Article
Genetics & Heredity
Tianbo Jin, Hongyan Lu, Zhanhao Zhang, Yuliang Wang, Wei Yang, Yuhe Wang, Xue He, Dongya Yuan, Yongjun He
Summary: Research has found that HAPE patients have abnormal DNA methylation at multiple CpG sites in the promoter regions of the CYP2S1 gene. Among these sites, the higher risk of hypermethylation was observed at CYP2S1_1_CPG_1.2.3, and the methylation level of CYP2S1 could effectively predict the risk of HAPE patients.
Article
Medicine, General & Internal
Jiahuan Xu, Lianggang Lv, Bo He, Guoqiang Wang, Bianbazhuoma, Delei Kong
Summary: A review of records from 429 patients with high altitude pulmonary edema (HAPE) found that 9.32% also had high altitude cerebral edema (HACE). White blood cell count, neutrophil count, lymphocytes, and hemoglobin concentrations in HAPE patients were significantly higher at admission compared to discharge. Patients with HAPE combined with HACE showed more severe damage in hepatocytes and the myocardium.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)
Article
Environmental Sciences
Ziquan Liu, Huanhuan Cui, Lei Zhao, Fucai Ma, Yanqing Liu, Yuansen Chen, Jiale Chen, Yaning Jia, Wenli Li, Jinxia Cai, Xun Bi, Penghui Li, Haojun Fan, Liqiong Guo, Shike Hou
Summary: In 2020, the monitored AQI in plateau-Tibet was between 24 and 98, averaging 48, with PM2.5 concentration ranging from 3.0 to 31 µg/m³ and averaging 10 µg/m³. The lower atmospheric pressure and oxygen concentration in plateau-Tibet can lead to high altitude pulmonary edema (HAPE) due to hypobaric hypoxia (HBH). This study found that exposure to HBH can cause alterations in platelet mtDNA methylation, potentially exacerbating HAPE through inflammatory responses.
AEROSOL AND AIR QUALITY RESEARCH
(2021)
Article
Evolutionary Biology
Peter Woods, Joe Alcock
Summary: High Altitude Pulmonary Edema (HAPE) is a potentially fatal disease of altitude characterized by fluid filling the lungs, which can be seen as a condition of a mismatch between current environment and evolutionary experience.
EVOLUTION MEDICINE AND PUBLIC HEALTH
(2021)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Infectious Diseases
Yumei Mi, Lisu Huang, Jieming Liu, Huamao Chao, Weilin Hu, Guodong Shan
Summary: From December 2022 to January 2023, seven children aged <= 14 years residing in an area without altitude change in the past month developed severe pulmonary lesions within 2-3 days after SARS-CoV-2 infection, diagnosed as high-altitude resident pulmonary edema. They completely recovered following treatment.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Toshihide Izumida, Teruhiko Imamura, Masakazu Hori, Masaki Nakagaito, Hiroshi Onoda, Shuhei Tanaka, Ryuichi Ushijima, Koichiro Kinugawa
Summary: This study compared the use of chest X-ray and ReDS for assessing pulmonary congestion. The results showed a correlation between ReDS values and the congestive score index (CSI) calculated from chest X-ray measurements. ReDS values were more accurate in stratifying the degree of congestion in patients with mild congestion, while both modalities were effective in assessing severe congestion.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pediatrics
Santiago Ucros, Camila Aparicio, Jose A. Castro-Rodriguez, Dunbar Ivy
Summary: This systematic review focuses on high altitude pulmonary edema (HAPE) occurring in children and adolescents. The study found that HAPE is most commonly seen in children between 6 and 10 years old, with a higher incidence in males and rare occurrence in children under 2 years old. HAPE can be classified into re-entry HAPE (R-HAPE) and classic HAPE (C-HAPE), with a higher prevalence of structural cardiac/pulmonary abnormalities in C-HAPE cases compared to R-HAPE cases.
