Article
Chemistry, Multidisciplinary
Mohammed Almijalli
Summary: This research utilized computer modeling to study the impact of intraluminal thrombus (ILT) on abdominal aortic aneurysm (AAA) rupture, and found that ILT does not lead to local hypoxia as previously theorized.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Aldona Siennicka, Monika Adamowicz, Natalie Grzesch, Magdalena Klysz, Jaroslaw Wozniak, Miloslaw Cnotliwy, Katarzyna Galant, Maria Jastrzebska
Summary: This study compared the levels of inflammatory mediators in different thicknesses of intraluminal thrombus (ILT) and adjacent abdominal aortic aneurysm (AAA) walls. The results showed that neutrophil elastase, TNF-a, and IL-6 levels were significantly higher in thick ILT and aneurysmal walls covered by thick ILT. Positive correlations were also found between thick ILT and the adjacent wall, as well as thin ILT and the adjacent wall. These findings suggest that neutrophil mediators and inflammatory cytokines may accumulate differently in AAA tissues based on ILT thickness, potentially weakening the AAA wall.
Article
Engineering, Multidisciplinary
Jie-min Zhan, Tian-dong Lu, Zhi-yun Yang, Wen-qing Hu, Wei Su
Summary: This study conducted numerical simulations and experiments on patient-specific normal abdominal aorta and abdominal aortic aneurysm (AAA) models with intraluminal thrombus (ILT), which were reconstructed from CT angiography (CTA) images published online. The distribution of wall shear stress (WSS), oscillatory shear index (OSI), and relative residence time (RRT) were compared between the normal abdominal aorta and AAA under rest and exercise conditions. The results indicated that ILT deposition positions were associated with low WSS, high OSI, and high RRT regions, and the distribution of AAA wall parameters correlated with nearby vortex structures and influenced ILT formation and development. Additionally, high WSS, low OSI, and low RRT regions in the middle and lower aneurysm walls under exercise condition reduced the risk of ILT formation and development.
ENGINEERING APPLICATIONS OF COMPUTATIONAL FLUID MECHANICS
(2022)
Article
Biophysics
Alexis Throop, Martina Bukac, Rana Zakerzadeh
Summary: This study investigates the biomechanical role of intraluminal thrombus (ILT) in abdominal aortic aneurysm (AAA). The results demonstrate that while ILT can reduce wall stress, it significantly decreases oxygen transport within the tissue, leading to wall hypoxia.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2022)
Article
Engineering, Mechanical
Alp Kalipcilar, Huseyin Enes Salman
Summary: Abdominal aortic aneurysm (AAA) is a widely prevalent condition characterized by the dilatation of the abdominal aorta. Computational fluid dynamics (CFD) simulations play an important role in studying AAA hemodynamics. This study investigates the effect of intraluminal thrombus (ILT) burden on AAA hemodynamics using CFD simulations, revealing that ILT significantly alters the biomechanical environment by influencing wall shear stress distribution.
