Article
Chemistry, Multidisciplinary
Zipei Zhang, Xiyu Li, Wei Zhang, Daniel S. Kohane
Summary: This review highlights recent advances in drug delivery systems for treating ear disorders by accessing the ear through the tympanic membrane (TM). The methods discussed include non-invasive (on the surface of the TM) and invasive (in the middle ear, ideally on the round window [RW]). Major hurdles to otic drug delivery are identified, along with representative examples of drug delivery systems used to deliver drugs across the TM to the middle and inner ear (crossing the RW as well).
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Adam J. Plaunt, Tam L. Nguyen, Michel R. Corboz, Vladimir S. Malinin, David C. Cipolla
Summary: While inhalation route has been used for pharmacologic effect, it posed challenges for treating lung disease until sophisticated device and formulation technologies emerged. Now, there are several inhalation device technologies that efficiently deliver therapeutics to the lung and avoid excessive deposition elsewhere. Formulation technologies and drug chemistry modifications have also emerged to overcome degradation and clearance mechanisms, improve tolerability, or facilitate intracellular uptake.
Article
Pharmacology & Pharmacy
Jie Zhuang, Yiming Yu, Rui Lu
Summary: Due to abuse of antibiotics, antibiotic resistance has become a global health threat. Many existing antibiotics have lost their effectiveness against drug-resistant bacteria, and the discovery of new antibiotics is becoming increasingly difficult. It is necessary to develop new strategies to combat antibiotic resistance. Nano-drug delivery systems, particularly mesoporous silica nano-particles (MSNs), have been extensively investigated as carriers of antibiotics. MSNs improve the delivery of antibiotics by reducing size, modifying surface, and regulating shapes. Furthermore, MSNs hybridized with metal ions or nanoparticles enhance the antibacterial effect by controlling the release of metal ions or increasing active oxygen species. Metal-capped MSNs can also load antibiotics to exert a synergistic antibacterial effect. This paper reviews the current application of various nanomaterials as antibacterial agents, with a focus on MSNs and approaches for improving their antibacterial effect.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Flavia Castro, Claudia Martins, Maria Jose Silveira, Rui Pedro Moura, Catarina Leite Pereira, Bruno Sarmento
Summary: Erythrocyte-mimicking nanovehicles (EM-NVs) have been extensively studied as biomimetic coating on artificial nanocarriers due to their upgraded biocompatibility, biodegradability, non-immunogenicity, and long-term blood circulation. These EM-NVs have a wide range of applications in drug delivery, imaging, phototherapy, and other areas, showing great potential for therapeutic and diagnostic applications in various diseases.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Health Care Sciences & Services
Alessandro Passardi, Patrizia Serra, Caterina Donati, Federica Fiori, Sabrina Prati, Roberto Vespignani, Gabriele Taglioni, Patrizia Farfaneti Ghetti, Giovanni Martinelli, Oriana Nanni, Mattia Altini, Giovanni Luca Frassineti, Martina Vittoria Minguzzi
Summary: This study aimed to establish a collaboration between a cancer institute and community pharmacies to improve medication reconciliation and validate a new integrated IT platform. Findings revealed that patients used an average of 5.9 drugs at home, with the most elderly group using 12 or more, and 60% of patients used nonconventional products or critical foods, potentially leading to interactions with cancer treatments.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Review
Chemistry, Multidisciplinary
Mythili Ramachandran, Zhao Ma, Kai Lin, Cristabelle De Souza, Yuanpei Li
Summary: Nanomedicine-based drug delivery platforms offer a promising avenue for the future of cancer treatment. By addressing barriers and utilizing stimuli-responsive transformations, nanomaterials provide a potential solution for overcoming challenges in drug delivery for cancer therapeutics.
NANOSCALE ADVANCES
(2022)
Review
Biotechnology & Applied Microbiology
Saquib Waheed, Zhibin Li, Fangyingnan Zhang, Anna Chiarini, Ubaldo Armato, Jun Wu
Summary: The rapid development of nanomedicine and nanoparticle materials has the potential to revolutionize healthcare by improving the effectiveness, bioavailability, targeting, and safety of drugs. Nanoparticles have unique properties that make them ideal for medical applications, but they must overcome biological barriers to deliver drugs to specific locations. Biointerface engineering can help overcome these barriers and optimize drug delivery in a personalized manner.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Xinyi Lv, Leichen Wang, Anqing Mei, Yan Xu, Xiaohong Ruan, Wenjun Wang, Jinjun Shao, Dongliang Yang, Xiaochen Dong
Summary: Bacterial biofilm-related infectious diseases have a severe impact on human health. The low permeability and enrichment of therapeutic agents within the biofilm pose a challenge for treatment. This article summarizes the current progress in nanotechnology methods to improve the penetrability of therapeutic agents and discusses the challenges and future implementations of engineered delivery systems to manage biofilm infections.
