Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 112, Issue 35, Pages 11084-11089Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1504172112
Keywords
working memory; prefrontal cortex; macaque; coherence
Categories
Funding
- NIH Ruth L. Kirschstein National Service Award from National Institute of Mental Health (NIMH) [F32-MH100884]
- Swartz Fellowship in Theoretical Neurobiology
- NIH [T32-EY007158]
- National Eye Institute (NEI) [R01-EY016407]
- NIMH [R03-MH097206]
- National Science Foundation [BCS-0955701]
- NEI [R01-EY024067]
- Direct For Social, Behav & Economic Scie
- Division Of Behavioral and Cognitive Sci [0955701] Funding Source: National Science Foundation
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Lateral prefrontal cortex (PFC) is regarded as the hub of the brain's working memory (WM) system, but it remains unclear whether WM is supported by a single distributed network or multiple specialized network components in this region. To investigate this problem, we recorded from neurons in PFC while monkeys made delayed eye movements guided by memory or vision. We show that neuronal responses during these tasks map to three anatomically specific modes of persistent activity. The first two modes encode early and late forms of information storage, whereas the third mode encodes response preparation. Neurons that reflect these modes are concentrated at different anatomical locations in PFC and exhibit distinct patterns of coordinated firing rates and spike timing during WM, consistent with distinct networks. These findings support multiple component models of WM and consequently predict distinct failures that could contribute to neurologic dysfunction.
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