Review
Cell & Tissue Engineering
Laura Lozano Navarro, Xueyi Chen, Lady Tatiana Girata Viviescas, Andrea K. Ardila-Roa, Maria L. Luna-Gonzalez, Claudia L. Sossa, Martha L. Arango-Rodriguez
Summary: Peripheral arterial disease affects hundreds of millions of people worldwide and can lead to limb amputation or death. Revascularization is crucial for preventing amputation, but a significant portion of patients are not suitable for traditional surgical treatment, resulting in higher amputation rates. Mesenchymal stem cells have emerged as a promising cell-based therapy for peripheral arterial disease due to their regenerative properties.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Monil Majmundar, Kunal N. Patel, Rajkumar Doshi, Harsh Mehta, Mohinder R. Vindhyal, Kirk A. Hance, Adam Ali, Kamal Gupta
Summary: This study demonstrates that the hospital frailty risk score can identify frailty and predict clinical outcomes in patients undergoing revascularization for critical limb-threatening ischemia.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Alessia Scatena, Pasquale Petruzzi, Filippo Maioli, Francesca Lucaroni, Cristina Ambrosone, Giorgio Ventoruzzo, Francesco Liistro, Danilo Tacconi, Marianna Di Filippi, Nico Attempati, Leonardo Palombi, Leonardo Ercolini, Leonardo Bolognese
Summary: The study showed that treatment with autologous PBMNC implants in NO-CLI patients with DFUs significantly reduced amputation rate, improved survival, and promoted wound healing. Autologous PBMNC injection may effectively prevent amputations in patients with DFUs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Matthew A. Popplewell, Lazaros Andronis, Huw O. B. Davies, Lewis Meecham, Lisa Kelly, Gareth Bate, Andrew W. Bradbury
Summary: Chronic limb-threatening ischemia (CLTI) is a global issue due to tobacco use and diabetes prevalence. The study compared the costs and effectiveness of primary infrapopliteal vein bypass surgery (BS), best endovascular treatment (BET), and major limb major amputation (MLLA) over a 12-month period, with BET being the most cost-effective option.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Waseem Wahood, Sue Duval, Edwin A. Takahashi, Eric A. Secemsky, Sanjay Misra
Summary: This study analyzes the disparities in the treatment of critical limb ischemia (CLI) among different races over a 14-year period. The findings indicate that non-White patients are more likely to receive invasive treatments, including major amputations and revascularization, compared with White patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Surgery
Chanean Ruangsetakit, Sanit Navikaputra, Kanin Pruekprasert, Tossapol Prapassaro, Nattawut Puangpunngam, Kiattisak Hongku, Suteekhanit Hahtapornsawan, Khamin Chinsakchai, Chumpol Wongwanit, Nuttawut Sermsathanasawadi
Summary: The aim of this study was to validate the Critical Limb Ischemia Frailty Index (CLIFI) as a predictor of 2-year amputation-free survival after infrapopliteal endovascular treatment for chronic limb-threatening ischemia (CLTI) in Thai patients. The results showed that the Geriatric Nutritional Risk Index (GNRI) was an independent risk factor for amputation within two years after revascularization, but the CLIFI did not significantly predict 2-year amputation in this patient population.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Cell Biology
Daniel Santillan-Cortez, Eduardo Vera-Gomez, Alejandro Hernandez-Patricio, Atzin Sua Ruiz-Hernandez, Juan Ariel Gutierrez-Buendia, Karen De la Vega-Moreno, Yasser Alberto Rizo-Garcia, Oscar Antonio Loman-Zuniga, Ignacio Escotto-Sanchez, Juan Miguel Rodriguez-Trejo, Mario Antonio Tellez-Gonzalez, Christian Gabriel Toledo-Lozano, Tania Ortega-Rosas, Silvia Garcia, Paul Mondragon-Teran, Juan Antonio Suarez-Cuenca
Summary: This study investigated the relationship between endothelial progenitor cells (EPCs) and outcomes in patients with critical limb ischemia (CLI) undergoing angioplasty. The results showed that EPCs were related to endothelial dysfunction, and a higher baseline number of CD45(+)CD34(+)KDR(+) subset, as well as an impaired reactivity of CD45(+)CD34(+)CD133(+)CD184(+) subset after angioplasty, were predictive for major limb amputation in CLI patients.
