Article
Medical Laboratory Technology
Laurence Dubourg, Sandrine Lemoine, Brune Joannard, Laurence Chardon, Vandrea de Souza, Pierre Cochat, Jean Iwaz, Muriel Rabilloud, Luciano Selistre
Summary: The studied formulas showed equivalent precision and accuracy in calculating plasma iohexol clearance, with Ng-Schwartz-Munoz formula demonstrating improved accuracy at higher levels of in-GFR.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Marcus Fransson, Anders Hellden, Ase Ostholm Balkhed, Dzeneta Nezirevic Dernroth, Maria Ha, Mats Haglund, Peter Milos, Hakan Hanberger, Bertil Kagedal
Summary: This case report highlights a patient with multiple brain abscesses caused by Streptococcus intermedius, ultimately recovering but requiring enucleation of the left eye. Subtherapeutic antibiotic concentrations were initially an issue, only resolved by increasing the dosage. It serves as a reminder that augmented renal clearance can impact the treatment of serious bacterial infections.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pediatrics
Evelyn Dhont, Tatjana Van der Heggen, Evelien Snauwaert, Jef Willems, Siska Croubels, Joris Delanghe, Jan J. De Waele, Roos Colman, Johan Vande Walle, Peter De Paepe, Pieter A. De Cock
Summary: The study aimed to identify predictors of ARC and describe its time-course in critically ill children. Major surgery other than cardiac surgery and eGFR were found as independent predictors of ARC.
PEDIATRIC NEPHROLOGY
(2023)
Article
Materials Science, Biomaterials
Xiuru Ji, Lan Zhu, Jessica C. Hsu, Han Wang, Jingwei Zhou, Qingbing Wang, Yuhan Li, Weibo Cai, Dalong Ni, Zhiyuan Wu
Summary: A novel class of tungsten-based contrast agents (WO3-x NPs) with excellent biocompatibility and minimal systemic toxicity for DECT was designed and presented a promising method for the accurate diagnosis of liver cancer.
BIOMATERIALS SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Laura Dhondt, Siska Croubels, Peter De Paepe, Klara Goethals, Pieter De Cock, Mathias Devreese
Summary: This study investigated the impact of continuous intravenous fluid administration on renal function and pharmacokinetics of renally excreted drugs using a piglet animal model. The findings suggest that fluid administration can increase the clearance of certain renally excreted drugs, leading to decreased systemic exposure. Further research is needed to confirm these results in children.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Thea Tislevoll Eide, Karl Ove Hufthammer, Atle Brun, Damien Brackman, Einar Svarstad, Camilla Tondel
Summary: The study aimed to investigate the feasibility and accuracy of using blood samples drawn from the injection access for iohexol GFR (iGFR) measurements in children. Results showed that iGFR based on samples drawn from the injection access at 2 and 3 hours were significantly lower than measurements from the contralateral arm, even after multiple procedures of blood discarding and saline flushing.
SCIENTIFIC REPORTS
(2021)
Article
Urology & Nephrology
Bjorn Steinar Lillas, Camilla Tondel, Anna Gjerde, Bjorn Egil Vikse
Summary: This study aimed to investigate the use of iohexol clearance to measure RFR in outpatients, and found that both one- and two-sample methods yielded similar results with some intra-individual variation.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Medicine, General & Internal
Zhicheng Jin, Rongrong Huang, Paul Christensen, Roger L. Bertholf, Xin Yi
Summary: This study aimed to establish a convenient laboratory test to evaluate the plasma clearance of iohexol in living kidney donors. Iohexol was measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS), and automated data integration and result calculation were achieved using a custom Python script and a laboratory informatics system (LIS) vendor's direct media interface for automated result reporting.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medical Laboratory Technology
Damiano Ognissanti, Moa Andresen Bergstrom, Elvar Theodorsson, Anders Larsson, Gunnar Nordin, Ola Hammarsten
Summary: In this study, we investigated the impact of optimizing sampling time points and estimating analytical uncertainty on calculating glomerular filtration rate (GFR). We found that incorrect time point selection could lead to inflation of analytical uncertainty in GFR calculations, but using optimal time points could yield the same uncertainty as analytical uncertainty. Among the three samples, the middle sample had little value. The first sample should be collected as early as possible after the distribution phase. Sampling before the patient-specific half-life of the kidney filtration marker resulted in exponential error inflation, while no error inflation was observed when sampling occurred later than 2 half-lives. Theoretical GFR uncertainty could be reduced by 2.6-fold if individually optimized time points were used in 731 clearance measurements. By using Taylor expansions to approximate the moments of transformed random variables, the uncertainty of individual GFR measurements could be calculated in a simple manner that can be applied by laboratory software.
