Article
Food Science & Technology
Sarah Auguste, Bing Yan, Maolin Guo
Summary: Polyphenols found in tea can induce mitophagy in human fibroblast cells, and the induction of mitophagy may play an important role in the anti-aging mechanism of tea.
Review
Biochemistry & Molecular Biology
Tsz Kin Ng, Kai On Chu, Chi Chiu Wang, Chi Pui Pang
Summary: Glaucoma is the leading cause of irreversible blindness and visual impairment worldwide, with over 80 million affected individuals. The main pathogenesis of glaucoma involves oxidative stress and inflammation-induced neurodegeneration of retinal ganglion cells, which have limited regenerative capacity. Currently, there is a lack of clinically effective treatments to rescue the degeneration of retinal ganglion cells. Green tea catechins, with their proven antioxidant and anti-inflammatory properties, offer potential as a treatment to ameliorate retinal ganglion cell degeneration. This review summarizes the chemistry, pharmacokinetics, therapeutic properties, and clinical potentials of green tea catechins for glaucoma treatment.
Article
Biochemistry & Molecular Biology
Caroline Waingeh Nain, Gwennaelle Berdal, Phan Thi Phuong Thao, Eric Mignolet, Marine Buchet, Melissa Page, Yvan Larondelle
Summary: This study found that green tea extracts have the potential to enhance the oxidative stability of DHA-enriched oils, while delaying the degradation of antioxidants in the oil. In contrast, traditional alpha-tocopherol had limited effect on stabilizing DHA-rich oils.
Review
Endocrinology & Metabolism
Vahid Maleki, Ehsaneh Taheri, Parisa Varshosaz, Fatemeh Pourteymour Fard Tabrizi, Jalal Moludi, Hamed Jafari-Vayghan, Mahdi Shadnoush, Seyed Hossein Yahyazadeh Jabbari, Mehri Seifoleslami, Mohammad Alizadeh
Summary: Green tea extract (GTE) may have therapeutic effects on polycystic ovary syndrome (PCOS), mainly reflected in weight loss and improvement of glycemic levels. Current research results show that GTE can reduce testosterone and luteinizing hormone levels, and increase follicle-stimulating hormone and progesterone levels in animal models. Additional studies are needed to determine the effects and mechanisms of GTE in PCOS.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yirong Xia, Xintong Wang, Hechen Sun, Ximing Huang
Summary: The research demonstrates that the proton-coupled electron-transfer process of catechin in tea wine can reduce the energy barrier of the redox reaction and enhance antioxidative capacity. DFT calculations can be employed to validate this mechanism.
Article
Food Science & Technology
Mengxuan Xiao, Yingqi Chen, Fangling Zheng, Qi An, Mingji Xiao, Huiqiang Wang, Luqing Li, Qianying Dai
Summary: A simple and fast Surface-enhanced Raman spectroscopy (SERS) strategy was established to predict changes in green tea during storage. Raman spectra of green tea with different storage times were obtained using SERS with silver nanoparticles. The PCA-SVM model based on SERS accurately predicted the storage time of green tea, with a prediction accuracy of 97.22%. The Raman peak at 730 cm(-1) caused by myricetin was identified as a characteristic peak, which increased with prolonged storage time and exhibited a linear positive correlation with myricetin concentration. Therefore, SERS provides a convenient method for identifying the concentration of myricetin in green tea and predicting its storage time.
NPJ SCIENCE OF FOOD
(2023)
Review
Biochemistry & Molecular Biology
Anchalee Rawangkan, Kirati Kengkla, Sukrit Kanchanasurakit, Acharaporn Duangjai, Surasak Saokaew
Summary: The meta-analysis showed that green tea catechins (GTCs) have a significant effect in preventing influenza infection, especially in randomized controlled trials and cohort studies, with no evidence of heterogeneity. Further longitudinal clinical trials are needed to confirm these findings before implementation.
