Article
Engineering, Biomedical
Siqi He, Tanaya Walimbe, Hongyuan Chen, Kewa Gao, Priyadarsini Kumar, Yifan Wei, Dake Hao, Ruiwu Liu, Diana L. Farmer, Kit S. Lam, Jianda Zhou, Alyssa Panitch, Aijun Wang
Summary: In this study, a multi-functional pro-angiogenic molecule was designed and synthesized to enhance the treatment of diabetic ischemic wounds. The modified extracellular matrix scaffolds significantly promoted cell attachment, growth, and survival, leading to improved wound healing and neovascularization in an ischemic environment.
BIOACTIVE MATERIALS
(2022)
Article
Cell & Tissue Engineering
Yan Jiang, Heng Luo, Zhengke Zhao, Lei Feng
Summary: Estrogen enhances the function of BM-EPC and BM-MSC in diabetic mice, promoting wound healing and neovascularization.
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
(2022)
Review
Endocrinology & Metabolism
Xiaoping Yu, Pan Liu, Zheng Li, Zhengdong Zhang
Summary: Diabetes is a global public health problem, with diabetic foot being one of its severe complications that have a significant impact on patients' economic burden and quality of life. Recent studies have shown that mesenchymal stem cells (MSCs) can effectively treat diabetic foot ulcers by promoting angiogenesis and re-epithelialization, regulating the immune response, and reducing inflammation. MSCs from different sources have similar characteristics and subtle differences, and understanding their features is crucial for improving the therapeutic effect of diabetic foot ulcers.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Engineering, Biomedical
Tsai-Yu Chen, Tsung-Kai Wen, Niann-Tzyy Dai, Shan-Hui Hsu
Summary: The study developed functional and antimicrobial hydrogel and cryogel biomaterials for treating diabetic skin wounds, achieving good wound healing outcomes.
Article
Chemistry, Multidisciplinary
Ying Zhang, Yi-yuan Zhang, Zhen-wei Pan, Qing-qi Li, Li-hua Sun, Xin Li, Man-yu Gong, Xue-wen Yang, Yan-ying Wang, Hao-dong Li, Li-na Xuan, Ying-chun Shao, Meng-meng Li, Ming-yu Zhang, Qi Yu, Zhange Li, Xiao-fang Zhang, Dong-hua Liu, Yan-meng Zhu, Zhong-yue Tan, Yuan-yuan Zhang, Yun-qi Liu, Yong Zhang, Lei Jiao, Bao-feng Yang
Summary: This study found that GDF11 can accelerate the healing of diabetic wounds by promoting neovascularization and regeneration of skin tissues through cellular and molecular mechanisms. Topical application of GDF11 stimulates the mobilization of endothelial progenitor cells and enhances neovascularization through the HIF-1 alpha-VEGF/SDF-1 alpha pathway.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Cell & Tissue Engineering
Nesrine Ebrahim, Arigue A. Dessouky, Ola Mostafa, Amira Hassouna, Mohamed M. Yousef, Yasmin Seleem, Eman Abd El Aziz M. El Gebaly, Mona M. Allam, Ayman Samir Farid, Bayan A. Saffaf, Dina Sabry, Ahmed Nawar, Ahmed A. Shoulah, Ahmed H. Khalil, Sami F. Abdalla, Mohamed El-Sherbiny, Nehal M. Elsherbiny, Rabab F. Salim
Summary: The combined therapy of PRP and ADSCs significantly accelerated wound healing in experimentally induced diabetic rats by modulating the Notch signaling pathway, promoting angiogenesis, and enhancing EPSC proliferation.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Yiqiang Hu, Ranyang Tao, Lang Chen, Yuan Xiong, Hang Xue, Liangcong Hu, Chenchen Yan, Xudong Xie, Ze Lin, Adriana C. Panayi, Bobin Mi, Guohui Liu
Summary: This study investigated the effect of exosomes derived from pioglitazone-pretreated MSCs on diabetic wound healing. The results showed that pioglitazone-pretreated exosomes enhanced the angiogenic function of HUVECs and accelerated diabetic wound healing. The findings suggest a promising novel cell-free therapy for treating diabetic wound healing.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jingbo Zhang, Xiang Qu, Junjun Li, Akima Harada, Ying Hua, Noriko Yoshida, Masako Ishida, Yoshiki Sawa, Li Liu, Shigeru Miyagawa
Summary: Diabetic foot ulceration is a common complication, and transplantation of hUC-MSC tissue sheets can promote wound healing, improve collagen deposition, and angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Min Jiang, Xupin Jiang, Hongmei Li, Can Zhang, Ze Zhang, Chao Wu, Junhui Zhang, Jiongyu Hu, Jiaping Zhang
Summary: Diabetic foot is a common complication of diabetes and often leads to amputation. Previous studies have shown that stem cell transplantation can promote the healing of chronic diabetic wounds, but safety concerns have limited its clinical application. Recently, it has been discovered that mesenchymal stem cell-derived extracellular vesicles (EVs) have similar therapeutic effects and offer advantages such as safety and reduced immune response. This paper summarizes the current understanding of mesenchymal stem cell-derived EVs in accelerating the healing of diabetic wounds and their potential clinical applications.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Endocrinology & Metabolism
Jia-Na Huang, Hao Cao, Kai-Ying Liang, Li-Ping Cui, Yan Li
Summary: Diabetic wounds are a common complication of diabetes mellitus and pose a significant medical problem worldwide. Traditional therapy has limitations in improving wound closure, making diabetic wounds difficult to heal. Stem cells and hydrogels show promise in treating diabetic wounds by promoting wound healing.
