Review
Agriculture, Dairy & Animal Science
Katarzyna Malin, Olga Witkowska-Pilaszewicz
Summary: C-reactive protein (CRP) is a major acute phase protein in dogs and is commonly used as a marker of inflammation due to its high sensitivity. It is a useful tool for guiding therapeutic decisions and can be used to monitor systemic inflammatory activity and treatment efficacy. The concentration of CRP changes rapidly with the onset and removal of inflammatory stimuli, making it a valuable indicator in clinical practice.
Article
Medicine, General & Internal
Ronnie Meilik, Hadas Ben-Assayag, Ahuva Meilik, Shlomo Berliner, David Zeltser, Itzhak Shapira, Ori Rogowski, Ilana Goldiner, Shani Shenhar-Tsarfaty, Asaf Wasserman
Summary: This study found a clear association between CRP concentration at admission and 7-day mortality, with higher CRP levels indicating higher mortality rates. Additionally, CRP values obtained 24 hours after hospital admission improved diagnostic accuracy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Veterinary Sciences
Priscilla Burnotte, Nicolas Graziano, Kris Gommeren
Summary: This study aimed to screen the occurrence of parapneumonic effusion in dogs with a presumptive diagnosis of bacterial pneumonia. The results showed that parapneumonic effusion occurred in 33.8% of dogs with a presumptive diagnosis of bacterial pneumonia, but thoracocentesis or chest tube placement was rarely performed, and the prognosis of dogs with and without parapneumonic effusion appeared to be similar.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Veterinary Sciences
Kate Turner, Corrin Boyd, Gabriele Rossi, Claire R. Sharp, Melissa A. Claus, Abbie Francis, Lisa Smart
Summary: This study compared concentrations of various biomarkers in dogs with anaphylaxis, critical illness, and healthy dogs. Histamine concentration was significantly higher in the anaphylaxis group, while IL-10, CCL2, and AST concentrations were increased in both anaphylaxis and critically ill groups. CRP and histamine showed potential for differentiating between anaphylaxis and other critical illness, with good discrimination.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Engineering, Biomedical
Brandon D. Wilson, Michael Eisenstein, H. Tom Soh
Summary: The assessment of molecular assays can be enhanced by quantifying the resolution of molecular concentration, which is a new metric proposed and evaluated in this study.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Veterinary Sciences
Nicole Tusa, Angel Abuelo, Nyssa A. Levy, Jeffery C. Gandy, Daniel K. Langlois, Harry Cridge
Summary: Oxidant status is altered in dogs with naturally occurring acute pancreatitis, but the clinical relevance of this finding is unknown.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Melissa M. Lane, Mojtaba Lotfaliany, Malcolm Forbes, Amy Loughman, Tetyana Rocks, Adrienne O'Neil, Priscila Machado, Felice N. Jacka, Allison Hodge, Wolfgang Marx
Summary: This study found an association between higher intake of ultra-processed food and elevated hsCRP concentration. This association appeared to be independent of body mass index.
Article
Veterinary Sciences
Emily McCobb, Seana Dowling-Guyer, Sharon Pailler, Nida P. Intarapanich, Elizabeth A. Rozanski
Summary: This study compared the outcome of canine pyometra surgeries performed at different treatment facilities and found no difference in surgical survival rate. Dogs treated at referral hospitals had significantly shorter diagnosis and surgery duration, but the delay time was not related to the survival rate.
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2022)
Article
Veterinary Sciences
Viktoriya Indzhova, Michal Czopowicz, Scott Kilpatrick, Rodrigo Gutierrez-Quintana, Josep Brocal
Summary: This retrospective multicenter study aimed to assess the ability of CRP concentration to differentiate between dogs with IMPA and SRMA. The study found that SRMA was diagnosed more frequently in dogs younger than 12 months, while IMPA was diagnosed more frequently in dogs aged 12 months or older. The results showed that CRP concentration varied depending on both patient age and definitive diagnosis, indicating that it may play a role in distinguishing between SRMA and IMPA but should not be used as the sole diagnostic modality.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Behavioral Sciences
Bo H. Jonsson, Funda Orhan, Sanna Bruno, Ana Osorio Oliveira, Timea Sparding, Mikael Landen, Carl M. Sellgren
Summary: The study found that serum zinc levels were increased in patients with bipolar disorder, which was not related to immune activation or mood symptoms. Additionally, serum zinc levels did not correlate with executive functioning or disease severity.
