Article
Biology
Zsofia Daradics, Cristian M. Crecan, Mirela A. Rus, Iancu A. Morar, Mircea V. Mircean, Adriana Florinela Catoi, Andra Diana Cecan, Cornel Catoi
Summary: Obesity is a serious health problem in human and animal populations, affecting cows and horses with conditions like Fat cow syndrome and Equine metabolic syndrome. These conditions, resembling Human metabolic syndrome in some aspects, require further research for better understanding and management.
Article
Veterinary Sciences
Harry B. Carslake, Gina L. Pinchbeck, Catherine M. McGowan
Summary: The prevalence of EMS is high in UK native ponies and cobs, with modifiable risk factors such as obesity and sedentary activities. Animals with a history of laminitis are more likely to have EMS.
EQUINE VETERINARY JOURNAL
(2021)
Review
Genetics & Heredity
Monika Stefaniuk-Szmukier, Katarzyna Piorkowska, Katarzyna Ropka-Molik
Summary: Equine metabolic syndrome (EMS) is an important issue in modern veterinary medicine, linked to the painful hoof laminitis. We have summarized available information on the genetic background, environmental factors, diagnosis, treatment, and management of EMS for both scientific and practical purposes. Clinical presentation in horses includes obesity, lameness, and insulin dysregulation, with ongoing research in regenerative medicine for promising therapies.
Article
Veterinary Sciences
A. Meier, J. McGree, R. Klee, J. Preuss, D. Reiche, M. de Laat, M. Sillence
Summary: The Meier method provides a reliable and consistent way to monitor the clinical status of horses with HAL. Despite variability, the improvement pattern described in this study can serve as a useful benchmark for evaluating individual cases and new treatments.
BMC VETERINARY RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Magdalena Senderska-Plonowska, Natalia Siwinska, Agnieszka Zak-Bochenek, Marta Rykala, Malwina Slowikowska, Jan P. Madej, Katarzyna Kaleta-Kuratewicz, Artur Niedzwiedz
Summary: Modern research indicates a significant role of obesity in equine health, specifically its association with equine metabolic syndrome (EMS) and laminitis. This study analyzed forelimbs from obese and lean horses to investigate the effects of obesity on hoof lamellae. The results showed differences in lamellae between the two groups, but no clear evidence to support the effects of obesity on lamellar failure. Additionally, the measurements taken suggest that the length of the primary epidermal lamellae (PEL) may depend on hoof size.
Article
Veterinary Sciences
Melody A. de Laat, Danielle M. Fitzgerald
Summary: Equine insulin dysregulation (ID) is characterized by increased insulin responses to oral carbohydrates or insulin resistance, leading to sustained or periodic hyperinsulinemia. This condition is associated with a higher risk of laminitis in horses, therefore better understanding of insulin and glucose homeostasis is needed. The enteroinsular axis (EIA) in the gastrointestinal tract (GIT) plays a role in regulating insulin secretion, with incretin peptides such as glucagon-like peptide-1 and 2 increasing insulin responses. However, the function of other EIA peptides in horses, such as glicentin and oxyntomodulin, remains unexplored. This review discusses the current knowledge of EIA in horses and its contribution to ID, comparing it to research conducted in other species and highlighting areas for future research.
VETERINARY JOURNAL
(2023)
Article
Veterinary Sciences
Maimaiti Tuniyazi, Junying He, Jian Guo, Shuang Li, Naisheng Zhang, Xiaoyu Hu, Yunhe Fu
Summary: The study found that horses with oligofructose-induced laminitis had lower fecal pH, but higher levels of lactic acid, histamine, and Lipopolysaccharide (LPS) in serum. Oligofructose also altered the composition of the hindgut bacterial community by increasing the abundance of Lactobacillus and Megasphaera. Metabolome analysis showed a decrease in 84 metabolites and an increase in 53 metabolites, including dihydrothymine, N3, N4-Dimethyl-L-arginine, 10E,12Z-Octadecadienoic acid, and asparagine.