PEDIATRIC PULMONOLOGY
(2023)
Article
Medicine, Research & Experimental
Yilan Wang, Zherui Shen, Caixia Pei, Sijing Zhao, Nan Jia, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang
Summary: Eleutheroside B alleviates HAPE-induced lung edema by inhibiting ferroptosis and necroptosis through Nrf2-antioxidant response signaling.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Liuyang Tian, Zhilong Jia, Yan Yan, Qian Jia, Wenjie Shi, Saijia Cui, Huining Chen, Yang Han, Xiaojing Zhao, Kunlun He
Summary: This study found that low-dose caffeine can alleviate high-altitude pulmonary edema (HAPE) by promoting PINK1/parkin-dependent mitophagy and mitochondrial fission to control mitochondrial quality. Therefore, caffeine could be a potential treatment for HAPE.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Zherui Shen, Demei Huang, Nan Jia, Sijing Zhao, Caixia Pei, Yilan Wang, Yongcan Wu, Xiaomin Wang, Shihua Shi, Fei Wang, Yacong He, Zhenxing Wang
Summary: This study found that Eleutheroside E (EE) has the potential to prevent High-altitude pulmonary edema (HAPE) by inhibiting the nuclear translocation of nuclear factor kappa-B (NF-kappa B), thus suppressing NLRP3 inflammasome-mediated pyroptosis and protecting the lungs from HAPE.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Zhaorui Zhang, Chengcheng Su, Jiguang Meng, Zhen Yang, Zhixin Liang, Yi Xu, Qiang Zhu, Dan Wang, Liang 'an Chen
Summary: Real-time assessment of high-altitude pulmonary edema (HAPE) remains a challenge. This study aimed to develop a new non-invasive method for analyzing microscopic images in a canine model of HAPE using probe-based confocal laser microscopy (pCLE). The results showed that pCLE may be a potential adjudicative bronchoscopic imaging technique for assessing HAPE, and volume air index (VAI) may be acquired from quantitative parameters in the analysis of images.
Article
Pharmacology & Pharmacy
Caixia Pei, Nan Jia, Yilan Wang, Sijing Zhao, Zherui Shen, Shihua Shi, Demei Huang, Yongcan Wu, Xiaomin Wang, Shuiqin Li, Yacong He, Zhenxing Wang
Summary: Notoginsenoside R1 can protect against hypobaric hypoxia-induced HAPE in rats by inhibiting inflammation, oxidative stress, and apoptosis, and may be a potential therapy for preventing HAPE.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Genetics & Heredity
Mingyue Chen, Faling Yi, Yijin Qi, Beibei Zhao, Zhanhao Zhang, Xue He, Dongya Yuan, Tianbo Jin
Summary: This study used whole-exome sequencing for the first time to directly screen genetic variations associated with high altitude pulmonary edema (HAPE). The study identified three potential genetic variations, rs368502694 (p. R1022Q) in NOS3, rs1595850639 (p. G61S) in MYBPC3, and rs1367895529 (p. R333H) in ITGAV, that are correlated with a high risk of HAPE.
Review
Biotechnology & Applied Microbiology
Raushni Choudhary, Swati Kumari, Manzoor Ali, Tashi Thinlas, Stanzen Rabyang, Aastha Mishra
Summary: The physiological changes at high altitude due to hypobaric hypoxia can increase susceptibility to high-altitude pulmonary edema (HAPE) in individuals with mild or asymptomatic infection. Respiratory tract infection (RTI) is an unfamiliar but significant risk factor for HAPE, as its symptoms resemble those of HAPE, and the imbalanced pathways contributing to vascular dysfunction in HAPE are also involved in the pathogenesis of RTI. Screening and identification of respiratory tract pathogens in HAPE patients can help determine their role in disease risk and severity, and provide insights into potential therapeutic options.
BRIEFINGS IN FUNCTIONAL GENOMICS
(2022)
Article
Hematology
Aastha Mishra, Mohammad Zahid Ashraf
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2020)
Editorial Material
Biochemistry & Molecular Biology
Sarvesh Chelvanambi, James M. Hester, Samantha Sharma, Tim Lahm, Andrea L. Frump
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Syed Mohammad, Aastha Mishra, Mohammad Zahid Ashraf
Review
Cell Biology
Shankar Chanchal, Aastha Mishra, Manvendra Kumar Singh, Mohammad Zahid Ashraf
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Physiology
Perwez Alam, Garima Agarwal, Rahul Kumar, Aastha Mishra, Neeru Saini, Ghulam Mohammad, M. A. Qadar Pasha
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2020)
Review
Genetics & Heredity
Samantha Sharma, Micheala A. Aldred
Letter
Hematology
Aastha Mishra, Mohammad Zahid Ashraf
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2021)
Article
Biochemistry & Molecular Biology
Kavita Sharma, Aastha Mishra, Himanshu N. Singh, Deepak Parashar, Perwez Alam, Tashi Thinlas, Ghulam Mohammad, Ritushree Kukreti, Mansoor Ali Syed, M. A. Qadar Pasha
Summary: This study investigated the role of two hypoxia-sensing genes in high-altitude adaptation and high-altitude pulmonary edema patients. Analysis of single nucleotide polymorphisms and gene expression differences revealed associations between genetic variations and diseases.
