Journal
JOURNAL OF VETERINARY INTERNAL MEDICINE
Volume 27, Issue 1, Pages 22-30Publisher
WILEY-BLACKWELL
DOI: 10.1111/jvim.12004
Keywords
Chronic pain; Lameness; NSAIDs; Outcome assessment
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Funding
- National Institutes of Health [1-K08-DA-017720-02]
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Background Lameness assessment using force plate gait analysis (FPGA) and owner assessment of chronic pain using the Canine Brief Pain Inventory (CBPI) are valid and reliable methods of evaluating canine osteoarthritis. There are no studies comparing these 2 outcome measures. Objective Evaluate the relationship between CBPI pain severity (PS) and interference (PI) scores with the vertical forces of FPGA as efficacy measures in canine osteoarthritis. Animals Sixty-eight client-owned dogs with osteoarthritis (50 hind limb and 18 forelimb). Methods Double-blind, randomized. Owners completed the CBPI, and dogs underwent FPGA on days 0 and 14. Dogs received carprofen or placebo on days 1 through 14. The change in PS and PI scores from day 0 to 14 were compared to the change in peak vertical force (PVF) and vertical impulse (VI). Results PS and PI scores significantly decreased in carprofen- compared with placebo-treated dogs (P=.002 and P=.03, respectively). PVF and VI significantly increased in carprofen- compared with placebo-treated dogs (P=.006 and P=.02, respectively). There was no correlation or concordance between the PS or PI score changes and change in PVF or VI. Conclusions and Clinical Importance In these dogs with hind limb or forelimb osteoarthritis, owner assessment of chronic pain using the CBPI and assessment of lameness using FPGA detected significant improvement in dogs treated with carprofen. The lack of correlation or concordance between the change in owner scores and vertical forces suggests that owners were focused on behaviors other than lameness when making efficacy evaluations in their dogs.
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