BRAIN AND BEHAVIOR
(2022)
Article
Immunology
Pavla Hamouzova, Sarka Stehlikova, Libuse Poldova, Zuzana Vlasata, Kristina Rehakova, Jaroslav Doubek
Summary: This study investigates the characteristics of lymphopenia in dogs and emphasizes the use of flow cytometry for lymphocyte immunophenotyping. The study found that lymphopenia often occurs in dogs over 7 years of age (79.5%), with the most common causes being postoperative lymphopenia (31.8%) and inflammatory diseases (29.5%). Flow cytometry results showed that the percentage of Th lymphocytes was significantly lower in patients with elevated CRP compared to patients with basal CRP (P=0.0329).
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2023)
Article
Veterinary Sciences
Alenka Nemec Svete, Barbara Verk, Nina Cebulj-Kadunc, Janez Salobir, Vida Rezar, Aleksandra Domanjko Petric
Summary: Inflammatory and oxidative stress markers are linked in canine CHF patients, but not in patients without CHF. These results suggest complex cross communication between the two biological pathways in advanced stages of CHF.
BMC VETERINARY RESEARCH
(2021)
Review
Integrative & Complementary Medicine
Yuanyuan Yue, Meng Gao, Yanru Deng, Jiemin Shao, Yingguang Sun
Summary: The study found that combining modified Yunu-Jian with western medicine for treating periodontitis significantly improved the total effective rate and periodontal indexes of patients. No serious adverse reactions were observed in the experimental groups.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Dermatology
Ceren Dinler Ay, Gulten Emek Tuna, Gamze Sevri Ekren Asici, Bulent Ulutas
Summary: The study found that serum concentrations of SAA were related to the severity of SM, and serum concentrations of CRP were effective in detecting the presence of pyoderma in dogs with severe SM.
VETERINARY DERMATOLOGY
(2022)
Article
Veterinary Sciences
Nana Dupont, Lisbeth Rem Jessen, Frida Moberg, Nathali Zyskind, Camilla Lorentzen, Charlotte Reinhard Bjornvad
Summary: Most dogs hospitalized with suspected AHDS improve rapidly with symptomatic treatment only, despite initial signs of systemic disease. The commonly used SIRS criteria may not be suitable for identifying dogs with AHDS in need of antimicrobial treatment, especially when hypovolemic. The role of CRP in clinical decision-making or prognostication requires further investigation.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Sanae Kubota-Aizawa, Yasuo Matsubara, Hideyuki Kanemoto, Hitomi Mimuro, Kazuyuki Uchida, James Chambers, Masaya Tsuboi, Koichi Ohno, Kenjiro Fukushima, Naoya Kato, Hiroshi Yotsuyanagi, Hajime Tsujimoto
Summary: The study revealed that two dogs and their owner were infected with the same H. pylori strain, indicating for the first time that H. pylori can be transmitted between humans and dogs. Further research is needed to investigate the risk factors for H. pylori transmission between humans and dogs from a preventive epidemiology perspective.
Article
Veterinary Sciences
A. Tani, Y. Saegusa, K. Ogawa, H. Tomiyasu, Y. Takeuchi, K. Harada, T. Kobayashi, A. Setoguchi, J. Nakamichi, T. Mizuno, M. Irie, M. Tokita, K. Fujita, M. Suenaga, T. Motegi, A. Ohmi, Y. Goto-Koshino, K. Ohno, H. Tsujimoto
Summary: Six genes associated with resistance to drugs used in CHOP-based protocol in canine lymphoma were identified in this study, and a novel scoring system to predict resistance to these drugs was proposed. This system may aid in selecting the most appropriate chemotherapy protocol for individual dogs with lymphoma.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Taisuke Nakagawa, Mari Kojima, Koichi Ohno, James K. Chambers, Kazuyuki Uchida, Aki Ohmi, Yuko Goto-Koshino, Hirotaka Tomiyasu, Hajime Tsujimoto
Summary: The study showed that continuous l-asparaginase administration is an effective and safe treatment option for dogs with large cell lymphoma of presumed GI origin. Most cases showed improvement in clinical signs at diagnosis, with a good treatment response.
