Article
Virology
Andrea M. Spiri, Marilisa Novacco, Marina L. Meli, Martina Stirn, Barbara Riond, Jonathan E. Fogle, Felicitas S. Boretti, Imogen Herbert, Margaret J. Hosie, Regina Hofmann-Lehmann
Summary: Feline calicivirus (FCV) is a common cat virus associated with oral ulcerations and virulent systemic disease. Efficacious vaccines protect against severe disease but not against infection. Vaccination induces neutralizing antibodies and cellular immune response. After two heterologous FCV challenges, vaccinated cats showed higher levels of cellular immunity compared to control cats.
Article
Dermatology
Caitlin E. Older, Alison B. Diesel, Johanna C. Heseltine, Amanda Friedeck, Carolyn Hedke, Stephanie Pardike, Katrina Breitreiter, Michael A. Rossi, James Messamore, Gary Bammert, Andrea J. Gonzales, Aline Rodrigues Hoffmann
Summary: The study aimed to investigate cytokine expression levels in healthy cats, cats with allergic dermatitis, and cats with asthma. The results showed that feline allergic diseases may have different pathomechanisms compared to allergic diseases in other species, which can guide further therapeutic development.
VETERINARY DERMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Raffaele Brancaccio, Giuseppe Murdaca, Rossella Casella, Teresa Loverre, Laura Bonzano, Eustachio Nettis, Sebastiano Gangemi
Summary: Skin inflammation is a common feature of atopic dermatitis, allergic contact dermatitis and chronic spontaneous urticaria, and the pathogenetic mechanisms are not fully understood. This study reviews the role of miRNA in regulating inflammatory mechanisms and innate and adaptive immune responses in these skin conditions. miRNAs are found to be involved in the pathogenesis and regulation of atopic dermatitis, chronic spontaneous urticaria, and allergic contact dermatitis, and they could serve as biomarkers and potential therapeutic targets for these chronic skin conditions.
Article
Immunology
Huijuan Ma, Qi Shu, Zhiming Li, Xiaodong Song, Huan Xu
Summary: Formaldehyde exacerbates inflammatory responses in allergic contact dermatitis by facilitating NLRP3 inflammasome activation in macrophages. These findings not only demonstrate that formaldehyde can aggravate inflammatory responses by promoting NLRP3 inflammasome activation in macrophages, but also suggest that NLRP3 may be a therapeutic target for alleviating formaldehyde-induced inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Kyunghoon Kim, Mina Kim, EunHee Rhee, Mi-Hee Lee, Hyeon-Jong Yang, Suyeon Park, Hwan Soo Kim
Summary: This systematic review and meta-analysis aimed to compare the effectiveness and safety between low-dose and high-dose CsA and other systemic immunomodulatory agents in treating moderate-to-severe atopic dermatitis (AD). The results showed that low-dose CsA was not inferior to high-dose CsA and other systemic immunomodulatory agents in reducing AD symptoms. However, high-dose CsA and other systemic immunomodulatory agents had a lower incidence of adverse events, although sensitivity analysis showed no significant difference between the two groups except in one study. The study suggests that low-dose CsA may be a suitable alternative in the treatment of moderate-to-severe AD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Allergy
Andrew W. Liu, Jacob E. Gillis, Tina L. Sumpter, Daniel H. Kaplan
Summary: The skin is populated by various immune cells and sensory neurons, and the interaction between the nervous and immune systems plays a crucial role in inflammatory skin diseases. Neurotransmitters secreted by nerve terminals mediate immune cell function, while immune factors derived from immune cells interact with neurons to induce itching. This review explores the effector functions of neurons on skin immune cells in mouse models of atopic and contact dermatitis, and discusses the contribution of specific neuronal subsets and immune factors to itch induction and inflammation. The findings also shed light on treatment strategies and the relationship between scratching and dermatitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Zheng Liu, Zhan Fan, Jinxin Liu, Jialu Wang, Mengli Xu, Xinlin Li, Yilun Xu, Yafang Lu, Chenlu Han, Zhihong Zhang
Summary: An immunomodulatory approach based on lipid nanoparticles carrying alpha-helical configurational melittin is developed to treat allergic contact dermatitis and atopic dermatitis by suppressing T cell-mediated inflammatory reactions.
Article
Allergy
Juan -Manuel Leyva-Castillo, Alex Mcgurk, Maria Strakosha, Daniela Vega-Mendoza, Sophia E. M. Smith, Kelsey Stafstrom, Megan Elkins, Janet Chou, Yui-Hsi Wang, Raif S. Geha
Summary: IL-4Ra blockade reduces allergic skin inflammation and promotes the clearance of S aureus strain SF8300 from sites of allergic skin inflammation by enhancing IL-17A expression.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Yu Ri Woo, Seok Hoon Moon, Jeesuk Yu, Sang Hyun Cho
Summary: This study investigated the synergistic effects of Korean Red ginseng (KRG) and conventional systemic therapeutics in atopic dermatitis (AD). The results showed that the combination treatment of KRG with hydroxyzine or evening primrose oil significantly reduced the severity of AD and dermal inflammation, as well as decreased serum IgE levels and IL-17 expression. This suggests that the combination of KRG and conventional systemic therapeutics can safely and effectively manage AD.
