tumor in dogs classified as a high-grade B-cell malignancy. Compared to the human counterpart, phenotypical differences are observed, and despite treatment, prognosis remains poor. However, around 30% of dogs can survive more than 1 year.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Agriculture, Dairy & Animal Science
Arianna Miglio, Carlotta Valente, Carlo Guglielmini
Summary: Red blood cell distribution width (RDW) is a laboratory parameter that reflects the variation in erythrocyte size and can be used as a diagnostic and prognostic biomarker in various human disorders. This narrative review summarizes the studies investigating the relationship between RDW and various canine disorders.
Article
Veterinary Sciences
Elizabeth A. Conway, Neil P. Evans, Alison E. Ridyard
Summary: In dogs with IMHA, urinary 11-dTXB:Cr concentrations are elevated, indicating a prothrombotic state. However, in this study, u11-dTXB:Cr was not significantly associated with survival or suspected thrombosis in the IMHA population.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Veterinary Sciences
Deanna D. Dailey, Ann M. Hess, Gerrit J. Bouma, Dawn L. Duval
Summary: miRNAs play a role in post-transcriptional gene regulation and can serve as prognostic markers in canine osteosarcoma. Dysregulation of miRNA expression is associated with prognosis in aggressive tumors, suggesting a potential link between miRNA regulatory networks and metastatic phenotype in dogs with osteosarcoma.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Clinical Neurology
Eleonora Rollo, Valerio Brunetti, Irene Scala, Antonio Callea, Jessica Marotta, Catello Vollono, Giovanni Frisullo, Aldobrando Broccolini, Paolo Calabresi, Giacomo Della Marca
Summary: The occurrence of delirium in patients with acute stroke negatively impacts their prognosis. Patients who develop delirium after stroke have worse functional outcomes and shorter survival.
JOURNAL OF NEUROLOGY
(2022)
Article
Medicine, General & Internal
Paul M. E. L. van Dam, Sien Lievens, Noortje Zelis, William P. T. M. van Doorn, Steven J. R. Meex, Jochen W. L. Cals, Patricia M. Stassen
Summary: This retrospective study compared the performance of different prediction models in identifying high-risk emergency department patients. The RISE UP and COPE scores were found to have the best discriminatory performance for predicting 31-day mortality.
ANNALS OF MEDICINE
(2023)
Review
Dentistry, Oral Surgery & Medicine
En Long, Dongling You, Shubin Wang, Shun Lu, Peng Xu, Jie Zhou, Lu Li, Jian Wu, Biqin Zhang, Guiquan Zhu, Jinyi Lang
Summary: This study investigates the prognostic factors and treatment of primary intraosseous carcinoma (PIOC). The results suggest that surgery combined with adjuvant therapy is the superior treatment strategy for PIOC, and radiotherapy plays a positive role in the treatment of PIOC.
Article
Medicine, General & Internal
Jonas Rusnak, Tobias Schupp, Kathrin Weidner, Marinela Ruka, Sascha Egner-Walter, Jan Forner, Thomas Bertsch, Maximilian Kittel, Kambis Mashayekhi, Peter Tajti, Mohamed Ayoub, Michael Behnes, Ibrahim Akin
Summary: Cardiogenic shock (CS) patients with in-hospital cardiac arrest (IHCA) have higher 30-day all-cause mortality compared to those with out-of-hospital cardiac arrest (OHCA). This association is primarily driven by patients with acute myocardial infarction (AMI), while IHCA is not associated with mortality in non-AMI patients. Multivariable analysis confirms that IHCA is solely associated with higher 30-day all-cause mortality in AMI patients, but not in the non-AMI group and CAD subgroups. CS patients with IHCA and AMI have significantly increased all-cause mortality at 30 days, while there is no difference when differentiated by CAD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Grace Shu Hui Chiang, Ma Shwe Zin Nyunt, Qi Gao, Shiou Liang Wee, Keng Bae Yap, Boon Yeow Tan, Tze Pin Ng
Summary: The study developed an 8-item multidimensional index for predicting 11-year mortality in primary care and validated its predictive accuracy in different cohorts. Results showed that for each additional point score increase in the index, the mortality hazard ratio increased by 53%, suggesting that the PCP Index can be a useful tool for predicting long-term mortality in older adults in primary care settings.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Review
Clinical Neurology
Peng Zhang, Chun Wang, Junhua Wu, Shiliang Zhang
Summary: This study reviewed 19 studies with data on 5,781 stroke patients, showing that increased levels of plasma D-dimer predict worsened functional outcomes and elevated mortality following stroke. Subgroup analysis indicated that D-dimer levels were more predictive of poorer functional outcomes for ischemic stroke compared to intracerebral hemorrhage. The study provides evidence that higher D-dimer levels are associated with poorer functional outcomes and higher mortality post-stroke.