VETERINARY AND COMPARATIVE ONCOLOGY
(2022)
Article
Veterinary Sciences
Kazushi Azuma, Aki Ohmi, Yuko Goto-Koshino, Hirotaka Tomiyasu, Koichi Ohno, James K. Chambers, Kazuyuki Uchida, Hiroyuki Namba, Masahiko Nagata, Eiji Nagamine, Kazumi Nibe, Mitsuhiro Irie, Hajime Tsujimoto
Summary: Canine cutaneous lymphoma, primarily of T-cell origin, is classified into epitheliotropic and nonepitheliotropic subtypes, each with distinct histological subtypes. Prognosis is influenced by histopathological subtype, clinical variables such as neoplastic lymphocytes in peripheral blood and treatment response.
VETERINARY AND COMPARATIVE ONCOLOGY
(2022)
Article
Immunology
Meg Nakazawa, Jiro Miyamae, Masaharu Okano, Hideyuki Kanemoto, Fumihiko Katakura, Takashi Shiina, Koichi Ohno, Hajime Tsujimoto, Tadaaki Moritomo, Toshihiro Watari
Summary: This study investigated the immunogenetic basis of refractory CE in French bulldogs and miniature dachshunds, identifying a protective haplotype against CE in French bulldogs and suggesting disease heterogeneity across breeds. The findings support the importance of further DLA studies in different breeds for improving early diagnosis, treatment, and prevention strategies.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2021)
Article
Veterinary Sciences
Jared A. Jaffey, Rachael Kreisler, Kate Shumway, Yan-Jane Lee, Chung-Hui Lin, Lawren L. Durocher-Babek, Kyoung-Won Seo, Hojung Choi, Ko Nakashima, Hiromi Harada, Hideyuki Kanemoto, Lee-Shuan Lin
Summary: The higher the developmental stage of GBM, the more likely it is to exhibit biliary tract related clinical signs. The nadir SBP value deserves further investigation as a prognostic or potentially modifiable variable, particularly in the presence of gallbladder rupture.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Veterinary Sciences
Megumi Yoshida, Keijiro Mizukami, Masaharu Hisasue, Ichiro Imanishi, Keigo Kurata, Masaki Ochiai, Masato Itoh, Tadahiro Nasukawa, Jumpei Uchiyama, Hajime Tsujimoto, Masahiro Sakaguchi
Summary: This study examined severe adverse reactions in cats after vaccination, and found that a significant percentage experienced anaphylaxis, with a high mortality rate. Analysis of commercially available feline vaccines detected high levels of bovine serum albumin, which may be related to the occurrence of anaphylactic reactions.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Article
Veterinary Sciences
Takuro Nagahara, Koichi Ohno, Itsuma Nagao, Taisuke Nakagawa, Yuko Goto-koshino, Masaya Tsuboi, James K. Chambers, Kazuyuki Uchida, Hirotaka Tomiyasu, Hajime Tsujimoto
Summary: Intestinal lymphangiectasia (IL) is a common complication in dogs. This study aimed to investigate the potential role of inducible nitric oxide synthase (iNOS) in the development of IL in dogs with lymphoplasmacytic enteritis (LPE). The results showed that there was a significant increase in iNOS expression in the duodenal tissues of dogs with IL-negative or IL-positive LPE compared to control dogs. However, there was no significant difference in iNOS expression between IL-positive and IL-negative tissues, suggesting that factors other than nitric oxide may contribute to the development of IL in dogs with LPE.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Article
Veterinary Sciences
Aki Ohmi, Miho Tanaka, Jun Rinno, Masaya Tsuboi, James K. Chambers, Kazuyuki Uchida, Yuko Goto-Koshino, Hirotaka Tomiyasu, Koichi Ohno, Hajime Tsujimoto
Summary: Lymphoma with Mott cell change (MCL) is a rare variant of canine lymphoma. This study investigated the clinical characteristics and outcomes of MCL in miniature dachshunds, and found that MCL mainly occurs in the gastrointestinal tract of these dogs and has a longer survival compared to other types of lymphoma.
