Review
Pharmacology & Pharmacy
Yuting Xiang, Niansheng Li, Min Liu, Qiaohui Chen, Xingyu Long, Yuqi Yang, Zuoxiu Xiao, Jia Huang, Xiaoyuan Wang, Yunrong Yang, Jinping Zhang, Chong Liu, Qiong Huang
Summary: This review comprehensively summarizes the advances in nanodrugs-induced lysosomal membrane permeabilization (LMP), including strategies such as nanoparticles aggregation-induced LMP, chemodynamic therapy (CDT)-induced LMP, and magnetic field-induced LMP. Selective induction of LMP by nanodrugs offers high-efficiency and low side effect anticancer effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Economics
Kjell Kuhne, Nils Bartsch, Julia Higson, Ryan Driskell Tate, Andre Habet
Summary: Meeting the Paris targets requires reducing fossil fuel demand and supply, and closing the gap between climate targets and energy policy. However, there is currently no mitigation roadmap for the supply side. This study identifies the 425 largest fossil fuel extraction projects globally and highlights the need to address these "carbon bombs" in order to meet the Paris targets.
Article
Physics, Multidisciplinary
Lluis Arola-Fernandez, Sergio Faci-Lazaro, Per Sebastian Skardal, Emanuel-Cristian Boghiu, Jesus Gomez-Gardenes, Alex Arenas
Summary: Research on network percolation and synchronization has advanced our understanding of abrupt changes in complex systems. This study introduces the concept of synchronization bombs, large networks of oscillators that transition abruptly from incoherence to synchronization by adding or removing a few links. The results have broad implications for understanding switch mechanisms in biological systems and designing networks that operate in this regime.
COMMUNICATIONS PHYSICS
(2022)
Article
Computer Science, Artificial Intelligence
Yehuii Wang, Jianxu Liu, Yuxuan Tang, Songsak Sriboonchitta
Summary: This paper investigates the linkage structure and risk contagion routes of China's provincial housing market using graph theory and epidemic modeling. The results show a relatively high probability of housing-market collapse in the southwest of China and suggest reducing housing-market linkage to prevent collapse.
Article
Chemistry, Physical
Langyu Yang, Yinshan Lin, Jian Zhang, Jionghua Huang, Aiping Qin, Yingling Miao, Peng Wang, Xiyong Yu, Le Wang, Lingmin Zhang
Summary: We have developed a novel approach for lung cancer therapy using biomimetic metal-organic frameworks to deliver biological bombs to tumor cells, leading to their efficient killing through the bystander effect.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Editorial Material
Chemistry, Physical
Wanli Yang
Summary: In this study, electron ptychography was used to image the atomic placements of a Li-rich material involving oxygen sublattice distortion, providing valuable discussions on oxygen activities in battery cathodes.
Article
Multidisciplinary Sciences
Yu Okamura, Hanna Dort, Michael Reichelt, Kalle Tunstroem, Christopher W. Wheat, Heiko Vogel
Summary: Coevolutionary interactions play a crucial role in Earth's biodiversity, and key innovations drive the speciation bursts of species involved. This study focused on the butterfly species Pieris brassicae and found that nitrile specifier protein (NSP) and major allergen (MA) genes are essential for survival on plants containing glucosinolates (GSLs), which are a key innovation in mustard-feeding butterflies. The expression differences of these genes correlated with detoxification performance, particularly when using natural host plants. Positive selection signatures were also detected for NSP and MA genes across Pieris species, highlighting their importance in recent coevolutionary interactions. This research emphasizes the necessity of including ecological relevant experiments to gain insights into coevolutionary dynamics.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Engineering, Civil
L. L. Ma, H. Wu, Q. Fang
Summary: This paper proposes a performance-based blast-resistant design approach for RC bridge piers under explosions of vehicular bombs. The distribution model of blast impulse and the fiber beam element-based model are established and validated. The response surface methodology is adopted to propose a performance-based blast-resistant design procedure.