FRONTIERS IN NEUROLOGY
(2021)
Article
Immunology
Amir Tahavvori, Reza Mosaddeghi-Heris, Faezeh Ghanbari Sevari, Seyed Mohammad Amin Alavi, Peghah Panahi, Niloufar Abbasi, Hamed Rahmani Youshanlouei, Seyyed Sina Hejazian
Summary: This study aimed to evaluate the predictive value of hematologic inflammatory indices in in-hospital mortality of ICU-admitted COVID-19 patients. The results showed that age and dNLR are valuable predictive factors for in-hospital death of ICU-admitted COVID-19 patients.
INFLAMMOPHARMACOLOGY
(2023)
Article
Infectious Diseases
Lidiane de Oliveira, Marcia de Souza Carvalho Melhem, Renata Buccheri, Oscar Jose Chagas, Jose Ernesto Vidal, Fredi Alexander Diaz-Quijano
Summary: Age and CSF yeast count were independently associated with in-hospital mortality of patients with cryptococcal meningitis, but Cryptococcus species identification and antifungal susceptibility were not associated with the outcomes. Quantitative CSF yeast counts used in this study can be evaluated and implemented in other low and middle-income settings.
BMC INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Paul M. E. L. van Dam, Noortje Zelis, Sander M. J. van Kuijk, Aimee E. M. J. H. Linkens, Renee A. G. Bruggemann, Bart Spaetgens, Iwan C. C. van der Horst, Patricia M. Stassen
Summary: This study evaluated the value of various prediction models in COVID-19 patients in the emergency department and found that the RISE UP score and 4 C mortality score had the best discriminatory performance for predicting 30-day mortality.
ANNALS OF MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Sanae Kubota-Aizawa, Yasuo Matsubara, Hideyuki Kanemoto, Hitomi Mimuro, Kazuyuki Uchida, James Chambers, Masaya Tsuboi, Koichi Ohno, Kenjiro Fukushima, Naoya Kato, Hiroshi Yotsuyanagi, Hajime Tsujimoto
Summary: The study revealed that two dogs and their owner were infected with the same H. pylori strain, indicating for the first time that H. pylori can be transmitted between humans and dogs. Further research is needed to investigate the risk factors for H. pylori transmission between humans and dogs from a preventive epidemiology perspective.
Article
Veterinary Sciences
Juraj Hlavaty, Reinhard Ertl, Tewodros Abere Mekuria, Barbara Ruetgen, Hajime Tsujimoto, Ingrid Walter, Birgitt Wolfesberger
Summary: The use of prednisolone prior to chemotherapy in small animal lymphoma patients negatively affects the susceptibility of lymphoma cells to doxorubicin or vincristine treatment, leading to increased expression of multidrug resistance proteins.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
A. Tani, Y. Saegusa, K. Ogawa, H. Tomiyasu, Y. Takeuchi, K. Harada, T. Kobayashi, A. Setoguchi, J. Nakamichi, T. Mizuno, M. Irie, M. Tokita, K. Fujita, M. Suenaga, T. Motegi, A. Ohmi, Y. Goto-Koshino, K. Ohno, H. Tsujimoto
Summary: Six genes associated with resistance to drugs used in CHOP-based protocol in canine lymphoma were identified in this study, and a novel scoring system to predict resistance to these drugs was proposed. This system may aid in selecting the most appropriate chemotherapy protocol for individual dogs with lymphoma.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Taisuke Nakagawa, Mari Kojima, Koichi Ohno, James K. Chambers, Kazuyuki Uchida, Aki Ohmi, Yuko Goto-Koshino, Hirotaka Tomiyasu, Hajime Tsujimoto
Summary: The study showed that continuous l-asparaginase administration is an effective and safe treatment option for dogs with large cell lymphoma of presumed GI origin. Most cases showed improvement in clinical signs at diagnosis, with a good treatment response.