VETERINARY MEDICINE AND SCIENCE
(2023)
Article
Veterinary Sciences
Hideyuki Kanemoto, Aki Fujiwara-Igarashi, Tetsuya Kobayashi, Kei Harada, Masanao Ichimata, Sangho Kim, Kenji Hosoya, Hirotaka Tomiyasu, Aki Ohmi, Hajime Tsujimoto
Summary: This multicentre, retrospective observational study aimed to describe the clinical presentation, diagnostic methods, treatment and outcomes of cats with tracheal masses. Lymphoma was the most prevalent diagnosis, and showed a good response to chemotherapy with or without radiation therapy. Ultrasound-guided fine-needle biopsy and cytology are good diagnostic procedures for cervical tracheal lesions.
JOURNAL OF FELINE MEDICINE AND SURGERY
(2023)
Article
Veterinary Sciences
Mona Uchida, Yuki Matsumiya, Masaya Tsuboi, Kazuyuki Uchida, Takayuki Nakagawa, Wataru Fujii, Tetsuya Kobayashi, Hajime Tsujimoto, Aki Ohmi, Hirotaka Tomiyasu, Tomoki Motegi, Shingo Maeda, Yasuyuki Momoi, Tomohiro Yonezawa
Summary: Histiocytic sarcoma (HS) is a rare malignancy in dogs, with poor prognosis. This study investigated the involvement of apoptosis inhibitor of macrophage (AIM) in the development of HS in dogs. The expression of AIM in tumor tissue and serum AIM levels were evaluated, and the effects of AIM overexpression on HS cells were studied. The results suggest that elevated expression of AIM in tumor and serum could induce the progression of HS cells in dogs, and serum AIM levels may serve as a biomarker for HS.
VETERINARY AND COMPARATIVE ONCOLOGY
(2023)
Article
Veterinary Sciences
Takuro Nagahara, Koichi Ohno, Itsuma Nagao, Taisuke Nakagawa, Nozomu Yokoyama, Aki Ohmi, Yuko Goto-Koshino, James K. Chambers, Kazuyuki Uchida, Hirotaka Tomiyasu, Hajime Tsujimoto
Summary: This study evaluated changes in coagulation parameters in dogs with PLE after treatment and found that hypercoagulability detected by ROTEM significantly improved in dogs with PLE after treatment.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)
Article
Veterinary Sciences
Megumi Yoshida, Keijiro Mizukami, Masaharu Hisasue, Ichiro Imanishi, Keigo Kurata, Masaki Ochiai, Masato Itoh, Tadahiro Nasukawa, Jumpei Uchiyama, Hajime Tsujimoto, Masahiro Sakaguchi
Summary: A study examined severe adverse reactions after rabies vaccination in dogs in Japan, finding a low rate of anaphylaxis but a higher death rate. Veterinarians should be prepared to handle vaccine-associated anaphylaxis.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)
Article
Veterinary Sciences
Aki Ohmi, Koichi Ohno, James K. Chambers, Kazuyuki Uchida, Taisuke Nakagawa, Hirotaka Tomiyasu, Hajime Tsujimoto
Summary: In Japan, there is an increasing incidence of gastrointestinal adenocarcinomas in Jack Russell Terriers (JRTs) compared to other breeds, with JRTs showing longer survival times and requiring different treatment strategies.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)
Article
Veterinary Sciences
Maho Nakazawa, Hirotaka Tomiyasu, Kanako Suzuki, Hajime Asada, Aki Fujiwara-Igarashi, Yuko Goto-Koshino, Aki Ohmi, Koichi Ohno, Michio Fujita, Hajime Tsujimoto
Summary: The study indicated that similar efficacy could be achieved by palliative hypofractionated radiotherapy, chemotherapy, or a combination of them for nasal lymphoma in cats, with no significant difference in overall survival and progression free survival among these three treatment groups.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)