Review
Immunology
Stephan En Jie Chee, Egle Solito
Summary: Alzheimer's Disease is a progressive neurodegenerative disease associated with aging, characterized by neuroinflammation and amyloid protein accumulation. Research suggests that AD may result from immune system dysregulation due to aging, and future therapies may focus on modulating the aged immune system.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell & Tissue Engineering
J. Lacy Kamm, Christopher B. Riley, Natalie A. Parlane, Erica K. Gee, C. Wayne Mcllwraith
Summary: The study found that MHC II-low MSCs are the most appropriate type of allogeneic MSC to prevent activation of the innate and cell-mediated component of the adaptive immune systems and have increased gene expression as compared to other allogeneic MSCs.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Immunology
Sapna P. Sadarangani, Barnaby E. Young, Weixiang Lian, Hwee Pin Phua, Mark I-C Chen, Ian Barr, Tsin Wen Yeo, Rinkoo Dalan, Angela Chow
Summary: Immunosenescence and inflamm-aging contribute to suboptimal immune responses to standard-dose influenza vaccines in older adults, which may be exacerbated by metabolic co-morbidities. In a Singaporean cohort of older adults, age, diabetes, obesity, and baseline vitamin D levels were not associated with vaccine response, while recent vaccination and physical activity were linked to different responses for specific influenza strains. Older adults with well-controlled metabolic conditions retained better vaccine response, with physical activity showing a positive effect, particularly for influenza A/HK/H3N2.
Letter
Cell Biology
Mohammad Amin Akbarzadeh, Mohammad-Salar Hosseini
Summary: Geriatric syndromes are medical conditions associated with aging, and older COVID-19 patients have a higher mortality rate, which could be related to these syndromes. A systematic review and meta-analysis revealed that older adults are more hesitant and uncertain about receiving the COVID-19 vaccine, which may impact vaccine uptake and mortality rate.
AGEING RESEARCH REVIEWS
(2022)
Article
Immunology
Lisa Mueller, Marcel Andree, Wiebke Moskorz, Ingo Drexler, Lara Walotka, Ramona Grothmann, Johannes Ptok, Jonas Hillebrandt, Anastasia Ritchie, Denise Rabl, Philipp Niklas Ostermann, Rebekka Robitzsch, Sandra Hauka, Andreas Walker, Christopher Menne, Ralf Grutza, Jorg Timm, Ortwin Adams, Heiner Schaal
Summary: The study compared antibody responses to the BNT162b2 COVID-19 vaccine in young vaccinees below 60 and elderly vaccinees over 80. The elderly group had lower antibody titers and a lower frequency of neutralizing antibodies post-vaccination, indicating a potential need for closer monitoring or different vaccination strategies for this population.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Immunology
Kathleen M. Hagen, Shalina S. Ousman
Summary: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune disease that affects the peripheral nervous system, potentially leading to disability. Patients' age may impact symptoms and functional recovery, especially in older patients. Changes in immune cell populations may play a role in the onset and progression of CIDP.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Esther Saiag, Yifat Alcalay, Or Marudi, Avi Orr-Urtreger, David Hagin
Summary: Israel began vaccinating individuals 60 years of age or older with a fourth dose of BNT162b2 vaccine, and longer follow-up showed clinical effectiveness. This study aimed to evaluate the immune response to the fourth vaccine dose in individuals aged 60 years or older, and the results showed a significant cellular immune response in most individuals.
Review
Cell Biology
Juana Serrano-Lopez, Beatriz Martin-Antonio
Summary: Advances in society and health have led to increased life expectancy, but aging also brings complications such as inflammaging, which can impact autoimmunity, neurodegenerative diseases, and cancer development. Inflammaging is related to imbalanced immune responses and can be naturally acquired with age or accelerated by external triggers. Different molecules and inflammatory processes play key roles in these events.
