Article
Endocrinology & Metabolism
Suman Baral, Satyan Rajbhandari
Summary: Nepal, a developing country, is facing a major health challenge with a high prevalence of diabetes (8.5%) affecting around 2 million people. Limited resources pose barriers to providing affordable and convenient diabetes care or regular screening for complications. There is no reliable data on the incidence, prevalence, and complications of diabetic foot problems in Nepal.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Angel Ortiz-Zuniga, Jordi Samaniego, Betina Biagetti, Nicolas Allegue, Anna Gene, Andrea Sallent, Almudena Crespo, Jordi Serracanta, Carme Torrents, Daniela Issa, Danilo Rivas, Maria Teresa Veintemillas, Nuria Fernandez-Hidalgo, Rosa Busquets, Josep Royo, Cristina Hernandez
Summary: The aim of this study was to compare the incidence of lower-extremity amputations (LEA-DFD) before and after the establishment of a Diabetic Foot Multidisciplinary Unit. The results showed a significant reduction in the rate of amputations due to foot disease in patients with diabetes after the establishment of the unit.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Xiaojuan Zhang, Ying Cheng, Ling Pei, Jie Tao, Rui Wang, Zhong Chen
Summary: Two patients with diabetic foot ulcers were successfully treated with low-intensity diagnostic ultrasound (LIDUS) combined with microbubbles, leading to complete healing of the ulcers without recurrence during one year of follow-up.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Health Care Sciences & Services
Alvaro Astasio-Picado, Alba angel Babiano, Miriam Lopez-Sanchez, Rocio Ruiz Lozano, Paula Cobos-Moreno, Beatriz Gomez-Martin
Summary: This article provides evidence on the effectiveness and safety of ozone therapy in the treatment of wounds in patients with diabetic foot. It compares ozone therapy with other treatment methods and presents the findings of a literature review.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Sohail Akhtar, Mujahid Latif, Omer Shabbir Ahmed, Aqsa Sarwar, Ayisham Alina, Muhammad Imran Khan
Summary: This study explores the prevalence of foot ulcers among diabetic patients in Punjab, Pakistan and identifies associated factors. The results indicate a relatively high prevalence of foot ulcers in Punjab, highlighting the need for better strategies and preventive measures to address this epidemic.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Dermatology
Mohamed S. Imam, Ahmed Khalid Almutairi, Abdullah Mutrik Alhajri, Mishary Mosleh Alharby, Mohammed H. Alanazi, Ahmad G. Alotaibi, Mohamed E. A. Abdelrahim
Summary: This meta-analysis aimed to assess the effect of hyperbaric oxygen treatment on diabetic foot ulcers. The results showed that hyperbaric oxygen treatment had significantly higher rates of healed ulcers, adverse events, and ulcer area reduction, as well as lower mortality, compared to standard treatment. However, there was no significant difference in amputation and healing time between the two treatments. It is important to note that the selected studies had small sample sizes and limited comparisons.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Medicine, General & Internal
Sujit Kumar Das, Pinki Roy, Prabhishek Singh, Manoj Diwakar, Vijendra Singh, Ankur Maurya, Sandeep Kumar, Seifedine Kadry, Jungeun Kim
Summary: Diabetes is a chronic condition caused by uncontrolled blood sugar levels, and early diagnosis of complications such as diabetic foot ulcers (DFUs) can help prevent severe consequences. The use of deep learning, machine learning, and computer vision techniques provides promising solutions for assisting clinicians in diagnosing DFUs. This article provides a comprehensive overview of the current status of automatic DFU identification and highlights the dominance of CNN-based solutions in the field. It emphasizes the importance of combining traditional ML and advanced DL techniques for more reliable and efficient diagnostic decisions.
Review
Medicine, Research & Experimental
Yujia Zhang, Jing Zhang, Zhou Xu, Deju Zhang, Panpan Xia, Jitao Ling, Xiaoyi Tang, Xiao Liu, Rui Xuan, Meiying Zhang, Jianping Liu, Peng Yu
Summary: Non-coding RNA (ncRNA) is a significant component of the human genome, controlling various biological processes. It plays a crucial role in the onset and development of diabetes-related complications, such as diabetic foot ulcer (DFU). Understanding the mechanism and progress of ncRNA-protein binding in DFU can contribute to the early diagnosis and targeted intervention of DFU.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, General & Internal
Wei Chai, Yuqing Wang, Huancheng Zheng, Song Yue, Yan Liu, Yili Wu, Xuezhi Li
Summary: The study analyzed the pathogen spectrum and antibiotic susceptibility of diabetic foot ulcers, finding that dominant pathogens were sensitive to at least one antibiotic, but the antibacterial efficacy of common antibiotics decreased over time. Identification and testing of antibiotic susceptibility of dominant pathogens are essential for effective treatment of diabetic foot ulcers.