VETERINARY AND COMPARATIVE ONCOLOGY
(2022)
Article
Veterinary Sciences
Kazushi Azuma, Aki Ohmi, Yuko Goto-Koshino, Hirotaka Tomiyasu, Koichi Ohno, James K. Chambers, Kazuyuki Uchida, Hiroyuki Namba, Masahiko Nagata, Eiji Nagamine, Kazumi Nibe, Mitsuhiro Irie, Hajime Tsujimoto
Summary: Canine cutaneous lymphoma, primarily of T-cell origin, is classified into epitheliotropic and nonepitheliotropic subtypes, each with distinct histological subtypes. Prognosis is influenced by histopathological subtype, clinical variables such as neoplastic lymphocytes in peripheral blood and treatment response.
VETERINARY AND COMPARATIVE ONCOLOGY
(2022)
Article
Veterinary Sciences
Megumi Yoshida, Keijiro Mizukami, Masaharu Hisasue, Ichiro Imanishi, Keigo Kurata, Masaki Ochiai, Masato Itoh, Tadahiro Nasukawa, Jumpei Uchiyama, Hajime Tsujimoto, Masahiro Sakaguchi
Summary: This study examined severe adverse reactions in cats after vaccination, and found that a significant percentage experienced anaphylaxis, with a high mortality rate. Analysis of commercially available feline vaccines detected high levels of bovine serum albumin, which may be related to the occurrence of anaphylactic reactions.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Article
Veterinary Sciences
Takuro Nagahara, Koichi Ohno, Itsuma Nagao, Taisuke Nakagawa, Yuko Goto-koshino, Masaya Tsuboi, James K. Chambers, Kazuyuki Uchida, Hirotaka Tomiyasu, Hajime Tsujimoto
Summary: Intestinal lymphangiectasia (IL) is a common complication in dogs. This study aimed to investigate the potential role of inducible nitric oxide synthase (iNOS) in the development of IL in dogs with lymphoplasmacytic enteritis (LPE). The results showed that there was a significant increase in iNOS expression in the duodenal tissues of dogs with IL-negative or IL-positive LPE compared to control dogs. However, there was no significant difference in iNOS expression between IL-positive and IL-negative tissues, suggesting that factors other than nitric oxide may contribute to the development of IL in dogs with LPE.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Article
Veterinary Sciences
Aki Ohmi, Miho Tanaka, Jun Rinno, Masaya Tsuboi, James K. Chambers, Kazuyuki Uchida, Yuko Goto-Koshino, Hirotaka Tomiyasu, Koichi Ohno, Hajime Tsujimoto
Summary: Lymphoma with Mott cell change (MCL) is a rare variant of canine lymphoma. This study investigated the clinical characteristics and outcomes of MCL in miniature dachshunds, and found that MCL mainly occurs in the gastrointestinal tract of these dogs and has a longer survival compared to other types of lymphoma.