Article
Immunology
Rebecca G. Reed, Steven R. Presnell, Ahmad Al-Attar, Charles T. Lutz, Suzanne C. Segerstrom
Summary: Stressful life events can accelerate immune aging, but using cognitive reappraisal as an emotion regulation strategy may reduce these effects. This study investigated whether cognitive reappraisal moderates the relationship between life stressors and immune aging markers in older adults. The results showed that experiencing more frequent life stressors was associated with higher levels of late-differentiated NK cells, but this effect was explained by health-related stressors. Surprisingly, experiencing more frequent and less desirable stressors was associated with lower average levels of TNF-alpha. Moreover, cognitive reappraisal was found to moderate the associations between life stressors and late-differentiated NK cells between individuals and IL-6 within individuals.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Biochemistry & Molecular Biology
Mi Eun Kim, Jun Sik Lee
Summary: Aging is associated with weakened immune function and increased susceptibility to diseases. Telomere shortening, tissue inflammation, and altered signaling pathways play key roles in immune dysfunction. Targeting tissue inflammation and immunomodulation is vital for treating immune disorders in older adults. Anti-inflammatory medications, immunotherapy, and novel approaches may enhance immune responses in this population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Bulmaro Cisneros, Ian Garcia-Aguirre, Juan Unzueta, Isabel Arrieta-Cruz, Oscar Gonzalez-Morales, Juan M. Dominguez-Larrieta, Aura Tamez-Gonzalez, Gerardo Leyva-Gomez, Jonathan J. Magana
Summary: The function of the immune system declines during aging, leading to compromised response against pathogens and chronic low-grade inflammation. This review discusses the molecules and mechanisms that regulate the relationship between immunosenescence and inflammaging, as well as therapeutic strategies to improve immunity in aged individuals.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Geriatrics & Gerontology
Wanxue He, Kun Xiao, Min Fang, Lixin Xie
Summary: Sepsis is a life-threatening organ dysfunction caused by dysregulated host responses to infection, with elderly individuals displaying increased susceptibility and mortality due to immune dysfunction. Alterations in immune cells of elderly sepsis patients, including endothelial cells, neutrophils, monocytes, macrophages, natural killer cells, dendritic cells, T lymphocytes, and B lymphocytes, largely contribute to their poor prognosis and increased mortality. Recent studies on elderly mice and sepsis patients have investigated changes affecting both innate and adaptive immune cells, shedding light on potential new therapeutic strategies.
Review
Cell Biology
Bastian Robinson Baarz, Lothar Rink
Summary: Nowadays, aging is recognized as a complex and dynamic process that affects almost all organs and cells in the human body. The immune system is particularly vulnerable to aging, and maintaining its integrity is crucial for preventing age-related diseases. Micronutrient intervention, especially adequate intake of the trace element zinc, has been identified as a potential strategy to slow immune aging. However, zinc deficiency is common among the elderly and can lead to increased susceptibility to infections and reduced immune response.
AGEING RESEARCH REVIEWS
(2022)
Article
Biology
Ericka Mochan, T. J. Sego, Bard Ermentrout
Summary: Age-induced dysregulation of the immune response is a major contributor to the increased morbidity and mortality related to influenza virus infections. We developed a model to simulate the immune response to pandemic H1N1 infection in old hosts, and found that the severity of infection in elderly hosts is caused by dysregulation in the innate immune response. We also observed that T cell exhaustion has more severe effects in the elderly population, as their dysregulated immune response cannot easily compensate for exhausted T cells. Furthermore, we explored a therapeutic approach to reversing T cell exhaustion through controlled inflammatory stimulation.
BULLETIN OF MATHEMATICAL BIOLOGY
(2022)
Article
Geriatrics & Gerontology
Jack Feehan, Nicholas Tripodi, Vasso Apostolopoulos
Summary: Cellular senescence is a critical part of human anti-tumor defence, but the accumulation of senescent cells with age can lead to various pathologies. Immunosenescence, the senescent change in immune cells, has a wide range of physiological effects and is partially responsible for many diseases associated with aging. Understanding the effects and mechanisms of immunosenescence can improve disease outcomes and prevention in older adults, and lead to new treatments for common illnesses.