Article
Food Science & Technology
Arpan Singha Deo, P. J. Asheela Devi, K. S. Sijisha, R. Anusha, Tripti Mishra, Siby Mathew, K. Mathew Abraham, R. Jagadish, S. Priya
Summary: The study compared the antioxidant, anticancer, and anti-inflammatory activities of green tea, orthodox black tea, and CTC black tea. The results showed that green tea had higher antioxidant and anticancer activities and exhibited the best anti-inflammatory effects.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Article
Endocrinology & Metabolism
Kai On Chu, Kwok Ping Chan, Yolanda Wong Ying Yip, Wai Kit Chu, Chi Chiu Wang, Chi Pui Pang
Summary: The study showed that GTE indirectly induced systemic phosphorylcholine lipids to suppress inflammatory responses, hepatic damage, and respiratory mitochondrial stress in EIU rats induced by LPS. Phospholipids may be a therapeutic target of GTE for anterior chamber inflammation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kazuhiko Nakadate, Kiyoharu Kawakami, Noriko Yamazaki
Summary: Chronic obesity leads to various diseases, highlighting the urgency for treatment and prevention. This study investigated the combined effects of tea catechins and beta-cryptoxanthin from mandarin oranges on reducing obesity using obese mice induced by monosodium glutamate. The results showed that the mice consuming both tea catechins and beta-cryptoxanthin for 4 weeks experienced a significant decrease in body weight, with no difference compared to control mice. In addition, blood biochemical tests were normal, and histopathological analysis indicated a decrease in body fat percentage. Moreover, the abundance of pro-inflammatory M1 macrophages in adipose tissue was significantly reduced, while beneficial M2 macrophages increased and adiponectin levels, involved in suppressing metabolic syndrome, were elevated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Green & Sustainable Science & Technology
Sha Lou, Bingru Zhang, Dehua Zhang
Summary: The abuse of pesticides poses major threats to human health, leading to approximately 180,000 deaths worldwide annually. The intention of tea farmers to adopt pro-green control technology is influenced by subjective norms and perceived behavioral control, with attitude having no significant impact.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Engineering, Chemical
Ming Liu, Mei Lin, Pan Wu, Gary Owens, Zuliang Chen
Summary: A green tea extract was used as a natural reducing agent to prepare three different manganese oxides (Mn3O4, Mn2O3 and MnO) for degradation of estriol (E3). The catalytic ability of the manganese oxides varied, with Mn2O3 showing the highest E3 degradation efficiency. The morphology of the manganese oxides was primarily olive-shaped with a uniform distribution of elements.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Songul Cakmakci, Ilhami Gulcin, Engin Gundogdu, Hatice Ertem Oztekin, Parham Taslimi
Summary: Oxidation is a significant factor impacting the shelf life and quality of food. Plant-derived antioxidants, such as green tea powder, have been studied for their health benefits and use in food. This study compares the antioxidant effects of green tea powder with commercial antioxidants in butter and evaluates their impact on various properties.
Article
Materials Science, Composites
Xiaohui Guo, Yuanfang Luo, Lijuan Chen, Bowen Zhang, Yongjun Chen, Demin Jia
Summary: Achieving both environmental protection and high-efficiency rubber antioxidant remains a significant and long-term challenge in the green rubber industry. A novel biomass antioxidant (silica-s-TP) was synthesized by supporting green tea polyphenols on silica, exhibiting remarkable anti-aging functionality. The hybrid particles of silica-s-TP were uniformly dispersed in the rubber matrix, leading to enhanced anti-aging properties and surpassing the performance of commercial antioxidants. Interestingly, the silica-s-TP showed better free radical scavenging activities and stability in the rubber matrix compared to directly added polyphenols, thanks to the chemical anchor on silica surface. This clay surface treatment technology with natural antioxidants may open a new pathway for the preparation of green and eco-friendly rubber additives.
COMPOSITES SCIENCE AND TECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Keiko Unno, Yoriyuki Nakamura
Summary: Epidemiological studies have shown that green tea intake reduces the risk of dementia. EGCG, the most important component of green tea, has been found to be more effective than EGC in promoting neuronal differentiation. Meanwhile, the stress-reducing effects of theanine and arginine in green tea help suppress brain aging.