FRONTIERS IN MEDICINE
(2021)
Article
Dermatology
Deborah Christensen, Albert Botchway
Summary: A retrospective chart cohort review over 3 years shows that using a felt foot plate can effectively heal a diabetic foot ulcer, and patient weight and growth factors do not affect healing times.
ADVANCES IN SKIN & WOUND CARE
(2023)
Article
Dermatology
Liu He, Ya-Qing Xia, Cai-Feng Yang, Jia-Li He, Xian-Yu Tang
Summary: A meta-analysis was conducted to evaluate the management of diabetic foot wound ulcers (DFWUs) using laser therapy (LT). The results showed that LT had a significant effect on reducing ulcer size and promoting complete healing in individuals with DFWUs compared to control. However, caution should be exercised in interpreting the results due to the small sample size of the selected studies.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Medicine, General & Internal
Jean-Baptiste Bonnet, Ariane Sultan
Summary: The diabetic foot ulcer (DFU), a common and serious complication of diabetes, is influenced by the individual's social environment and access to healthcare. Financial insecurity and social protection systems play a significant role in DFU prognosis, while the relationship between socioeconomic and socio-educational deprivations and DFU is more complex. Understanding the correlation between DFU risk and social deprivation depends on how social deprivation is calculated and how questions about the relationship are framed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dermatology
Li Zhang, Guifen Fu, Yongqing Deng, Yuechou Nong, Jianhao Huang, Xiulu Huang, Fenglian Wei, Yanqing Yu, Litian Huang, Wenjiao Zhang, Meizhu Tang, Licai Deng, Jiaxia Han, Xing Zhou, Qiu Wang, Wensheng Lu
Summary: This study identified urine albumin-creatinine ratio (UACR) and vibration perception threshold (VPT) as independent risk factors for foot ulcer recurrence in patients with comorbid diabetic foot osteomyelitis and diabetic nephropathy. The study also suggested that microcirculation disorders play a major role in the recurrence of foot ulcer in these patients.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Infectious Diseases
Ines D. Teixeira, Eugenia Carvalho, Ermelindo C. Leal
Summary: Diabetic foot ulcers (DFU) are a serious complication of diabetes, affecting approximately 15% of patients and leading to lower limb amputations. However, impaired healing process and antimicrobial resistance pose challenges to effective treatment. This review explores the use of antimicrobial peptides derived from environmentally friendly processes as potential therapeutic compounds for DFUs, offering better quality of life to patients while preserving bio-resources.
Article
Chemistry, Multidisciplinary
Paramjit S. Tappia, Brett Hiebert, Rohan Sanjanwala, Paul Komenda, Chris Sathianathan, Amarjit S. Arneja, Bram Ramjiawan
Summary: This study suggests that bathing in CO2-enriched water may accelerate the healing of foot ulcers, although no significant differences were observed in the group/time interaction effect.
APPLIED SCIENCES-BASEL
(2021)
Article
Surgery
Nader Zamani, Sherene E. Sharath, Rocky C. Browder, Neal R. Barshes, Jonathan D. Braun, Joseph L. Mills, Panos Kougias, Houssam K. Younes
Summary: This study compared the treatment outcomes of long-segment SFA lesions, showing that DES had better primary-assisted and secondary patency compared to BMS and CS during long-term follow-up. However, CS was associated with a higher risk of acute limb ischemia when stent occlusion occurred.
ANNALS OF VASCULAR SURGERY
(2021)
Review
Oncology
Richard S. Whitlock, Kingsley Ebare, Lily S. Cheng, Douglas S. Fishman, Joseph L. Mills, HaiThuy N. Nguyen, Jed G. Nuchtern, Wenly Ruan, Valeria E. Smith, Kalyani A. Patel, Kevin E. Fisher, Sanjeev A. Vasudevan
Summary: This is the first reported case of pediatric pancreatic angiosarcoma with an activating KDR-internal tandem duplication. Literature on this disease process is very limited.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2022)
Article
Surgery
Jessica M. Mayor, Ourania Preventza, Katharine McGinigle, Joseph L. Mills, Miguel Montero-Baker, Ramyar Gilani, Zachary Pallister, Jayer Chung
Summary: Women have been historically under-represented in vascular surgery and cardiovascular medicine trials, and the rate and change in representation of women in trials of common vascular diseases over the last decade is not completely understood. Participants in trials for common vascular diseases are generally not representative of the actual disease population, with women consistently being underrepresented.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Surgery
Jorge A. Miranda, Jayer Chung, Joseph L. Mills
Summary: During the COVID-19 pandemic, patients with CLTI experienced increased rates of major and minor amputations. Vascular clinical volume decreased significantly during the pandemic, and further research is needed to improve strategies for treating this vulnerable population.