ENGINEERING STRUCTURES
(2023)
Article
Astronomy & Astrophysics
Marzena Ciszak, Francesco Marino
Summary: This study explores phenomena similar to black-hole bombs and equilibrium pure bound states in a rotating photon-fluid model. The research shows that, in the presence of suitable vortex flows, acoustic counterparts and superradiant instabilities are generated.
Article
Chemistry, Physical
Teresa Paez, FeiFei Zhang, Miguel Angel Munoz, Lara Lubian, Shibo Xi, Robert Sanz, Qing Wang, Jesus Palma, Edgar Ventosa
Summary: Different battery technologies have their own advantages and disadvantages, and by merging these technologies, a new battery technology can achieve high energy density, recyclability, and independent scalability. This new battery technology opens up previously unforeseen market opportunities, such as domestic energy storage and heavy-duty vehicle transportation.
ADVANCED ENERGY MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Jian Wu, Jinzhe Chang, Jun Liu, Jiajian Huang, Zixia Song, Xiaofeng Xie, Liting Wei, Jiaxin Xu, Suqing Huang, Dongmei Cheng, Youzhi Li, Hanhong Xu, Zhixiang Zhang
Summary: A chitosan-based nanoparticle with superior antifungal activity and adhesion performance was prepared. It is of great significance for the development and application of biocompatible chitosan-based nanopesticides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Environmental
Yilin Yang, Ning Wang, Zhihua Wang, Mingda Han, Fei Yan, Zhan Shi, Shouhua Feng
Summary: Sonodynamic therapy (SDT) has emerged as a promising strategy for treating tumors. However, improving the efficiency of sonosensitizers and alleviating the hypoxic tumor microenvironment are major challenges. In this study, a defect-rich titanium-based metal-organic framework (MOFs) was fabricated, and platinum nanoparticles were embedded onto its surface to enhance electron-hole separation and ultrasound-generated singlet oxygen (1O2) production. Perfluorobromooctane was encapsulated in the MOFs as an oxygen carrier. The nanoplatform demonstrated high 1O2 production under ultrasound irradiation and relieved the immunosuppressive tumor microenvironment. Combination with anti-PDL1 antibodies effectively inhibited primary and metastatic tumors.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Mengxue Yang, Cong Cong, Jiaxin Bian, Zichuang Xu, Xiaokang Liu, Lanxiang Liu, Xuwu Zhang, Desong Wang, Dawei Gao
Summary: A novel nano-bombs strategy was proposed for rapid tumor penetration, with Ag NCs-triggered photothermal therapy and rapid phase transitions of PFH with oxygen to burst lysosomes, enhancing delivery efficiency of nanomedicines and enabling catalytic and chemodynamic therapy.
APPLIED MATERIALS TODAY
(2021)
Article
Energy & Fuels
Kevin Winter, Matthew J. Hornsey, Lotte Pummerer, Kai Sassenberg
Summary: This study explores the association between opposition to wind farms and conspiracy beliefs. Through eight studies, it was found that there is a moderate-to-large correlation between conspiracy beliefs and opposition to wind farms. Information provision can increase support, but it is less effective when presented as a debate or among participants who endorse specific conspiracy theories about wind farms. Therefore, preventive measures are more realistic than informational interventions.
Article
Astronomy & Astrophysics
Jie Hong, Ying Li, M. D. Ding, Qi Hao
Summary: Ellerman bombs and UV bursts are small-scale solar activities occurring in active regions at different heights in the lower atmosphere. Heating in various atmospheric layers can generate specific spectral features, with different intensity evolution patterns observed in H alpha line wings and Si iv 1403 angstrom line centers for EBs and UV bursts, respectively. The predicted enhancement of the FUV continuum near 1400 angstrom for EBs requires further observations for verification.