JOURNAL OF THE BRAZILIAN SOCIETY OF MECHANICAL SCIENCES AND ENGINEERING
(2023)
Article
Cardiac & Cardiovascular Systems
Mostafa Rezaeitaleshmahalleh, Nan Mu, Zonghan Lyu, Weihua Zhou, Xiaoming Zhang, Todd E. Rasmussen, Robert D. McBane III, Jingfeng Jiang
Summary: The objective is to predict the growth status of abdominal aortic aneurysms (AAA) using the structural information of intraluminal thrombus (ILT) through an automated workflow. Deep-learning image segmentation models were used to generate 3D geometrical AAA models, followed by automated analysis and classification using a support vector machine. The most accurate predictive model considered four geometrical parameters, two parameters quantifying the constitution of ILT, antihypertensive medication, and the presence of co-existing coronary artery disease, achieving an AUROC of 0.89 and a total accuracy of 83%.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Aykut Can Arslan, Huseyin Enes Salman
Summary: Abdominal aortic aneurysm (AAA) is a serious health condition characterized by the enlargement of the abdominal aorta beyond its normal diameter. The risk of rupture in AAA can be determined using computational techniques such as computational fluid dynamics (CFD) and fluid-structure interaction (FSI). This study investigates the effect of intraluminal thrombus (ILT) and arterial material properties on the mechanical stresses in AAA using CFD simulations and FSI analysis.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Biotechnology & Applied Microbiology
Burton Carbino, Alexander Guy, Michael Durka, Rana Zakerzadeh
Summary: The objective of this study is to analyze the impact of intraluminal thrombus (ILT) presence and morphology on oxygen transport in abdominal aortic aneurysms (AAA). The study found that ILT reduces oxygen flux to the arterial wall, creating an inflammatory environment and decreasing its strength. The geometry of ILT was also found to potentially affect AAA rupture. ILT thickness and length were found to be the parameters that most significantly influence decreased oxygen flow and concentration values, while thick thrombi exacerbate hypoxic conditions in the arterial wall. Conversely, arterial wall oxygen concentration was nearly independent of the AAA bulge diameter.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Surgery
Regent Lee, Ismail Cassimjee, Honglei Huang, Pierfrancesco Lapolla, Elisha Ngetich, Anirudh Chandrashekar, Philip Charles, Benedikt Kessler, Roman Fischer, Ashok Handa
Summary: This study discovered novel biomarkers for predicting AAA growth using a mass spectrometry proteomics pipeline. These biomarkers, including Attractin, showed significant correlation with future AAA growth and could be used to predict the growth of AAA.
Article
Radiology, Nuclear Medicine & Medical Imaging
Eva Aalbregt, Reza Indrakusuma, Hamid Jalalzadeh, R. Nils Planken, Joost van Schuppen, Lilian Meijboom, Ron Balm, Aart J. Nederveen, Kak Khee Yeung, Pim van Ooij
Summary: 4D flow MRI is a reliable method for assessing the hemodynamics within AAA, but there is no correlation between hemodynamic parameters and maximum diameter, ILT volume and growth rate.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Daizo Ishii, Shigeyuki Sakamoto, Takahito Okazaki, Masashi Kuwabara, Masahiro Hosogai, Nobutaka Horie
Summary: Abdominal aortic calcification is significantly associated with increased wall enhancement of UIAs, indicating that systemic atherosclerosis may be a risk factor for the instability of UIAs.
WORLD NEUROSURGERY
(2022)
Article
Peripheral Vascular Disease
Sean P. Steenberge, Daniel G. Clair, Matthew J. Eagleton, Francis J. Caputo, Christopher J. Smolock, Sean P. Lyden
Summary: Preoperative aortic thrombus and endovascular repair are both associated with an increased risk of future aortic degeneration after infrarenal abdominal aortic aneurysm repair. These factors may predict patients at higher risk of developing proximal aortic aneurysms that may require complex aortic repairs.
Article
Neuroimaging
D. Andrew Wilkinson, Badih J. Daou, Jeffrey L. Nadel, Neeraj Chaudhary, Joseph J. Gemmete, Byron Gregory Thompson, Aditya S. Pandey
Summary: The study evaluated the incidence of aneurysmal SAH in patients diagnosed with AAA using longitudinal claims data. Results showed a higher SAH rate in patients with AAA, with AAA being the strongest predictor for SAH even after adjusting for comorbidities. The study suggested that the common genetic and environmental risk factors for both diseases should be further investigated.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2021)
Article
Surgery
Milos Sladojevic, Igor Koncar, Petar Zlatanovic, Zeljka Stanojevic, David Matejevic, Sasenka Vidicevic Novakovic, Jelena Tasic, Perica Mutavdzic, Ivan Tomic, Aleksandra Isakovic, Lazar Davidovic
Summary: The study found a significant correlation between ILT volume and the largest AAA diameter, but no statistical significance in relation to proteolytic activity and protein content of the vascular wall. However, a positive correlation was found between ILT and catalase activity in the AAA wall. Future studies are needed to investigate the impact of ILT on aneurysm progression.