BMC VETERINARY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Fayaz Ahmad Mir, Ehsan Ullah, Raghvendra Mall, Ahmad Iskandarani, Tareq A. Samra, Farhan Cyprian, Aijaz Parray, Meis Alkasem, Ibrahem Abdalhakam, Faisal Farooq, Abdul-Badi Abou-Samra
Summary: This study found differential expression of serum metabolites and pathways between Arabic subjects with obesity and metabolic syndrome compared to subjects with obesity only. Lipids, including sphingomyelin, were significantly decreased in the group with metabolic syndrome. Non-lipid metabolites, such as quinolinate, kynurenine, and tryptophan, were also decreased in the group with metabolic syndrome. Metabolites and pathways associated with chronic inflammation were found to be dysregulated in subjects with metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Bashir Ahmad Laway, Mohammad Salem Baba
Summary: Sheehan syndrome caused by postpartum hemorrhage leads to pituitary hormone deficiency, resulting in various abnormalities including lipid and glucose abnormalities, increased body fat, insulin resistance, coagulation abnormalities, increased leptin concentration, low-grade inflammation, and endothelial dysfunction. Replacement with growth hormone in addition to standard hormone replacement improves the cardiometabolic profile of patients with Sheehan syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Lars Lind, Samira Salihovic, Johan Sundstrom, Solve Elmstahl, Ulf Hammar, Koen Dekkers, Johan Arnlov, J. Gustav Smith, Gunnar Engstrom, Tove Fall
Summary: This study compared the plasma metabolome in obese subjects with and without metabolic syndrome (MetS) to normal-weight subjects without MetS. The results showed significant differences in metabolite profiles between obese and normal-weight individuals without MetS, with a gradual deterioration in metabolite profile from lean to obese to MetS. The pathways highlighted in this study, such as amino acid synthesis/metabolism and sphingolipid metabolism, may play a role in this metabolic deterioration, with insulin resistance as a potential mediator.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Qi Zhu, Yawei Xing, Yunfeng Fu, Xiaqin Chen, Langyi Guan, Foqiang Liao, Xiaodong Zhou
Summary: This study used Mendelian randomization analysis to assess the causal effect of MetS on cholelithiasis. The results showed that MetS increased the risk of cholelithiasis, especially in MetS patients with abdominal obesity. Control and treatment of MetS can effectively reduce the risk of gallstone formation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Aki Juhani Karajamaki, Arto Korkiakoski, Janne Hukkanen, Y. Antero Kesaniemi, Olavi Ukkola
Summary: The presence of metabolic syndrome (MetS), but not obesity only, entails a greater risk of mortality and cardiovascular diseases. The risk of atrial fibrillation is increased only in subjects with both obesity and MetS. Obesity without MetS tends to progress eventually to obesity with MetS.
ANNALS OF MEDICINE
(2022)
Review
Endocrinology & Metabolism
Ming Yang, Chongbin Liu, Na Jiang, Yan Liu, Shilu Luo, Chenrui Li, Hao Zhao, Yachun Han, Wei Chen, Li Li, Li Xiao, Lin Sun
Summary: Metabolic syndrome is a complex metabolic disorder characterized by obesity, hyperglycemia, hypertension, and hyperlipidemia. Insulin resistance, adipose tissue dysfunction, and chronic inflammation are believed to play a role in the development of metabolic syndrome, but effective clinical prevention and treatment measures are still lacking. Studies have shown that myostatin (MSTN) may be a potential therapeutic target for metabolic syndrome as it is involved in the development of obesity, hyperlipidemia, diabetes, and hypertension. This article discusses the transcriptional regulation and receptor binding pathway of MSTN, its role in regulating mitochondrial function and autophagy, and reviews the progress of MSTN research in metabolic syndrome. Additionally, MSTN inhibitors under clinical trial are summarized and proposed as potential targets for the treatment of metabolic syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Khairun-Nisa Hashim, Kok-Yong Chin, Fairus Ahmad
Summary: Honey has shown beneficial effects in reversing metabolic syndrome through its anti-obesity, hypoglycemic, hypolipidemic, and hypotensive actions, largely due to the antioxidant and anti-inflammatory properties of its polyphenol and flavonoid contents.
Review
Endocrinology & Metabolism
Ming Yang, Chongbin Liu, Na Jiang, Yan Liu, Shilu Luo, Chenrui Li, Hao Zhao, Yachun Han, Wei Chen, Li Li, Li Xiao, Lin Sun
Summary: Metabolic syndrome is a complex metabolic disorder characterized by obesity, insulin resistance/diabetes, hyperlipidemia, and hypertension. The increasing incidence of metabolic syndrome poses a heavy medical burden, yet effective prevention and treatment strategies are still lacking. Fibroblast growth factor 21 (FGF21) is a key protein involved in maintaining metabolic homeostasis and has potential as a target for the treatment of metabolic syndrome by reducing fat mass and improving glucose and lipid metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Veterinary Sciences
Alison K. Gardner, Elizabeth M. Santschi, Margaret C. Mudge, James K. Belknap, Anne G. Metzler
VETERINARY SURGERY
(2020)
Article
Veterinary Sciences
Simon M. Stokes, Teresa A. Burns, Mauria R. Watts, Francois-Rene Bertin, Darko Stefanovski, Carlos E. Medina-Torres, James K. Belknap, Andrew W. van Eps
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2020)
Article
Veterinary Sciences
Andrew W. van Eps, James K. Belknap, Xavier Schneider, Darko Stefanovski, Julie B. Engiles, Dean W. Richardson, Steven T. Zedler, Carlos E. Medina-Torres, Mauria R. Watts
Summary: The study demonstrated that lamellar ischemia, characterized by increased L:P ratio and decreased urea clearance, was detected exclusively in the lamellar dermis of feet subjected to prolonged increased load, indicating a potential association between lamellar ischemia and the development of supporting limb laminitis (SLL).