ASTROPHYSICAL JOURNAL
(2021)
Article
Multidisciplinary Sciences
Chih-Hung Ko, Qirong Zhu, Francesco Tassinari, George Bullard, Peng Zhang, David N. Beratan, Ron Naaman, Michael J. Therien
Summary: A critical challenge in spintronics is to develop molecular wires that can efficiently generate spin-polarized currents. By using chiral binucleating ligands to induce interplanar torsional twisting in highly conjugated molecular wires, the rotational strengths in the near-infrared region are significantly enhanced. The large scalar product of electric and magnetic dipole transition moments in the low-energy absorptive manifolds of these wires enables enhanced chirality-induced spin selectivity and spin polarization. Experimental results from magnetic-conductive atomic force microscopy and spin-Hall devices demonstrate that these designs provide a pathway towards achieving high spin selectivity and large-magnitude spin currents in chiral materials.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Chemistry, Multidisciplinary
Clarice D. Aiello, John M. Abendroth, Muneer Abbas, Andrei Afanasev, Shivang Agarwal, Amartya S. Banerjee, David N. Beratan, Jason N. Belling, Bertrand Berche, Antia Botana, Justin R. Caram, Giuseppe Luca Celardo, Gianaurelio Cuniberti, Aitzol Garcia-Etxarri, Arezoo Dianat, Ismael Diez-Perez, Yuqi Guo, Rafael Gutierrez, Carmen Herrmann, Joshua Hihath, Suneet Kale, Philip Kurian, Ying-Cheng Lai, Tianhan Liu, Alexander Lopez, Ernesto Medina, Vladimiro Mujica, Ron Naaman, Mohammadreza Noormandipour, Julio L. Palma, Yossi Paltiel, William Petuskey, Joao Carlos Ribeiro-Silva, Juan Jose Saenz, Elton J. G. Santos, Maria Solyanik-Gorgone, Volker J. Sorger, Dominik M. Stemer, Jesus M. Ugalde, Ana Valdes-Curiel, Solmar Varela, David H. Waldeck, Michael R. Wasielewski, Paul S. Weiss, Helmut Zacharias, Qing Hua Wang
Summary: This review focuses on the study of chiral degrees of freedom in matter and electromagnetic fields, discussing the recent observations of the chiral-induced spin selectivity effect and the nanophotonic strategies designed to amplify chiral light-matter interactions. The CISS effect offers opportunities for spin control and the design of room-temperature quantum devices, while chiral-optical effects could have advantages in all-optical and quantum information technologies. The review presents a vision for the future roles of chiral-influenced quantum effects in enabling room-temperature quantum technologies.
Article
Chemistry, Physical
William Shen, Ruijie D. Teo, David N. Beratan, Jeffrey J. Warren
Summary: This study investigates the relative roles of hydrogen bonds in electron transport in cytochrome c. Through the construction of a series of cytochrome c variants and simulation experiments, it is found that the replacement of hydrogen bond residues has almost no effect on electron transport rate, while changes in the composition of another transport pathway lead to a decrease in electron transport rate. Molecular dynamics simulations show that these changes are related to alterations in donor-acceptor distance and electronic coupling. Furthermore, variations in the core of the protein also influence cofactor dynamics at the protein surface, affecting pathway strength and electron transport rate.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Nancy Wiebelhaus, Niven Singh, Peng Zhang, Stephen L. Craig, David N. Beratan, Michael C. Fitzgerald
Summary: This study utilizes protein folding stability measurements and the SPROX and LiP techniques to discover protein-xenon interactions on the proteomic scale. The results enrich our understanding of biologically relevant xenon interactions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Physics, Multidisciplinary
Hiromichi Nakazato, Alessandro Sergi, Agostino Migliore, Antonino Messina
Summary: We present a method to construct the exact expression for the evolution operator U(t) of a localized and isolated qubit in a time-dependent field. We demonstrate the usefulness of our approach by solving the quantum dynamics of a qubit subject to a controllable time-dependent field. Our method has potential applications in SU(2) models and realistic physical scenarios with different symmetry properties.
