Article
Hematology
Zhao-Xuan Lu, Heng-Le Wei, Yadong Shi, Hao Huang, Haobo Su, Liang Chen
Summary: This study examines the safety and efficacy of endovascular treatments for pregnancy-related iliofemoral deep vein thrombosis (DVT). The results show that CDT combined with PMT or angioplasty/stenting is comparatively safe and effective, with better midterm outcomes.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2022)
Article
Medicine, General & Internal
Sang Hyun Jeon, Geon Ho Kwon, Man Soo Kim
Summary: The incidence of VTE after arthroscopic meniscus surgery is low, but can be life-threatening. Risk factors for VTE should be evaluated before and after surgery, and appropriate thromboprophylaxis should be provided when necessary.
Review
Surgery
Mohammed Ashrafi, Saad B. Ahmad, Stavros A. Antoniou, Taha Khan, George A. Antoniou
Summary: This study aims to investigate the outcomes of treatment strategies for proximal and iliofemoral DVT. The results suggest that USCDT may improve patency rates for proximal DVT. However, no treatment modality showed superiority in reducing PTS and the overall quality of available evidence is poor.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Surgery
Ali Baran Budak, Orhan Eren Gunertem, Kanat Ozisik, Serdar Gunaydin
Summary: This study analyzed the results of using PMCDT to treat acute iliofemoral deep vein thrombosis (IFDVT) and found that this treatment strategy is safe and effective, improving the quality of life for patients. During the follow-up period, there was a significant reduction in clot burden, leg pain, and swelling.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2022)
Article
Pediatrics
Eric J. Monroe, Michael A. Woods, David S. Shin, Joseph Reis III, John Swietlik, Aaron Eifler, Jason W. Pinchot, Jeffrey Forris Beecham Chick
Summary: This retrospective study aimed to analyze the technical success and outcomes of large-bore deep venous thrombectomy in adolescent patients. The results showed high rates of technical success and clinical success among patients with thrombus at different stages and locations.
PEDIATRIC RADIOLOGY
(2023)
Review
Hematology
Gregoire Longchamp, Sara Manzocchi-Besson, Alban Longchamp, Marc Righini, Helia Robert-Ebadi, Marc Blondon
Summary: The incidence of VTE in COVID-19 hospitalized patients is high, especially in ICU patients. Screening and absence of anticoagulation are associated with a higher VTE incidence.
THROMBOSIS JOURNAL
(2021)
Article
Obstetrics & Gynecology
Tal Paz, Allan Bloom, Batia Roth, Yosef Kalish, Amihai Rottenstreich, Uriel Elchalal, Nael Da'as, David Varon, Galia Spectre
Summary: The efficacy of pharmacomechanical catheter-directed thrombolysis (PCDT) in preventing post thrombotic syndrome (PTS) for pregnancy related deep vein thrombosis (DVT) seems promising based on an observational cross-sectional study comparing women who underwent PCDT with those who received anticoagulation only. Further larger studies are needed to confirm the benefits of PCDT in preventing PTS in this specific population.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Marios Sagris, Andreas Tzoumas, Damianos G. Kokkinidis, Grigorios Korosoglou, Michael Lichtenberg, Georgios Tzavellas
Summary: VTE is a common disease with a high annual incidence in the United States and Europe. The primary treatment for DVT is oral anticoagulation, but more invasive treatments can be used for severe symptoms. However, there is limited knowledge about the outcomes of invasive treatment for VTE.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Hematology
Ya-dong Zhou, Ying-ying Chen, Ming Xue, Xue-xun Zheng, Xing-sheng Chen, Yun-biao Guan
Summary: This study compared the efficacy of direct stenting alone versus continued catheter-directed thrombolysis after stenting in treating acute left iliofemoral deep vein thrombosis, both showing effectiveness when clot removal degree reached grade III. Continued catheter-directed thrombolysis after stenting demonstrated better stent patency rates and lower 1-year post-thrombotic syndrome risk compared to direct stenting alone, although it may lead to increased hospitalization time and costs.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2021)
Review
Oncology
Guofu Hu, Jian Wang
Summary: This study reviewed the outcomes of percutaneous endovenous intervention (PEVI) versus anticoagulation in the treatment of acute lower extremity deep vein thrombosis (DVT). PEVI was found to be effective in reducing the incidence of post-thrombolytic syndrome (PTS), inhibiting moderate-to-severe PTS, decreasing pulmonary embolism (PE), and improving venous patency. However, it did not significantly reduce recurrent thromboembolism and had no marked increase in bleeding events.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Surgery
Karim M. Salem, Zein Saadeddin, Catherine Go, Othman A. Malak, Mohammad H. Eslami, Eric Hager, Georges Al-Khoury, Rabih A. Chaer, Efthymios D. Avgerinos
Summary: Pharmacomechanical thrombolysis (PMT) for acute deep vein thrombosis (DVT) may lead to acute kidney injury (AKI) and progress to chronic renal failure in some patients. Patients with bilateral extensive DVTs are at higher risk of AKI, suggesting longer priming with a thrombolytic drip before PMT should be considered.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2021)
Article
Peripheral Vascular Disease
Hakan Guven
Summary: SGVOP is a non-invasive method for acquiring hemodynamic data, which is more effective than other routine methods for the diagnosis and follow-up of venous diseases. This study compares the plethysmographic data of patients with acute deep-vein thrombosis who underwent pharmacomechanical thrombolysis, and the results show significant improvement in symptoms and quality of life with this treatment approach.
