Article
Oncology
Amanda E. Yung, Michael S. Que, Serigne Lo, Shagun Aggarwal, Angela M. Hong, Mo Mo Tin, Jonathan R. Clark, Ruta Gupta, Sydney Ch'ng
Summary: Restaging of vermilion lip squamous cell carcinoma using AJCC8 resulted in 19% of patients being upstaged to pT3 and 16% being upstaged to stage III, with no patients being downstaged. This emphasizes the importance of understanding the limitations in order to make informed decisions about treatment escalation.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wenjie Huang, Tingting Quan, Qin Zhao, Shuqi Li, Yi Cai, Jian Zhou, Chao Luo, Guangying Ruan, Chunyan Cui, Shaobo Liang, Haojiang Li, Lizhi Liu
Summary: The study found that the risk of death increased with the number of parapharyngeal subspaces involved. The degree of PPSI is recommended to optimize T3 heterogeneity.
EUROPEAN RADIOLOGY
(2022)
Article
Immunology
Chengdong Qin, Siyuan Liu, Shiqi Zhou, Qibo Wang, Xianghou Xia, Jiejie Hu, Xiaohong Yuan, Zongping Wang, Yang Yu, Dening Ma
Summary: PIK3C2A expression is decreased in various tumors, particularly in renal clear cell carcinoma (KIRC). It is significantly correlated with tumor stage, grade, and other clinicopathological features in KIRC. PIK3C2A serves as a potential biomarker for tumor progression and is associated with immune infiltration in KIRC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Jiasheng Yan, Yunqiu Gao
Summary: This study aimed to investigate the role of tissue inhibitor of metalloproteinase-1 (TIMP1) in kidney renal clear cell carcinoma (KIRC). Analysis of data from the TCGA database revealed that TIMP1 expression was associated with patient prognosis and may play a crucial role in the development and spread of KIRC. TIMP1 could serve as a prognostic marker for KIRC.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Oncology
Lei Wang, Xiu-Xiu Liu, Yu-Meng Yang, Yan Wang, Yuan-Yuan Song, Shan Gao, Lu-Yuan Li, Zhi-Song Zhang
Summary: The study identified the important role of rhomboid family genes in the progression of kidney renal clear cell carcinoma, particularly highlighting the correlation between high expression levels of RHBDF2 gene and poor prognosis in the disease. Furthermore, it revealed that high RHBDF2 expression may promote cell migration in cancer tissues and inhibit immune cell activity by sustaining PD-L1 protein levels.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Wenbiao Zhu, Huiming Jiang, Shoucheng Xie, Huanqin Xiao, Qinghua Liu, Nanhui Chen, Pei Wan, Shanming Lu
Summary: The study demonstrated that PPA2 is an important energy metabolism-associated biomarker correlated with a favorable prognosis in KIRC, and decreased expression of PPA2 might be related to the epithelial-mesenchymal transition in KIRC.
Article
Biochemistry & Molecular Biology
Jianrong Bai, Axiu Zheng, Yanping Ha, Xiaoqing Xu, Yaping Yu, Yanda Lu, Shaojiang Zheng, Zhihua Shen, Botao Luo, Wei Jie
Summary: LAMC1 expression is associated with prognosis in kidney cancer, high expression indicates poor prognosis in KIRP and better prognosis in KIRC. LAMC1 expression is correlated with immune cell infiltration and signaling pathways.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Endocrinology & Metabolism
Andrew H. Nguyen, Michael P. O'Leary, James P. De Andrade, Philip H. G. Ituarte, Jonathan Kessler, Daneng Li, Gagandeep Singh, Sue Chang
Summary: Renal neuroendocrine neoplasms are rare and their natural history is poorly understood. The study found that patients with earlier stage and favorable histologies had increased survival rates.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Fenfang Zhou, Dexin Shen, Yaoyi Xiong, Songtao Cheng, Huimin Xu, Gang Wang, Kaiyu Qian, Lingao Ju, Xinhua Zhang
Summary: CTHRC1 expression is elevated in KIRP and KIRC, associated with tumor stage, histology, lymph node metastasis, and clinical prognosis in KIRP, as well as tumor grade, stage, nodal metastasis, and survival prognosis; it is also positively related to various tumor-infiltrating immune cells in KIRP and KIRC.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Leandro Luongo Matos, Yasmin Laryssa Moura Guimaraes, Ana Kober Leite, Claudio Roberto Cernea
Summary: Oral squamous cell carcinoma (OSCC) patients with larger depth of invasion (DOI) and/or width are included in stage III, which is a heterogeneous group. Features such as extranodal extension, positive or close margins, specific tumor and nodal characteristics are associated with adverse prognosis and warrant adjuvant treatment. However, for stage III OSCC without adverse features, there is no strong evidence to recommend or exclude adjuvant treatment. Further studies are needed to determine the appropriate management for these patients.