Article
Physics, Multidisciplinary
Alessandro Sergi, Daniele Lamberto, Agostino Migliore, Antonino Messina
Summary: The conceptual analysis of quantum mechanics reveals that a theory consistent with observations should be capable of describing both quantum and classical systems, known as quantum-classical hybrids. We extended the Ehrenfest theorem to bipartite quantum systems and used a formalism based on operator-valued Wigner functions and quantum-classical brackets to study quantum-classical hybrids. Our results show that the time variation of the average energy of each component in a bipartite system is equal to the average of the symmetrized quantum dissipated power in both quantum and quantum-classical cases. These theoretical findings are expected to be valuable for analyzing quantum-classical hybrids and developing self-consistent numerical algorithms for Ehrenfest-type simulations.
Article
Physics, Multidisciplinary
Liubov A. Markovich, Agostino Migliore, Antonino Messina
Summary: We introduce the concept of the almost-companion matrix (ACM), which relaxes the non-derogatory property of the standard companion matrix (CM). The ACM is defined as a matrix whose characteristic polynomial coincides with a given monic and generally complex polynomial. Compared to the CM, the ACM provides greater flexibility in constructing matrices with desired additional conditions and specific properties of the polynomial coefficients. We demonstrate the construction of Hermitian and unitary ACMs using third-degree polynomials, with applications in physical-mathematical problems.
Article
Chemistry, Physical
Benjamin J. G. Rousseau, Agostino Migliore, Robert J. Stanley, David N. Beratan
Summary: Comparative study of DNA repair by mesophilic and extremophilic photolyases helps to understand the evolution of these enzymes and their role in preserving life on our changing planet.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Physics, Multidisciplinary
Antonio Sergio Magalhaes de Castro, Roberto Grimaudo, Davide Valenti, Agostino Migliore, Hiromichi Nakazato, Antonino Messina
Summary: We study the time evolution of a Jaynes-Cummings model and find universal features on a dynamical time scale. By using the total excitation number as a constant of motion and the symmetry properties of the Hamiltonian, we decompose the Hilbert space into invariant subspaces and solve the dynamical problem using the Messina-Nakazato parameterization method. The results reveal Rabi-like oscillations and revivals of the atomic population inversion over the dynamical time under different initial conditions.
EUROPEAN PHYSICAL JOURNAL PLUS
(2023)
Article
Chemistry, Physical
Benjamin J. G. Rousseau, Agostino Migliore, Robert J. Stanley, David N. Beratan
Summary: The comparative study of DNA repair enzymes by mesophilic and extremophilic photolyases helps us understand their evolution and their role in preserving life on Earth. Our study finds that adenine plays a critical role in mediating electron transfer in both mesophile and extremophile DNA photolyases through similar mechanisms. Adenine is present in 10-20% of the strongest-coupling tunneling pathways between the electron donor and acceptor.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Chemistry, Physical
Sutirtha N. Chowdhury, Peng Zhang, David N. Beratan
Summary: Cavity polaritonics provides new strategies for manipulating and directing nanoscale electron flow by modulating interference and rates of electron transfer pathways.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Materials Science, Multidisciplinary
Kai T. Liu, Feng-Feng Song, David N. Beratan, Peng Zhang
Summary: In quantum dynamical simulations, using nonunitary transformations can suppress entanglement growth rate and improve the efficiency. These transformations control entanglement by inducing biased transitions and energy exchange. The method is applicable to many-body systems and enhances the numerical efficiency of matrix product state simulations.
Article
Optics
Kai T. Liu, David N. Beratan, Peng Zhang
Summary: Modeling open quantum systems has great value in various fields, such as condensed-matter theory, cavity quantum electrodynamics, nanosciences, and biophysics. Recent advancements in chain mapping techniques and the use of matrix product states have significantly improved the real-time simulation of such systems. However, the computational cost remains high when the bath is excited to high-lying quantum states. In this study, we propose an approach using the interaction representation to reduce the computational costs and achieve faster calculations.