Article
Multidisciplinary Sciences
Courtney Hoskinson, Darlene L. Y. Dai, Kate L. Del Bel, Allan B. Becker, Theo J. Moraes, Piushkumar J. Mandhane, B. Brett Finlay, Elinor Simons, Anita L. Kozyrskyj, Meghan B. Azad, Padmaja Subbarao, Charisse Petersen, Stuart E. Turvey
Summary: Allergic diseases that affect millions of people worldwide have been linked to changes in the gut microbiome. The development of the infant immune system and gut microbiota occur simultaneously, and the composition of the microbiome may determine the development of tolerant immune programming in infants. A study with 1115 participants from the CHILD birth cohort revealed that early-life influences and microbiome features were consistently associated with four different allergic diagnoses at 5 years old. Additionally, impaired microbiota maturation at age 1 year was found to be a common factor in pediatric allergies, and specific functional and metabolic imbalances were identified as significant mediators between microbiota maturation and allergic diagnoses at age 5 years. This suggests that microbiota maturation could be a key factor in predicting and preventing allergic diseases.
NATURE COMMUNICATIONS
(2023)
Article
Allergy
Nisal Punchihewa, Amanda Palmer, Rosemary Nixon
Summary: The research investigation revealed that ACD caused by contact with Compositae plants primarily stems from gardening activities, but personal products also make up a considerable proportion. Treatment options are limited, with avoidance being the key aspect of management.
CONTACT DERMATITIS
(2022)
Review
Biochemistry & Molecular Biology
Francesco Borgia, Paolo Custurone, Federica Li Pomi, Mario Vaccaro, Clara Alessandrello, Sebastiano Gangemi
Summary: IL-37 and IL-33 are newly identified cytokines that play a role in various inflammatory conditions. This review aims to collect and organize data from multiple studies to establish a comprehensive understanding of their role. The studies assessed mainly focused on atopic dermatitis and immunologic pathways. The collective data suggests a pro-inflammatory role for IL-33 and an anti-inflammatory role for IL-37, potentially linked in an IL-33/IL-37 axis. Early results indicate that both cytokines may serve as markers of disease activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Mohammad-Hossein Shams, Reza Jafari, Nahid Eskandari, Mohsen Masjedi, Farnaz Kheirandish, Mazdak Ganjalikhani Hakemi, Ramin Ghasemi, Ali-Mohammad Varzi, Seyyed-Mohsen Sohrabi, Peyman Amanolahi Baharvand, Mozhgan Safari
Summary: Allergic diseases have significantly increased globally in recent decades, influenced by genetic factors, industrialization, improved hygiene, and climate change. Changes in lifestyle and diet habits also play a key role in the prevalence of allergic diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Ji-Sun Paik, Kyungdo Han, Gahee Nam, Sun-Kyoung Park, Ho Sik Hwang, Yoon Hong Chun, Kyung-Sun Na
Summary: This study investigated the association between cataract and allergic diseases. The findings suggest that individuals with allergic diseases are more likely to develop cataract compared to those without allergies. This association is particularly significant in male patients under the age of 50.
SCIENTIFIC REPORTS
(2022)
Article
Dermatology
Holly Neale, Anna Cristina Garza-Mayers, Idy Tam, JiaDe Yu
Summary: ACD is a delayed hypersensitivity skin reaction to environmental allergens that affects children and adults similarly. However, pediatric patch testing for ACD is less common due to challenges such as smaller surface area for testing and difficulty in cooperation, particularly with younger children. Clinical suspicion guided by patient presentation and history is key in diagnosing ACD in children.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Correction
Multidisciplinary Sciences
Ichiro Imanishi, Aurelie Nicolas, Ana-Carolina Barbosa Caetano, Thiago Luiz de Paula Castro, Natayme Rocha Tartaglia, Ricardo Mariutti, Eric Guedon, Sergine Even, Nadia Berkova, Raghuvir K. Arni, Nubia Seyffert, Vasco Azevedo, Koji Nishifuji, Yves Le Loir
SCIENTIFIC REPORTS
(2020)
Article
Veterinary Sciences
J. S. Yoon, K. Nishifuji, T. Iwasaki
RESEARCH IN VETERINARY SCIENCE
(2020)
Article
Veterinary Sciences
Ichiro Imanishi, Jumpei Uchiyama, Keijiro Mizukami, Junichi Kamiie, Keigo Kurata, Keita Iyori, Masato Fujimura, Kuniyoshi Shimakura, Koji Nishifuji, Masahiro Sakaguchi
BMC VETERINARY RESEARCH
(2020)
Article
Dermatology
Ji-Seon Yoon, Koji Nishifuji, Toshiro Iwasaki
VETERINARY DERMATOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Mami Oba, Wen Rongduo, Akatsuki Saito, Tamaki Okabayashi, Tomoko Yokota, Junko Yasuoka, Yoko Sato, Koji Nishifuji, Hitoshi Wake, Yutaka Nibu, Tetsuya Mizutani
Summary: The study demonstrated that a protease present in natto extract inhibits SARS-CoV-2 and BHV-1 infection by degrading viral proteins. However, heat treatment of the natto extract reverses this inhibitory effect.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Dermatology
Saki Onishi-Sakamoto, Kiichi Makishi, Kazumoto Takami, Ryota Asahina, Sadatoshi Maeda, Masahiko Nagata, Peter F. Moore, Kaori Ide, Koji Nishifuji
Summary: The study found that NB-UVB phototherapy had a certain effect on inflamed canine skin, reducing symptoms caused by cell-mediated reactions.