CURRENT ONCOLOGY REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Natalie L. Demirjian, Bino A. Varghese, Steven Y. Cen, Darryl H. Hwang, Manju Aron, Imran Siddiqui, Brandon K. K. Fields, Xiaomeng Lei, Felix Y. Yap, Marielena Rivas, Sharath S. Reddy, Haris Zahoor, Derek H. Liu, Mihir Desai, Suhn K. Rhie, Inderbir S. Gill, Vinay Duddalwar
Summary: This study evaluated the utility of CT-based radiomics signatures in discriminating low-grade and high-grade, as well as low-stage and high-stage clear cell renal cell carcinomas (ccRCC). The results suggest that CT-based radiomics signatures have the potential to be valuable in distinguishing between different grades and stages of ccRCC.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Peirong Xu, Sihong Zhang, Bohong Cao, Yaohui Li, Jiaqi Huang, Wenyao Lin, Jie Cheng, Huifeng Li, Weijie Chen, Yanjun Zhu, Shuai Jiang, Xiaoyi Hu, Jiawen Wu, Zhenqi Wu, Jianjun Zhou, Jianming Guo, Hang Wang
Summary: This study explored the predictive value of renal tumor contour irregularity (CID) in the pathological T3a upstaging of clinical T1 renal cell carcinoma (RCC). The results showed that age, tumor maximum diameter, and CID were independent predictors of pathological T3a upstaging in clinical T1 RCC. The inclusion of CID in the predictive model significantly improved the ability to predict T3a upstaging and had important prognostic implications for patients with clinical T1 RCC.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Pathology
Julien Dagher, Angelique Brunot, Bertrand Evrard, Solene-Florence Kammerer-Jacquet, Marion Beaumont, Laurence Cornevin, Fanny Derquin, Gregory Verhoest, Karim Bensalah, Alexandra Lespagnol, Frederic Dugay, Marc-Antoine Belaud-Rotureau, Frederic Chalmel, Nathalie Rioux-Leclercq
Summary: Metastatic evolution in clear cell renal cell carcinoma is complex, with tumor heterogeneity resulting from clonal evolution playing a role in metastatic dissemination. Using an integrative multiomics strategy, it was found that all sites were heterogeneous and polyclonal, with each tumor site containing two aggressive subclonal populations.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Genetics & Heredity
Jian Hu, Yajun Chen, Liang Gao, Chengguo Ge, Xiaodu Xie, Pan Lei, Yuanfeng Zhang, Peihe Liang
Summary: This study investigated the expression of Pyroptosis-related genes in KIRP, identified differentially expressed PRGs between tumor and normal tissues, built prognostic risk model, and explored the impact of immune cell infiltration and tumor immunity on KIRP progression.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Zhixian Wang, Jing Wang, Yunpeng Zhu, Chang Liu, Xing Li, Xiaoyong Zeng
Summary: The detection of T1N0M0 renal cell carcinoma (RCC) has increased and prognosis has improved, but there is still a superficial focus on non-RCC-related mortality. This study found that heart disease, diabetes, and cerebrovascular disease were the primary causes of non-RCC-related mortality within the first year after diagnosis, with heart disease becoming the leading cause of death over 5 years after diagnosis. Targeted prevention strategies for non-RCC-related causes of death could significantly reduce mortality for RCC survivors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Health Care Sciences & Services