Article
Surgery
Eva Torbjornsson, Ann-Mari Fagerdahl, Lena Blomgren, Lennart Bostrom, Carin Ottosson, Jonas Malmstedt
Summary: The study revealed that patients with CLTI undergoing amputation with ischemic pain as an indication have a significantly higher risk of reamputation, while older age is associated with an increased risk of mortality.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Mahesh Anantha-Narayanan, Rajkumar P. Doshi, Krunalkumar Patel, Azfar Bilal Sheikh, Fiorella Llanos-Chea, Jinnette Dawn Abbott, Mehdi H. Shishehbor, Raul J. Guzman, William R. Hiatt, Sue Duval, Carlos Mena-Hurtado, Kim G. Smolderen
Summary: In recent years, there has been an increase in admissions for CLI patients, with a slight decrease in overall in-hospital mortality and major amputations, as well as a shorter length of stay, but an increase in admission costs. Endovascular interventions have increased while surgical interventions have decreased in frequency.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2021)
Article
Multidisciplinary Sciences
Farina Mohamad Yusoff, Masato Kajikawa, Takayuki Yamaji, Yuji Takaeko, Yu Hashimoto, Aya Mizobuchi, Yiming Han, Shinji Kishimoto, Tatsuya Maruhashi, Ayumu Nakashima, Yukihito Higashi
Summary: The study aimed at evaluating outcomes of CLI patients treated with LIPUS, showing a significant reduction in major amputations and deaths in the LIPUS group compared to historical controls.
Article
Peripheral Vascular Disease
Jeremy B. Provance, John A. Spertus, Philip G. Jones, Mark A. Hoffman, Matthew C. Bunte, Todd R. Vogel, Carlos Mena-Hurtado, Kim G. Smolderen
Summary: This study used an EHR database to investigate the 30-day major amputation rates following PVI in patients with CLI. The results showed that amputation rates varied across institutions, and patient-level factors and site characteristics accounted for most of the variation in these rates.
Review
Biochemistry & Molecular Biology
Lucia Beltran-Camacho, Marta Rojas-Torres, Ma Carmen Duran-Ruiz
Summary: Critical limb ischemia is the most severe form of peripheral arterial disease, commonly caused by atherosclerosis leading to progressive blockage of arterial vessels. For patients not suitable for surgical intervention, angiogenic cell therapy has emerged as a promising alternative, showing potential for enhancing revascularization by promoting vessel formation and blood flow recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Ayman Elbadawi, Islam Y. Elgendy, Devesh Rai, Dhruv Mahtta, Michael Megaly, Ashish Pershad, Ali Denktas, Emmanouil S. Brilakis, Douglas E. Drachman, Subhash Banerjee, Mehdi H. Shishehbor, Hani Jneid
Summary: This study evaluated the relationship between hospital eLER volume and outcomes after eLER for CLI. Results showed that annual eLER volume did not influence in-hospital mortality, but high eLER volume (>550 procedures) was associated with better rates of limb preservation after eLER for CLI.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Surgery
Jorge A. Miranda, Zachary Pallister, Sherene Sharath, Lucas Ferrer, Jayer Chung, Brian Lepow, Joseph L. Mills, Miguel Montero-Baker
Summary: This study reviewed the outcomes of venous arterialization (VA) in chronic limb-threatening ischemia (CLTI). The findings suggest that superficial and deep VA are feasible options for limb salvage in patients who cannot undergo conventional revascularization methods.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Surgery
Zane B. Perkins, Alexander J. Kersey, Joseph M. White, Alexis L. Lauria, Brandon W. Propper, Nigel R. M. Tai, Todd E. Rasmussen
Summary: The study found that successful limb salvage is closely related to the duration of ischemia, with a 10% reduction in the probability of successful limb salvage for every hour delay to revascularization. Military trauma systems should prioritize rapid hemorrhage control and early limb revascularization.