CLINICAL CHEMISTRY
(2022)
Article
Transplantation
Bjorn Steinar Lillas, Camilla Tondel, Joerg Assmus, Bjorn Egil Vikse
Summary: Low birthweight (LBW) may be associated with lower measured GFR in middle-aged mainly healthy women, but not in men.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Medical Laboratory Technology
Ke Gong, Yingshu Zou, Haifeng Zhu, Xu Peng, Dongfang Qin, Bixuan Sun, Xuejing Wang
Summary: The metabolic curves of iohexol at the standard dose and contrast-level dose were found to be substantially identical. This suggests that the standard dose can be used for measuring GFR, and blood collection at 2 hours and 4 hours after injection is optimal.
CLINICA CHIMICA ACTA
(2022)
Article
Pharmacology & Pharmacy
Sarah Baklouti, Didier Concordet, Vitaliano Borromeo, Paola Pocar, Paola Scarpa, Petra Cagnardi
Summary: This study aimed to develop a population pharmacokinetic model to estimate iohexol plasma clearance in dogs and determine the best sampling times for accurate estimation of clearance in different situations. The two-compartment model showed creatinine and kidney status as covariates affecting clearance variability. Different optimal sampling times were identified based on health status and creatinine levels, providing a method that could potentially be applied to other population pharmacokinetic models for precise estimation of GFR.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Urology & Nephrology
Hans Pottel, Elke Schaeffner, Natalie Ebert, Markus van der Giet, Pierre Delanaye
Summary: The fitting procedure has a significant impact on the precision of calculated AUC and GFR. The simplified late-sample protocols and one-sample methods are not affected by fitting issues and show acceptable equivalence to the full compartment GFR results.
Article
Pediatrics
Nori J. L. Smeets, Esther M. M. Teunissen, Kim van der Velden, Maurice J. P. van der Burgh, Demi E. Linders, Elodie Teesselink, Dirk-Jan A. R. Moes, Camilla Tondel, Rob Ter Heine, Arno van Heijst, Michiel F. Schreuder, Saskia N. de Wildt
Summary: This study aimed to compare the prevalence of AKI and ARC in critically ill children using iohexol-based mGFR and SCr-based eGFR methods, and investigate the performance of different SCr-based eGFR methods. The results showed that AKI prevalence was higher and ARC prevalence was lower when using mGFR, and age- and sex-dependent equations had the highest accuracy for diagnosing AKI and ARC.
PEDIATRIC NEPHROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas M. Grist, Cheri L. Canon, Elliot K. Fishman, Maureen P. Kohi, Mahmud Mossa-Basha
Summary: The recent shortage of iohexol has disrupted the pharmaceutical supply chain critical to radiologic imaging and affected the global availability of iodinated contrast media (ICM). This shortage has created a national crisis in radiology departments, hampering their ability to provide contrast-enhanced examinations for patients. This report aims to provide short-term strategies for dealing with the shortage and discuss long-term issues and potential solutions to supply chain problems impacting radiology departments.
Article
Veterinary Sciences
Pak-Kan Tang, Rosanne E. Jepson, Yu-Mei Chang, Rebecca F. Geddes, Mark Hopkinson, Jonathan Elliott
Summary: This study found that higher plasma total calcium concentration and intake of a phosphate-restricted diet are associated with nephrocalcinosis in cats, but nephrocalcinosis is not related to rapid progression of CKD.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Veterinary Sciences
Edward J. Knowles, Jonathan Elliott, Patricia A. Harris, Yu-Mei Chang, Nicola J. Menzies-Gow
Summary: This study aimed to identify the most useful physical examination, metabolic, and management factors to predict the development of laminitis in nonlaminitic ponies. Through multivariable analysis, it was found that basal and post-60 minutes insulin concentrations were the best indicators for predicting the risk of future laminitis development.
EQUINE VETERINARY JOURNAL
(2023)
Article
Veterinary Sciences
J. S. Lawson, H. M. Syme, P. R. Antrobus, J. M. Karttunen, S. E. Stewart, Karet F. E. Frankl, T. L. Williams
Summary: This study successfully isolated feline urinary extracellular vesicles and characterized their proteome. The proteomic analysis showed that the urinary extracellular vesicles contained markers and proteins from all nephron segments. Renal disease or hypertension did not affect the concentration and size of urinary extracellular vesicles. While no differentially expressed proteins were found between the healthy category and the combined chronic kidney disease category, five differentially expressed proteins were identified between the normotensive chronic kidney disease and hypertensive chronic kidney disease categories.
