Article
Virology
Daisuke Tamura, Wataru Sako, Rina Watanabe, Akihiro Shitara, Fumiko Saito, Misa Yamauchi, Akihiro Sugita, Akihiro Karube
Summary: In this retrospective cohort study, we found that the quantitatively measured area of CIN2/3 was closely associated with patient age, high-risk HPV status, especially single HPV16 infection, and uterine position.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Oncology
Huei-Jean Huang, Hsiu-Jung Tung, Lan-Yan Yang, Angel Chao, Yun-Hsin Tang, Hung-Hsueh Chou, Wei-Yang Chang, Ren-Chin Wu, Chu-Chun Huang, Chiao-Yun Lin, Min-Jie Liao, Wei-Chun Chen, Cheng-Tao Lin, Min-Yu Chen, Kuan-Gen Huang, Chin-Jung Wang, Ting-Chang Chang, Chyong-Huey Lai
Summary: This observational study investigated the long-term outcomes and HPV genotype changes after conization for high-grade cervical intraepithelial neoplasia (HG-CIN). Results showed that active surveillance may reduce the severity of progression to cancer, and a majority of patients with recurrent CIN2+ had persistent type-specific HPV infections. Effective therapeutic vaccines for such cases are still needed.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Luca Giannella, Giovanni Delli Carpini, Jacopo Di Giuseppe, Giorgio Bogani, Francesco Sopracordevole, Nicolo Clemente, Giorgio Giorda, Rosa Pasqualina De Vincenzo, Maria Teresa Evangelista, Barbara Gardella, Mattia Dominoni, Ermelinda Monti, Chiara Alessi, Lara Alessandrini, Alessio Pagan, Marta Caretto, Alessandro Ghelardi, Andrea Amadori, Massimo Origoni, Maggiorino Barbero, Francesco Raspagliesi, Tommaso Simoncini, Paolo Vercellini, Giovanni Scambia, Andrea Ciavattini
Summary: This study examined the impact of HPV status on the prognosis of early stage cervical glandular lesions. The results showed that HPV status did not affect the recurrence rate, but most adenocarcinomas were positive for high-risk HPV.
Article
Obstetrics & Gynecology
Afsaneh Tehranian, Akram Ghahghaei-Nezamabadi, Akram Seifollahi, Parisa Mansouri, Arezoo Maleki-Hajiagha, Reyhaneh Aghajani
Summary: This study found no correlation between abnormal cervical cytology, dysplasia, or cervical high-risk HPV with anal abnormal cytology.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Oncology
Marta del Pino, Isabel Matas, Pilar Carrillo, Cristina Marti, Ariel Glickman, Nuria Carreras-Dieguez, Lorena Marimon, Adela Saco, Natalia Rakislova, Aureli Torne, Jaume Ordi
Summary: Women with anal HPV infection treated for HSIL/CIN2-3 should be re-tested for anal HPV after treatment. Those who have persisting anal HPV infection after treatment are at high risk of developing HSIL/AIN and may benefit from anal exploration. Additionally, women with anal HPV infection treated for HSIL/CIN might have a higher risk of recurrent cervical HPV infection.
Article
Oncology
Li Dong, Mari Nygard, Nathalie C. Stoer, Ole Klungsoyr, Bo T. Hansen
Summary: This study conducted in Norway presents the first real-world effectiveness study of HPV vaccination on high-grade cervical lesions outside the routine program. The findings indicate that HPV vaccination is effective against high-grade cervical lesions among women vaccinated below age 20, but may not have the desired impact among women vaccinated at age 20 or older.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Erika Hurtado-Salgado, Luz Cardenas-Cardenas, Jorge Salmeron, Rufino Luna-Gordillo, Eduardo Ortiz-Panozo, Betania Allen-Leigh, Nenetzen Saavedra-Lara, Eduardo L. Franco, Eduardo Lazcano-Ponce
Summary: This study analyzed screening data from Mexico's public cervical cancer prevention program from 2010 to 2015, and found that hrHPV testing with cytological triage can detect twice as many CIN2+ cases compared to screening using cytology alone in women aged 35 to 64.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Editorial Material
Medicine, General & Internal
Danijela Dejanovic, Marie Boennelycke, Annemarie Gjelstrup Amtoft, Charlotte Birk Christensen, Victoria Wetterstroem, Annika Loft, Trine Jakobi Noettrup
Summary: This study presents the rare case of primary uterine hepatoid adenocarcinoma with metastases to bone, vagina, and lymph nodes on F-18-Fluorodeoxyglucose PET/CT. It highlights the potential role of F-18-Fluorodeoxyglucose PET/CT in staging primary post-menopausal uterine bleeding tumors.
