Article
Gastroenterology & Hepatology
Majid Alsahafi, Hebah Mimish, Fatma Salem, Mohammed Hijazi, Emad Aljahdli, Hani Jawa, Salim Bazarah, Rana Bokhary, Yousef Qari, Mahmoud Mosli
Summary: BE was reported endoscopically in 0.64% and histologically confirmed in 0.32% of this cohort of Saudi patients. Male gender was the only factor associated with BE.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Multidisciplinary Sciences
Krisztina Helle, Lenke Balint, Veronika Szekeres, Georgina Olle, Andras Rosztoczy
Summary: This study aimed to investigate the prevalence of GERD-related symptoms in South-East Hungarian subjects. The results showed that the prevalence of GERD-related symptoms in this region was significantly lower than that in Western countries and closer to Eastern values. The presence of mild chronic diseases, positive family history of GERD, height, BMI, coffee consumption, and smoking were identified as significant factors associated with the increased prevalence of GERD-related symptoms.
Article
Medicine, General & Internal
Sung-Goo Kang, Hyun Jee Hwang, Youngwoo Kim, Junseak Lee, Jung Hwan Oh, Jinsu Kim, Chul-Hyun Lim, Seung Bae Youn, Sung Hoon Jung
Summary: The study evaluated the association between reflux esophagitis and fatigue, finding no statistically significant association between reflux esophagitis and daytime sleepiness, fatigue, anxiety, or depression. However, fatigue was associated with GERD symptoms, being women, anxiety, and depression. Further research is needed to clarify the relationship between fatigue and reflux esophagitis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Abdurrahman Sahin, Gokhan Artas
Summary: The study aimed to determine the prevalence of BE among patients undergoing EGD in a tertiary care center in Eastern Turkey and compare it with other regions. They found a higher prevalence of BE in the study compared to other regions, with most cases being short-segment BE in middle-aged women, and a majority being positive for Helicobacter pylori.
ACTA MEDICA MEDITERRANEA
(2022)
Article
Gastroenterology & Hepatology
Theresa H. Nguyen, Aaron P. Thrift, Massimo Rugge, Hashem B. El-Serag
Summary: This study examined the prevalence of Barrett's esophagus in a previously unscreened primary care population and evaluated the performance of various BE screening guidelines. The findings suggest that guidelines requiring GERD symptoms have low sensitivity, while those not requiring GERD have low specificity. The study proposes a screening guideline with better utilization of known risk factors.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Tarek Sawas, Shawn A. Zamani, Sarah Killcoyne, Andrew Dullea, Kenneth K. Wang, Prasad G. Iyer, Rebecca C. Fitzgerald, David A. Katzka
Summary: Existing Barrett's esophagus screening guidelines have limitations in detecting prevalent esophageal adenocarcinoma. An optimized approach is needed to identify individuals most suitable for esophageal adenocarcinoma screening, particularly one that does not rely on chronic reflux symptoms.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ahmed Sam Beydoun, Kaleigh A. Stabenau, Kenneth W. Altman, Nikki Johnston
Summary: Esophageal adenocarcinoma (EAC) is increasing rapidly and has a poor prognosis, often preceded by Barrett's esophagus (BE). This review provides an overview of BE, EAC, and the progression from BE to EAC. The definition, diagnosis, epidemiology, and risk factors for both conditions are discussed, with special attention given to areas of debate. The progression from BE to EAC is likely driven by inflammatory pathways, pepsin exposure, upregulation of growth factor pathways, and mitochondrial changes. Surveillance is conducted through serial endoscopic evaluation, with shorter intervals recommended for high-risk features.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Gary E. Markey, Claire L. Donohoe, Eoin N. McNamee, Joanne C. Masterson
Summary: MicroRNAs (miRNAs) are small endogenous RNA molecules that regulate mRNA targets through RNA interference. They play a crucial role in physiological and pathological processes including cell proliferation, differentiation, apoptosis, and inflammation. This review discusses the potential of miRNAs in overall esophageal disease, focusing on eosinophilic esophagitis (EoE), gastroesophageal reflux disease (GERD), and the progression from Barrett's esophagus (BE) to esophageal adenocarcinoma (EAC). The dysregulation of miRNA expression in these diseases highlights their key role in disease progression and suggests their potential as diagnostic and prognostic biomarkers. Furthermore, targeting miRNAs could be a therapeutic option for esophageal disease.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2023)
Article
Surgery
Marialuisa Lugaresi, Benedetta Mattioli, Niccolo Daddi, Francesco Bassi, Vladimiro Pilotti, Luca Ferruzzi, Sandro Mattioli
Summary: The study found that 31.8% of patients undergoing GERD/HH surgery had true short esophagus (TSE), and satisfactory results can be achieved using CN and SASF surgeries performed according to determined surgical principles. This finding necessitates confirmation through a prospective multicenter study.
