Review
Cardiac & Cardiovascular Systems
Jonathan Golledge, Shivshankar Thanigaimani, Janet T. Powell, Phil S. Tsao
Summary: Abdominal aortic aneurysm (AAA) causes a high number of deaths worldwide every year, but no drug therapy has been proven to effectively limit AAA growth in randomized controlled trials. Genome-wide association studies have identified potential drug targets, and treatments to reduce low-density lipoprotein cholesterol and smoking cessation are also being considered. However, previous placebo-controlled randomized trials have not shown convincing evidence of drug efficacy, mainly due to limitations such as small sample sizes and poor participant retention. Further large prospective studies on other targets are needed to address this issue.
EUROPEAN HEART JOURNAL
(2023)
Article
Surgery
Vy T. Ho, Kenneth Tran, Elizabeth L. George, Steven M. Asch, Jonathan H. Chen, Ronald L. Dalman, Jason T. Lee
Summary: Since 2005, the United States Preventative Services Task Force has recommended AAA ultrasound screening for 65-to 75-year-old male ever-smokers. Compliance rates in integrated health systems are higher than in the private sector.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Saray Varona, Lidia Puertas, Maria Galan, Mar Orriols, Laia Canes, Silvia Aguilo, Mercedes Camacho, Marc Sirvent, Vicente Andres, Jose Martinez-Gonzalez, Cristina Rodriguez
Summary: The upregulation of PDE4B is correlated with abdominal aortic aneurysm (AAA), and treatment with the PDE4 selective inhibitor rolipram can effectively inhibit AAA formation and progression, reducing vascular oxidative stress and inflammatory response.
Article
Medicine, General & Internal
Tan Li, Bo Jiang, Yijun Wu, Jun Yang, Chunyan Ma, Yuan Yuan
Summary: This study investigated the correlation of single nucleotide polymorphisms (SNPs) in pri-miR-1-3p and mature miR-1-3p expression with postoperative mortality of abdominal aortic aneurysm (AAA) patients. The results showed that the variant genotypes of rs2155975 and rs4591246 were associated with increased all-cause mortality. Furthermore, low serum miR-1-3p levels before surgery were independently related to the incidents of all-cause death. This study demonstrated the importance of rs2155975 and rs4591246 polymorphisms and baseline serum miR-1-3p levels as promising markers to predict mortality among AAA patients following surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Petroula Nana, Konstantinos Dakis, Alexandros Brodis, Konstantinos Spanos, George Kouvelos
Summary: A systematic review examined the correlation of abdominal aortic aneurysm expansion rates with serum circulating biomarkers, identifying specific biomarkers potentially useful for individualized surveillance of patients with increased AAA growth rates. Various biomarkers, including D-dimers, LDL-C, HDL-C, and genetic factors, were found to be significantly associated with AAA growth rates, suggesting a potential role for serum biomarkers in patient monitoring.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
John Anagnostakos, Brajesh K. Lal
Summary: Abdominal aortic aneurysms (AAA) are common in older adults and can lead to serious morbidity and mortality if not treated promptly. The causes include trauma, infection, and inflammatory disorders, with risk factors such as smoking, advanced age, dyslipidemia, hypertension, and coronary artery disease. The pathophysiology involves arterial insult leading to inflammation and weakening of the arterial wall, requiring monitoring of size and growth rate to prevent rupture. Management options include controlling risk factors, surgical intervention based on risk assessment, and post-operative monitoring for complications. Advancements in technology have improved the diagnosis and treatment of AAA in recent years.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Article
Surgery
Sydney L. Olson, Annalise M. Panthofer, William Blackwelder, Michael L. Terrin, John A. Curci, B. Timothy Baxter, Fred A. Weaver, Jon S. Matsumura
Summary: This study examines the predictors of abdominal aortic aneurysm (AAA) volume growth and finds that baseline volume, tortuosity, maximum transverse diameter (MTD), current tobacco use, angiotensin II receptor blocker use, and history of diabetes mellitus are predictive of volume growth over time.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Alexandra M. M. Filipkowski, Suman Kundu, Svetlana K. K. Eden, Charles W. W. Alcorn, Amy C. C. Justice, Kaku A. A. So-Armah, Hilary A. A. Tindle, Quinn S. S. Wells, Joshua A. A. Beckman, Matthew S. S. Freiberg, Aaron W. W. Aday
Summary: Compared with individuals without HIV infection, people with HIV do not have an increased risk of abdominal aortic aneurysm (AAA), but the risk of AAA is increased among HIV-infected individuals with low CD4+ T-cell counts or high HIV viral load.
