Review
Clinical Neurology
Boulenouar Mesraoua, Francesco Brigo, Simona Lattanzi, Bassel Abou-Khalil, Hassan Al Hail, Ali A. Asadi-Pooya
Summary: There are over 51 million people with epilepsy worldwide, with more than 4.9 million new cases each year. Although drug therapy is the main treatment for epilepsy, approximately one-third of patients do not respond well to medication (drug-resistant epilepsy). This review aims to discuss the definition of drug-resistant epilepsy, explore its biological underpinnings and clinical biomarkers, and suggest practical management strategies to address this issue effectively.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Veterinary Sciences
Sandra R. P. Kriechbaumer, Konrad Jurina, Franziska Wielaender, Henning C. Schenk, Tanja A. Steinberg, Sven Reese, Gesine Buhmann, Stefanie Doerfelt, Heidrun Potschka, Andrea Fischer
Summary: This study compares the effectiveness and tolerability of two add-on treatment strategies in dogs with drug-resistant idiopathic epilepsy. The results show low overall success rates and highlight the need for further research on better pharmacological and non-pharmacological treatment strategies for dogs with drug-resistant epilepsy.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Shinichi Kanazono, Masayasu Ukai, Akira Hiramoto
Summary: Psychiatric adverse effects associated with zonisamide, including aggressive behavior, were observed in three dogs with presumptive idiopathic epilepsy. The abnormal behavior episodes improved significantly after discontinuation of zonisamide, but relapsed after re-administration. MRI studies and cerebrospinal fluid analysis in two dogs were unremarkable.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
E. Chawner, M. Ukai, W. Sears, F. James
Summary: This retrospective study aimed to understand the frequency and prevalence of non-generalized tonic clonic seizures (non-GTCS) in dogs. The results showed that approximately one third of seizure cases in the referral population consisted of non-GTCS. This study emphasizes the importance of recognizing, diagnosing, and treating these types of seizures in dogs.
VETERINARY JOURNAL
(2023)
Article
Veterinary Sciences
E. Chawner, M. Ukai, W. Sears, F. James
Summary: This retrospective study aimed to evaluate the frequency and prevalence of non-generalized tonic clonic seizures (non-GTCS) in dogs. The results suggest that non-GTCS are relatively common in the dog population, providing new insights and treatment options for this subset of seizures.
VETERINARY JOURNAL
(2023)
Article
Veterinary Sciences
Paul J. J. Mandigers, Koen M. Santifort
Summary: Epilepsy is a common chronic neurological syndrome in dogs, which significantly affects the quality of life for both dogs and their owners. This article discusses the seizure-precipitating factors (SPFs) in dogs with idiopathic epilepsy, including stress, hormones, sleep deprivation, and the weather. The study focuses on Border Collies, a breed predisposed to idiopathic epilepsy, and identifies several remarkable SPFs specific to each dog. Recognizing and avoiding these factors can reduce seizure frequency or even achieve seizure freedom.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Veterinary Sciences
Gabriel A. A. Garcia, Stephanie Kube, Sheila Carrera-Justiz, David Tittle, Joseph J. J. Wakshlag
Summary: The use of CBD/CBDA-rich hemp extract can effectively reduce the frequency of epileptic seizures in dogs and significantly improve the reduction of seizure activity. This treatment has no significant adverse effects on blood tests and drug concentrations, and has minimal side effects.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Ga-Won Lee, Min-Hee Kang, Hee-Myung Park
Summary: This case report presents a rare case of a male castrated Chihuahua dog with hypoadrenocorticism and presumed osmotic demyelination syndrome (ODS) after rapid correction of hyponatremia leading to neurologic signs including seizures and ataxia. The neurologic signs resolved completely after treatment.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Theresa Elisabeth Ostermann, Jasmin Nicole Nessler, Hildegard Urankar, Norbert Bachmann, Christel Fechler, Andrea Bathen-Noethen, Andrea Tipold
Summary: This study investigated the genetic predisposition and seizure characteristics of idiopathic epilepsy in Great Swiss Mountain Dogs. The results showed a high incidence of seizures in this breed, with a severe phenotype often characterized by cluster seizures and status epilepticus. The study provides valuable insights for further genetic evaluations and individualized treatment recommendations.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Koen M. Santifort, Elise Bertijn, Sofie F. M. Bhatti, Peter Leegwater, Andrea Fischer, Paul J. J. Mandigers
Summary: This retrospective study analyzed data of Border Collies with idiopathic epilepsy, revealing a correlation between the age of onset of the first epileptic seizure and the severity of epilepsy. The study also characterized the phenotype of idiopathic epilepsy in Border Collies and emphasized the significant impact of epilepsy on their quality of life.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Multidisciplinary Sciences
Anni Guo, Huiqi Zhang, Huanhuan Li, Arthur Chiu, Claudia Garcia-Rodriguez, Carlos F. Lagos, Juan C. Saez, Chunyue Geoffrey Lau
Summary: Temporal lobe epilepsy is a common type of epilepsy, but many patients are resistant to current drugs. Dysfunction of astrocytes and microglia is related to neuroinflammation and hyperexcitability. This study introduces a new compound, D4, that targets glial hemichannels, leading to improved symptoms and survival rates in a mouse model of epilepsy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Veterinary Sciences