Article
Gastroenterology & Hepatology
Yuto Shimamura, Haruhiro Inoue, Mayo Tanabe, Kei Ushikubo, Kazuki Yamamoto, Yoshiaki Kimoto, Yohei Nishikawa, Ryohei Ando, Kazuya Sumi, Marc Julius Navarro, Carlos Teruel Sanchez-Vegazo, Beatriz Penas, Sofia Parejo, Alba Martinez Sanchez, Enrique Vazquez-Sequeiros, Manabu Onimaru, Agustin Albillos, Enrique Rodriguez de Santiago
Summary: This study aimed to evaluate the feasibility, effectiveness, and safety of anti-reflux mucosal ablation (ARMA) in the treatment of gastroesophageal reflux disease (GERD). The results showed that ARMA is a feasible and safe procedure that effectively reduces GERD symptoms in the short term, with clinical success achieved in approximately two-thirds of patients. Both reflux hypersensitivity and confirmed GERD patients, regardless of their response to acid suppression medication, may be suitable candidates for ARMA treatment.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Immunology
Ikenna C. Okereke, Aaron L. Miller, Daniel C. Jupiter, Catherine F. Hamilton, Gabriel L. Reep, Timothy Krill, Clark R. Andersen, Richard B. Pyles
Summary: The microbial community structures differ between patients with and without Barrett's esophagus, with certain organisms less likely to be detected as the severity of Barrett's esophagus worsens.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Surgery
L. Lallemand, E. Duchalais, N. Musquer, D. Jacobi, E. Coron, S. Bruley des Varannes, E. Mirallie, C. Blanchard
Summary: The study highlights the incidence of postoperative GERD and endoscopic lesions following sleeve gastrectomy. While SG is not contraindicated in cases of reflux, patients may require close endoscopic surveillance post-surgery. Some patients also reported a lack of regular medical follow-up after 5 years.
Article
Pediatrics
Charlotte Flatres, Madeleine Aumar, Delphine Ley, Rony Sfeir, Audrey Nicolas, Michel Bonnevalle, Alain Duhamel, Frederic Gottrand
Summary: This study demonstrates a high prevalence of acid gastroesophageal reflux disease (GERD) in late infancy and supports the recommendation of systematic checking for acid GERD when treatment with proton pump inhibitors (PPI) is stopped.
PEDIATRIC RESEARCH
(2022)
Article
Gastroenterology & Hepatology
David A. Leiman, Karthik Ravi, Daniel E. Freedberg, C. Prakash Gyawali
Summary: This study investigated the proton pump inhibitor (PPI) practice habits among US gastroenterology practitioners and found that a significant proportion of practitioners discontinue PPI use due to patient concerns about side effects, despite evidence-based literature suggesting the safety of long-term PPI use without routine monitoring. The majority of practitioners obtain information on PPI safety from published journals and colleagues.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Article
Behavioral Sciences
Xiaoduo Liu, Tao Wei, Lubo Shi, Shaojiong Zhou, Yufei Liu, Weiyi Song, Xinwei Que, Zhibin Wang, Yi Tang
Summary: A bidirectional Mendelian randomization analysis revealed a potential risk-increasing effect of GERD on epilepsy, particularly generalized epilepsy. However, BE did not show a significant causal relationship with the risks of generalized and focal epilepsy.
BRAIN AND BEHAVIOR
(2023)
Article
Veterinary Sciences
Merve Ider, Amir Naseri, Mahmut Ok, Kamil Uney, Alper Erturk, Murat K. Durgut, Tugba M. Parlak, Nimet Ismailoglu, Muhammed M. Kapar
Summary: Evaluation of PAH in premature calves with and without RDS using lung-specific epithelial and endothelial biomarkers showed significant differences in serum ET-1 concentrations, highlighting its utility in diagnosis and prognosis, with ET-1 being a reliable biomarker for PAH and predicting mortality in premature calves.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Veterinary Sciences
M. Ok, R. Yildiz, B. Tras, P. Coskun, A. Akar
Summary: This study aimed to investigate changes in lipid peroxide, antioxidant capacity, and acute-phase proteins in premature calves with respiratory distress syndrome (RDS) before and after different nebulization treatments. The results showed that supportive and nebulizer treatments alleviated oxidative stress in premature calves with RDS.
