Journal
APPLIED RADIATION AND ISOTOPES
Volume 97, Issue -, Pages 182-187Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2015.01.002
Keywords
[C-11]harmine; PET; MAO-A; Carbon-11; Monoamine oxidase; Radiosynthesis
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Funding
- Austrian Science Fund [FWF P24359]
- Austrian Science Fund (FWF) [P 24359] Funding Source: researchfish
- Austrian Science Fund (FWF) [P24359] Funding Source: Austrian Science Fund (FWF)
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The aim of the present study was the evaluation and automation of the radiosynthesis of [C-11]harmine for clinical trials. The following parameters have been investigated: amount of base, precursor concentration, solvent, reaction temperature and time. The optimum reaction conditions were determined to be 2-3 mg/mL precursor activated with 1 eq. 5 M NaOH in DMSO, 80 degrees C reaction temperature and 2 min reaction time. Under these conditions 6.1 +/- 1 GBq (51.0 +/- 11% based on [C-11]CH3I, corrected for decay) of [C-11]harmine (n=72) were obtained. The specific activity was 10132 +/- 28.2 GBq/mu mol (at EOS). All quality control parameters were in accordance with the standards for parenteral human application. Due to its reliability and high yields, this fully-automated synthesis method can be used as routine setup. (C) 2015 The Authors. Published by Elsevier Ltd.
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