Article
Multidisciplinary Sciences
Samuel A. Hendley, Aarushi Bhargava, Christy K. Holland, Geoffrey D. Wool, Osman Ahmed, Jonathan D. Paul, Kenneth B. Bader
Summary: The study aimed to determine the influence of lytic dose on histotripsy-enhanced fibrinolysis. The results showed that the dose of rt-PA can be significantly reduced when combined with histotripsy while still promoting fibrinolysis.
Article
Immunology
Ki Joo Pahk, Jeongmin Heo, Chanmin Joung, Kisoo Pahk
Summary: Pressure-modulated shockwave histotripsy (PSH) is a promising HIFU technique that can mechanically fractionate solid tumors noninvasively. Experimental results showed that PSH can induce partial mechanical destruction in rat liver tissue, creating smaller lesions compared to the non-modulated approach. PSH also demonstrated the feasibility of inducing a highly localized tissue fractionation with a desired level of mechanical damage.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Acoustics
Thomas J. Matula, Yak-Nam Wang, Tatiana Khokhlova, Daniel F. Leotta, John Kucewicz, Andrew A. Brayman, Matthew Bruce, Adam D. Maxwell, Brian E. MacConaghy, Gilles Thomas, Valery P. Chernikov, Sergey Buravkov, Vera A. Khokhlova, Keith Richmond, Keith Chan, Wayne Monsky
Summary: Infected abscesses are collections of pus and bacteria surrounded by a wall, commonly occurring as a complication of surgery, trauma, systemic infections, and other diseases. Current treatment involves antibiotics and drainage, or surgical intervention. Focused ultrasound shows potential as a non-invasive treatment option for abscesses.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cemran Toydemir, Sarah Hall, Erhan Demirel, Dilsah Nur Elmaci, Deniz Gol, Eli Vlaisavljevich, Yasemin Yuksel Durmaz
Summary: This study focuses on the development and functionalization of nanocone clusters (NCCs) to enhance nanoparticle-mediated histotripsy (NMH) therapy. The bioconjugation potential of NCCs was demonstrated through the examples of targeting, PEGylation, and fluorescent labeling. The obtained bioconjugates successfully lowered the cavitation threshold pressure, showing promise for improved NMH as a targeted noninvasive ablation method.
Article
Multidisciplinary Sciences
Aarushi Bhargava, Samuel A. Hendley, Kenneth B. Bader
Summary: Deep vein thrombosis (DVT) is a global health concern, and catheter-directed thrombolytics (CDT) are commonly used for vessel recanalization. However, histotripsy, a focused ultrasound therapy, has shown promising synergy with thrombolytics in clot degradation. This report outlines a benchtop method to assess the efficacy of histotripsy-aided thrombolytic therapy for DVT treatment.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Surgery
Adeline Schwein, Louis Magnus, Judit Markovits, Ponraj Chinnadurai, Kyle Autry, Leslie Jenkins, Rebecca Barnes, Dragoslava P. Vekilov, Dipan Shah, Nabil Chakfe, Jean Bismuth
Summary: This study developed a large animal model of iliocaval deep venous thrombosis (DVT) for the development and evaluation of interventional management and existing imaging modalities. The researchers used an endovascular approach combined with thrombin infusion to successfully induce acute and subacute DVT.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Engineering, Biomedical
Ning Lu, Timothy L. Hall, Jonathan R. Sukovich, Sang Won Choi, John Snell, Nathan McDannold, Zhen Xu
Summary: This study improved the 2-step phase aberration correction method and developed a suitable correction workflow for clinical applications, showing better refocusing results in transcranial histotripsy therapy.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Oncology
Jessica Gannon, Khan Mohammad Imran, Alissa Hendricks-Wenger, Michael Edwards, Hannah Covell, Lauren Ruger, Neha Singh, Margaret Nagai-Singer, Benjamin Tintera, Kristin Eden, Mishal Mendiratta-Lala, Joan Vidal-Jove, David Luyimbazi, Martha Larson, Sherrie Clark-Deener, Sheryl Coutermarsh-Ott, Irving C. Allen, Eli Vlaisavljevich
Summary: This study investigates a novel noninvasive pancreas ablation method using histotripsy in a pig model. Results show that the method can generate bubble clouds in the pancreas with no serious complications. This study provides initial evidence for the efficacy and safety of histotripsy for noninvasive pancreas ablation.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2023)