EQUINE VETERINARY JOURNAL
(2021)
Article
Veterinary Sciences
Jacob M. Swink, Lindsey M. Rings, Hailey A. Snyder, Rachel C. McAuley, Teresa A. Burns, Katarzyna A. Dembek, William F. Gilsenan, Nimet Browne, Ramiro E. Toribio
Summary: This study aimed to measure androgen concentrations in serum of newborn foals and investigate their association with disease severity and outcome. The results showed that increased serum androgen concentrations were correlated with disease severity and adverse outcomes in hospitalized newborn foals, while androgen levels decreased over time in healthy foals.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Veterinary Sciences
Hannah M. Kinsella, Laura D. Hostnik, Lindsey M. Rings, Jacob M. Swink, Teresa A. Burns, Ramiro E. Toribio
Summary: The endocrine response in healthy newborn foals to fasting and carbohydrate administration, as well as nursing, suggests that factors in milk other than carbohydrates are strong stimulators of the endocrine pancreas and HPAA.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Veterinary Sciences
Simon M. Stokes, Darko Stefanovski, Francois-Rene Bertin, Carlos E. Medina-Torres, James K. Belknap, Andrew W. van Eps
Summary: Hyperinsulinemia may cause hypoaminoacidemia, which could be a potential mechanism in the development of laminitis. Further investigation into the role of hypoaminoacidemia in hyperinsulinemia-associated laminitis is warranted.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
L. M. Rings, A. M. Kamr, H. M. Kinsella, L. D. Hostnik, J. M. Swink, T. A. Burns, K. Christie, J. B. David, R. E. Toribio
Summary: This study investigated the enteroinsular axis (EIA) in hospitalized foals by measuring serum insulin and plasma incretin concentrations, revealing differences between hospitalized/septic foals and healthy foals. The study found that certain hormone concentrations were associated with disease severity and outcome in foals, suggesting potential mechanisms contributing to reduced insulin secretion in critically ill foals.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Stephen A. Schumacher, Ahmed M. Kamr, Jeffrey Lakritz, Teresa A. Burns, Alicia L. Bertone, Ramiro E. Toribio
Summary: The study found that short-term experimental hypermagnesemia alters calcium-regulating hormones (PTH, CT), reduces plasma Ca2+ concentrations, and increases the urinary excretion of Mg2+, Ca2+, K+, Na+ and Cl- in healthy horses.
Article
Multidisciplinary Sciences
Hannah M. Kinsella, Laura D. Hostnik, Hailey A. Snyder, Sarah E. Mazur, Ahmed M. Kamr, Teresa A. Burns, John C. Mossbarger, Ramiro E. Toribio
Summary: This study compared insulin sensitivity between neonatal foals and adult horses using the insulin-modified frequently sampled intravenous glucose tolerance test. The results showed that neonatal foals have higher insulin sensitivity in the first days of life.
Article
Veterinary Sciences
Teresa A. Burns
VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE
(2021)
Editorial Material
Veterinary Sciences
Valerie J. Parker
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2022)
Article
Veterinary Sciences
Teresa A. Burns, Mauria R. Watts, James K. Belknap, Andrew W. van Eps
Summary: The study aimed to investigate the role of digital lamellar inflammatory signaling in the pathophysiology of supporting limb laminitis (SLL) in horses. It found that lamellar inflammatory signaling was higher in horses subjected to prolonged unilateral weight-bearing, suggesting its relevance to the pathophysiology of SLL.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Veterinary Sciences
Kathryn J. Timko, Laura D. Hostnik, Mauria R. Watts, Chiaming Chen, Adam Bercz, Ramiro E. Toribio, James K. Belknap, Teresa A. Burns
Summary: The research assessed the effects of dexamethasone on insulin and glucose dynamics in light-breed horses, and evaluated the agreement of different diagnostic tests for insulin dysregulation. Dexamethasone treatment worsened insulin dysregulation, and the variability of common diagnostic tests for insulin dysregulation may impact clinical decisions.
CANADIAN VETERINARY JOURNAL-REVUE VETERINAIRE CANADIENNE
(2022)