Article
Urology & Nephrology
Amir Toussi, Matthew Ziegelmann, David Yang, Madeleine Manka, Igor Frank, Stephen A. Boorjian, Matthew Tollefson, Tobias Kohler, Landon Trost
Summary: The study investigates the effects of using a novel penile traction therapy device on erectile function and penile length post prostatectomy. Results demonstrate significant improvements in penile length, erectile function, intercourse satisfaction, and overall sexual satisfaction in the penile traction therapy group compared to controls.
JOURNAL OF UROLOGY
(2021)
Article
Andrology
Joo Yong Lee, Dae Chul Jung, Seungsoo Lee, Nam Gyu Kang, Young Taik Oh, Kyunghwa Han
Summary: Using SWE to quantitatively measure the Young's modulus of the corpus cavernosum may be an objective technique for assessing penile erectile rigidity and the vascular subtype in patients with ED.
WORLD JOURNAL OF MENS HEALTH
(2021)
Article
Urology & Nephrology
Reza Sari Motlagh, Mohammad Abufaraj, Lin Yang, Keiichiro Mori, Benjamin Pradere, Ekaterina Laukhtina, Hadi Mostafaei, Victor M. Schuettfort, Fahad Quhal, Francesco Montorsi, Mohsen Amjadi, Christian Gratzke, Shahrokh F. Shariat
Summary: This systematic review and network meta-analysis assessed the efficacy of different penile rehabilitation strategies post radical prostatectomy. The findings suggest that daily or nightly 100 mg sildenafil is the best strategy to improve erectile function recovery, while pelvic floor muscle training also shows effectiveness in increasing erectile function recovery rate.
JOURNAL OF UROLOGY
(2021)
Article
Andrology
Samuel Sorkhi, Christopher Cano Sanchez, Min Chul Cho, Sung Yong Cho, Hong Chung, Min Gu Park, Susan Lahey, Tung-Chin Hsieh, Valmik Bhargava, Mahadevan Raj Rajasekaran
Summary: The study aimed to investigate the effects of TPMS on penile microvascular perfusion (MVP), evaluate the impact of cavernosal nerve injury (CNI) on MVP, and determine the time-course of cavernosal tissue elastin changes after CNI in rats. The results showed that TPMS had beneficial effects on penile MVP after CNI, potentially improving erectile dysfunction and sexual function preservation.
WORLD JOURNAL OF MENS HEALTH
(2022)
Article
Clinical Neurology
Hanife Dogan, Hanife Abakay, Gozde Tekin, Hikmet Sacmaci, Merve Basol Goksuluk, Nuriye Ozengin
Summary: This study aimed to evaluate the psychometric properties of the Turkish version of MSISQ-15 in women with MS. The results showed that the Turkish MSISQ-15 has good reliability and validity, making it a comprehensive and reliable tool for assessing sexual dysfunction in Turkish women with MS.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Review
Nursing
Francesc Rogers, Amineh Rashidi, Beverley Ewens
Summary: Men with prostate cancer do not receive sufficient education and support to initiate penile rehabilitation post-prostatectomy. There is particularly a lack of knowledge regarding the needs of gay, bisexual, and single men. Nurses and nurse practitioners can contribute positively to meeting educational needs.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2022)
Article
Public, Environmental & Occupational Health
Prajwala Yogi, Shova Sapkota, Samir Shiwakoti, Udaya Man Singh Dongol, Prajwal Paudyal, Anup Karki
Summary: Penile fracture is a rare condition caused by vigorous sexual intercourse and masturbation. Patients usually experience pain and swelling of the penis and can be diagnosed clinically. Ultrasound is the most reliable investigation method. Prompt exploration and repair are necessary to prevent long-term sequelae.
JOURNAL OF NEPAL MEDICAL ASSOCIATION
(2022)
Review
Urology & Nephrology
Isabel Lake, Alisa O. Girard, Christopher D. Lopez, Damon S. Cooney, Arthur L. Burnett, Gerald Brandacher, Byoung Chol Oh, Richard J. Redett
Summary: Penile vascularized composite allotransplantation is an effective tool for penile reconstruction, but it carries its own ethical, surgical, and medical complications. Only 5 attempts have been made and unique surgical considerations are necessary.