Article
Nutrition & Dietetics
Masaki Takahashi, Yui Mineshita, Jumpei Yamagami, Chunyi Wang, Kyoko Fujihira, Yu Tahara, Hyeon-Ki Kim, Takashi Nakaoka, Shigenobu Shibata
Summary: This study found that taking mulberry leaf extract in the evening can improve glucose tolerance. Additionally, taking mulberry leaf extract in the morning can reduce insulin concentrations. Therefore, the timing of mulberry leaf extract intake is crucial for improving blood sugar control.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Damoon Ashtary-Larky, Sara Niknam, Meysam Alipour, Reza Bagheri, Omid Asbaghi, Mehrnaz Mohammadian, Salvador J. Jaime, Julien S. Baker, Alexei Wong, Katsuhiko Suzuki, Reza Afrisham
Summary: This study aimed to evaluate the cardiometabolic abnormalities in women with normal-weight obesity (NWO) in comparison with lean, overweight, and obese women. Significant differences were observed in HDL concentrations between NWO, lean, and obese participants. Individuals with NWO had a significantly higher incidence of cardiometabolic abnormalities when compared to lean participants.
Article
Physiology
Noriaki Kawanishi, Takaki Tominaga, Katsuhiko Suzuki
Summary: This study found that resistance exercise, specifically electrical pulse stimulation-induced muscle contraction, resulted in changes in the miRNA and mRNA profiles of circulating extracellular vesicles. Muscle-specific miRNAs such as miR-1, miR-133, and miR-206 showed significant upregulation after 90 minutes of muscle contraction. Additionally, mRNA expression changes in circulating extracellular vesicles after muscle contraction were found to promote angiogenesis and regulate the immune response. These changes in extracellular vesicle properties may play a crucial role in resistance exercise-induced physiological adaptations.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Takaki Tominaga, Jiapeng Huang, Shuo Wang, Miwa Noguchi, Yishan Tong, Momoko Asano-Oritani, Katsuhiko Suzuki
Summary: Several food components, including polyphenols and phytonutrients, have immunomodulatory effects. Collagen, known for its various bioactivities, can promote wound healing and relieve symptoms of bone/joint disease. This study investigated the immunomodulatory effects of collagen-derived dipeptides and amino acids on macrophages and peripheral blood mononuclear cells (PBMC), and found that there is no difference in cytokine secretion between dipeptides and amino acids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shiori Wakasugi-Onogi, Sihui Ma, Ruheea Taskin Ruhee, Yishan Tong, Yasuhiro Seki, Katsuhiko Suzuki
Summary: This study found that sulforaphane has various effects on neutrophil functions, including inhibiting reactive oxygen species (ROS) production, degranulation, phagocytosis, and neutrophil extracellular trap (NET) formation. Sulforaphane also has direct antioxidant activity. It was observed that sulforaphane can decrease the release of inflammatory cytokines and myeloperoxidase from neutrophils. In addition, sulforaphane directly removes ROS, including hypochlorous acid (HOCl).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jung Lo, Hsin-En Wu, Ching-Chih Liu, Kun-Che Chang, Po-Yen Lee, Po-Len Liu, Shu-Pin Huang, Pei-Chang Wu, Tzu-Chieh Lin, Yu-Hung Lai, Yo-Chen Chang, Yuan-Ru Chen, Sheng- Lee, Yu-Kai Huang, Shu-Chi Wang, Chia-Yang Li
Summary: In this study, the researchers investigated the effect of nordalbergin, a compound derived from Dalbergia sissoo wood bark, on inflammation in microglial cells. They found that nordalbergin could suppress the production of inflammatory molecules and reduce oxidative stress through inhibiting specific signaling pathways. These findings suggest that nordalbergin has the potential to inhibit the progression of neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Michiko Hirata, Tsukasa Tominari, Ryota Ichimaru, Naruhiko Takiguchi, Yuki Tanaka, Masaru Takatoya, Daichi Arai, Shosei Yoshinouchi, Chisato Miyaura, Chiho Matsumoto, Sihui Ma, Katsuhiko Suzuki, Florian M. W. Grundler, Masaki Inada
Summary: In this study, the demethylated forms of citrus nobiletin and tangeretin, 4'-demethylnobiletin and 4'-demethyltangeretin, were found to inhibit osteoclast differentiation and function via the suppression of the NF-KB pathway. These compounds may have potential applications in maintaining bone health and preventing metabolic bone diseases such as osteoporosis.