ANNALS OF VASCULAR SURGERY
(2022)
Article
Surgery
Kristian Smidfelt, Joakim Nordanstig, Axel Davidsson, Kristina Torngren, Marcus Langenskiold
Summary: Misdiagnosis is common in patients with rAAA, and is associated with a significantly higher risk of mortality. In patients undergoing surgical intervention, the mortality rate is slightly higher in misdiagnosed patients compared to correctly diagnosed patients.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Byron G. DuBois, Ignas B. Houben, Minhaj S. Khaja, Bo Yang, Karen M. Kim, Joost A. van Herwaarden, David M. Williams, Himanshu J. Patel
Summary: This study reports the short-term and intermediate-term outcomes of two distinct approaches to thoracic endovascular aortic repair (TEVAR) for descending aortic aneurysms in patients with compromised distal landing zones. The perioperative complication rate was 20%, with a 5% 30-day mortality rate. Intermediate-term outcomes showed that the distal landing zone diameter decreased annually in the adjunct cohort, which may be beneficial for patients.
ANNALS OF THORACIC SURGERY
(2021)
Article
Emergency Medicine
Dennis Hundersmarck, Quirine M. J. van der Vliet, Lotte M. Winterink, Luke P. H. Leenen, Joost A. van Herwaarden, Constantijn E. V. B. Hazenberg, Falco Hietbrink
Summary: This study demonstrates good long-term radiographic outcomes of TEVAR for the treatment of BTAIs. Coverage of the left subclavian artery did not lead to complications. However, patients experienced impairment in health-related quality of life and were unable to return to an age-adjusted level of daily functioning, possibly due to concomitant orthopedic and neurological injuries.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Surgery
Laurien S. Kuhrij, Eleonora G. Karthaus, Anco C. Vahl, Martine C. M. Willems, Jan W. Elshof, Gert J. de Borst
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2020)
Review
Surgery
Constance J. H. C. M. van Laarhoven, Nikita K. N. Jorritsma, Jessica Balderston, Waleed Brinjikji, Martin Bjorck, Joost A. van Herwaarden, Gert J. de Borst
Summary: Aneurysms are focal manifestations of systemic vascular conditions, and studies have shown co-prevalence of aneurysms in different vascular beds. The presence of multiple aneurysms in patients with a primary aneurysm is relatively common, especially in those with higher age, hypertension, stenotic disease, and larger primary aneurysms. Clinical predictors such as age, hypertension, and number of aneurysms may help determine the need for screening for additional aneurysms in patients with a primary aneurysm.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Surgery
Joost A. van Herwaarden, Marloes M. Jansen, Evert-jan P. A. Vonken, Trijntje Bloemert-Tuin, Roland W. M. Bullens, Gert J. de Borst, Constantijn E. V. B. Hazenberg
Summary: The FORS technology, as a new visualization tool, showed high feasibility and safety in clinical practice. Most navigational tasks using FORS enabled devices achieved technical success, with good user experience and reduced fluoroscopy time.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Surgery
Quirina M. B. de Ruiter, Frans L. Moll, Constantijn E. V. B. Hazenberg, Joost A. van Herwaarden
Summary: A study developed an operator radiation dose prediction model and translated it into an instant operator risk chart. Results showed that the operator's radiation risk may disproportionately increase compared to the patient's when there are changes in C-arm angulation and vascular access site. An instant risk chart could improve operator radiation dose awareness during EVAR procedures.
JOURNAL OF ENDOVASCULAR THERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Pieter A. J. van Bakel, Matthew Henry, Karen M. Kim, Bo Yang, Joost A. van Herwaarden, C. Alberto Figueroa, Himanshu J. Patel, David M. Williams, Nicholas S. Burris
Summary: This study investigated the association between renal enhancement and renal malperfusion in patients with aortic dissection. The findings suggest that differential enhancement of the kidney on computed tomography angiography can predict the presence of renal malperfusion. However, the diagnosis of renal malperfusion requires close monitoring and often invasive assessment.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Tim J. Mandigers, Joost A. Van Herwaarden, Gabriele Piffaretti, Santi Trimarchi
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Review
Surgery
Tim J. Mandigers, Daniele Bissacco, Maurizio Domanin, Ilenia D'Alessio, Valerio S. Tolva, Gabriele Piffaretti, Joost A. van Herwaarden, Santi Trimarchi
Summary: This systematic review investigates the cardiovascular modifications after thoracic endovascular aortic repair (TEVAR) in patients with blunt thoracic aortic injury (BTAI). The results highlight adverse cardiac and aortic modifications after TEVAR, emphasizing the need for lifelong surveillance and the development of more compliant endografts to prevent long-term cardiovascular complications.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Surgery
Anna J. Alberga, Jorg L. de Bruin, Frederico Bastos Goncalves, Eleonora G. Karthaus, Janneke A. Wilschut, Joost A. van Herwaarden, Jan J. Wever, Hence J. M. Verhagen
Summary: The purpose of this study was to evaluate the perioperative outcomes of octogenarians undergoing repair for ruptured abdominal aortic aneurysm (rAAA) and identify factors associated with mortality and major complications. The results showed that octogenarians had higher perioperative mortality and major complication rates following rAAA repair, but a proportion of patients had an uneventful recovery. Cardiac or pulmonary comorbidity and loss of consciousness were associated with worse outcomes in octogenarians.