VETERINARY MEDICINE AND SCIENCE
(2023)
Article
Veterinary Sciences
Hideyuki Kanemoto, Aki Fujiwara-Igarashi, Tetsuya Kobayashi, Kei Harada, Masanao Ichimata, Sangho Kim, Kenji Hosoya, Hirotaka Tomiyasu, Aki Ohmi, Hajime Tsujimoto
Summary: This multicentre, retrospective observational study aimed to describe the clinical presentation, diagnostic methods, treatment and outcomes of cats with tracheal masses. Lymphoma was the most prevalent diagnosis, and showed a good response to chemotherapy with or without radiation therapy. Ultrasound-guided fine-needle biopsy and cytology are good diagnostic procedures for cervical tracheal lesions.
JOURNAL OF FELINE MEDICINE AND SURGERY
(2023)
Article
Veterinary Sciences
Mona Uchida, Yuki Matsumiya, Masaya Tsuboi, Kazuyuki Uchida, Takayuki Nakagawa, Wataru Fujii, Tetsuya Kobayashi, Hajime Tsujimoto, Aki Ohmi, Hirotaka Tomiyasu, Tomoki Motegi, Shingo Maeda, Yasuyuki Momoi, Tomohiro Yonezawa
Summary: Histiocytic sarcoma (HS) is a rare malignancy in dogs, with poor prognosis. This study investigated the involvement of apoptosis inhibitor of macrophage (AIM) in the development of HS in dogs. The expression of AIM in tumor tissue and serum AIM levels were evaluated, and the effects of AIM overexpression on HS cells were studied. The results suggest that elevated expression of AIM in tumor and serum could induce the progression of HS cells in dogs, and serum AIM levels may serve as a biomarker for HS.
VETERINARY AND COMPARATIVE ONCOLOGY
(2023)
Article
Veterinary Sciences
Takuro Nagahara, Koichi Ohno, Itsuma Nagao, Taisuke Nakagawa, Nozomu Yokoyama, Aki Ohmi, Yuko Goto-Koshino, James K. Chambers, Kazuyuki Uchida, Hirotaka Tomiyasu, Hajime Tsujimoto
Summary: This study evaluated changes in coagulation parameters in dogs with PLE after treatment and found that hypercoagulability detected by ROTEM significantly improved in dogs with PLE after treatment.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)
Article
Veterinary Sciences
Megumi Yoshida, Keijiro Mizukami, Masaharu Hisasue, Ichiro Imanishi, Keigo Kurata, Masaki Ochiai, Masato Itoh, Tadahiro Nasukawa, Jumpei Uchiyama, Hajime Tsujimoto, Masahiro Sakaguchi
Summary: A study examined severe adverse reactions after rabies vaccination in dogs in Japan, finding a low rate of anaphylaxis but a higher death rate. Veterinarians should be prepared to handle vaccine-associated anaphylaxis.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)
Article
Veterinary Sciences
Mitsuhiro Irie, Hirotaka Tomiyasu, Hajime Tsujimoto, Chiaki Kita, Yumiko Kagawa
Summary: This study investigated the overall survival and prognostic factors for dogs with GIST treated by surgical resection alone, finding that primary tumor site, particularly tumors in the small intestine, was a significant factor associated with shorter overall survival in these cases.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)
Article
Pathology
Yuki Morinaga, Masaya Igase, Takuma Yanase, Yusuke Sakai, Hiroki Sakai, Aki Fujiwara-Igarashi, Hajime Tsujimoto, Masaru Okuda, Takuya Mizuno
Summary: The elevated expression of DEPDC1B in canine lymphoma suggests its potential as a marker or therapeutic target for canine malignancies. However, the exact oncogenic mechanism remains unknown.
JOURNAL OF COMPARATIVE PATHOLOGY
(2021)
Article
Veterinary Sciences
Maho Nakazawa, Hirotaka Tomiyasu, Kanako Suzuki, Hajime Asada, Aki Fujiwara-Igarashi, Yuko Goto-Koshino, Aki Ohmi, Koichi Ohno, Michio Fujita, Hajime Tsujimoto
Summary: The study indicated that similar efficacy could be achieved by palliative hypofractionated radiotherapy, chemotherapy, or a combination of them for nasal lymphoma in cats, with no significant difference in overall survival and progression free survival among these three treatment groups.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)