Review
Cardiac & Cardiovascular Systems
Jinping Lin, Shuwei Chen, Yuanyuan Yao, Min Yan
Summary: Abdominal aortic aneurysms (AAAs) are characterized by localized dilation of the abdominal aorta and can lead to serious consequences. Aortic rupture is the main complication and causes a significant number of deaths worldwide. Despite progress in research, there is still a lack of established methods to slow down aneurysm dilation, emphasizing the need for further studies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Li Yin, Eric William Kent, Bowen Wang
Summary: Abdominal aortic aneurysm (AAA) is a common focal dilation of the aorta in the elderly population, which can lead to aneurysmal rupture with a mortality rate of around 80%. Despite increased screening efforts, there is currently no cure to halt the expansion of AAA, partly due to incomplete understanding of its pathogenesis. Animal models provide valuable insights into AAA pathophysiology, but no single experimental model fully captures the complexity of the disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Thermodynamics
E. Y. K. Ng, E. Y. L. Pang
Summary: This study employed coupled CFD and CHT simulations to investigate the impact of pulsatile blood flow through the infrarenal aorta on the temperature distribution of the midriff skin, finding a thermal elevation on the abdomen surface for AAA cases. Experiment validation showed similar thermal trends, suggesting potential for Infrared Thermography as a diagnostic tool for AAA.
INTERNATIONAL JOURNAL OF THERMAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Leander Gaarde Melin, Julie Husted Dall, Jes S. Lindholt, Lasse B. Steffensen, Hans Christian Beck, Sophie L. Elkrog, Pernille D. Clausen, Lars Melholt Rasmussen, Jane Stubbe
Summary: Supplementation of cycloastragenol can inhibit the progression of abdominal aortic aneurysm, possibly by reducing matrix metalloprotease-2 activity, preserving elastin, and reducing calcification.
Review
Cardiac & Cardiovascular Systems
Hecheng Wang, Zhenwu Zhong, Deying Jiang, Hao Zhang, Fanxing Yin, Panpan Guo, Junyu Chen, Xinyu Zhu, Kui You, Yanshuo Han, Kun Liu
Summary: This study investigated the levels of circulating inflammatory factors and the influence of SNP sites on AAA susceptibility. The results showed associations of CRP and IL-6 levels with AAA, while IL-10 and TNF-alpha levels were not correlated. Gene polymorphisms may serve as potential predictive biomarkers for AAA susceptibility, with further investigations needed for confirmation.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Jingyuan Li, Sicong Ma, Xiu Jia, Yingzhen Bu, Tienan Zhou, Lei Zhang, Miaohan Qiu, Xiaozeng Wang
Summary: This study aims to investigate the effect of rivaroxaban on the progression of abdominal aortic aneurysm (AAA) in patients with elevated hs-CRP. Sixty subjects are randomly assigned to the intervention arm (rivaroxaban) or the control arm (aspirin). The primary outcome is the level of serum hs-CRP at 6 months, and secondary outcomes include imaging examination, major adverse cardiovascular and cerebrovascular events, and other laboratory tests.
Article
Biochemistry & Molecular Biology
Juri Lieberg, Anders Wanhainen, Aigar Ottas, Mare Vahi, Mihkel Zilmer, Ursel Soomets, Martin Bjorck, Jaak Kals
Summary: The study found that levels of certain amino acids and phosphatidylcholines were significantly lower in abdominal aortic aneurysm (AAA) patients compared to controls. However, there were no significant differences in metabolites distinguishing between patients with slow or fast growth of the AAA.
Editorial Material
Medical Laboratory Technology
Ian S. Young
CLINICAL CHEMISTRY
(2018)
Article
Ophthalmology
Ravilla D. Ravindran, Periasamy Sundaresan, Tiruvengada Krishnan, Praveen Vashist, Giovanni Maraini, Vijayan Saravanan, Usha Chakravarthy, Liam Smeeth, Dorothea Nitsch, Ian S. Young, Astrid E. Fletcher
BRITISH JOURNAL OF OPHTHALMOLOGY
(2019)
Article
Nutrition & Dietetics
Claire Casey, Jayne Woodside, Ann McGinty, Ian S. Young, Jennifer McPeake, Usha Chakravarthy, Mati Rahu, Johan Seland, Gisele Soubrane, Laura Tomazzoli, Fotis Topouzis, Jesus Vioque, A. E. Fletcher
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2019)
Article
Endocrinology & Metabolism
P. K. Thaware, C. C. Patterson, I. S. Young, C. Casey, D. R. McCance
Article
Cell Biology
Giovanni Fiorito, Cathal McCrory, Oliver Robinson, Cristian Carmeli, Carolina Ochoa Rosales, Yan Zhang, Elena Colicino, Pierre-Antoine Dugue, Fanny Artaud, Gareth J. Mckay, Ayoung Jeong, Pashupati P. Mishra, Therese H. Nost, Vittorio Krogh, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Domenico Palli, Giuseppe Matullo, Simonetta Guarrera, Martina Gandini, Murielle Bochud, Emmanouil Dermitzakis, Taulant Muka, Joel Schwartz, Pantel S. Vokonas, Allan Just, Allison M. Hodge, Graham G. Giles, Melissa C. Southey, Mikko A. Hurme, Ian Young, Amy Jayne McKnight, Sonja Kunze, Melanie Waldenberger, Annette Peters, Lars Schwettmann, Eiliv Lund, Andrea Baccarelli, Roger L. Milne, Rose A. Kenny, Alexis Elbaz, Hermann Brenner, Frank Kee, Trudy Voortman, Nicole Probst-Hensch, Terho Lehtimaki, Paul Elliot, Silvia Stringhini, Paolo Vineis, Silvia Polidoro, Jan Alberts, Harri Alenius, Mauricio Avendano, Valeria Baltar, Mel Bartley, Henrique Barros, Michele Bellone, Eloise Berger, David Blane, Murielle Bochud, Giulia Candiani, Cristian Carmeli, Luca Carra, Raphaele Castagne, Marc Chadeau-Hyam, Sergio Cima, Francoise Clavel-Chapelon, Giuseppe Costa, Emilie Courtin, Cyrille Delpierre, Angelo D'Errico, Manolis, Dermitzakis, Pierre-Antoine Dugue, Marko Elovainio, Paul Elliott, Guy Fagherazzi, Giovanni Fiorito, Silvia Fraga, Martina Gandini, Valerie Gares, Pascale Gerbouin-Rerolle, Graham Giles, Marcel Goldberg, Dario Greco, Idris Guessous, Jose Haba-Rubio, Raphael Heinzer, Allison Hodge, Stephane Joost, Maryam Karimi, Michelle Kelly-Irving, Mika Kahonen, Piia Karisola, Leyla Khenissi, Mika Kivimaki, Vittorio Krogh, Jessica Laine, Thierry Lang, Audrey Laurent, Richard Layte, Benoit Lepage, Dori Lorsch, Frances MacGuire, Giles Machell, Johan Mackenbach, Michael Marmot, Carlos de Mestral, Cathal McCrory, Cynthia Miller, Roger Milne, Peter Muennig, Wilma Nusselder, Salvatore Panico, Dusan Petrovic, Lourdes, Pilapil, Silvia Polidoro, Martin Preisig, Laura Pulkki-Raback, Olli Raitakari, Ana Isabel Ribeiro, Fulvio Ricceri, Paolo Recalcati, Erica Reinhard, Oliver Robinson, Jose Rubio Valverde, Severine Saba, Carlotta Sacerdote, Frank Santegoets, Roberto Satolli, Terrence Simmons, Gianluca Severi, Martin J. Shipley, Silvia Stringhini, Adam Tabak, Vesa Terhi, Joannie Tieulent, Rosario Tumino, Salvatore Vaccarella, Federica Vigna-Taglianti, Paolo Vineis, Peter Vollenweider, Nicolas Vuilleumier, Marie Zins