HUMAN MOLECULAR GENETICS
(2021)
Article
Biology
Kavita Sharma, Neha Chanana, Ghulam Mohammad, Tashi Thinlas, Mohit Gupta, Mansoor Ali Syed, Rajat Subhra Das, Qadar Pasha, Aastha Mishra
Summary: Elevated THBS1 levels in hypertensive patients in high-altitude area were significantly higher compared to those in sea-level area, showing a stronger positive correlation with mean arterial pressure. Genotype interactions associated with increased THBS1 levels in hypertension were observed, indicating a complex role of THBS1 in the presence of its family members and related receptor molecules at high altitude.
Review
Physiology
Khan Sadia, Mohammad Zahid Ashraf, Aastha Mishra
Summary: Hypoxia disrupts endothelial cell integrity, leading to an imbalance in coagulation proteins. Sirtuins play a crucial role in reducing ER stress and inflammation, offering a novel therapeutic approach for hypoxia-induced thrombosis.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Kavita Sharma, Aastha Mishra, Himanshu Singh, Tashi Thinlas, M. A. Qadar Pasha
Summary: This study found that the DNA methylation levels in the oxygen-sensing genes EGLN1 and HIF1AN were altered in individuals with high-altitude pulmonary edema (HAPE). Specific CpG sites in EGLN1 showed significant associations with the risk of HAPE. The methylation levels in EGLN1 correlated with plasma levels of PHD2 and peripheral blood oxygen saturation. These findings suggest a functional epigenetic relevance of EGLN1 in HAPE pathophysiology.
CLINICAL EPIGENETICS
(2022)
Review
Biotechnology & Applied Microbiology
Raushni Choudhary, Swati Kumari, Manzoor Ali, Tashi Thinlas, Stanzen Rabyang, Aastha Mishra
Summary: The physiological changes at high altitude due to hypobaric hypoxia can increase susceptibility to high-altitude pulmonary edema (HAPE) in individuals with mild or asymptomatic infection. Respiratory tract infection (RTI) is an unfamiliar but significant risk factor for HAPE, as its symptoms resemble those of HAPE, and the imbalanced pathways contributing to vascular dysfunction in HAPE are also involved in the pathogenesis of RTI. Screening and identification of respiratory tract pathogens in HAPE patients can help determine their role in disease risk and severity, and provide insights into potential therapeutic options.
BRIEFINGS IN FUNCTIONAL GENOMICS
(2022)
Article
Chemistry, Multidisciplinary
Zhuolong Zhou, Kevin Van der Jeught, Yujing Li, Samantha Sharma, Tao Yu, Ishara Moulana, Sheng Liu, Jun Wan, Paul R. Territo, Mateusz Opyrchal, Xinna Zhang, Guohui Wan, Xiongbin Lu
Summary: Pancreatic ductal adenocarcinoma (PDA) is a challenging disease with limited treatment options, especially for cases without defective mismatch DNA repair (dMMR). A high-throughput drug screen platform using T cell-incorporated pancreatic tumor organoid model has been established to accelerate drug discovery for this immunosuppressive cancer. The screen identified epigenetic inhibitors ITF2357 and I-BET151, which showed significantly improved anti-tumor effect when combined with anti-PD-1 therapy, transforming the tumor microenvironment from immunosuppressive to immunoactive.
Article
Biophysics
Kanika Singh, Swati Kumari, Manzoor Ali, Manoja Das, Aastha Mishra, Arun Singh
Summary: The Muzaffarpur district in Bihar, India has experienced recurrent outbreaks of acute encephalitis syndrome (AES) among young children during the peak-summer season. The exact cause of AES is unknown, but pesticide exposure, viral encephalitis, and litchi toxin intake have been suggested as potential sources. Recent findings indicate a correlation between higher environmental temperature and AES cases, suggesting that mitochondrial dysfunction during heat stress may be one of the contributing factors. Further studies are needed to substantiate this association.
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
(2023)
Meeting Abstract
Critical Care Medicine
S. Sharma, G. Mohammad, T. Thinlas, M. A. Q. Pasha
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)