SEMINARS IN VASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Joep G. J. Wijnand, Devin Zarkowsky, Bian Wu, Steven T. W. van Haelst, Evert-Jan P. A. Vonken, Thomas A. Sorrentino, Zachary Pallister, Jayer Chung, Joseph L. Mills, Martin Teraa, Marianne C. Verhaar, Gert J. de Borst, Michael S. Conte
Summary: The Global Vascular Guidelines in 2020 aim to improve decision-making in Chronic Limb-Threatening Ischemia by providing an evidence-based revascularization framework. The Global Limb Anatomic Staging System (GLASS) serves to estimate the success of lower extremity arterial revascularization based on the extent and distribution of atherosclerotic lesions. The study suggests that a stepwise component scoring provides acceptable agreement for GLASS and lays a solid foundation for further validation studies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Richard S. Whitlock, Steven C. Mehl, Daniel C. Chelius, John C. Koshy, Joseph L. Mills, Julina Ongkasuwan, Susan L. McGovern, M. Fatih Okcu, Bindi Naik-Mathuria
Summary: MRT, highly aggressive with poor prognosis, can occur in various locations; cervical rhabdoid tumors are extremely rare. Successful surgical resection led to over one year survival in this case.
JOURNAL OF PEDIATRIC SURGERY CASE REPORTS
(2021)
Article
Surgery
Jorge Miranda, Deepa Dongarwar, Hamisu M. Salihu, Miguel Montero-Baker, Ramyar Gilani, Zachary S. Pallister, Joseph L. Mills, Jayer Chung
Summary: The study found that rates of iatrogenic vascular injuries (IaVI's) increased among the top ten most frequently performed inpatient procedures in the United States from 2008 to 2015. Females, the elderly, and Hispanics were more likely to experience IaVI's. Overall, IaVI's independently increased the adjusted odds of mortality by 25%, with Blacks facing a 50% elevated risk compared to Non-Hispanic Whites.
ANNALS OF VASCULAR SURGERY
(2022)
Article
Surgery
Neal R. Barshes, Deeksha Bidare, Panos Kougias, Joseph L. Mills, Scott A. LeMaire
Summary: This study found that AAA screening has lower diagnostic rates among minority populations and suggests the need for various targeted strategies to address this disparity.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Surgery
Edward D. Gifford, Nicolas J. Mouawad, Kathryn E. Bowser, Ruth L. Bush, Venita Chandra, Dawn M. Coleman, Elizabeth Genovese, Daniel K. Han, Misty D. Humphries, Joseph L. Mills, Erica L. Mitchell, Carla C. Moreira, Reginald Nkansah, Jeffrey J. Siracuse, Jordan R. Stern, Dongjin Suh, Lauren West-Livingston
Summary: The use of social media in medicine has shown potential to improve networking among healthcare professionals, disseminate research, provide up-to-date information, and engage medical students and the public. It is important to uphold patient privacy, encourage appropriate consent and imagery use, disclose conflicts of interest, and prevent negative interactions online. The Society for Vascular Surgery is dedicated to promoting honest, well-informed, and accurate use of social media content in the medical field.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Surgery
Karen Woo, Jeffrey J. Siracuse, Kyle Klingbeil, Larry W. Kraiss, Nicholas H. Osborne, Niten Singh, Tze-Woei Tan, Shipra Arya, Subhash Banerjee, Marc P. Bonaca, Thomas Brothers, Michael S. Conte, David L. Dawson, Young Erben, Benjamin M. Lerner, Judith C. Lin, Joseph L. Mills, Derek Mittleider, Deepak G. Nair, Leigh Ann O'Banion, Robert B. Patterson, Matthew J. Scheidt, Jessica P. Simons
Summary: The Society for Vascular Surgery created appropriate use criteria (AUC) for managing intermittent claudication using a validated method that combines evidence from medical literature with expert opinion. These criteria serve as a framework for shared decision-making between patients and clinicians. It is important to note that these criteria are not absolute and should be periodically reviewed for relevance.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Surgery
Mahmood Kabeil, Max Wohlauer, Mario D'Oria, Vipul Khetarpaul, Riley Gillette, Ethan Moore, Kathryn Colborn, Robert F. Cuff, Leigh Ann O'Banion, Issam Koleilat, Faisal Aziz, Nicolas J. Mouawad
Summary: The study found that during the COVID-19 pandemic, delays in carotid artery operations were primarily due to hospital policies, with most patients not deteriorating or requiring emergency surgery during the delay.