VETERINARY DERMATOLOGY
(2021)
Article
Dermatology
Keita Iyori, Shinichi Tamagawa, Kaori Ide, Koji Nishifuji
Summary: Bathing with artificially carbonated water showed significant improvement in clinical scores and skin surface pH in dogs with superficial bacterial folliculitis caused by Staphylococcus pseudintermedius. It could be an effective and safe adjunctive therapy for this condition.
VETERINARY DERMATOLOGY
(2022)
Article
Veterinary Sciences
Ji-Seon Yoon, Ako Sasaki, Kenichiroh Shimada, Kaori Ide, Toshiroh Iwasaki, Koji Nishifuji
Summary: The study found weak negative correlations between age and the amount of free extractable CERs in the skin of dogs, but there were no significant differences in this quantity related to sex or breed.
VETERINARY RESEARCH COMMUNICATIONS
(2022)
Article
Veterinary Sciences
Danfu Ma, Ahmed S. Mandour, Ahmed Elfadadny, Hanan Hendawy, Tomohiko Yoshida, Hussein M. El-Husseiny, Koji Nishifuji, Ken Takahashi, Zhenlei Zhou, Yanbing Zhao, Ryou Tanaka
Summary: This study evaluated changes in cardiac function in uremic cardiomyopathy and assessed the efficacy of Sal B therapy using IVPG and 2DSTE techniques, confirming the potential of Sal B in alleviating pathological changes in the heart.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Dermatology
Kaori Ide, Makoto Tokunaga, Shogo Hiratsuka, Toshiroh Iwasaki, Koji Nishifuji
Summary: This study demonstrates the utility of laser Doppler flowmetry in measuring dermal blood flow in canine pinnae. It accurately detects blood flow changes and characterizes dermal blood flow in dogs with pinnal alopecia. This noninvasive method is valuable for monitoring ischemic conditions of the dog's skin.
VETERINARY DERMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Yuta Baba, Saki Onishi-Sakamoto, Kaori Ide, Koji Nishifuji
Summary: This study determines the stage when nestin-expressing ORS stem/precursor cells or their descendants appear during HF morphogenesis and confirms their presence in adult HFs.
SCIENTIFIC REPORTS
(2022)
Article
Dermatology
Keita Iyori, Shinichi Tamagawa, Kaori Ide, Koji Nishifuji
Summary: This study evaluated the impact of artificially carbonated water bathing on skin parameters in healthy beagles. The results showed that after ACW bathing, skin blood flow significantly increased, while there were no significant changes in body temperature, skin temperature, TEWL, or skin hydration. These findings suggest that ACW bathing could potentially increase skin blood flow without affecting skin temperature, body temperature, and skin barrier function in dogs, similar to its effects in humans.
VETERINARY DERMATOLOGY
(2023)
Article
Genetics & Heredity
Yotaro Shimazaki, Shion Yoneya, Shigeru Fujita, Tomomi Nakashima, Kei Nabeshima, Sumire Sudoh, Katsuki Matsubara, Naka Okumura, Hirotaka Kondo, Koji Nishifuji, Ryota Koba, Yukinobu Tohya
Summary: The present study investigated the clinical and pathological characteristics of skin lesions in two four-toed hedgehogs. Papillomavirus (PV) was identified in the skin lesions using inverse PCR, and the full genome of the virus, named Atelerix albiventris papillomavirus 1 (AalbPV1), was sequenced. This study provides novel insights into the presence and genetic information of a new PV in Japanese four-toed hedgehogs.
Article
Veterinary Sciences
Kaori Ide, Mikako Shinohara, Shohei Yamagishi, Akihito Endo, Koji Nishifuji, Takumi Tochio
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2020)
Meeting Abstract
Allergy
Ichiro Imanishi, Jumpei Uchiyama, Takako Matsuda, Keijiro Mizukami, Hidekatsu Shimakura, Tadahiro Nasukawa, Junichi Kamiie, Keigo Kurata, Masato Fujimura, Kuniyoshi Shimakura, Koji Nishifuji, Masahiro Sakaguchi
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