Marta Plonek, Montse M. Diaz-Espineira, Quirine E. M. Stassen, Koen M. Santifort, Peter A. J. Leegwater, Paul J. J. Mandigers
Summary: This study characterized the phenotype of idiopathic epilepsy in Irish Setters and investigated its mode of inheritance.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Tina Loncarica, Federica Balducci, Marco Bernardini
Summary: This retrospective study evaluated the prevalence of structural and idiopathic epilepsy in Boxer dogs. The majority of Boxer dogs with epilepsy were found to have suspected intracranial neoplasia, regardless of their age. The study suggests that patients meeting specific criteria should undergo brain MRI examination.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Veterinary Sciences
Jos Bongers, Rodrigo Gutierrez-Quintana, Catherine Elizabeth Stalin
Summary: The unpredictable nature of seizures in epileptic dogs poses challenges for caregivers, necessitating the use of alternative management strategies like seizure detection devices. These systems aim to detect seizures and provide prompt intervention to improve the overall seizure history of the dog.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Neurosciences
Ahmad Movahedpour, Rasul Taghvaeefar, Ali-Akbar Asadi-Pooya, Yousof Karami, Ronia Tavasolian, Seyyed Hossein Khatami, Elahe Soltani Fard, Sina Taghvimi, Neda Karami, Khojaste Rahimi Jaberi, Mortaza Taheri-Anganeh, Hassan Ghasemi
Summary: Epilepsy is a neurological disorder characterized by erratic neuronal electrical activity. Antiseizure medications (ASMs) are the primary treatment but are limited by their inability to cross the blood-brain barrier (BBB). Recent research has focused on synthetic nanoparticles and exosomes as potential drug delivery systems to enhance the effectiveness of ASMs. This review discusses various synthetic nanoparticles studied for delivering ASMs and highlights the potential of exosomes as a promising drug delivery tool for treating epilepsy.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Agriculture, Dairy & Animal Science
Evelina Stonciute, Katja Schulz, Alvydas Malakauskas, Franz J. Conraths, Marius Masiulis, Carola Sauter-Louis
Summary: Hunters' willingness and motivation play a crucial role in the effectiveness of control measures for African swine fever in wild boar. Understanding their attitudes and beliefs towards these measures is essential for successful implementation. The study in Lithuania revealed that hunters reject certain measures like hunting restrictions and selective female hunting, while highlighting the importance of improving relationships with stakeholders for better acceptance of control measures.
Article
Veterinary Sciences
Nico Urner, Carola Sauter-Louis, Christoph Staubach, Franz Josef Conraths, Katja Schulz
Summary: This study compared two research studies conducted in Estonia and Latvia using participatory epidemiology with hunters, identifying similarities and differences in the perceptions and opinions of the hunters in both countries. The research demonstrated that participatory methods are effective in evaluating the acceptance of ASF control systems and highlight further opportunities to improve cooperation with hunters in the future. It also emphasized the importance of gathering and analyzing the opinions of hunters in all ASF affected countries individually.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Infectious Diseases
Carola Sauter-Louis, Katja Schulz, Michael Richter, Christoph Staubach, Thomas C. Mettenleiter, Franz J. Conraths
Summary: The study compared the epidemiological course of African swine fever in Germany, Czech Republic, and Belgium in the first 6 months since its introduction. Germany had more cases and a larger affected area compared to Czech Republic and Belgium. Germany experienced multiple independent introductions, while Czech Republic and Belgium only had single introductions.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Infectious Diseases
Mikolaj Adamek, Max Heling, Julia Bauer, Felix Teitge, Sven M. Bergmann, Dirk Willem Kleingeld, Alice Welzel, Nelly Scuda, Johannes Bachmann, Carola Sauter Louis, Kerstin Boettcher, Grit Braeuer, Dieter Steinhagen, Verena Jung-Schroers
Summary: This study investigated the presence of CEV in carp and koi populations in Germany, finding a detection rate of 69% in carp populations from the main carp-producing areas and 41% in koi populations from all over Germany. KSD mainly occurred in carp populations in Germany at water temperatures ranging from 8 to 12 degrees C and in koi populations at water temperatures ranging from 18 to 22 degrees C.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Veterinary Sciences
Theresa Tschoner, Carola Sauter-Louis, Verena Peinhofer, Melanie Feist
Summary: The study found that farmers and veterinarians have similar assessments of pain severity in cattle, but they recognize pain differently and disagree in their opinions regarding the use of analgesics. Communication between both groups needs to be improved for proper pain management.
Article
Virology
Katja Schulz, Marius Masiulis, Christoph Staubach, Alvydas Malakauskas, Gediminas Pridotkas, Franz J. Conraths, Carola Sauter-Louis
Summary: The study analyzed ASF surveillance data from 2016-2021 in Lithuania and found that ASF is still present in the wild boar population, indicating a need for interdisciplinary efforts to more successfully control and combat the disease.