Article
Instruments & Instrumentation
Shann S. Yu, Jeffrey A. Hubbell, Melody A. Swartz
Summary: Immunotherapies aim to treat diseases by modulating immune cell activity, but transport barriers may hinder delivery and retention at diseased sites. Overcoming these barriers by exploiting immunobiology to engineer molecular and cellular approaches is crucial. Integrating expertise from pathologists, clinicians, immunologists, biophysicists, immunoengineers and more is essential for impactful and practical solutions across various diseases.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Eva Ramsay, Tatu Lajunen, Madhushree Bhattacharya, Mika Reinisalo, Kirsi Rilla, Heidi Kidron, Tetsuya Terasaki, Arto Urtti
Summary: Retinal drug delivery is challenging due to anatomical and physiological barriers, resulting in limited bioavailability. Current methods like intravitreal injections have limitations for different types of drugs. Selective delivery technologies for retinal drug delivery are not well studied, but they hold promise for cell-specific drug delivery in the eyes.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Engineering, Biomedical
Mehdi Azizi, Rana Jahanban-Esfahlan, Hadi Samadian, Masoud Hamidi, Khaled Seidi, Alireza Dolatshahi-Pirouz, Amirhossein Ahmadieh Yazdi, Amin Shavandi, Sophie Laurent, Mahsa Be Omide Hagh, Nahid Kasaiyan, Helder A. Santos, Mohammad-Ali Shahbazi
Summary: In the past three decades, nanoscience has provided a unique solution for reducing the systemic toxicity and increasing therapeutic efficiency of chemotherapy drugs. However, the poor accumulation and pharmacokinetics of nanoparticles hinder their translation into clinical use. New findings suggest that the efficacy based on enhanced permeability and retention may be as low as 1%. This review focuses on the current barriers, available solutions, and strategies for efficient drug delivery using nanocarriers and the tumor environment.
MATERIALS TODAY BIO
(2023)
Review
Pharmacology & Pharmacy
Thomas C. Chen, Clovis O. da Fonseca, Daniel Levin, Axel H. Schoenthal
Summary: Perillyl alcohol (POH) is a naturally occurring monoterpenoid with versatile applications, particularly in drug development and delivery, with its potential in cancer therapy highlighted through research.
Article
Chemistry, Multidisciplinary
Ying Wang, Zhanzhan Zhang, Chunxiong Zheng, Xinzhi Zhao, Yadan Zheng, Qi Liu, Yang Liu, Linqi Shi
Summary: Multistage adaptive nanoparticles (MAN) with a core-shell structure made of responsive polymers can adapt to the biological microenvironment, achieve stability in blood circulation, accumulate in tumor tissues, release drugs effectively in cells, and suppress tumors with reduced systemic toxicity. MAN can load various hydrophobic drugs, providing a general strategy for targeted delivery of hydrophobic drugs to overcome multiple biological barriers and enhance chemotherapy efficacy.
Article
Oncology
Bryan A. Sisk, Annie B. Friedrich, Erica C. Kaye, Justin N. Baker, Jennifer W. Mack, James M. DuBois
Summary: The study identified six levels of communication barriers in pediatric oncology, ranging from individual to policy levels. Clinicians from different professions experience different manifestations of these barriers, providing insights for interventions to improve communication experiences for families in pediatric oncology.
Review
Engineering, Biomedical
Xiaoxuan Xu, Yao Wu, Xindi Qian, Yuqi Wang, Jiaoying Wang, Jie Li, Yaping Li, Zhiwen Zhang
Summary: By regulating the physiochemical properties of nanomedicines and remodeling the components and structure of the ECM, intratumor ECM barriers can be effectively overcome, leading to improved drug delivery and anticancer efficacy.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Hassan Albadawi, Izzet Altun, Jingjie Hu, Zefu Zhang, Anshuman Panda, Han-Jun Kim, Ali Khademhosseini, Rahmi Oklu
Summary: The bioengineered tantalum-loaded nanocomposite hydrogel for gel embolic material (Ta-GEM) can achieve instant hemostasis through clinical catheters, with high visibility and retrievability, unaffected by patient's coagulation state. In animal experiments, it demonstrates safe and durable characteristics, with potential to replace traditional coil embolization.
Article
Medicine, General & Internal
Sailendra Naidu, Sadeer Alzubaidi, Grace Knuttinen, Indravadan Patel, Andrew Fleck, John Sweeney, Bashar Aqel, Brandon Larsen, Matthew Buras, Michael Golafshar, Rahmi Oklu
Summary: The study examined the use of stents for hepatic artery stenosis after liver transplant, with drug-eluting stents showing improved patency rates compared to bare-metal stents, especially in arteries with diameters less than 4.5mm.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Jingjie Hu, Hassan Albadawi, Zefu Zhang, Marcela A. Salomao, Seyda Gunduz, Suliman Rehman, Luciana D'Amone, Joseph L. Mayer, Fiorenzo Omenetto, Rahmi Oklu
Summary: A novel silk-based embolic material (SEM) has been developed and optimized for embolization and therapeutic drug delivery. In vitro studies show sustained release of drugs from SEM over 28 days, while in vivo experiments demonstrate successful embolization and drug delivery in porcine arteries. SEM has the potential to be a next-generation embolic agent for treating vascular diseases, including tumors.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Zefu Zhang, Hassan Albadawi, Richard J. Fowl, Izzet Altun, Marcela A. Salomao, Jama Jahanyar, Brian W. Chong, Joseph L. Mayer, Rahmi Oklu
Summary: Saccular aneurysms are outpouchings from artery walls and have limitations with current treatment options. A nanoclay-based hydrogel, called STH, is developed and shows promising results in preclinical studies, effectively treating saccular aneurysms and potentially changing medical practice.