JOURNAL OF ENDOVASCULAR THERAPY
(2023)
Review
Surgery
Daniele Bissacco, Tim J. Mandigers, Laura Savare, Maurizio Domanin, Mario D'Oria, Francesca Ieva, Joost A. Van Herwaarden, Kevin Mani, Anders Wanhainen, Santi Trimarchi
Summary: The objective of this study was to assess the reproducibility of different ultrasound methods for measuring the maximum anteroposterior abdominal aortic diameter. The results showed that the interobserver reproducibility of outer to outer (OTO) and inner to inner (ITI) methods was 2.5 times smaller, indicating better reproducibility, compared to the leading edge to leading edge (LELE) method. However, there were no statistically significant differences between the methods.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Surgery
Tim J. Mandigers, Anna Ramella, Daniele Bissacco, Maurizio Domanin, Joost A. van Herwaarden, Giulia Luraghi, Francesco Migliavacca, Santi Trimarchi
Summary: This study presents a numerical simulation methodology for thoracic endovascular aortic repair (TEVAR) and demonstrates its application in a case of an 82-year-old female patient. The simulation successfully predicted perioperative adverse events and postoperative technical results, highlighting the potential and reliability of this simulation method.
JOURNAL OF VASCULAR SURGERY CASES INNOVATIONS AND TECHNIQUES
(2023)
Article
Surgery
Maria Katsarou, Tim J. Mandigers, Marton Berczeli, M. Mujeeb Zubair, Viony M. Belvroy, Daniele Bissacco, Joost A. van Herwaarden, Santi Trimarchi, Jean Bismuth
Summary: This study aims to evaluate sex-specific morphometric differences in aortic disease and find insights into endovascular treatment of the ascending aorta and arch. The findings show that in women, increased body surface area is associated with larger aortic arch diameters, while diabetes is associated with smaller ascending aorta and arch diameters. In men, increased body surface area and age are linked to larger ascending aorta and arch diameters, while smoking and diabetes are associated with smaller diameters. Men have 7.4% larger aortic arch and ascending aorta diameters than women.
JOURNAL OF ENDOVASCULAR THERAPY
(2023)
Article
Medicine, General & Internal
Jurre Klaassen, Joost A. van Herwaarden, Martin Teraa, Constantijn E. V. B. Hazenberg
Summary: This article reports a successful case of endovascular recanalization of an occluded superficial femoral artery using Fiber Optic RealShape (FORS) technology, which shows good prospects for application without the use of fluoroscopy. The corkscrew shape formed during recanalization may improve hemodynamics and reduce the risk of in-stent restenosis.
MEDICINA-LITHUANIA
(2022)
Review
Cardiac & Cardiovascular Systems
Yunus Ahmed, Ignas B. Houben, C. Alberto Figueroa, Nicholas S. Burris, David M. Williams, Frans L. Moll, Himanshu J. Patel, Joost A. van Herwaarden
Summary: This study provides a comprehensive overview of catheter-based interventions in patients with acute type A aortic dissection, showing that endovascular repair is feasible with high technical success and acceptable short-term outcomes, despite higher rates of reintervention and endoleak. Further studies with longer follow-up and careful patient selection are needed before endovascular interventions can be widely introduced.
JOURNAL OF CARDIAC SURGERY
(2021)