Article
Engineering, Biomedical
Connor Edsall, Emerson Ham, Hal Holmes, Timothy L. Hall, Eli Vlaisavljevich
Summary: The study found that frequency has an impact on the behavior of histotripsy bubble clouds and ablation efficiency, with lower frequencies generating more effective tissue ablation. The size of the bubble cloud closely matched theoretical predictions, with bubble density increasing with frequency and individual bubble size decreasing at higher frequencies.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Acoustics
Ki Joo Pahk, Sunho Lee, Pierre Gelat, Matheus Oliveira de Andrade, Nader Saffari
Summary: Boiling histotripsy is a technique that utilizes high intensity short pulses at the HIFU focus to induce tissue fractionation, involving the formation of a boiling vapor bubble and cavitation clouds. Formation of a cavitation cloud in boiling histotripsy depends primarily on the size and location of the boiling bubble, as well as the sum of incident and scattered fields.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Bar Glickstein, Ramona Aronovich, Yi Feng, Tali Ilovitsh
Summary: Low pressure histotripsy has been developed to achieve precise and large-volume mechanical lesions in tissues with reduced pressure threshold. By integrating a rotating imaging transducer and a low frequency therapeutic transducer, the vaporization and detonation of nanodroplets are achieved, resulting in circular lesions.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Emily A. Knott, Katherine C. Longo, Eli Vlaisavljevich, Xaiofei Zhang, John F. Swietlik, Zhen Xu, Allison C. Rodgers, Annie M. Zlevor, Paul F. Laeseke, Timothy L. Hall, Fred T. Lee, Timothy J. Ziemlewicz
Summary: In this study, transcostal hepatic histotripsy ablation was found to be feasible and effective in creating human-scale ablations in a porcine model, with no severe injuries identified. Prolonged cooling time during treatment can help minimize body wall heating and enhance the safety of the procedure.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Mike Bismuth, Sharon Katz, Tamar Mano, Ramona Aronovich, Dov Hershkovitz, Agata A. Exner, Tali Ilovitsh
Summary: Scaling down the size of microbubble contrast agents to the nanometer level enables noninvasive cancer therapy, as nanobubbles can trigger potent mechanical effects in tumors under low frequency ultrasound. This approach provides a unique platform for safe, noninvasive, and low energy tumor mechanotherapy.
Article
Oncology
Ellen Yeats, Timothy L. Hall
Summary: This paper reviews and discusses the aberration effects in histotripsy and related therapeutic ultrasound techniques, with a focus on soft tissue-induced aberrations. Two groups of aberration correction methods, model-based and signal-based, are reviewed and their relative advantages and disadvantages are discussed. It is suggested that a combination of both methods can improve histotripsy treatments.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2023)
Article
Medicine, General & Internal
Tejal N. Amin, Hannah Cohen, Michael Wong, Sara-Louise Pointer, Naaila Aslam, Davor Jurkovic
Summary: Managing incidental uterine venous plexus thrombosis (UVPT) is challenging, often extrapolated from studies on symptomatic deep venous thrombosis (DVT). This study found that a high proportion of women with UVPT could be successfully managed without the need for anticoagulation, based on individualized clinical risk assessments.
Article
Cardiac & Cardiovascular Systems
Francesco Moroni, Hitinder S. Gurm, Zachary Gertz, Antonio Abbate, Lorenzo Azzalini
Summary: The mortality rate associated with percutaneous coronary intervention (PCI) has declined over the past decade, but the causes and circumstances of death in contemporary practice are still poorly described. This study found that death after PCI is most often related to pre-existing acute cardiovascular conditions, such as acute coronary syndrome and cardiogenic shock, with procedural complications accounting for a minority of cases. Future efforts should focus on treating acute cardiovascular conditions, particularly cardiogenic shock, to reduce acute mortality after PCI.