JOURNAL OF SMALL ANIMAL PRACTICE
(2023)
Article
Veterinary Sciences
Lea Henze, Sarah Foth, Sebastian Meller, Friederike Twele, Marios Charalambous, Hannah Kenward, Jonathan Elliott, Ludovic Pelligand, Holger A. Volk
Summary: The objective of this study is to assess and confirm the effect of ondansetron on nausea behavior in dogs with vestibular syndrome. The results showed that the administration of ondansetron intravenously is beneficial for dogs with nausea secondary to acute vestibular syndrome.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Veterinary Sciences
Sophie E. Broughton, Dan G. O'Neill, Harriet M. Syme, Rebecca F. Geddes
Summary: This study aimed to investigate the clinical details and association with urolithiasis of ionized hypercalcemia in cats. The most common diagnoses associated with ionized hypercalcemia were kidney diseases, neoplasia, and idiopathic hypercalcemia. A high proportion of urolithiasis cases were observed in cats with acute kidney injury, iatrogenic hypercalcemia, and chronic kidney disease/renal diet-associated hypercalcemia. This study provides important information for understanding the clinical features of ionized hypercalcemia in cats and its association with urolithiasis.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Veterinary Sciences
Elizabeth J. T. Finding, Jonathan Elliott, Patricia A. Harris, Nicola J. Menzies-Gow
Summary: The study found that ponies with laminitis have higher blood pressure relative to non-laminitic ponies, which may be related to endothelial cell dysfunction. Inhibition of NOS leads to a decrease in blood NO concentration and an increase in blood pressure, with a greater rate of increase in systolic BP in PL ponies compared to NL ponies.
RESEARCH IN VETERINARY SCIENCE
(2022)
Editorial Material
Veterinary Sciences
Jonathan Elliott, Simon R. Bailey
EQUINE VETERINARY JOURNAL
(2023)
Review
Veterinary Sciences
Jonathan Elliott, Simon R. R. Bailey
Summary: Equine laminitis has been a focus of research for many years. Recent studies have discovered that ponies with pasture-associated laminitis have insulin-dysregulated phenotype, and prolonged insulin and glucose infusions can experimentally induce laminar pathology. This review aims to synthesize data from various models and naturally occurring cases of laminitis, proposing a hypothesis that basal epithelial cell stress is a central event in each type of laminitis. Pathways involved in different laminitis types contribute to laminar pathology to varying extents, and interactions between these pathways have been identified based on experimental models.
EQUINE VETERINARY JOURNAL
(2023)
Article
Veterinary Sciences
Rene E. Paschall, Jessica M. Quimby, Rachel E. Cianciolo, Shannon M. McLeland, Katharine F. Lunn, Jonathan Elliott
Summary: This study investigated capillary rarefaction in the kidneys of cats with chronic kidney disease (CKD) and found that capillary number and area were significantly decreased in CKD cats, and correlated with renal dysfunction and histopathologic lesions.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Veterinary Sciences
Rebecca F. Geddes, Lucy J. Davison, Jonathan Elliott, Harriet M. Syme, Dan G. O'Neill
Summary: This study aimed to identify risk factors for upper urinary tract uroliths (UUTUs) and obstructive UUTU in cats. The study found that female sex, certain breeds, and younger age were risk factors for UUTU. Risk factors for obstructive UUTU included female sex, bilateral uroliths, and younger age. Cats diagnosed with UUTU at a younger age had a higher risk of obstructive UUTU.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Jonathan Elliott
Summary: Reduced red cell mass in CKD patients can impair the oxygen delivery to kidney cells and contribute to kidney injury. Resistance to EPO treatment due to iron deficiency is a common problem in CKD patients. The use of HIF-prolyl hydroxylase inhibitors as an alternative treatment to increase red cell mass is discussed.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2023)
Article
Veterinary Sciences
Marine A. Barnabe, Jonathan Elliott, Patricia A. Harris, Nicola J. Menzies-Gow
Summary: This study aimed to investigate the feasibility of measuring insulin and adiponectin in equine saliva using automated assays, and to examine the potential stress-inducing effects of saliva collection. The correlation between serum and salivary insulin was also examined.
EQUINE VETERINARY JOURNAL
(2023)
Article
Veterinary Sciences
Marine A. Barnabe, Jonathan Elliott, Patricia A. Harris, Nicola J. Menzies-Gow
Summary: This study investigated the relationship between obesity and circulating plasma adiponectin levels in native-breed ponies in England. The study found that morphometric measures such as body condition score do not closely reflect adiponectin levels. It suggests that circulating adiponectin and basal insulin levels should be determined in all animals with predisposing factors, regardless of obesity status.
EQUINE VETERINARY JOURNAL
(2023)
Article
Veterinary Sciences
Marine A. Barnabe, Jonathan Elliott, Patricia A. Harris, Nicola J. Menzies-Gow
Summary: Short-term induced hyperinsulinaemia and dexamethasone challenge did not affect circulating total adiponectin in insulin-sensitive ponies. However, dexamethasone administration was associated with upregulation of two receptors linked to adiponectin signalling, suggesting that a physiological response occurred possibly to counteract dexamethasone-associated changes in tissue insulin sensitivity.
EQUINE VETERINARY JOURNAL
(2023)
Article
Veterinary Sciences
Edward J. Knowles, Patricia A. Harris, Jonathan Elliott, Yu-Mei Chang, Nicola J. Menzies-Gow
Summary: The association between serum insulin concentration and physical and owner-reported factors can help clinicians select individuals for insulin dysregulation testing and elucidate the pathophysiology. High-risk insulin concentration is associated with age, body condition score, and bulging supraorbital fatpads.
EQUINE VETERINARY JOURNAL
(2023)