Niranjan Jude Sathianathen, Robert Lane, Declan G. Murphy, Stacy Loeb, Caitlin Bakker, Alastair D. Lamb, Christopher J. Weight
JOURNAL OF MEDICAL INTERNET RESEARCH
(2020)
Article
Urology & Nephrology
Peter T. Hanna, Matt Peterson, Jacob Albersheim, Paul Drawz, Joseph Zabell, Badrinath Konety, Christopher Weight
JOURNAL OF UROLOGY
(2020)
Article
Oncology
Nir Kleinmann, Surena F. Matin, Phillip M. Pierorazio, John L. Gore, Ahmad Shabsigh, Brian Hu, Karim Chamie, Guilherme Godoy, Scott Hubosky, Marcelino Rivera, Michael O'Donnell, Marcus Quek, Jay D. Raman, John J. Knoedler, Douglas Scherr, Joshua Stern, Christopher Weight, Alon Weizer, Michael Woods, Hristos Kaimakliotis, Angela B. Smith, Jennifer Linehan, Jonathan Coleman, Mitchell R. Humphreys, Raymond Pak, David Lifshitz, Michael Verni, Mehrad Adibi, Mahul B. Amin, Elyse Seltzer, Ifat Klein, Marina Konorty, Dalit Strauss-Ayali, Gil Hakim, Mark Schoenberg, Seth P. Lerner
Correction
Urology & Nephrology
Niranjan J. Sathianathen, Isaac Thangasamy, Robert Lane, Benjamin Condon, Declan G. Murphy, Nathan Lawrentschuk, Christopher J. Weight, Alastair D. Lamb
EUROPEAN UROLOGY FOCUS
(2021)
Article
Urology & Nephrology
Peter Hanna, Joseph Zabell, Yasser Osman, Mohamed M. Hussein, Magdy Mostafa, Christopher Weight, Badrinath Konety
Summary: This study found that implementing the ERAS protocol in patients undergoing radical cystectomy can significantly improve gastrointestinal recovery, especially for low-risk patients. However, ERAS did not reduce the length of hospital stay or readmission rates.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Computer Science, Artificial Intelligence
Nicholas Heller, Fabian Isensee, Klaus H. Maier-Hein, Xiaoshuai Hou, Chunmei Xie, Fengyi Li, Yang Nan, Guangrui Mu, Zhiyong Lin, Miofei Han, Guang Yao, Yaozong Gao, Yao Zhang, Yixin Wang, Feng Hou, Jiawei Yang, Guangwei Xiong, Jiang Tian, Cheng Zhong, Jun Ma, Jack Rickman, Joshua Dean, Bethany Stai, Resha Tejpaul, Makinna Oestreich, Paul Blake, Heather Kaluzniak, Shaneabbas Raza, Joel Rosenberg, Keenan Moore, Edward Walczak, Zachary Rengel, Zach Edgerton, Ranveer Vasdev, Matthew Peterson, Sean McSweeney, Sarah Peterson, Arveen Kalapara, Niranjan Sathianathen, Nikolaos Papanikolopoulos, Christopher Weight
Summary: The anatomic and geometric characteristics of kidney tumors have significant impact on surgical and oncologic outcomes. Deep learning methods have shown promising results in automatic 3D segmentations, but there is still debate on the best approach. The KiTS19 challenge provided a platform for researchers worldwide to develop automated systems for kidney and tumor segmentation using a large dataset of CT images.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Chemistry, Analytical
Scott J. Walmsley, Jingshu Guo, Paari Murugan, Christopher J. Weight, Jinhua Wang, Peter W. Villalta, Robert J. Turesky
Summary: The novel software is designed for comprehensive analysis and characterization of DNA modifications in human specimens, detecting DNA adducts at trace levels. The software processes mass spectral data acquired by wide selected ion monitoring (wSIM) coupled with wide MS2 fragmentation.