JOURNAL OF UROLOGY
(2022)
Article
Andrology
Bac Nguyen Hoai, Quan Pham Minh, Thang Nguyen Cao, Andrea Sansone, Elena Colonnello, Emmanuele A. Jannini
Summary: The study investigated the penile dimensions of Vietnamese men, revealing different measurements and variations, especially among men with erectile dysfunction. Results showed differences in penile dimensions among different groups, with a correlation between circumcision and penis length.
Review
Urology & Nephrology
Paolo Verze, Ioannis Sokolakis, Celeste Manfredi, Claudia Colla Ruvolo, Georgios Hatzichristodoulou, Javier Romero-Otero
Summary: Penile prosthesis implantation (PPI) can be an effective treatment option for patients with Peyronie's disease (PD) and erectile dysfunction (ED), with excellent outcomes and minimal risk of side effects. Different surgical techniques for PPI can be tailored to individual patients based on the severity of penile curvature and other factors.
MINERVA UROLOGY AND NEPHROLOGY
(2021)
Article
Andrology
Chan Ming Tow, Jonathan Tang, Chan Ming Chun, Joe Lee King Chien
Summary: This article presents a rare case of penile schwannoma, in which the patient experienced painful nocturnal penile tumescence and had multiple nodules. Surgical excision confirmed the diagnosis of benign schwannoma. The authors propose a possible etiology and suggest further research to validate their hypothesis.
BASIC AND CLINICAL ANDROLOGY
(2022)
Article
Reproductive Biology
Daiki Hashimoto, Tsuyoshi Hirashima, Hisao Yamamura, Tomoya Kataoka, Kota Fujimoto, Taiju Hyuga, Atsushi Yoshiki, Kazunori Kimura, Shunsuke Kuroki, Makoto Tachibana, Kentaro Suzuki, Nobuhiko Yamamoto, Shin Morioka, Takehiko Sasaki, Gen Yamada
Summary: A novel murine corpus cavernosum (CC) explant culture system is established to analyze the penile erectile contraction/relaxation, providing valuable insights into the structural changes and physiological responses in the field of penile medicine.
BIOLOGY OF REPRODUCTION
(2021)
Review
Urology & Nephrology
Edoardo Agostini, Antonio Vinci, Dorian Bardhi, Fabio Ingravalle, Mario Muselli, Giulio Milanese
Summary: The purpose of this study was to define the typical clinical presentation of false penile fractures (FPF) and determine the diagnostic indicators for distinguishing them from true penile fractures (TPF), providing clinicians with more useful tools for decision-making.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Andrology
Gianmaria Salvio, Alessandro Ciarloni, Simone Cordoni, Melissa Cutini, Nicola Delli Muti, Federica Finocchi, Francesca Firmani, Lara Giovannini, Michele Perrone, Giancarlo Balercia
Summary: Hyperhomocysteinemia is highly prevalent in patients with erectile dysfunction, and it correlates with velocimetric parameters assessed by basal penile duplex ultrasound.
Article
Pediatrics
Marco Pensabene, Maria Sergio, Fabio Baldanza, Francesco Grasso, Gregorio Serra, Benedetto Spataro, Roberta Bonfiglio, Maria Patti, Valentina Maggiore, Chiara Cambiaso, Mario Giuffre, Giovanni Corsello, Marcello Cimador, Maria Rita Di Pace
Summary: Primary buried penis is caused by a penile ligaments anomaly and its ability to reach a normal length is unclear. We evaluated 49 patients post-operatively after one year and found that a normal penile length was observed in most pre-pubertal patients, but not in higher PH stages where micropenis was detected. It is suggested that primary buried penis should be considered as an incomplete manifestation of micropenis due to growth slowdown in late puberty.
Review
Urology & Nephrology
Ayad Yousif, Caleb Natale, Wayne J. G. Hellstrom
Summary: Conservative treatment options for Peyronie's disease include intralesional collagenase clostridium histolyticum (CCH) and penile traction therapy (PTT), which have been shown to be safe and effective. Intralesional therapy is the mainstay treatment, with a combination of therapies likely to be the most effective approach.