Article
Surgery
Mustafa Aldag, Ufuk Ciloglu
Summary: This study aimed to evaluate the characteristics and outcomes of combined percutaneous pharmacomechanical thrombectomy with selective catheter-directed thrombolysis for acute iliofemoral deep vein thrombosis. The results showed that this combined treatment is effective and safe, with a high freedom from re-thrombosis rate.
TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Surgery
Charlotte L. Bendon, Alexandra Crick
Summary: Delayed microsurgical reconstruction of lower extremity trauma is associated with increased risk of free flap loss, often due to venous anastomosis failure. Thrombocytosis has been blamed for this, but occult DVT may also be a contributing factor. Prevalence of DVT is high in severe lower limb injuries, potentially increasing the risk of free flap loss. Preoperative identification of occult DVT may influence the microsurgical plan and mitigate this risk.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2021)
Article
Surgery
Tim Fuller, Evan Neville, Jacob Shapiro, Audrey E. Muck, Mark Broering, Aaron Kulwicki, Brian Kuhn, Matthew Recht, Patrick Muck
Summary: This study evaluated the technical success of various endovascular therapies for the treatment of acute upper extremity deep venous thrombosis (DVT). The results showed that mechanical aspiration thrombectomy (AT) can achieve higher treatment rates and minimize the risk of bleeding complications.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2022)
Article
Pediatrics
Julie Jaffray, Brian Branchford, Neil Goldenberg, Jemily Malvar, Stacy E. Croteau, Michael Silvey, John H. Fargo, James D. Cooper, Nihal Bakeer, Richard Sposto, Lingyun Ji, Neil A. Zakai, E. Vincent S. Faustino, Amy Stillings, Emily Krava, Guy Young, Arash Mahajerin
Summary: This study aimed to identify clinical variables discernible on the day of hospital admission that can be used to assess risk for hospital-acquired venous thromboembolism (HA-VTE) in children. The results showed significant risk factors for HA-VTE include age <1 year and 10-22 years, cancer, congenital heart disease, recent hospitalization, immobility, high platelet count, central venous catheter, recent surgery, steroids, and mechanical ventilation. The risk assessment model developed in this study may help identify low-risk and high-risk groups of hospitalized children for further investigation of prophylactic strategies in future clinical trials.
JOURNAL OF PEDIATRICS
(2021)
Article
Oncology
Wyatt MacNevin, Kedar Padhye, Yasser Alkhalife, Victoria Price, Ron El-Hawary, Brian R. Branchford, Sarah Stevens, Ketan Kulkarni
Summary: This study demonstrates the successful implementation of a VTE thromboprophylaxis screening tool in pediatric orthopedic surgical patients, resulting in a significant reduction in the use of thromboprophylaxis without increasing VTE or bleeding complications.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Hematology
Peter Doan, Allaura Cox, Emily Rao, Brian Branchford
Summary: Recent studies have shown a link between superficial-vein thrombosis (SVT) and deep-vein thrombosis (DVT) in hospitalized children, with 33% of DVT patients also having SVT. This relationship is particularly evident in patients with central venous catheters.
THROMBOSIS RESEARCH
(2021)
Article
Hematology
Justyne E. Ross, Bing M. Zhang, Kristy Lee, Shruthi Mohan, Brian R. Branchford, Paul Bray, Stefanie N. Dugan, Kathleen Freson, Paula G. Heller, Walter H. A. Kahr, Michele P. Lambert, Lori Luchtman-Jones, Minjie Luo, Juliana Perez Botero, Matthew T. Rondina, Gabriella Ryan, Sarah Westbury, Wolfgang Bergmeier, Jorge Di Paola
Summary: Accurate interpretation of sequence variants is crucial for the diagnosis and management of inherited genetic disorders. ACMG/AMP guidelines have been adapted for GT by ClinGen PD-EP to increase specificity and consistency, reducing variants of unknown significance and improving overall concordance with expert assertions.
Article
Hematology
Christopher J. Ng, Nancy Spomer, Rick Shearer, Audra LeBlanc, Sharon Funk, Marilyn Manco-Johnson, Brian Branchford, Beth Warren, Tyler W. Buckner, Amy Cowell, Genevieve Moyer, Michael Wang, Elizabeth Gibson, Christine Mashburn
Summary: By establishing primary teams, we successfully improved coordination and communication with patients, as well as increased satisfaction and coordination and communication skills among clinical staff members.