Article
Agriculture, Dairy & Animal Science
Alvydas Malakauskas, Katja Schulz, Indre Kukanauskaite, Marius Masiulis, Franz Josef Conraths, Carola Sauter-Louis
Summary: This study investigated potential risk factors associated with African swine fever (ASF) outbreaks in pig farms in Lithuania in 2019. The study found that veterinary inspections significantly reduced the risk of ASF occurrence in a pig farm, while certain activities increased the odds of an outbreak. These findings are important for improving ASF control and prevention.
Article
Agriculture, Dairy & Animal Science
Florian Diel, Elke Rauch, Rupert Palme, Carola Sauter-Louis, Eva Zeiler
Summary: This study investigates the factors influencing the successful rescue of year-round housed cattle in case of a barn fire. The research found that preparing the exits according to the sensory perception of the cattle, providing familiar surfaces and adequate lighting, and herding cattle correctly result in a speedy rescue, even if the animals were not habituated to leaving the barn before.
Article
Microbiology
Katja Schulz, Edvins Olsevskis, Arvo Viltrop, Marius Masiulis, Christoph Staubach, Imbi Nurmoja, Kristine Lamberga, Martins Serzants, Alvydas Malakauskas, Franz Josef Conraths, Carola Sauter-Louis
Summary: This study evaluated surveillance data on African swine fever (ASF) in Lithuania, Latvia, and Estonia, and found a decreasing trend in virus prevalence in wild boar, a slight increase in seroprevalence, and a significant decrease in wild boar population density. The results suggest that controlling ASF has become more difficult and calls for a reevaluation of current control strategies.
Review
Virology
Hannes Bergmann, Johanna Dups-Bergmann, Katja Schulz, Carolina Probst, Laura Zani, Melina Fischer, Joern Gethmann, Nicolai Denzin, Sandra Blome, Franz J. Conraths, Carola Sauter-Louis
Summary: African swine fever (ASF) is a viral pig disease that has a severe impact on agricultural pork production and trade economy. Understanding the risk factors associated with ASF is crucial for disease control. This study compiles and categorizes the currently known ASF risk factors, providing important information for problem-solving.
Article
Multidisciplinary Sciences
Martina Schlipf, Andrea Fischer, Martina Patzl, Katrin Hartmann, Alexander Pankraz, Martina Dick, Yury Zablotski, Helmut Kuechenhoff, Astrid Wehner
Summary: This study retrospectively analyzed thyroid profiles of 1,501 Eurasian dogs from a German breeding club and found a high prevalence of hypothyroidism and thyroglobulin autoantibodies in the breed. The results demonstrate that thyroglobulin autoantibodies have a high predictive value for hypothyroidism in Eurasian dogs.
Article
Microbiology
Michael Richter, Katja Schulz, Tobias Elflein, Jens Achterberg, Edvins Olsevskis, Martins Serzants, Kristine Lamberga, Franz Josef Conraths, Carola Sauter-Louis
Summary: African swine fever (ASF) first emerged in Latvia in 2014 and then in Saxony, Germany in 2020. The virus was most likely introduced by infected wild boar from neighboring countries. The control measures for ASF differed between the two regions due to the lack of a developed strategy in Latvia. Comparing the ASF epidemic in Saxony and Latvia, it was found that Saxony had a lower prevalence of ASF virus-positive wild boar, indicating better preparation and control strategies.
Article
Genetics & Heredity
Tiina Heinonen, Thomas Flegel, Hanna Mueller, Alexandra Kehl, Sruthi Hundi, Kaspar Matiasek, Andrea Fischer, Jonas Donner, Oliver P. Forman, Hannes Lohi, Marjo K. Hytoenen
Summary: In this study, a Miniature Australian Shepherd family with symptoms similar to hereditary hyperekplexia in humans was reported. Whole genome sequence data analysis revealed a 36-bp deletion in the GLRA1 gene, which was found to be completely associated with the disease in pedigree samples and additional cohorts of related dog breeds. This study establishes a spontaneous large animal disease model for human hereditary hyperekplexia by associating a variant in the canine GLRA1 gene with the disorder for the first time.
Article
Virology
Lisa Rogoll, Ann-Kathrin Guettner, Katja Schulz, Hannes Bergmann, Christoph Staubach, Franz J. Conraths, Carola Sauter-Louis
Summary: African swine fever (ASF) has shown seasonal patterns in both domestic pigs and wild boar in affected European countries, with domestic pigs experiencing a peak in summer and wild boar showing peaks in both winter and summer, influenced by wild boar population dynamics and seasonality in pig farming.
Article
Veterinary Sciences
Paula Heine, Eva Zeiler, Carola Sauter-Louis, Michael Erhard, Mona Goeff, Martin Kammer, Stefan Scholz, Felix Versen, Carsten Huemmer, Elke Rauch
Summary: This study aimed to investigate the correlations between different husbandry systems in organic dairy farming and milk yield, ketosis risk, and fertility. The results showed that free stall housing systems with free-range area achieved the highest milk yield and lowest ketosis risk in 2017.
BERLINER UND MUNCHENER TIERARZTLICHE WOCHENSCHRIFT
(2021)