ANALYTICAL CHEMISTRY
(2021)
Article
Urology & Nephrology
Peter Hanna, Subodh Regmi, Arveen Kalapara, Kalyana Srujana Mulpuri, Joseph Zabell, Jacob Albersheim, Joyce Wahr, Darrel Randle, Alexander Kaizer, Luke Patten, Badrinath Konety, Christopher Weight
Summary: The study retrospectively analyzed 296 patients undergoing radical cystectomy, showing significant effects of Enhanced Recovery After Surgery protocol and alvimopan on length of hospital stay, gastrointestinal recovery time, and postoperative ileus rate. Particularly, alvimopan had the most obvious impact when used with an open surgical approach, while no significant difference was observed with robotic-assisted surgery.
INTERNATIONAL JOURNAL OF UROLOGY
(2021)
Editorial Material
Urology & Nephrology
[Anonymous]
JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
N. Heller, R. Tejpaul, F. Isensee, T. Benidir, M. Hofmann, P. Blake, Z. Rengal, K. Moore, N. Sathianathen, A. Kalapara, J. Rosenberg, S. Peterson, E. Walczak, A. Kutikov, R. G. Uzzo, D. A. Palacios, E. M. Remer, S. C. Campbell, N. Papanikolopoulos, Christopher J. Weight
Summary: The purpose of this study was to develop an artificial intelligence algorithm for automated scoring of R.E.N.A.L. nephrometry scores and evaluate its predictive ability for oncologic and perioperative outcomes. The results showed that AI-scores were comparable to H-scores and predicted a wide variety of meaningful patient outcomes.
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Isaac M. Melin, Sergio M. Navarro, Jacob Albersheim, Khushabu Kasabwala, Christopher Weight, James V. Harmon
Summary: Parastomal hernias are a common complication following ileal conduit urinary diversion. This case report demonstrates successful laparoscopic repair using an inverted top-hat technique in a woman in her mid-nineties, resulting in a pain-free patient without evidence of hernia recurrence at eighteen months follow-up.
UROLOGY CASE REPORTS
(2021)
Review
Chemistry, Medicinal
Jingshu Guo, Joseph S. Koopmeiners, Scott J. Walmsley, Peter W. Villalta, Lihua Yao, Paari Murugan, Resha Tejpaul, Christopher J. Weight, Robert J. Turesky
Summary: Well-done cooked red meat consumption is associated with aggressive prostate cancer risk. This study measured the levels of PhIP, a potential carcinogen found in cooked meat, in the hair of prostate cancer patients and analyzed the correlation with prostate pathology biomarkers and Gleason scores.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Urology & Nephrology
Nour Abdallah, Andrew Wood, Tarik Benidir, Nicholas Heller, Fabian Isensee, Resha Tejpaul, Dillon Corrigan, Chalairat Suk-ouichai, Griffin Struyk, Keenan Moore, Nitin Venkatesh, Onuralp Ergun, Alex You, Rebecca Campbell, Erick M. Remer, Samuel Haywood, Venkatesh Krishnamurthi, Robert Abouassaly, Steven Campbell, Nikolaos Papanikolopoulos, Christopher J. Weight
Summary: This study aims to improve the prediction ability of pathological outcomes by using an artificial intelligence-generated R.E.N.A.L.+ score (AI+ score) compared to the traditional H-score.
Article
Health Care Sciences & Services
Niranjan J. Sathianathen, Nicholas Heller, Resha Tejpaul, Bethany Stai, Arveen Kalapara, Jack Rickman, Joshua Dean, Makinna Oestreich, Paul Blake, Heather Kaluzniak, Shaneabbas Raza, Joel Rosenberg, Keenan Moore, Edward Walczak, Zachary Rengel, Zach Edgerton, Ranveer Vasdev, Matthew Peterson, Sean McSweeney, Sarah Peterson, Nikolaos Papanikolopoulos, Christopher Weight
Summary: Clinicians rely on imaging features and validated scoring systems to assess renal masses complexity. This study introduced a machine learning competition (KiTS19) to develop automatic segmentation system for kidney tumors in CT scans. The winning team achieved high accuracy in kidney segmentation but faced challenges in tumor segmentation.
FRONTIERS IN DIGITAL HEALTH
(2022)
Letter
Urology & Nephrology
Sari Khaleel, Subodh Regmi, Peter Hannah, Bradly Watarai, Niranjan Sathianathen, Christopher Weight, Badrinath Konety
JOURNAL OF UROLOGY
(2021)