Article
Pharmacology & Pharmacy
Damian Nilsson, Russ Chess-Williams, Donna Sellers
Summary: Recent studies suggest that lower urinary tract dysfunction may be caused by changes in local blood flow. Phosphodiesterase-5 inhibitors can improve blood flow to the bladder, although the exact mechanisms are not fully understood. This study aimed to characterize the vascular supply to the bladder and determine the mechanisms of action of the phosphodiesterase-5 inhibitors tadalafil and sildenafil.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Food Science & Technology
Joseph Festa, Mariasole Da Boit, Aamir Hussain, Harprit Singh
Summary: Cardiovascular disease is the leading cause of global death, with endothelial dysfunction being a predictor for most CVD. Polyphenols from sources like wine and grape extracts can help prevent endothelial dysfunction, while anthocyanin flavonoids found in berries also improve vascular function.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Kevin O'Gallagher, Francesca Puledda, Owen O'Daly, Matthew Ryan, Luke Dancy, Philip J. Chowienczyk, Fernando Zelaya, Peter J. Goadsby, Ajay M. Shah
Summary: This study reveals the fundamental physiological role of nNOS in regulating cerebral blood flow and functional connectivity in the human hippocampus.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Laurent Kiger, Julia Keith, Abdullah Freiwan, Alfonso G. Fernandez, Heather Tillman, Brant E. Isakson, Mitchell J. Weiss, Christophe Lechauve
Summary: This study examines the expression and cellular localization of eNOS, CyB5a, and CyB5R3 in mouse arterial endothelial cells, showing that alpha-globin can be reduced by two independent redox systems, CyB5R3/CyB5a and eNOS. These findings provide new insights into the regulation of blood vessel contractility.
Review
Biochemistry & Molecular Biology
Han-Yan Zhu, Fen-Fang Hong, Shu-Long Yang
Summary: Vascular dementia is the second most common form of dementia worldwide, caused by cerebrovascular disease. Nitric oxide and nitric oxide synthase play vital roles in the pathogenesis of this disease, with different NOS subtypes having partitioned activities in the brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Laia Cros-Brunso, Laura Camacho-Rodriguez, Angel Martinez-Gonzalez, Pablo Llevenes, Mercedes Salaices, Ana Belen Garcia-Redondo, Javier Blanco-Rivero
Summary: The study indicated that hyperthyroidism alters the function of sympathetic and nitrergic components of mesenteric innervation, leading to a decrease in vascular resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Francesca Fagiani, Marieva Vlachou, Daniele Di Marino, Ilaria Canobbio, Alice Romagnoli, Marco Racchi, Stefano Govoni, Cristina Lanni
Summary: Pin1 functions as a key regulator of vascular homeostasis by modulating nitric oxide bioavailability and influencing various pathways involved in vascular diseases. Understanding the role of Pin1 in vascular endothelium could provide new insights for potential therapeutic strategies in vascular pathologies and neurodegenerative diseases.
Article
Gastroenterology & Hepatology
Yan-Rong Li, Yan Li, Yuan Jin, Mang Xu, Hong-Wei Fan, Qian Zhang, Guo-He Tan, Jing Chen, Yun-Qing Li
Summary: This study investigates the effects of nitric oxide (NO) on colonic motility in a rat model of ulcerative colitis (UC), and the role of the enteric nervous system (ENS) in UC-related colonic motility. The results suggest that changes in the expression of nitric oxide synthase (NOS) in nitrergic neurons can influence colonic motility, and intervention in NOS activity may prevent colonic motor dysfunction in UC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Engineering, Biomedical
Maheshika Somarathna, Patrick TJ. Hwang, Reid C. Millican, Grant C. Alexander, Tatyana Isayeva-Waldrop, Jennifer A. Sherwood, Brigitta C. Brott, Isabelle Falzon, Hannah Northrup, Yan-Ting Shiu, Chris J. Stubben, John Totenhagen, Ho-Wook Jun, Timmy Lee
Summary: The study found that nitric oxide plays an important regulatory role in AVF development, but there are currently no effective treatments to prevent AVF maturation failure. By using a self-assembled NO releasing nanomatrix gel, intimal hyperplasia formation can be inhibited, and vascular outward remodeling and hemodynamic adaptation can be improved, thereby enhancing AVF development. This research is crucial for providing long-term and durable vascular access for hemodialysis patients.
Article
Biochemistry & Molecular Biology
Krzysztof Milewski, Anna Maria Czarnecka, Jan Albrecht, Magdalena Zielinska
Summary: Acute liver failure leads to deregulated nitric oxide signaling in the brain, resulting in reduced NOS activity and cofactor BH4 content, as well as eNOS uncoupling. These changes are associated with increased reactive oxidative species and decreased cerebral cortical blood flow, indicating a potential causal relationship between eNOS dysfunction and neurologic complications of ALF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Francesca Leo, Tatsiana Suvorava, Sophia K. Heuser, Junjie Li, Anthea LoBue, Frederik Barbarino, Eugenia Piragine, Rebekka Schneckmann, Beate Hutzler, Miranda E. Good, Bernadette O. Fernandez, Lukas Vornholz, Stephen Rogers, Allan Doctor, Maria Grandoch, Johannes Stegbauer, Eddie Weitzberg, Martin Feelisch, Jon O. Lundberg, Brant E. Isakson, Malte Kelm, Miriam M. Cortese-Krott
Summary: This study demonstrates that eNOS in ECs and RBCs independently contribute to blood pressure homeostasis. EC eNOS KO mice exhibited significantly impaired aortic dilatory responses to acetylcholine, loss of flow-mediated dilation, and increased blood pressure. On the other hand, RBC eNOS KO mice showed no alterations in acetylcholine-mediated dilation or flow-mediated dilation but were hypertensive.
Article
Pathology
Siyuan Xu, Shaochan Liang, Ying Pei, Rui Wang, Yao Zhang, Yifei Xu, Bin Huang, Haiwen Li, Juanjuan Li, Bo Tan, Hongying Cao, Shaoju Guo
Summary: This study suggests that dysfunction of TRPV1 channels may contribute to the impaired gastric relaxation in diabetic gastroparesis (DGP) induced by high-fat diet.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Peripheral Vascular Disease
Kristen J. Bubb, Owen Tang, Carmine Gentile, Seyed M. Moosavi, Thomas Hansen, Chia-Chi Liu, Belinda A. Di Bartolo, Gemma A. Figtree
Summary: FXYD1 plays a crucial role in protecting eNOS from oxidative stress and contributes to cardiovascular health; FXYD1 regulates oxidative dysregulation within caveolae where it is colocalized; In addition to impacting eNOS function, FXYD1 is closely associated with hypertension and diabetic vascular oxidative stress.
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)