Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress

Prefrontal Cortical Circuit for Depression- and Anxiety-Related Behaviors Mediated by Cholecystokinin: Role of  FosB

(2014) V. Vialou et al.   JOURNAL OF NEUROSCIENCE

Reward processing by the lateral habenula in normal and depressive behaviors

(2014) Christophe D Proulx et al.   NATURE NEUROSCIENCE

5HT1B receptor-mediated pre-synaptic depression of excitatory inputs to the rat lateral habenula

(2014) Eun-Kyung Hwang et al.   NEUROPHARMACOLOGY

Prefrontal cortex reactivity underlies trait vulnerability to chronic social defeat stress

(2014) Sunil Kumar et al.   Nature Communications

DREADDs: novel tools for drug discovery and development

(2013) Hyeong-Min Lee et al.   DRUG DISCOVERY TODAY

A new translational target for deep brain stimulation to treat depression

(2013) Karl Kiening et al.   EMBO Molecular Medicine

Functionally altered neurocircuits in a rat model of treatment-resistant depression show prominent role of the habenula

(2013) Natalia Gass et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress

(2013) Benjamin D. Sachs et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Cortical-Amygdalar Circuit Dysfunction in a Genetic Mouse Model of Serotonin Deficiency

(2013) K. Dzirasa et al.   JOURNAL OF NEUROSCIENCE

Cortical Control of Affective Networks

(2013) S. Kumar et al.   JOURNAL OF NEUROSCIENCE

Congenital brain serotonin deficiency leads to reduced ethanol sensitivity and increased ethanol consumption in mice

(2013) Benjamin D. Sachs et al.   NEUROPHARMACOLOGY

Anxiolytic function of the orexin 2/hypocretin A receptor in the basolateral amygdala

(2013) David H. Arendt et al.   PSYCHONEUROENDOCRINOLOGY

Sex differences in response to chronic mild stress and congenital serotonin deficiency

(2013) Benjamin D. Sachs et al.   PSYCHONEUROENDOCRINOLOGY

 CaMKII in Lateral Habenula Mediates Core Symptoms of Depression

(2013) K. Li et al.   SCIENCE

The effects of congenital brain serotonin deficiency on responses to chronic fluoxetine

(2013) B D Sachs et al.   Translational Psychiatry

Chronic SSRI Treatment Exacerbates Serotonin Deficiency in Humanized Tph2 Mutant Mice

(2012) William B. Siesser et al.   ACS Chemical Neuroscience

DREADDing the lateral habenula: A review of methodological approaches for studying lateral habenula function

(2012) Sunila G. Nair et al.   BRAIN RESEARCH

Tryptophan hydroxylase 2 gene polymorphisms and poststroke anxiety disorders

(2012) Song Chi et al.   JOURNAL OF AFFECTIVE DISORDERS

Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance

(2012) Alice M Stamatakis et al.   NATURE NEUROSCIENCE

Input to the Lateral Habenula from the Basal Ganglia Is Excitatory, Aversive, and Suppressed by Serotonin

(2012) Steven J. Shabel et al.   NEURON

The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439His knockin mouse

(2012) J. P. R. Jacobsen et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A Novel Role of the WNT-Dishevelled-GSK3  Signaling Cascade in the Mouse Nucleus Accumbens in a Social Defeat Model of Depression

(2011) M. B. Wilkinson et al.   JOURNAL OF NEUROSCIENCE

Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice

(2011) J P R Jacobsen et al.   MOLECULAR PSYCHIATRY

Synaptic potentiation onto habenula neurons in the learned helplessness model of depression

(2011) Bo Li et al.   NATURE

A Role for Repressive Histone Methylation in Cocaine-Induced Vulnerability to Stress

(2011) Herbert E. Covington et al.   NEURON

Pharmacological inhibition of the lateral habenula improves depressive-like behavior in an animal model of treatment resistant depression

(2010) C. Winter et al.   BEHAVIOURAL BRAIN RESEARCH

The Effects of Tryptophan Depletion on Neural Responses to Emotional Words in Remitted Depression

(2009) Jonathan P. Roiser et al.   BIOLOGICAL PSYCHIATRY

Remission of Major Depression Under Deep Brain Stimulation of the Lateral Habenula in a Therapy-Refractory Patient

(2009) Alexander Sartorius et al.   BIOLOGICAL PSYCHIATRY

Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment

(2009) Mladen Vassilev Tzvetkov et al.   Pharmacogenetics and Genomics

Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response

(2009) Shih-Jen Tsai et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Representation of negative motivational value in the primate lateral habenula

(2008) Masayuki Matsumoto et al.   NATURE NEUROSCIENCE

Role of GSK3  in behavioral abnormalities induced by serotonin deficiency

(2008) J.-M. Beaulieu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA