Article
Biochemistry & Molecular Biology
Fan Yang, Matthew J. Smith, Alexander Griffiths, Alexander Morrell, Sarah J. Chapple, Richard C. M. Siow, Theodora Stewart, Wolfgang Maret, Giovanni E. Mann
Summary: Zinc has various beneficial effects on human coronary artery smooth muscle cells, including antioxidant, anti-inflammatory, and anti-proliferative actions. The supplementation of zinc increases the total intracellular zinc content and enhances the NRF2 signaling pathway, providing protection against oxidative stress. These effects are more pronounced under high oxygen tension compared to normal oxygen conditions.
Review
Plant Sciences
Jose Leon, Mari Cruz Castillo, Beatriz Gayubas
Summary: Plants are highly adaptable to changing adverse environmental conditions, particularly in response to oxygen levels which have significant impacts on growth and development. The transition from hypoxia to reoxygenation can lead to cell damage due to oxidative stress, and further research is needed to understand this process. Studying molecular events related to gene expression regulation during hypoxia and reoxygenation will be crucial for improving agricultural biotechnology in the context of global climate change.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Pharmacology & Pharmacy
Satomi Kagota, Kana Morikawa, Hirotake Ishida, Junko Chimoto, Kana Maruyama-Fumoto, Shizuo Yamada, Kazumasa Shinozuka
Summary: The study found that the direct vasodilatory effects of certain benzodiazepines and non-BDZ sedative-hypnotics can cause vasorelaxation to varying extents, potentially contributing to their adverse effects, and may partly explain the decreased blood pressure observed in individuals taking these medications.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Uihwan Kim, You Kyoung Shin, Jubin Park, Geun Hee Seol
Summary: This study demonstrates the vasorelaxant effects of Codonopsis lanceolata extract under high potassium conditions, particularly in the presence of endothelial dysfunction. The mechanism of action involves voltage-dependent calcium channels (VDCCs) rather than potassium channels.
Article
Physiology
Charles E. Norton, Rebecca L. Shaw, Ron Mittler, Steven S. Segal
Summary: This study found that endothelial cells (ECs) are more resistant to oxidative stress than smooth muscle cells (SMCs) in cerebral arteries. The endothelium protects SMCs by reducing calcium ion entry through TRPC3 channels. These findings provide insights into the cellular response to acute oxidative stress in the cerebral vascular supply.
Article
Neurosciences
Sri Meghana Yerrapragada, Harshal Sawant, Shuzhen Chen, Trevor Bihl, Jinju Wang, Ji Chen Bihl
Summary: In this study, it was demonstrated through cell experiments that EPCs-EXs carrying miR-210 can provide stronger protective effects against apoptosis, oxidative stress, and decreased viability in neurons during ischemic stroke. This indicates that loading miR-210 enhances the effects of EPC-EXs.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jae Min Cho, Seul-Ki Park, Oh Sung Kwon, D. Taylor La Salle, James Cerbie, Caitlin C. Fermoyle, David Morgan, Ashley Nelson, Amber Bledsoe, Leena P. Bharath, Megan Tandar, Satya P. Kunapuli, Russell S. Richardson, Pon Velayutham Anandh Babu, Sohom Mookherjee, Bellamkonda K. Kishore, Fei Wang, Tianxin Yang, Sihem Boudina, Joel D. Trinity, J. David Symons
Summary: This study explores the importance of endothelial cell autophagy in maintaining vascular homeostasis and its role in nitric oxide generation. The findings suggest that autophagy is necessary for glycolysis-dependent purinergic signaling to eNOS, and impaired autophagy leads to arterial dysfunction. The activation of P2Y(1)-Rs improves arterial function in cases of compromised autophagy.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Anne Virsolvy, Aurelie Fort, Lucie Erceau, Azzouz Charrabi, Maurice Hayot, Franck Aimond, Sylvain Richard
Summary: The study revealed the important role of Na-v channels in vasomotion of human arteries, with activation of these channels leading to rhythmic oscillatory contractile activity in the vasculature.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Pei Long, Yong Li, Qing Wen, Maohua Huang, Songtao Li, Yuning Lin, Xiaojun Huang, Minfeng Chen, Jie Ouyang, Yunlin Ao, Qi Qi, Haipeng Zhang, Wencai Ye, Guohua Cheng, Xiaoqi Zhang, Dongmei Zhang
Summary: The study shows that OTNA relaxes pulmonary arteries by antagonizing AhR, providing a potential therapeutic mechanism for PAH.
Article
Physiology
Josh T. Arnold, Stephen J. Bailey, Simon G. Hodder, Naoto Fujii, Alex B. Lloyd
Summary: The study found that hypoxia accelerated shivering onset time by increasing skin blood flow and core-cooling rate, while nitrate ingestion delayed shivering onset time by changing central thermoeffector thresholds independent of peripheral heat exchange. The data improve understanding of how hypoxia and nitric oxide modulate cold thermoregulation.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Anatomy & Morphology
Lin Zhu, Shaolei Chen, Xulei Dai
Summary: This study elucidated the role of CTRP9 in PIH and demonstrated its protective effects on HPVECs injuries mediated by H/R through the regulation of AMPK/Nrf2 signaling pathway, suggesting its potential as a therapy for PIH.