Article
Infectious Diseases
M. Aldrin, P. A. Jansen, H. Stryhn
Article
Veterinary Sciences
Niorn Ratanapob, John VanLeeuwen, Shawn McKenna, Maureen Wichtel, Juan C. Rodriguez-Lecompte, Paula Menzies, Jeffrey Wichtel
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
(2019)
Article
Education, Scientific Disciplines
D. Paul Lunn, Roger B. Fingland, Richard Goldstein, Ted Y. Mashima, Ron McLaughlin, Laura L. Nelson, Ira G. Roth, Corinne R. Sweeney, Dana Zimmel
JOURNAL OF VETERINARY MEDICAL EDUCATION
(2019)
Article
Veterinary Sciences
Skye Badger, Sam Abraham, Henrik Stryhn, Darren J. Trott, David Jordan, Charles G. B. Caraguel
PREVENTIVE VETERINARY MEDICINE
(2019)
Article
Veterinary Sciences
D. N. Makau, J. A. VanLeeuwen, G. K. Gitau, S. L. McKenna, C. Walton, J. Muraya, J. J. Wichtel
PREVENTIVE VETERINARY MEDICINE
(2019)
Article
Veterinary Sciences
A. S. Boerlage, H. Stryhn, B. Armstrong, K. L. Hammell
PREVENTIVE VETERINARY MEDICINE
(2019)
Article
Agriculture, Dairy & Animal Science
Michael S. Cockram, Ketan Jung Dulal, Henrik Stryhn, Crawford W. Revie
CANADIAN JOURNAL OF ANIMAL SCIENCE
(2020)
Article
Veterinary Sciences
S. Kananub, P. Pechkerd, J. VanLeeuwen, H. Stryhn, P. Arunvipas
AUSTRALIAN VETERINARY JOURNAL
(2020)
Article
Agriculture, Dairy & Animal Science
E. E. John, G. Keefe, M. Cameron, H. Stryhn, J. T. McClure
JOURNAL OF DAIRY SCIENCE
(2020)
Article
Veterinary Sciences
Niorn Ratanapob, John VanLeeuwen, Shawn McKenna, Maureen Wichtel, Henrik Stryhn, Juan C. Rodriguez-Lecompte, Paula Menzies, Jeffery Wichtel
PREVENTIVE VETERINARY MEDICINE
(2020)
Article
Infectious Diseases
Adel Elghafghuf, Raphael Vanderstichel, Larry Hammell, Henrik Stryhn
Article
Veterinary Sciences
Antonia DeGroot, Jason Coe, David Kelton, Cynthia Miltenburg, Jeffrey Wichtel, Todd Duffield
Summary: This study identified factors associated with producer visit-specific satisfaction, which include producer age, gender, and perception of producer-centeredness. The findings emphasize the importance of a producer's perception of producer-centeredness in food-animal practice.
Article
Veterinary Sciences
Antonia DeGroot, Jason B. Coe, David Kelton, Cynthia Miltenburg, Jeffrey Wichtel, Todd Duffield
Summary: This study explored food-animal veterinarians' and producers' perceptions of producer-centered communication during on-farm interactions, revealing significant asymmetry with veterinarians evaluating PPC lower than producers. Factors associated with PPC included veterinarian burnout (negatively correlated with PPPC), veterinarian compassion satisfaction, length of interaction, and producers identifying as female (positively correlated with VPPC). Further examination of veterinarians' delivery of PPC is important for food-animal practice.
Article
Fisheries
Marianne I. Parent, Henrik Stryhn, K. Larry Hammell, Mark D. Fast, Jon Grant, Raphael Vanderstichel
Summary: This study aimed to estimate the impact of infestation pressures on the abundance of parasitic sea louse in the Bay of Fundy, New Brunswick, Canada, using the Fish-iTrends database for the years 2009-2018. The results showed that infestation pressures within and among sites significantly increased the abundance of sea lice, suggesting that synchronizing treatments between sites could improve sea lice burdens in Atlantic salmon farms.
JOURNAL OF FISH DISEASES
(2021)
Review
Veterinary Sciences
Klaus Osterrieder, David C. Dorman, Brandy A. Burgess, Lutz S. Goehring, Peggy Gross, Claire Neinast, Nicola Pusterla, Gisela Soboll Hussey, David P. Lunn
Summary: This study found that commercial and experimental vaccines minimally reduce the incidence of clinical disease associated with EHV-1 infection.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)