Review
Medicine, General & Internal
Fatemeh Khodadadi, Reza Bagheri, Raoof Negaresh, Sajjad Moradi, Michael Nordvall, Donny M. Camera, Alexei Wong, Katsuhiko Suzuki
Summary: This systematic review and meta-analysis examined the effects of different types of high-intensity interval training (HIIT) on body composition changes. The results showed that HIIT, particularly cycling-based HIIT, led to reductions in fat mass and body fat percentage, as well as increased fat-free mass. These findings suggest that cycling-based HIIT may be the most effective for improving body composition.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Sport Sciences
Hyeon-Ki Kim, Zsolt Radak, Masaki Takahashi, Takayuki Inami, Shigenobu Shibata
Summary: Exercise is an effective strategy to prevent and improve obesity and metabolic diseases. It exerts metabolic effects through skeletal muscle adaptations as well as inter-organ signaling in the liver, adipose tissue, and pancreas. Additionally, circadian rhythms play a role in metabolic functions, such as glucose and lipid tolerance, which may be influenced by exercise timing.
SPORTS MEDICINE AND HEALTH SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Hiroaki Sako, Mohieldin Youssef, Olga Elisseeva, Takayuki Akimoto, Katsuhiko Suzuki, Takashi Ushida, Tadashi Yamamoto
Summary: Slower translation rates reduce protein misfolding by allowing time for proper folding. MicroRNAs (miRNAs), which are absent in prokaryotes, can stall translating ribosomes, preventing misfolding with little effect on protein abundance. This eukaryote-specific mechanism provides insights into co-translational protein folding and has potential in targeting protein misfolding diseases.
Article
Biochemistry & Molecular Biology
Erna Sulistyowati, Shang-En Huang, Tsung-Lin Cheng, Yu-Ying Chao, Chia-Yang Li, Ching-Wen Chang, Meng-Xuan Lin, Ming-Chung Lin, Jwu-Lai Yeh
Summary: Baicalein has the potential to prevent the development of abdominal aortic aneurysms by reducing inflammation, inhibiting aberrant vascular smooth muscle cell proliferation, and decreasing oxidative stress reactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Cong Wu, Katsuhiko Suzuki
Summary: Flavonoids may have a great potential to treat sarcopenia by improving skeletal muscle mass, muscle strength, and physical performance in older adults.
Article
Nutrition & Dietetics
Javad Nemati, Mohammad Hemmatinafar, Alireza Niknam, Mohammad Nikahd, Narjes Zeighami, Babak Imanian, Kousar Safari, Nima Jahaniboushehri, Katsuhiko Suzuki
Summary: The study aimed to evaluate the effects of acute caffeine supplementation on collegiate volleyball players' specific performance and skills. Results showed significant improvements in agility, Sargent's jump, attacking, and serving skills with higher doses of caffeine. However, there were no significant differences in hand movement speed, handgrip, and medicine ball throwing among the different supplementation conditions.
Article
Nutrition & Dietetics
Mohammad Hemmatinafar, Leila Zaremoayedi, Maryam Koushkie Jahromi, Stacey Alvarez-Alvarado, Alexei Wong, Alireza Niknam, Katsuhiko Suzuki, Babak Imanian, Reza Bagheri
Summary: This study aimed to evaluate the effects of beetroot juice (BRJ) on recovery and muscle soreness indicators in female volleyball players after exercise-induced muscle damage (EIMD). The results showed that BRJ supplementation improved muscle endurance performance and reduced muscle soreness and tissue edema after EIMD, compared to placebo.
Article
Medicine, General & Internal
Mahsa Naghashpour, Dian Dayer, Hadi Karami, Mahshid Naghashpour, Mahin Taheri Moghadam, Seyed Mohammad Jafar Haeri, Katsuhiko Suzuki
Summary: This study demonstrates that magnolol has a significant anti-tumor effect on MKN-45 cells and can be used to overcome cisplatin resistance in gastric cancer cells when combined with cisplatin.
MEDICINA-LITHUANIA
(2023)