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Stephanie M. Spehar, Milan Seth, Peter Henke, Khaldoon Alaswad, Theodore Schreiber, Aaron Berman, John Syrjamaki, Omar E. Ali, Yousef Bader, David Nerenz, Hitinder Gurm, Devraj Sukul
Summary: The study found that Black patients had a higher risk of 90-day readmission and cumulative mortality following PCI compared with White patients. Associations were mediated by dual eligibility, community economic well-being, and traditional cardiovascular risk factors.
AMERICAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Devraj Sukul, Hitinder S. Gurm
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Hitinder S. Gurm, George Hanna
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Renu Virmani, Aloke V. Finn, Matthew Kutyna, Yu Sato, Karen Meess, Cody Smith, Robert S. Chisena, Hitinder S. Gurm, Jon C. George
Summary: This study aims to assess the feasibility and treatment effect of pulsatile intravascular lithotripsy (PIVL) on calcified lesions in a cadaveric model of peripheral artery disease. The results show that PIVL treatment was successful and resulted in new fractures and luminal expansion of the vessels. Therefore, PIVL could be a promising new approach for the treatment of vascular calcification.
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2023)
Article
Surgery
Chloe A. Powell, Jeremy Albright, Jacob Culver, Nicholas H. Osborne, Matthew A. Corriere, Devraj Sukul, Hitinder Gurm, Peter K. Henke
Summary: This study evaluates the impact of race and socioeconomic status on outcomes after lower extremity bypass surgery. Black patients and socioeconomically disadvantaged patients are more likely to present with severe CLTI, leading to increased risk of amputation and other complications after the surgery.
Article
Cardiac & Cardiovascular Systems
Brett. L. L. Wanamaker, Ahmad Shoaib, Milan Seth, Devraj Sukul, Mamas. A. A. Mamas, Hitinder. S. S. Gurm
Summary: This study compared data from PCI registries in the United States and the United Kingdom, and found significant differences between the two countries in terms of the prevalence of diabetes and other comorbidities, the proportion of primary PCI, adoption of transradial PCI, and trends in mechanical support utilization.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Engineering, Biomedical
Jessie Jingxuan Lyu, Yao Liu, Hitinder S. Gurm, Albert Shih, Yihao Zheng
Summary: A miniature grinding wheel was successfully fabricated for atherectomy to remove calcified plaques in coronary and peripheral arteries. The wheel was made by nickel-diamond electroplating on a thin, flexible hollow stainless steel drive shaft. Experimental validation showed that the wheel effectively removed the calcified plaque. This research could lead to a more effective and safer treatment device for lesions deep in coronary and peripheral arteries.
MEDICAL ENGINEERING & PHYSICS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Hitinder S. Gurm, David E. Hamilton
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Hitinder S. Gurm, Nabeel Hyder
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Ashwini Kerkar, Devraj Sukul, Milan Seth, Michael A. Lauer, M. Chadi Alraies, Elizabeth Jane Pielsticker, Gerald C. Koenig, Mamas A. Mamas, Hitinder S. Gurm
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Proceedings Paper
Engineering, Biomedical
Robert S. Chisena, Hitinder Gurm, Albert J. Shih
Summary: Micro-computed tomography (μCT) is a powerful tool for generating three-dimensional images of objects using penetrative X-rays. It is useful for imaging hardened biological tissues and studying the efficacy of cardiovascular devices for the treatment of intravascular calcium (IVC). This article presents a generalized approach that utilizes μCT for qualitative and quantitative analyses of the treatment effect of new devices on IVC tissue.
V CIRP CONFERENCE ON BIOMANUFACTURING
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Brett Wanamaker, Ahmad Shoaib, Milan Seth, Devraj Sukul, A. Mamas Mamas, Hitinder S. Gurm
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Stephanie Spehar, Devraj Sukul, Hitinder S. Gurm, Milan Seth
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Daniel Kobe, Milan Seth, David Hamilton, Manoj Sharma, Douglas J. Wunderly, David Alan Sutter, Ronald V. Miller, Thomas A. LaLonde, Hitinder S. Gurm, Devraj Sukul
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)