Article
Hematology
Maureen M. Okam, Elyse Mandell, Nathanael Hevelone, Rachel Wentz, Ainsley Ross, Gregory A. Abel
AMERICAN JOURNAL OF HEMATOLOGY
(2012)
Article
Surgery
Yue-Yung Hu, Megan L. Fix, Nathanael D. Hevelone, Stuart R. Lipsitz, Caprice C. Greenberg, Joel S. Weissman, Jo Shapiro
ARCHIVES OF SURGERY
(2012)
Article
Urology & Nephrology
Keith J. Kowalczyk, Toni K. Choueiri, Nathanael D. Hevelone, Quoc-Dien Trinh, Stuart R. Lipsitz, Paul L. Nguyen, John H. Lynch, Jim C. Hu
Letter
Cardiac & Cardiovascular Systems
Andres Schanzer, Roy Greenberg, Nathanael Hevelone, William Robinson, Mohammad Eslami, Robert Goldberg, Louis Messina
Article
Urology & Nephrology
Hua-yin Yu, Nathanael D. Hevelone, Stuart R. Lipsitz, Keith J. Kowalczyk, Paul L. Nguyen, Toni K. Choueiri, Adam S. Kibel, Jim C. Hu
Article
Urology & Nephrology
Mehrdad Alemozaffar, Antoine Duclos, Nathanael D. Hevelone, Stuart R. Lipsitz, Tudor Borza, Hua-Yin Yu, Keith J. Kowalczyk, Jim C. Hu
Article
Urology & Nephrology
Keith J. Kowalczyk, Mehrdad Alemozaffar, Nathanael D. Hevelone, William D. Ulmer, Blakely A. Plaster, Stuart R. Lipsitz, Hua-Yin Yu, Jim C. Hu
JOURNAL OF ENDOUROLOGY
(2012)
Article
Urology & Nephrology
Hua-yin Yu, Nathanael D. Hevelone, Stuart R. Lipsitz, Keith J. Kowalczyk, Jim C. Hu
JOURNAL OF UROLOGY
(2012)
Article
Urology & Nephrology
Hua-yin Yu, Nathanael D. Hevelone, Stuart R. Lipsitz, Keith J. Kowalczyk, Paul L. Nguyen, Jim C. Hu
JOURNAL OF UROLOGY
(2012)
Article
Urology & Nephrology
David F. Friedlander, Mehrdad Alemozaffar, Nathanael D. Hevelone, Stuart R. Lipsitz, Jim C. Hu
JOURNAL OF UROLOGY
(2012)
Article
Surgery
Christopher D. Owens, Ji Min Kim, Nathanael D. Hevelone, Warren J. Gasper, Michael Belkin, Mark A. Creager, Michael S. Conte
JOURNAL OF VASCULAR SURGERY
(2012)
Article
Surgery
Jessica P. Simons, Philip P. Goodney, Donald T. Baril, Brian W. Nolan, Nathanael D. Hevelone, Jack L. Cronenwett, Louis M. Messina, Andres Schanzer
JOURNAL OF VASCULAR SURGERY
(2013)
Article
Surgery
Antonia J. Henry, Nathanael D. Hevelone, Alexander T. Hawkins, Michael T. Watkins, Michael Belkin, Louis L. Nguyen
JOURNAL OF VASCULAR SURGERY
(2013)
Article
Urology & Nephrology
Keith J. Kowalczyk, Andy C. Huang, Nathanael D. Hevelone, Stuart R. Lipsitz, Hua-yin Yu, John H. Lynch, Jim C. Hu
WORLD JOURNAL OF UROLOGY
(2013)
Article
Urology & Nephrology
Hua-yin Yu, Nathanael D. Hevelone, Sunil Patel, Stuart R. Lipsitz, Jim C. Hu
ADVANCES IN UROLOGY
(2012)