Article
Multidisciplinary Sciences
Fabian Vega-Tapia, Estefania Penaloza, Bernardo J. Krause
Summary: This study showed that the arterial-venous differences of primary endothelial cells from human umbilical artery and vein are preserved in vitro, with differences in nitric oxide- and hypoxia-related genes. The findings were supported by transcriptomic data analysis and functional enrichment analysis, confirming the maintenance of key vascular pathways post-transcriptionally regulated in vitro.
Article
Cardiac & Cardiovascular Systems
Christine Veith, Ipek Varturk-Ozcan, Magdalena Wujak, Stefan Hadzic, Cheng-Yu Wu, Fenja Knoepp, Simone Kraut, Aleksandar Petrovic, Marija Gredic, Oleg Pak, Monika Brosien, Marie Heimbrodt, Jochen Wilhelm, Friederike C. Weisel, Kathrin Malkmus, Katharina Schaefer, Henning Gall, Khodr Tello, Djuro Kosanovic, Akylbek Sydykov, Akpay Sarybaev, Andreas Guenther, Ralf P. Brandes, Werner Seeger, Friedrich Grimminger, Hossein A. Ghofrani, Ralph T. Schermuly, Grazyna Kwapiszewska, Natascha Sommer, Norbert Weissmann
Summary: This study provides evidence for the involvement of SPARC in the pathogenesis of human PH and chronic hypoxia-induced PH in mice, most likely by affecting vascular cell function.
Article
Surgery
Yinhua Zhao, Yanyu Shi, Huang Lin
Summary: The study showed that co-culture with ADSCs could reduce apoptosis and enhance proliferation of HDMECs, with hypoxic preconditioning of ADSCs having a more pronounced effect. This approach increased vascular endothelial growth factor levels, demonstrating the potential to reduce I/R injury associated with skin flap transplantation surgery.
JOURNAL OF SURGICAL RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Rebecca L. Shaw, Charles E. Norton, Steven S. Segal
Summary: Oxidative stress can lead to apoptosis of vascular cells, with smooth muscle cells (SMCs) showing greater susceptibility compared to endothelial cells (ECs). Further research is needed to validate these findings in intact resistance arteries.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Urology & Nephrology
Jeppe S. M. Olsen, Samuel Svendsen, Peder Berg, Vibeke S. Dam, Mads V. Sorensen, Vladimir V. Matchkov, Jens Leipziger, Ebbe Boedtkjer
Summary: The study demonstrates that the Na+/HCO3- cotransporter NBCn1 plays a crucial role in basolateral HCO3- uptake and NH4+ reabsorption in the renal thick ascending limbs, essential for the rapid recovery of arterial blood pH and [HCO3-] during metabolic acidosis.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Microbiology
Malene Risager Lykke, Naja Becher, Thor Haahr, Ebbe Boedtkjer, Jorgen Skov Jensen, Niels Uldbjerg
Summary: This study found a pronounced pH gradient within the female genital tract, and this gradient was not disrupted in women with an abnormal vaginal microbiota.
Article
Behavioral Sciences
Inyeong Choi, Kristian Beedholm, Vibeke S. Dam, Seong-Ho Bae, Donald J. Noble, Sandra M. Garraway, Christian Aalkjaer, Ebbe Boedtkjer
Summary: Deletion of the NBCn1 gene leads to reduced locomotor activity in mice by affecting their exploratory behaviors or emotionality. The deletion also causes hearing loss, but its effect on vision varies between different lines of knockout mice.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biology
Nicolai J. Toft, Trine Axelsen, Helene L. Pedersen, Marco Mele, Mark Burton, Eva Balling, Tonje Johansen, Mads Thomassen, Peer M. Christiansen, Ebbe Boedtkjer
Summary: Breast cancer heterogeneity in histology and molecular subtype influences metabolic and proliferative activity, leading to varied acid load on cancer cells. The study indicates that Na+,HCO3- cotransport and Na+/H+ exchange play crucial roles in breast cancer cells, with different breast cancer subtypes showing distinct acid-base regulation characteristics.