WORLD JOURNAL OF DIABETES
(2022)
Article
Biochemistry & Molecular Biology
Zheng Kou, Balun Li, Aili Aierken, Ning Tan, Chenchen Li, Miao Han, Yuanxiang Jing, Na Li, Shiqiang Zhang, Sha Peng, Xianjun Zhao, Jinlian Hua
Summary: The existing treatment modalities for skin injuries, such as dressings, negative-pressure wound treatment, autologous skin grafting, and high-pressure wound treatment, have limitations such as high time cost and inability to remove inactivated tissue in a timely manner. Mesenchymal stem cells (MSCs) have great potential in cell therapy and regenerative medicine due to their unique self-renewal ability and differentiation potential. The addition of collagen to cell cultures promotes cell proliferation and accelerates the healing of skin wounds in mice and canines by promoting epidermal layer repair, collagen deposition, hair follicle angiogenesis, and an inflammatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Flavy Roseren, Martine Pithioux, Stephane Robert, Laure Balasse, Benjamin Guillet, Edouard Lamy, Sandrine Roffino
Summary: The study showed that G-CSF can accelerate bone regeneration and modulate the mobilization of progenitor cells during the process of distraction osteogenesis, promoting bone consolidation. In the early phase of consolidation, the G-CSF group exhibited lower osteoclast activity and a trend of increased osteoblast activity, while significantly lower neovascularization was observed in the late phase of consolidation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Shune Xiao, Chunfang Xiao, Yong Miao, Jin Wang, Ruosi Chen, Zhexiang Fan, Zhiqi Hu
Summary: The study demonstrated that hAAM scaffolds incorporated with ADSC-Exos can promote diabetic skin wound healing by regulating inflammation, stimulating vascularization, and promoting the production of extracellular matrix.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Biotechnology & Applied Microbiology
Golnaz Mahmoudvand, Arian Karimi Rouzbahani, Zahra Sadat Razavi, Mohamad Mahjoor, Hamed Afkhami
Summary: Diabetic foot ulcer (DFU) is a severe complication of diabetes mellitus (DM) that can lead to amputation. The wound-healing process is impaired in diabetic patients, making conventional treatments ineffective. Mesenchymal stem cells (MSCs) have gained attention for their potential in improving wound healing. MSC therapy improves healing in DFU through immunomodulation, differentiation, and angiogenesis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cell & Tissue Engineering
Andreas Kerstan, Kathrin Dieter, Elke Niebergall-Roth, Sabrina Klingele, Michael Junger, Christoph Hasslacher, Georg Daeschlein, Lutz Stemler, Ulrich Meyer-Pannwitt, Kristin Schubert, Gerhard Klausmann, Titus Raab, Matthias Goebeler, Korinna Kraft, Jasmina Esterlechner, Hannes M. Schroder, Samar Sadeghi, Seda Ballikaya, Martin Gasser, Ana M. Waaga-Gasser, George F. Murphy, Dennis P. Orgill, Natasha Y. Frank, Christoph Ganss, Karin Scharffetter-Kochanek, Markus H. Frank, Mark A. Kluth
Summary: This study suggests that GMP-manufactured ABCB5(+) dermal mesenchymal stem cells might be a safe adjunctive therapy for incurable diabetic foot ulcers. The results from mouse models and clinical trials demonstrate the efficacy of these stem cells in promoting wound healing and restoring blood perfusion.
STEM CELL RESEARCH & THERAPY
(2022)