Article
Obstetrics & Gynecology
Yoshimitsu Wada, Hironori Takahashi, Manabu Ogoyama, Kenji Horie, Hirotada Suzuki, Rie Usui, Seung Chik Jwa, Akihide Ohkuchi, Hiroyuki Fujiwara
Summary: This study investigated the association between conisation and chorioamnionitis (CAM), and found that conisation was associated with an increased risk of clinical CAM. The association was more significant in the preterm period. Bacterial infections may play an important role in the relationship between conisation and preterm birth.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Oncology
Fangfang Zhong, Zaibo Li, Yihua Sun, Yaoxing Xiao, Juan Li, Xianrong Zhou, Qing Cong, Long Sui, Xiang Tao, Chengquan Zhao
Summary: In this study, HPV genotypes were investigated in a large group of patients with cervical histologic diagnosis. The prevalence of HPV genotypes in the Chinese population differed from that in Western populations. Some high-risk HPV types were identified in cervical precancerous lesions and cancers that are not covered by current HPV vaccines. These findings provide important baseline knowledge for future HPV vaccine development.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Robine Donken, Dirk van Niekerk, Jeremy Hamm, John J. Spinelli, Laurie Smith, Manish Sadarangani, Arianne Albert, Deborah Money, Simon Dobson, Dianne Miller, Marette Lee, Sheona Mitchell-Foster, Mel Krajden, Monika Naus, Gina Ogilvie
Summary: The HPV vaccination program in British Columbia, Canada has led to a significant decrease in CIN 2 and 3 rates among women aged 16-23, but no decline was observed in women aged 24-28. This suggests a successful population impact of the school-based HPV vaccination program.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Liye Shi, Xue Yang, Ling He, Chunying Zheng, Zhen Ren, Juweria Abdisamad Warsame, Suye Suye, Lei Yan, Haiyi Cai, Xiao Xiao, Chun Fu
Summary: This study investigated the diagnostic value of methylation biomarkers of six tumor suppressor genes in cervical precancerous lesions and cervical cancer. The results showed a positive correlation between methylation score and lesion severity, and the GynTect (R) assay was found to be valuable in detecting CIN2 + and CIN3 +.
Article
Veterinary Sciences
Jillian Kazmierczak, Nicole J. Sugai, Katie E. Withowski, Abe Jonatan, Tanya LeRoith, Julie T. Cecere
Summary: This article describes a rare case of oviductal and uterine leiomyosarcoma in a dog and highlights the treatment option of surgery for this condition.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Obstetrics & Gynecology
Malene Skorstengaard, Petra Hall Viborg, Ane Birgitte Telen Andersen, Berit Andersen, Mary Holten Bennetsen, Kirsten Marie Jochumsen, Tonje Johansen, Lise Grupe Larsen, Maja Ulrikka Bruun Laustsen, Rouzbeh Salmani, Reza Serizawa, Marianne Waldstrom, Elsebeth Lynge
Summary: This study assessed the outcomes of a one-time HPV screening in Danish women aged 70+. The study found that the prevalence of high-risk HPV in women aged 70-74 was 4.3%, and there were 5 cases of CIN2+ detected per 1000 screened women, with a recommended treatment threshold of CIN2.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Oncology
Sarah J. Bowden, Barbara Bodinier, Ilkka Kalliala, Verena Zuber, Dragana Vuckovic, Triada Doulgeraki, Matthew D. Whitaker, Matthias Wielscher, Rufus Cartwright, Konstantinos K. Tsilidis, Phillip Bennett, Marjo-Riitta Jarvelin, James M. Flanagan, Marc Chadeau-Hyam, Maria Kyrgiou
Summary: The study identified genetic susceptibility to cervical cancer, specifically involving PAX8, CLPTM1L, and HLA genes. The research also highlighted the role of genetic factors, smoking, older age at first pregnancy, and number of sexual partners in the risk of developing cervical cancer.