Letter
Cardiac & Cardiovascular Systems
Ebbe Boedtkjer, Christian Aalkjaer
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Oncology
Rasmus A. Sloth, Trine V. Axelsen, Maria Sofia Espejo, Nicolai J. Toft, Ninna C. S. Voss, Mark Burton, Mads Thomassen, Pernille Vahl, Ebbe Boedtkjer
Summary: By analyzing data from human cohorts and conducting experiments on transgenic mice, this study reveals that the expression of RPTP gamma decreases during breast carcinogenesis and is associated with poor prognosis. Knocking out RPTP gamma in mice promotes premalignant changes in breast tissue, accelerates primary breast cancer development, and shortens recurrence-free survival. Loss of RPTP gamma enhances cellular net acid extrusion and upregulates the expression of Na+/HCO3- cotransporter NBCn1 in breast tissue.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Mikkel B. Henningsen, Kezia McWhan, Vibeke S. Dam, Marco Mele, Katrine R. Hauerslev, Ninna C. S. Voss, Parag D. Dabir, Eva Balling, Helene L. Pedersen, Pernille Vahl, Tonje Johansen, Trine Tramm, Peer M. Christiansen, Ebbe Boedtkjer
Summary: Intracellular Ca2+ dynamics play a crucial role in shaping malignant behaviors of cancer cells, with amplified Ca2+ responses observed in breast cancer tissue but not colon cancer tissue.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Cell Biology
Christian Aalkjaer, Tobias Wang
Summary: Giraffes, as the tallest animals on Earth, face challenges posed by gravity. Their cardiovascular system needs to adapt and there are interesting questions regarding how they avoid edema in their legs, how their heart produces high blood pressure, how their kidneys tolerate the pressure, among others. Some answers to these questions are presented in this short review.
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
(2023)
Article
Cardiac & Cardiovascular Systems
Nigopan Gopalasingam, Kristian Hylleberg Christensen, Kristoffer Berg Hansen, Roni Nielsen, Mogens Johannsen, Lars Christian Gormsen, Ebbe Boedtkjer, Rikke Norregaard, Niels Moller, Henrik Wiggers
Summary: The increase in cardiac output during 3-hydroxybutyrate infusion was not affected by aspirin, and niacin had no hemodynamic effects. These findings indicate that HCA(2) receptor-mediated effects were not involved in the hemodynamic response to 3-OHB.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Roni Nielsen, Kristian Hylleberg Christensen, Nigopan Gopalasingam, Kristoffer Berg-Hansen, Jacob Seefeldt, Casper Homilius, Ebbe Boedtkjer, Mads Jonsson Andersen, Henrik Wiggers, Niels Moller, Hans Erik Botker, Soren Mellemkjaer
Summary: The study demonstrates that 3-hydroxybutyrate (3-OHB) infusion in patients with PAH or CTEPH can decrease pulmonary vascular resistance, improve cardiac output, and enhance right ventricular function. Experimental rat studies also support the relaxing effect of ketone bodies on pulmonary arteries.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Oncology
Soojung Lee, Nicolai J. Toft, Trine V. Axelsen, Maria Sofia Espejo, Tina M. Pedersen, Marco Mele, Helene L. Pedersen, Eva Balling, Tonje Johansen, Mark Burton, Mads Thomassen, Pernille Vahl, Peer Christiansen, Ebbe Boedtkjer
Summary: Carbonic anhydrases play a crucial role in cancer and stromal cell functions, impacting pH dynamics and immune infiltration. They elevate pH levels in breast carcinomas, enhance immune response, restrict tumor growth, and improve patient survival.
BREAST CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Salome Rognant, Samuel N. Baldwin, Harry A. T. Pritchard, Adam Greenstein, Kirstine Calloe, Christian Aalkjaer, Thomas A. Jepps
Summary: Prorenin enhances arterial contractility by inhibiting BKCa and increasing intracellular Ca2+ release, which is likely mediated through a local shift in pH upon activation of (P)RR and stimulation of V-ATPase.
Review
Oncology
Pawel Swietach, Ebbe Boedtkjer, Stine Falsig Pedersen
Summary: Changes in proton concentration and sensing play a crucial role in cancer progression by influencing protein activity and pH balance. The acidic microenvironment of tumors, caused by metabolic changes, affects various aspects of tumor biology and accelerates disease progression. Targeting acid-base disturbances in cancer presents potential therapeutic opportunities.
NATURE REVIEWS CANCER
(2023)
Article
Cardiac & Cardiovascular Systems
Casper Homilius, Jacob Marthinsen Seefeldt, Julie Sorensen Axelsen, Tina Myhre Pedersen, Trine Monberg Sorensen, Roni Nielsen, Henrik Wiggers, Jakob Hansen, Vladimir V. Matchkov, Hans Erik Botker, Ebbe Boedtkjer
Summary: The ketone body 3-hydroxybutyrate (3-OHB) directly acts on the heart to increase cardiac contractility and directly acts on blood vessels to lower systemic vascular resistance, leading to increased cardiac output and improved coronary perfusion. This finding strengthens the therapeutic rationale for 3-OHB in heart failure management.
BASIC RESEARCH IN CARDIOLOGY
(2023)
Article
Evolutionary Biology
Barbara Natterson-Horowitz, Basil M. Baccouche, Jennifer Mary, Tejas Shivkumar, Mads Frost Bertelsen, Christian Aalkjaer, Morten H. Smerup, Olujimi A. Ajijola, Joseph Hadaya, Tobias Wang
Summary: The physiological adaptations of other species may serve as a bioinspired roadmap for preventive and therapeutic strategies for human pathologies.
EVOLUTION MEDICINE AND PUBLIC HEALTH
(2021)