Article
Cardiac & Cardiovascular Systems
Zhi Zeng, Luoxing Xia, Shunyang Fan, Junmeng Zheng, Jinhong Qin, Xuejiao Fan, Yunfeng Liu, Jun Tao, Yingying Liu, Kang Li, Zhenwei Ling, Yun Bu, Kathleen A. Martin, John Hwa, Renjing Liu, Wai Ho Tang
Summary: The study demonstrates that circMAP3K5 acts as a regulator of neointimal hyperplasia by sequestering miR-22-3p to inhibit TET2 expression, and subsequently affecting vascular smooth muscle cell differentiation and proliferation. Targeting the circMAP3K5/miR-22-3p/TET2 axis may offer a potential therapeutic strategy for diseases associated with intimal hyperplasia, including restenosis and atherosclerosis.
Article
Biochemistry & Molecular Biology
Utsab Subedi, Shrivats Manikandan, Susmita Bhattarai, Papori Sharma, Sudha Sharma, Hong Sun, Sumitra Miriyala, Manikandan Panchatcharam
Summary: Neointimal hyperplasia is characterized by a loss of the contractile phenotype of vascular smooth muscle cells (VSMCs). Our study found that autotaxin (ATX) and lysophosphatidic acid (LPA) play a role in VSMC proliferation and migration during restenosis. Inhibition of the ATX-LPA axis could potentially be used as a therapeutic target to minimize VSMC phenotypic modulation and inflammation after vascular injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Ubashini Vijakumaran, Muhammad Dain Yazid, Ruszymah Bt Hj Idrus, Mohd Ramzisham Abdul Rahman, Nadiah Sulaiman
Summary: Hydroxytyrosol, a polyphenol of olive plant, shows antioxidant, anti-inflammatory, and anti-atherogenic properties by regulating molecular pathways to promote reendothelization and inhibit VSMCs migration, thereby inhibiting the development of intimal hyperplasia.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xu Li, Yong Ding, Min Zhou, Zhenyu Zhou, Tianchen Xie, Yonggang Wang, Zhenjie Liu, Yi Si, Zhenyu Shi
Summary: This study found that Tsp2 is involved in the pathogenesis of intimal hyperplasia (IH) by regulating the proliferation and migration of vascular smooth muscle cells. Inhibition of Tsp2 can mitigate the progression of IH, suggesting that it may serve as a therapeutic target for this disorder.
Article
Cardiac & Cardiovascular Systems
Allison C. Ostriker, Yi Xie, Raja Chakraborty, Ashley J. Sizer, Yalai Bai, Min Ding, Wen-Liang Song, Anita Huttner, John Hwa, Kathleen A. Martin
Summary: The study found that TET2 is suppressed in CAV and GA, likely mediated by IFN gamma. TET2 helps to protect VSMCs from apoptosis in the context of transplant vasculopathy or IFN gamma stimulation. Enhancing TET2 enzymatic activity with high-dose ascorbic acid reduces VSMC apoptosis and intimal thickening, suggesting that promoting TET2 activity in CAV may be an effective strategy for limiting CAV progression.
Article
Cardiac & Cardiovascular Systems
Mingliang Wang, Chenming Qiu, Quanrong Pan, Yongjian Yang, Dachun Yang, Xiongshan Sun
Summary: NR1D1 reduces vascular neointimal hyperplasia by suppressing proliferation and migration of VSMCs in an AKT/mTORC1-dependent manner.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Jong Min Choi, Seung Eun Baek, Ji On Kim, Eun Yeong Jeon, Eun Jeong Jang, Chi Dae Kim
Summary: In injured vasculatures, 5-LO-derived LTB4 plays a key role in MCP-1 expression in HMGB1-exposed VSMCs via BLTR1 signaling, suggesting the LTB4-BLTR1 signaling axis as a potential therapeutic target for vascular inflammation.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Diane Macabrey, Alban Longchamp, Michael R. MacArthur, Martine Lambelet, Severine Urfer, Sebastien Deglise, Florent Allagnat
Summary: Intimal hyperplasia (IH) is a major limitation in the long-term success of revascularization. This study investigated the use of sodium thiosulfate (STS) as a potential treatment to limit IH. The findings showed that STS inhibited IH in mice and human vein segments, as well as inhibited cell proliferation and promoted microtubule depolymerization. This suggests that STS acts as an H2S donor to limit vascular smooth muscle cell migration and proliferation.