Article
Veterinary Sciences
Christof A. Bertram, Olivia Kershaw, Robert Klopfleisch, Kerstin Mueller
JOURNAL OF EXOTIC PET MEDICINE
(2019)
Article
Pathology
Sophie E. Merz, Robert Klopfleisch, Angele Breithaupt, Achim D. Gruber
VETERINARY PATHOLOGY
(2019)
Article
Multidisciplinary Sciences
Christof A. Bertram, Marc Aubreville, Christian Marzahl, Andreas Maier, Robert Klopfleisch
Article
Immunology
Katarina Liedtke, Christina Alter, Anne Guenther, Nadine Hoevelmeyer, Robert Klopfleisch, Ronald Naumann, F. Thomas Wunderlich, Jan Buer, Astrid M. Westendorf, Wiebke Hansen
JOURNAL OF IMMUNOLOGY
(2020)
Article
Pathology
Christof A. Bertram, Michael M. Garner, Drury Reavill, Robert Klopfleisch, Matti Kiupel
VETERINARY PATHOLOGY
(2020)
Article
Veterinary Sciences
Sophia Punsmann, Judith Hoppe, Robert Klopfleisch, Monica Venner
Summary: Acute interstitial pneumonia in foals is a complex disease with a multifactorial etiology. Recovery from acute interstitial pneumonia in foals appears to result in complete regeneration of the lungs without permanent changes. The study highlights the presence of various bacterial pathogens, viral infections, and Pneumocystis carinii in affected foals.
EQUINE VETERINARY JOURNAL
(2021)
Article
Pathology
Christof A. Bertram, Beate Bertram, Alexander Bartel, Anja Ewringmann, Marco A. Fragoso-Garcia, Nancy A. Erickson, Kerstin Mueller, Robert Klopfleisch
Summary: The prevalence and age distribution of tumors in pet rabbits are largely unknown. Previous studies on laboratory rabbits suggested a low tumor prevalence in young adult animals. However, in a retrospective analysis of archived pet rabbit samples, tumor types and prevalence were found to vary significantly with respect to age, revealing some differences from previous studies on laboratory rabbits.
VETERINARY PATHOLOGY
(2021)
Article
Pathology
Taryn A. Donovan, Frances M. Moore, Christof A. Bertram, Richard Luong, Pompei Bolfa, Robert Klopfleisch, Harold Tvedten, Elisa N. Salas, Derick B. Whitley, Marc Aubreville, Donald J. Meuten
Summary: Standardizing the methods of counting mitotic figures and distinguishing atypical mitotic figures versus mitotic-like figures is crucial in improving consistency and accuracy in tumor evaluation. Digital imaging techniques are now widely used among veterinary pathologists and can aid in easily calculating field of view area for mitotic figure counting.
VETERINARY PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Marc Aubreville, Christof A. Bertram, Taryn A. Donovan, Christian Marzahl, Andreas Maier, Robert Klopfleisch
Review
Pathology
Christof A. Bertram, Nikolas Stathonikos, Taryn A. Donovan, Alexander Bartel, Andrea Fuchs-Baumgartinger, Karoline Lipnik, Paul J. van Diest, Federico Bonsembiante, Robert Klopfleisch
Summary: Digital microscopy is increasingly used in pathology for routine diagnostic and research work, with validation studies showing high reliability. However, individual laboratories are encouraged to conduct their own validation studies to ensure expected performance in their specific clinical or research setting.