ADVANCED MATERIALS
(2022)
Article
Urology & Nephrology
John Fasolino, Rahmi Oklu, Jeanne Palmer, Musab S. Hommos
JOURNAL OF NEPHROLOGY
(2022)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Haluk B. Sayman, Fatih Gulsen, Sait Sager, Elife Akgun, Nami Yeyin, Seckin Bilgic, Kubra N. Toplutas, Feifei An, Fatih Beytur, Rahmi Oklu, Omer Aras
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Review
Medicine, General & Internal
Sadeer J. Alzubaidi, Harris Liou, Gia Saini, Nicole Segaran, J. Scott Kriegshauser, Sailendra G. Naidu, Indravadan J. Patel, Rahmi Oklu
Summary: Percutaneous image-guided lung ablation, including cryoablation, is considered a promising treatment option for lung tumors, with recent encouraging results in protocol optimization for cryoablation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Sailendra G. Naidu, Harish Narayanan, Gia Saini, Nicole Segaran, Sadeer J. Alzubaidi, Indravadan J. Patel, Rahmi Oklu
Summary: PAE is a novel treatment option for LUTS due to BPH, offering clinical efficacy comparable to TURP but with fewer complications and side effects, without the need for general anesthesia or hospitalization.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Gia Saini, Nicole Segaran, Joseph L. Mayer, Aman Saini, Hassan Albadawi, Rahmi Oklu
Summary: Regenerative medicine focuses on restoring and regenerating damaged tissue, with tissue engineering as an application seeking to create functional tissue components and organs using 3D printing technologies. The use of 3D bioprinting has advanced tissue engineering by creating specialized tissue models, which could improve upon conventional methods.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Kenneth S. Zurcher, Sasha O. Staack, E. Brooke Spencer, Addison Liska, Sadeer J. Alzubaidi, Indravadan J. Patel, Sailendra G. Naidu, Rahmi Oklu, Ryanne A. Dymek, Martha-Gracia Knuttinen
Summary: The pelvic venous system is complex and has various collateral pathways. Knowledge of these pathways is important for diagnosis and treatment of related diseases in the field of medical imaging and surgery.
Review
Radiology, Nuclear Medicine & Medical Imaging
Kenneth S. Zurcher, Mathew Smith, Sailendra G. Naidu, Gia Saini, Indravadan J. Patel, M. Grace Knuttinen, J. Scott Kriegshauser, Rahmi Oklu, Sadeer J. Alzubaidi
Summary: Transsplenic access (TSA) is an effective and safe method for accessing the portal system in patients with contraindications to traditional approaches. It has a high technical success rate and low rate of procedural complications.
Editorial Material
Chemistry, Multidisciplinary
Warren C. W. Chan, Natalie Artzi, Chunying Chen, Xiaodong Chen, Dean Ho, Tony Hu, Kazunori Kataoka, Luis M. Liz-Marzan, Rahmi Oklu, Wolfgang J. Parak
Article
Chemistry, Multidisciplinary
Zefu Zhang, Hassan Albadawi, Richard J. Fowl, Joseph L. Mayer, Brian W. Chong, Rahmi Oklu
Summary: It is shown that instant hemostasis can be achieved by filling the aneurysm sac with a novel biomaterial, rescuing catastrophic bleeding in large-animal models. The optimized gel embolic agent with catheter-injectable and X-ray visible versions outperforms the control groups. The combinatorial approach using gel embolic agent and flow diverter stent may change medical practice and save lives.
ADVANCED MATERIALS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lisa Rotellini-Coltvet, Alex Wallace, Gia Saini, Sailendra Naidu, Jefferey Scott Kriegshauser, Indravadan Patel, Grace Knuttinen, Sadeer Alzubaidi, Rahmi Oklu
Summary: The study aimed to demonstrate the safety and effectiveness of percutaneous transesophageal gastrostomy (PTEG) as a palliative option for patients with malignant bowel obstructions (MBOs). The study also provided a comprehensive review of PTEG indications, placement technique, and short- and long-term outcomes. The results showed that PTEG is an effective and safe option for improving clinical symptoms and enhancing the quality of life in patients with MBOs.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Review
Automation & Control Systems
Seyda Gunduz, Hassan Albadawi, Rahmi Oklu
Summary: Minimally invasive endovascular interventions are crucial in treating vascular diseases, but facing challenges when adopting an all-endovascular approach. Next-generation smart soft-body robots have the potential to replace existing clinical devices and set the future standards for minimally invasive endovascular therapies.
ADVANCED INTELLIGENT SYSTEMS
(2021)