CURRENT UROLOGY REPORTS
(2021)
Review
Urology & Nephrology
William M. Hughes, Caleb Natale, Wayne J. G. Hellstrom
Summary: Immediate repair of traumatic penile fracture is crucial for long-term sexual health; Corporal disruption following CCH injections has unique features that require conservative management; Traumatic penile fracture repair has excellent outcomes when performed promptly, but post-CCH treatment may pose challenges that can be dealt with through conservative measures.
CURRENT UROLOGY REPORTS
(2021)
Review
Urology & Nephrology
Scott C. Brimley, Ayad Yousif, Joseph Kim, Wayne J. G. Hellstrom
Summary: Proper patient selection and antibiotic prophylaxis are crucial in reducing IPP infections. It is essential to sterilize the skin and minimize direct device skin contact to prevent infections. Immediate antibiotic coverage combined with salvage procedures can help preserve erectile function in infected IPPs.
ARAB JOURNAL OF UROLOGY
(2021)
Letter
Urology & Nephrology
Jacob W. Greenberg, Brian P. Dick, Wayne J. G. Hellstrom, Anil Paramesh, Omer Raheem
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
David Healy, Audrey Bahrick, Maarten Bak, Angelo Barbato, Rocco Salvatore Calabro, Barbara M. Chubak, Fiammetta Cosci, Antonei B. Csoka, Barbara D'Avanzo, Silvia Diviccaro, Silvia Giatti, Irwin Goldstein, Heiko Graf, Wayne J. G. Hellstrom, Michael S. Irwig, Emmanuele A. Jannini, Paddy K. C. Janssen, Mohit Khera, Manoj Therayil Kumar, Joanna Le Noury, Michal Lew-Starowicz, David E. J. Linden, Celine Luning, Dee Mangin, Roberto Cosimo Melcangi, Omar Walid Muquebil Ali Al Shaban Rodriguez, Jalesh N. Panicker, Arianna Patacchini, Amy M. Pearlman, Caroline F. Pukall, Sanjana Raj, Yacov Reisman, Rachel S. Rubin, Rudy Schreiber, Stuart Shipko, Barbora Vaseckova, Ahad Waraich
Summary: This study aimed to develop diagnostic criteria for post-SSRI sexual dysfunction, persistent genital arousal disorder, post-finasteride syndrome, and post-retinoid sexual dysfunction. The criteria were agreed upon for each condition, and the study concluded that these criteria will be helpful in clinical and research settings.
INTERNATIONAL JOURNAL OF RISK & SAFETY IN MEDICINE
(2022)
Article
Medicine, Research & Experimental
Wayne J. G. Hellstrom, Radboud J. E. M. Dolhain, Timothy E. Ritter, Timothy R. Watkins, Sarah J. Arterburn, Goele Dekkers, Angi Gillen, Caroline Tonussi, Leen Gilles, Alessandra Oortwijn, Katrien Van Beneden, Dick E. de Vries, Suresh C. Sikka, Dirk Vanderschueren, Walter Reinisch
Summary: The MANTA and MANTA-RAy studies were designed to investigate the potential impacts of filgotinib on semen parameters in men with active inflammatory diseases. These studies included strict methodology and extensive analysis of secondary/exploratory measures for conclusions.
ADVANCES IN THERAPY
(2022)
Article
Urology & Nephrology
William J. Conlon, Bryan J. Herzog, Wayne J. G. Hellstrom
Summary: The question of whether manual modeling (MM), an older technique, still has a place in penile prosthesis (PP) surgery for Peyronie's disease with erectile dysfunction arises with the advent of new surgical techniques. Even with concurrent MM during implantation, penile curvature can still be greater than 30 degrees despite the correction provided by the PP. Recently, new variations of the MM technique have been utilized to achieve penile curvature less than 30 degrees when the implant is fully inflated. The long-term efficacy, noninvasive approach, and significantly low risk of adverse effects make MM the first line of treatment for persisting intraoperative penile curvature after PP placement.