Article
Nutrition & Dietetics
Karen Mullan, Lesley Hamill, Katy Doolan, Ian Young, Peter Smyth, Albert Flynn, Janette Walton, Andrew A. Meharg, Manus Carey, Claire McKernan, Marcia Bell, Neil Black, Una Graham, David McCance, Cathy McHugh, Paul McMullan, Siobhan McQuaid, Aonghus O'Loughlin, Antoinette Tuthill, Sarah C. Bath, Margaret Rayman, Jayne Woodside
EUROPEAN JOURNAL OF NUTRITION
(2020)
Article
Nutrition & Dietetics
Helen J. Wallace, Lauren Holmes, Cieran N. Ennis, Christopher R. Cardwell, Jayne V. Woodside, Ian S. Young, Patrick M. Bell, Steven J. Hunter, Michelle C. McKinley
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2019)
Article
Ophthalmology
Paul McCann, Ruth E. Hogg, David M. Wright, Bernadette McGuinness, Ian S. Young, Frank Kee, Augusto Azuara-Blanco
Article
Nutrition & Dietetics
Amy Wotherspoon, Sarah Elshahat, Nicholas McAlinden, Katrina Dean, Ian S. Young, Peter C. Sharpe, Stefan Blankenburg, Chris C. Patterson, Michelle C. McKinley, Alun Evans, Jayne Woodside
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
(2020)
Article
Water Resources
Natalia V. de Moraes, Manus Carey, Charlotte E. Neville, Sharon Cruise, Bernadette McGuinness, Frank Kee, Ian S. Young, Jayne V. Woodside, Andrew A. Meharg
EXPOSURE AND HEALTH
(2020)
Article
Ophthalmology
Paul McCann, Ruth Hogg, David M. Wright, Sara Pose-Bazarra, Usha Chakravarthy, Tunde Peto, Sharon Cruise, Bernardette McGuinness, Ian S. Young, Frank Kee, Augusto Azuara-Blanco
BRITISH JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Medical Laboratory Technology
Kelly-Ann Eastwood, Alyson J. Hunter, Christopher C. Patterson, David R. Mc Cance, Ian S. Young, Valerie A. Holmes
ANNALS OF CLINICAL BIOCHEMISTRY
(2020)
Article
Nutrition & Dietetics
Alyson J. Hill, C. C. Patterson, I. S. Young, V. A. Holmes, D. R. McCance
Summary: This study explored the relationships between carbohydrate intake, BMI, and glycaemic control in pregnant women with type 1 diabetes. The findings suggest that the average quantity of dietary carbohydrate influences HbA1c, while BMI has less impact. Additionally, differences were observed in fibre and glycaemic index in relation to glycaemic control.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Article
Ophthalmology
Nicola B. Quinn, David H. Steel, Usha Chakravarthy, Tunde Peto, Barbra Hamill, Alyson Muldrew, Katie Graham, David Elliott, Riona Hennessy, Sharon Cruise, Bernadette McGuinness, Ian S. Young, Frank Kee, Ruth E. Hogg
OPHTHALMOLOGY RETINA
(2020)
Article
Cardiac & Cardiovascular Systems
Gavin Robertson, Alan Fleming, Michelle Claire Williams, Emanuele Trucco, Nicola Quinn, Ruth Hogg, Gareth J. Mckay, Frank Kee, Ian Young, Enrico Pellegrini, David E. Newby, Edwin J. R. van Beek, Tunde Peto, Baljean Dhillon, Jano van Hemert, Thomas J. MacGillivray