JOURNAL OF THE HELLENIC VETERINARY MEDICAL SOCIETY
(2021)
Article
Reproductive Biology
M. Ider, A. Naseri, M. Ok, E. Gulersoy, T. M. Bas, K. Uney, T. M. Parlak, A. Abdelaziz
Summary: The objective of this study was to evaluate the role of biomarkers specific to lung endothelial and epithelial damage in determining lung injury and its severity in calves with perinatal asphyxia. The study also aimed to assess the prognostic importance of these biomarkers among survivors and non-survivors. The results showed that serum concentrations of sRAGE and sE-selectin played a significant role in determining lung injury, and pH, pCO(2), lactate, HCO3, BE, and respiratory rate were useful indicators for predicting mortality.
Article
Pharmacology & Pharmacy
Orhan Corum, Devran Coskun, Duygu Durna Corum, Merve Ider, Ramazan Yildiz, Mahmut Ok, Kamil Uney
Summary: The aim of this study was to determine the pharmacokinetics of carprofen in sheep following single and repeated intravenous administrations. The results showed that the plasma concentrations and pharmacokinetic parameters were dose-dependent after single administration. After repeated administration, significant changes in pharmacokinetic parameters were observed, indicating the impact of repeated doses on drug metabolism and excretion.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Bunyamin Tras, Mahmut Ok, Tugba Melike Parlak, Merve Ider, Ramazan Yildiz, Hatice Eser Faki, Zeynep Ozdemir Kutahya, Kamil Uney
Summary: This study aimed to determine the pharmacokinetics of racecadotril, an antisecretory drug used for treating diarrhea, in healthy and infectious diarrhea neonatal calves. The results showed that racecadotril had a long half-life, high maximum concentration, and AUC values in healthy calves, while in calves with infectious diarrhea, the drug concentration was lower and only detected during a short period of time.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2022)
Article
Veterinary Sciences
Kurtulus Parlak, Amir Naseri, Mustafa Yalcin, Eyup Tolga Akyol, Mahmut Ok, Mustafa Arican
Summary: This study evaluated the modified Glasgow Coma Scale (mGCS) and Animal Trauma Triage (ATT) scores, laboratory variables, and prognostic features of trauma-induced endothelial glycocalyx injury in cats with head trauma. The results showed that syndecan-1 and thrombomodulin levels did not differ significantly between healthy cats and cats with head trauma, and the mGCS scoring system was more sensitive than the ATT scoring system in cats with head trauma.
SLOVENIAN VETERINARY RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Mahmut Ok, Amir Naseri, Mehmet Burak Ates, Merve Ider, Kamil Uney, Mutlu Sevinc, Fatih Hatipoglu, Ramazan Yildiz, Alper Erturk, Nuri Baspinar, Suleyman Serhat Iyigun
Summary: The aim of this study was to determine hypoxic brain damage in calves with perinatal asphyxia using brain-specific damage biomarkers. The results showed that asphyxia and hypoxemia caused hypoxic-ischemic encephalopathy in perinatal calves, and UCHL1 and S100B concentrations were found to be useful markers for the determination of hypoxic-ischemic encephalopathy in calves with perinatal asphyxia. Neurological status scores and some blood gas parameters were helpful in mortality prediction.
Article
Agriculture, Dairy & Animal Science
Merve Ider, Mahmut Ok, Amir Naseri, Alper Erturk, Tugba Melike Parlak, Ramazan Yildiz, Murat Kaan Durgut
Summary: The aim of this study was to evaluate hypoxic acute kidney injury (AKI) in premature calves with respiratory distress syndrome (RDS) using kidney-specific biomarkers. The study included 10 healthy full-term calves and 70 premature calves with RDS. Arterial blood gas analysis and measurements of kidney function biomarkers were performed at admission and 72 h. The results showed that 38.5% of premature calves with RDS developed AKI, and the mortality risk was four times higher in those with AKI. Serum concentrations of cystatin-C and neutrophil gelatinase-associated lipocalin were significantly higher in calves with AKI.