Article
Pharmacology & Pharmacy
Tamara Melnik, Ksenia Kapitanova, Laurent Vinet, Marie-Luce Bochaton-Piallat, Olivier Jordan, Florence Delie
Summary: This study aimed to encapsulate a high payload of atorvastatin (ATV) to prevent intimal hyperplasia (IH) in vascular bypass grafts and evaluate its impact on synthetic smooth muscle cells (SMCs) involved in IH progression. Poly(lactic-co-glycolic acid) microparticles (MPs) were formulated with different drug loadings and tested for ATV release, sterilization, and effects on SMCs. The results showed sustained ATV release from 10% and 20% ATV-loaded MPs for 90 days. The ATV-loaded MPs reversed the synthetic phenotype of SMCs and attenuated their migratory and proliferative capacities.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Cell Biology
Ji-Ting Liu, Han Bao, Yang-Jing Fan, Zi-Tong Li, Qing-Ping Yao, Yue Han, Ming-Liang Zhang, Zong-Lai Jiang, Ying-Xin Qi
Summary: The study demonstrated that platelet-derived microvesicles (PMVs) released by activated platelets after endothelial injury promote VSMC dedifferentiation via the Src/Lamtor1/mTORC1 signaling pathway, suggesting Lamtor1 as a potential therapeutic target for intimal hyperplasia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Wei Liu, Mengxian Liu, Hui Xiong, Luoxing Xia, Qiuping Yang, Min Chen, Yao Cai, Sitao Li
Summary: The study demonstrates that bempedoic acid, an ATP citrate lyase (ACLY) inhibitor, reduces ACLY expression to restrain vascular smooth muscle cell (VSMC) proliferation and dedifferentiation. This inhibition is achieved by activating the AMPK/ACC signaling pathway. Bempedoic acid also attenuates neointima formation in wire-injured mouse femoral arteries. These findings suggest that bempedoic acid may serve as a potential therapeutic strategy for diseases associated with intimal hyperplasia.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Ju Han, Guangyan Xu, Qihao Dong, Guoxian Jing, Qiang Liu, Ju Liu
Summary: The study suggests that CIZ1 may be a novel repressor of neointimal lesion formation by inhibiting proliferation and migration of vascular smooth muscle cells, as shown by decreased p21 expression and MMP9 levels in CIZ1 knockdown cells.
Review
Physiology
Sebastien Deglise, Clemence Bechelli, Florent Allagnat
Summary: Arterial occlusive disease is the leading cause of death in Western countries. Core contemporary therapies suffer from high failure rates due to re-occlusive vascular wall adaptations and restenosis. Restenosis following vascular surgery is largely due to intimal hyperplasia.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xinlong Lian, Ming Lv, Bo Shi
Summary: MiR-144 is upregulated in carotid arteries with intimal hyperplasia and in dedifferentiated VSMCs stimulated by PDGF-BB. Knockdown of miR-144 decreases VSMC proliferation and migration, while increasing expression of differentiated SMC marker genes.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Pharmacology & Pharmacy
Ya Zhang, Peidong Yuan, Xiaoping Ma, Qiming Deng, Jiangang Gao, Jianmin Yang, Tianran Zhang, Cheng Zhang, Wencheng Zhang
Summary: This study found that LGL1 inhibits VSMC proliferation and migration by promoting proteasomal degradation of STAT3, thereby suppressing neointimal hyperplasia.
FRONTIERS IN PHARMACOLOGY
(2022)