ANNALS OF VASCULAR SURGERY
(2023)
Review
Endocrinology & Metabolism
Vivienne Chuter, Nicolaas Schaper, Joseph Mills, Robert Hinchliffe, David Russell, Nobuyoshi Azuma, Christian-Alexander Behrendt, Edward J. Boyko, Michael S. Conte, Misty Humphries, Lee Kirksey, Katharine C. McGinigle, Sigrid Nikol, Joakim Nordanstig, Vincent Rowe, Jos C. van den Berg, Maarit Venermo, Robert Fitridge
Summary: Early diagnosis and ongoing monitoring and treatment of peripheral artery disease (PAD) is crucial for reducing the risk of foot ulcer development, non-healing of wounds, infection, amputation, and cardiovascular complications in patients with diabetes. Various non-invasive bedside tests are available for diagnosing PAD, but the most accurate test and its reliability for ongoing monitoring are still uncertain. This systematic review aimed to determine the diagnostic accuracy of non-invasive bedside tests for identifying PAD and their reliability in adults with diabetes. The review included 40 studies on diagnostic accuracy and 7 studies on reliability. Ankle-brachial index (ABI) was the most investigated test. The review found that an ABI <0.9 increases the likelihood of disease, while an ABI within the normal range (≥0.90 and <1.3) does not exclude PAD. Toe-brachial index (TBI) and Doppler waveforms in the pedal arteries were also associated with PAD presence. Several bedside tests showed acceptable reliability, but the margin of error was wide. No single or combination of bedside tests demonstrated superior diagnostic accuracy for PAD in patients with diabetes. However, an ABI of 1.3, TBI <0.70, and absent or monophasic pedal Doppler waveforms can help identify the presence of disease.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Endocrinology & Metabolism
Vivienne Chuter, Nicolaas Schaper, Robert Hinchliffe, Joseph Mills, Nobuyoshi Azuma, Christian-Alexander Behrendt, Edward J. Boyko, Michael S. Conte, Misty Humphries, Lee Kirksey, Katharine C. McGinigle, Sigrid Nikol, Joakim Nordanstig, Vincent Rowe, Russell David, Jos C. van den Berg, Maarit Venermo, Robert Fitridge
Summary: This systematic review aimed to determine the performance of non-invasive bedside tests for predicting the outcomes of DFU healing, minor amputation, and major amputation in people with diabetes and DFU or gangrene. The results showed that a toe pressure of ≥30 mmHg, TcPO2 of ≥25 mmHg, and skin perfusion pressure of ≥40 mmHg were associated with a moderate to large increase in the likelihood of DFU healing. However, there is limited research on the prognostic capacity of bedside testing for healing post-minor amputation or major amputation in people with DFU. Current evidence suggests that an ABI <0.4 may be associated with a large increase in the risk of major amputation.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Robert Fitridge, Vivienne Chuter, Joseph Mills, Robert Hinchliffe, Nobuyoshi Azuma, Christian-Alexander Behrendt, Edward J. Boyko, Michael S. Conte, Misty Humphries, Lee Kirksey, Katharine C. Mcginigle, Sigrid Nikol, Joakim Nordanstig, Vincent Rowe, David Russell, Jos C. van den Berg, Maarit Venermo, Nicolaas Schaper
Summary: Diabetes-related foot complications, including peripheral artery disease (PAD), are increasing globally and causing major and minor amputations. The International Working Group on the Diabetic Foot (IWGDF) has published evidence-based guidelines since 1999. This updated guideline, developed in collaboration with other vascular surgery societies, provides recommendations for diagnosing PAD, estimating healing and amputation outcomes, and treating PAD in individuals with diabetes mellitus and foot ulcers.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Dermatology
Hailey R. Donnelly, Erin D. Clarke, Clare E. Collins, Rebecca A. Collins, David G. Armstrong, Joseph L. Mills, Peta E. Tehan
Summary: The inaugural expert consensus and guidance for Nutrition Interventions in Adults with Diabetic Foot Ulcers (DFU) have provided important guidance for clinicians and revealed inadequacies in the dietary intake of individuals with DFU. Future guidelines should consider evidence-based recommendations and include all essential nutrients for wound healing in DFU.
INTERNATIONAL WOUND JOURNAL
(2023)