VETERINARY PATHOLOGY
(2022)
Editorial Material
Pathology
Donald J. Meuten, Frances M. Moore, Taryn A. Donovan, Christof A. Bertram, Robert Klopfleisch, Robert A. Foster, Rebecca C. Smedley, Michael J. Dark, Milan Milovancev, Paul Stromberg, Bruce H. Williams, Marc Aubreville, Giancarlo Avallone, Pompei Bolfa, John Cullen, Michelle M. Dennis, Michael Goldschmidt, Richard Luong, Andrew D. Miller, Margaret A. Miller, John S. Munday, Paola Roccabianca, Elisa N. Salas, F. Yvonne Schulman, Renee Laufer-Amorim, Midori G. Asakawa, Linden Craig, Nick Dervisis, D. Glen Esplin, Jeanne W. George, Marlene Hauck, Yumiko Kagawa, Matti Kiupel, Keith Linder, Kristina Meichner, Laura Marconato, Michelle L. Oblak, Renato L. Santos, R. Mark Simpson, Harold Tvedten, Derick Whitley
Summary: Standardization of tumor assessment is crucial for validating grading systems, ensuring reproducibility in oncologic studies, and increasing confidence in study results. This article provides standard guidelines for tumor assessment parameters to address the lack of methodological standardization in veterinary medicine. By updating and revising these guidelines regularly and providing them as living documents on a website, collaboration between pathologists and institutions can be facilitated to advance veterinary oncologic pathology and patient care.
VETERINARY PATHOLOGY
(2021)
Article
Veterinary Sciences
Nicole Schulze, Natasha Werpy, Jennifer Gernhardt, Guido Fritsch, Thomas Hildebrandt, Katrien Vanderperren, Robert Klopfleisch, Racem Ben Romdhane, Christophorus Lischer, Anna Ehrle
Summary: This study investigated the feasibility of using dynamic CT for diagnostic imaging of equine cervical articular process joints (APJs) and provided a detailed description of the APJ movement pattern. The results showed that the image quality of dynamic 3D videos was significantly lower than 2D videos, and the translational displacement of the APJ surface was greater in flexion movement than extension movement.
EQUINE VETERINARY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Christian Marzahl, Jenny Hill, Jason Stayt, Dorothee Bienzle, Lutz Welker, Frauke Wilm, Joern Voigt, Marc Aubreville, Andreas Maier, Robert Klopfleisch, Katharina Breininger, Christof A. Bertram
Summary: This study introduces a novel, fully annotated multi-species P-Hem dataset, and develops an annotation pipeline using deep learning and data visualization techniques. The dataset is one of the largest publicly available WSIs datasets in terms of the number of annotations, scanned area, and species covered.
Article
Multidisciplinary Sciences
Frauke Wilm, Marco Fragoso, Christian Marzahl, Jingna Qiu, Chloe Puget, Laura Diehl, Christof A. Bertram, Robert Klopfleisch, Andreas Maier, Katharina Breininger, Marc Aubreville
Summary: The study presents a dataset consisting of 350 whole slide images and 12,424 polygon annotations for studying histological classification of canine cutaneous tumors. The provided labels show high consistency, and the dataset is validated by training a deep neural network for tissue segmentation and tumor subtype classification.
Article
Pathology
Elena Riccardi, Robert Klopfleish, Frazer Bell, Sophie Le Calvez, Louise J. Dawson
Summary: This study investigated the expression of MUM1 antigen in canine peripheral T-cell lymphoma (PTCL) and diffuse large B cell lymphoma (DLBCL). The results showed that MUM1 antigen was expressed in both PTCL and DLBCL. These findings suggest that a subset of neoplastic T and B lymphocytes can express MUM1. Further research is needed to understand the role of MUM1 in the biological behavior and prognosis of canine lymphoma.
VETERINARY PATHOLOGY
(2023)