Article
Agriculture, Dairy & Animal Science
M. K. Durgut, M. Ok
Summary: This study aimed to assess the usefulness of injury biomarkers specific to the intestines in identifying the presence and degree of intestinal epithelial damage in coccidiosis-infected calves. The study measured various biomarkers in blood samples from infected calves before and after treatment, and compared them to healthy calves. The results showed that certain biomarkers, including I-FABP, TFF-3, CLD-3, ACTG2, and IL-8, were elevated in infected calves and can be reliable indicators of intestinal epithelium injury.
TROPICAL ANIMAL SCIENCE JOURNAL
(2023)
Article
Veterinary Sciences
R. Yildiz, D. Durna Corum, O. Corum, M. Ider, O. Atik, M. Ok, K. Uney
Summary: The study aimed to investigate the cardiotoxic effect of combining tilmicosin and diclofenac sodium in sheep. Thirty-two sheep were divided into four groups: tilmicosin only, diclofenac sodium only, combination of tilmicosin and diclofenac sodium, and control group. Blood samples were taken at different time points to measure cardiac markers. The results showed that the combination group exhibited significantly higher levels of cardiac biomarkers compared to the other groups, indicating potential cardiac damage.
POLISH JOURNAL OF VETERINARY SCIENCES
(2023)
Article
Veterinary Sciences
Erdem Gulersoy, Mahmut Ok, Kamil Uney, Murat Kaan Durgut, Tugba Melike Parlak, Yusuf Emre Ekici
Summary: This study investigates the diagnostic utility of clinical and laboratory examinations in cats with symptomatic feline infectious peritonitis (FIP) or asymptomatic feline enteric coronavirus (FECV). The results show that pH, HCO3, base excess, lactate, MCV, and magnesium levels are important in the course of the disease, and AGP is useful for evaluating the presence of an inflammatory state. Clinical, laboratory, and serum AGP evaluations can be used to determine the likelihood of FIP and FECV development.
ACTA VETERINARIA-BEOGRAD
(2023)
Article
Pharmacology & Pharmacy
Huseyin Gungor, Orhan Corum, Duygu Durna Corum, Alper Serhat Kumru, Gokhan Yilmaz, Devran Coskun, Alparslan Coskun, Kamil Uney
Summary: The aim of this study was to determine the pharmacokinetic change of meloxicam in sheep after intravenous administration at different doses. The results showed that the duration of meloxicam in plasma, as well as the elimination half-life and area under the concentration-time curve, increased as the dose increased, while the total clearance decreased. Meloxicam exhibited non-linear pharmacokinetics in sheep, and when administered intravenously at a dose of 1 mg/kg or above, plasma concentrations became unpredictable.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2023)
Article
Veterinary Sciences
H. Guzelbektes, I. Sen, U. Aydogdu, C. Er, A. Coskun
Summary: This study aimed to detect changes in clinical parameters, biochemical and serum cytokine levels in calves with naturally occurring sepsis. The study found significant changes in clinical parameters and increased serum cytokine levels in calves with sepsis, along with significant changes in biochemical markers.
JOURNAL OF THE HELLENIC VETERINARY MEDICAL SOCIETY
(2022)
Article
Veterinary Sciences
Ibrahim Kubilay Yildiz, Mahmut Ok
Summary: This study aimed to investigate the potential efficacy of selected intestinal damage biomarkers in determination of the presence of intestinal epithelial damage in dogs with isosporiasis. The results showed that serum levels of intestinal-fatty acid-binding protein, trefoil factor 3, intestinal alkaline phosphatase, and gamma-enteric smooth muscle actin were significantly higher in dogs with isosporiasis. These biomarkers are useful and reliable in determining intestinal epithelial damage caused by isosporiasis in dogs.
MAGYAR ALLATORVOSOK LAPJA
(2022)
Article
Veterinary Sciences
Erdem Gulersoy, Muhammed Mustafa Kapar, Murat Kaan Durgut, Amir Naseri, Mahmut Ok
Summary: The clinical, hematochemical, and cerebrospinal fluid examination findings are useful for diagnosing the neurological form of canine distemper in naturally infected dogs. These findings provide valuable information on various symptoms and help in evaluating the disease.
MAGYAR ALLATORVOSOK LAPJA
(2022)