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Zachary Melchiode, Tivoli Nguyen, Omar Dawood, Graham A. Bobo, Wayne J. G. Hellstrom
Summary: Erectile dysfunction (ED) is a common condition where men are unable to achieve or maintain a satisfactory erection for sexual performance. There are various treatment options available, with phosphodiesterase 5 (PDE5) inhibitors being the first-line treatment. This review examines the safety, efficacy, and pharmacokinetic properties of new ED drugs such as udenafil, mirodenafil, youkenafil, lodenafil, and SLx-2101.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Review
Urology & Nephrology
Robert H. Drury, Brendan King, Bryan Herzog, Wayne J. G. Hellstrom
Summary: Hematospermia refers to the presence of blood in ejaculatory fluid. It is a rare condition that is often idiopathic or associated with sexual behavior. Iatrogenic interventions, such as transrectal ultrasound-guided prostate biopsies, are the most common cause of HS. Infection and/or nonspecific inflammation are the most common non-iatrogenic etiology. HS can have various sexual ramifications, including anxiety affecting libido, social repercussions, increased risk of erectile dysfunction or transmission of sexual infections, and compromised fertility, especially with cryopreservation.
SEXUAL MEDICINE REVIEWS
(2022)
Review
Urology & Nephrology
Taylor P. Kohn, Saneal Rajanahally, Wayne J. G. Hellstrom, Tung -Chin Hsieh, Omer A. Raheem
Summary: Penile prosthetic surgery remains a viable treatment option for erectile dysfunction, and there are global trends such as a decline in surgery rates and an increase in outpatient procedures.
EUROPEAN UROLOGY FOCUS
(2022)
Review
Urology & Nephrology
Ayman Soubra, Caleb Natale, Scott Brimley, Wayne J. G. Hellstrom
Summary: Many men mistakenly believe their penis is too small, leading to increased anxiety and potential psychological disorders. Psychological counseling is recommended as the initial standard of care for these men.
SEXUAL MEDICINE REVIEWS
(2022)
Review
Urology & Nephrology
Caleb Natale, David M. McLellan, Ayad Yousif, Wayne J. G. Hellstrom
Summary: CCH is a safe and effective injectable agent for treating PD, either alone or in combination with other therapies. It can be used with penile modeling techniques, sildenafil, and shorter administration protocols. However, further studies are needed to optimize treatment protocols and investigate specific conditions and phases of PD.
SEXUAL MEDICINE REVIEWS
(2021)
Review
Urology & Nephrology
Amit G. Reddy, Brian P. Dick, Caleb Natale, Kole P. Akula, Ayad Yousif, Wayne J. G. Hellstrom
Summary: Research suggests that BoNT could potentially play a role in treating certain types of male sexual pathologies. However, more randomized controlled trial data on its long-term safety and efficacy are needed before widespread clinical adoption can occur.
SEXUAL MEDICINE REVIEWS
(2021)
Review
Urology & Nephrology
Robert Drury, Caleb Natale, Wayne J. G. Hellstrom
Summary: Erectile dysfunction (ED) is a common and complex disease process for which regenerative therapies such as low-intensity extracorporeal shockwave therapy (Li-ESWT), platelet rich plasma (PRP), and stem cell therapy (SCT) show potential as adjunct or alternative treatments. While some studies have demonstrated the effectiveness of these therapies in improving erectile function, there is a lack of sufficient evidence to support their safety and efficacy, necessitating further research.
THERAPEUTIC ADVANCES IN UROLOGY
(2021)
Review
Urology & Nephrology
Brian Dick, Caleb Natale, Amit Reddy, Kole Prasad Akula, Ayad Yousif, Wayne J. G. Hellstrom
Summary: The use of botulinum neurotoxin (BoNT) as a treatment for female sexual and genitourinary dysfunction has been increasingly studied and shows potential as a safe and effective option for patients. More research is needed to further understand the mechanisms through which BoNT treats these disorders.
SEXUAL MEDICINE REVIEWS
(2021)