Article
Surgery
Raju Ahluwalia, Nicola Maffulli, Jose L. Lazaro-Martinez, Klaus Kirketerp-Moller, Ines Reichert
Summary: Surgery plays a crucial role in offloading and preventing diabetic foot ulcers, and should not only be reserved for refractory cases but also extended to ulcer prevention and remission. Further comparative studies are needed to optimize surgical decision making and define the optimal time point for surgical off-loading to prevent tissue loss or re-ulceration.
SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND
(2021)
Review
Medicine, General & Internal
Aroa Tardaguila-Garcia, Irene Sanz-Corbalan, Josep M. Garcia-Alamino, Raju Ahluwalia, Luigi Uccioli, Jose Luis Lazaro-Martinez
Summary: This study conducted a systematic review and quality assessment on the management of diabetic foot osteomyelitis. It found that there is a lack of high-quality clinical trials in this field, making the management of this condition still challenging.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biology
Florin Bobirca, Catalin Gabriel Smarandache, Anca Bobirca, Cristina Alexandru, Dan Dumitrescu, Anca Pantea Stoian, Cristina Bica, Lacramioara Aurelia Brinduse, Anca Musetescu, Daniela-Elena Gheoca-Mutu, Sebastian Isac, Ioan Ancuta
Summary: This study describes the appropriate surgical intervention for complicated neuropathic diabetic foot and identifies risk factors associated with amputation and surgical outcomes.
Review
Medicine, General & Internal
David G. Armstrong, Tze-Woei Tan, Andrew J. M. Boulton, Sicco A. Bus
Summary: Approximately 18.6 million people worldwide are affected by diabetic foot ulcers each year, with 1.6 million people in the United States. These ulcers precede 80% of lower extremity amputations among people with diabetes and are associated with an increased risk of death.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Rebecca Voelker
Summary: This article describes diabetic foot ulcers and their evaluation and treatment.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Endocrinology & Metabolism
Suman Baral, Satyan Rajbhandari
Summary: Nepal, a developing country, is facing a major health challenge with a high prevalence of diabetes (8.5%) affecting around 2 million people. Limited resources pose barriers to providing affordable and convenient diabetes care or regular screening for complications. There is no reliable data on the incidence, prevalence, and complications of diabetic foot problems in Nepal.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Angel Ortiz-Zuniga, Jordi Samaniego, Betina Biagetti, Nicolas Allegue, Anna Gene, Andrea Sallent, Almudena Crespo, Jordi Serracanta, Carme Torrents, Daniela Issa, Danilo Rivas, Maria Teresa Veintemillas, Nuria Fernandez-Hidalgo, Rosa Busquets, Josep Royo, Cristina Hernandez
Summary: The aim of this study was to compare the incidence of lower-extremity amputations (LEA-DFD) before and after the establishment of a Diabetic Foot Multidisciplinary Unit. The results showed a significant reduction in the rate of amputations due to foot disease in patients with diabetes after the establishment of the unit.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Iulia Iovanca Dragoi, Florina Georgeta Popescu, Frank L. Bowling, Cosmina Ioana Bondor, Mihai Ionac
Summary: This study investigated the buying behaviors of removable off-loading devices for diabetic foot ulcers and their impact on treatment outcomes during the COVID-19 pandemic. The results showed that patients with high blood pressure, peripheral arterial disease, history of amputation, and ulcers on the left foot were more likely to buy removable cast walkers as off-loading devices. Patients from rural areas and male patients were less likely to purchase removable walkers. Additionally, high blood pressure had a negative influence on healing time.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Dermatology
Susana Velasco-Rodriguez-Rabadan, Aroa Tardaguila-Garcia, Irene Sanz-Corbalan, Marta Garcia-Madrid, Mateo Lopez-Moral, Jose Luis Lazaro-Martinez
Summary: This systematic review examined the effectiveness of off-loading in diabetic foot care. 14 papers with 822 patients were included, mostly conducted in European countries. The total contact cast was found to be the most effective off-loading method.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2023)
Article
Surgery
Yuta Terabe, Nobuhito Kaneko, Keisuke Nakabayashi, Akihiro Matsui, Hiroshi Ando
Summary: Foot deformity is a common cause of foot ulcers, which often recur due to this deformity. Treating foot ulcers with simultaneous surgical off-loading can reduce the risk of recurrence and improve patients' daily activities.
Review
Chemistry, Multidisciplinary
Fang Huang, Xiangyu Lu, Yan Yang, Yushan Yang, Yongyong Li, Le Kuai, Bin Li, Haiqing Dong, Jianlin Shi
Summary: Diabetic foot ulcers (DFU) are one of the most serious complications of diabetes, characterized by chronic, nonhealing wounds caused by diabetic neuropathy, vascular disease, and bacterial infection. Current clinical therapies for DFU are unsatisfactory, leading researchers to focus on advanced nanotechnology. The development of multifunctional nanosystems based on the microenvironment of DFU has shown positive effects in therapy, forming a novel concept of DFU nanomedicine.
Article
Medicine, General & Internal
Kor H. Hutting, Wouter B. aan de Stegge, Jaap J. van Netten, Wouter A. ten Cate, Luuk Smeets, Gijs M. J. M. Welten, Dick M. Scharn, Jean-Paul P. M. de Vries, Jeff G. van Baal
Summary: A retrospective cohort study evaluated the efficacy of surgical treatment with gentamicin-loaded CaS-HA biocomposite in patients with diabetic foot ulcers complicated by osteomyelitis, showing a success rate of 66% with treatment failures resulting in amputations in a subset of patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Analytical
M. G. Finco, Gozde Cay, Myeounggon Lee, Jason Garcia, Elia Salazar, Tze-Woei Tan, David G. Armstrong, Bijan Najafi
Summary: This study investigated the perspectives of diabetic foot ulcer patients using offloading walkers in order to understand how to promote adherence. The findings showed that users of the smart removable walker reported that learning how to use it was easy. People who identified as Hispanic or Latino were more likely to report liking and future use of the smart boot compared to those who did not. Non-fallers also reported that the design of the smart boot made them want to wear it longer and it was easy to take on and off.
Review
Chemistry, Multidisciplinary
Mayland Chang, Trung T. Nguyen
Summary: Diabetic foot ulcers (DFUs) are chronic wounds that affect 30% of diabetic patients, with dysregulation of the normal wound healing process. Infection in DFUs increases inflammation and delays wound healing. Selective inhibition of MMP-9 may be a promising strategy for treatment of DFUs.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Immunology
David H. Truong, Roger Bedimo, Matthew Malone, Dane K. Wukich, Orhan K. Oz, Amanda L. Killeen, Lawrence A. Lavery
Summary: The clinical outcomes of medical and surgical management for diabetic foot osteomyelitis (DFO) were evaluated. The average success rate was 68.2% for medical treatment and 85.7% for surgical and medical treatment. Further prospective studies are required to determine whether medical management can be successful without surgical intervention.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Orthopedics
Robert G. Frykberg, Nicholas J. Bevilacqua, Geoffrey Habershaw
JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
(2010)