ACTA HAEMATOLOGICA
(2021)
Article
Hematology
C. Heleen van Ommen, Manuela Albisetti, Mohir Bhatt, Marianne Bonduel, Brian Branchford, Elizabeth Chalmers, Anthony Chan, Neil A. Goldenberg, Susanne Holzhauer, Paul Monagle, Ulrike Nowak-Goettl, Shoshana Revel-Vilk, Gabriela Sciuccatie, Nongnuch Sirachainan, Christoph Male
Summary: Pediatric thromboembolism is a rare and heterogeneous disease, requiring international cooperation to fill knowledge gaps. The International Pediatric Thrombosis Network aims to initiate international prospective studies and establish a network of pediatric thrombosis centers.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Genetics & Heredity
Daniel P. Hart, Brian R. Branchford, Sarah Hendry, Robert Ledniczky, Robert F. Sidonio, Claude Negrier, Michelle Kim, Michelle Rice, Matthew Minshall, Claire Arce, Steve Prince, Maria Kelleher, Sharon Lee
Summary: The study highlighted the importance of using a consistent lexicon to describe hemophilia and its management within the hemophilia community. Expert linguistic analysis led to a consensus on vocabulary and an optimized narrative for discussing gene therapy among people affected by hemophilia A. While preferences were largely consistent across audiences and countries, some country-specific recommendations were made.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Critical Care Medicine
Julie Jaffray, Arash Mahajerin, Brian Branchford, Anh Thy H. Nguyen, E. Vincent S. Faustino, Michael Silvey, Stacy E. Croteau, John H. Fargo, James D. Cooper, Nihal Bakeer, Neil A. Zakai, Amy Stillings, Emily Krava, Ernest K. Amankwah, Guy Young, Neil A. Goldenberg
Summary: This study identified five independent risk factors for hospital-acquired venous thromboembolism in critically ill children and developed a risk assessment model. Prospective validation study is underway to investigate the efficacy and safety of prophylactic anticoagulation in high-risk children.
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Hematology
Stephanie Springborn, Sourav Ghosh, Marie L. Schulte, Carla Rothlin, Brian R. Branchford
Article
Hematology
Gary M. Woods, Leslie Raffini, Leonardo R. Brandao, Julie Jaffray, Brian R. Branchford, Christopher J. Ng, Sarah E. Sartain, Jennifer Pak, Christoph Male, Ayesha Zia, Mattia Rizzi, Nongnuch Sirachainan, Edward Vincent S. Faustino, Shannon L. Carpenter, Neil A. Goldenberg
Summary: Caring for children and adolescents with disorders of hemostasis and thrombosis (HAT) requires specialized skills that are not commonly obtained in pediatric hematology/oncology/bone marrow transplant fellowship training programs. The complexity of HAT management and the need for experienced providers and collaboration in the inpatient setting are increasing. While there is evidence supporting the benefits of inpatient hemostasis, thrombosis, and anticoagulation management services in adult hospitals, there is limited pediatric data. This article summarizes current practices in the inpatient management of HAT patients in pediatric institutions and provides a consensus opinion for the development of pediatric inpatient HAT services at tertiary care referral centers.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Meeting Abstract
Hematology
Adam Kidwell, Stephanie Springborn, Peter Newman, Jorge DiPaola, Deborah DeRyckere, Douglas K. Graham, Brian R. Branchford
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Hematology
Elizabeth T. Stephens, Anh Thy H. Nguyen, Julie Jaffray, Brian Branchford, Ernest K. Amankwah, Neil A. Goldenberg, E. Vincent S. Faustino, Neil A. Zakai, Amy Stillings, Emily Krava, Guy Young, John H. Fargo
Summary: In children undergoing noncardiac surgery, the placement of central venous catheters (CVCs), admission/transfer to the intensive care unit (ICU), or hospitalization in the month prior to surgery were positively associated with HA-VTE.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Christina M. Abrams, Julie Jaffray, Amy Stillings, Brian R. Branchford, Guy Young, Neil A. Goldenberg, Yasmina L. Abajas
Summary: Practices and risk assessment for preventing hospital-acquired venous thromboembolism (HA-VTE) in pediatric hospitals vary, highlighting the need for further research and consensus.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Beth Boulden Warren, Adrian Chan, Brian R. Branchford, Tyler W. Buckner, Genevieve Moyer, Elizabeth Gibson, Dianne Thornhill, Michael Wang, Christopher J. Ng
Summary: This study evaluated the early impact of Emicizumab on hemophilia patients through a retrospective chart review and structured phone interview. The results showed variations in prescribing practices and bleeding outcomes with no severe adverse reactions in real-world Emicizumab use at the center.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2021)
Meeting Abstract
Hematology
Julie Jaffray, Lisa Baumann Kreuziger, Brian Branchford, Arash Mahajerin, Choo Phei A. Wee, E. Vince S. Faustino, Zakai A. Neil, Stacy E. Croteau, Michael Silvey, John Fargo, James D. Cooper, Nihal Bakeer, Amy Stillings, Emily Krava, Guy Young, Neil A. Goldenberg