Article
Engineering, Electrical & Electronic
Shifeng Zhang, Longyin Wen, Zhen Lei, Stan Z. Li
Summary: In this research, a novel single-shot based object detector, RefineDet++, is proposed to combine the advantages of both two-stage and one-stage approaches. The method consists of two inter-connected modules: anchor refinement module and alignment detection module, which work together to improve the accuracy and efficiency of object detection. Extensive experiments on PASCAL VOC and MS COCO dataset show that RefineDet++ achieves state-of-the-art detection accuracy with high efficiency.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS FOR VIDEO TECHNOLOGY
(2021)
Article
Medicine, General & Internal
Zhen Li, Nienie Qi, Zhimin Gao, Li Ding, Jiawei Zhu, Qingxiang Guo, Junqi Wang, Rumin Wen, Hailong Li
Summary: This study aimed to investigate whether the original IVC regimen should be continued or restarted after the second TURBT. A retrospective analysis was conducted on 137 patients who underwent a second TURBT. The results showed that there was a significant difference in recurrence-free survival between patients in the two IVC regimens. For patients without residual tumor, continuing the previous treatment regimen without restarting IVC induction phase is recommended, while for patients with residual tumor, restarting the IVC induction phase should be emphasized to improve prognosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Computer Science, Artificial Intelligence
Enze Xie, Wenhai Wang, Mingyu Ding, Ruimao Zhang, Ping Luo
Summary: PolarMask is an anchor-box free and single-shot instance segmentation framework that reformulates the instance segmentation problem by predicting object contours in polar coordinates. It unifies instance segmentation and object detection into a single framework, making it more efficient in training and performance.
IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE
(2022)
Article
Infectious Diseases
Lorenz Leitner, Aleksandre Ujmajuridze, Nina Chanishvili, Marina Goderdzishvili, Irina Chkonia, Sophia Rigvava, Archil Chkhotua, Giorgi Changashvili, Shawna McCallin, Marc P. Schneider, Martina D. Liechti, Ulrich Mehnert, Lucas M. Bachmann, Wilbert Sybesma, Thomas M. Kessler
Summary: This study aimed to determine the effectiveness of intravesical bacteriophage therapy in treating UTIs. Findings showed that bacteriophage therapy was non-inferior to standard antibiotic treatment, but not superior to placebo bladder irrigation in terms of efficacy or safety. The safety profile of bacteriophages appears to be favorable, suggesting potential for further large-scale clinical studies on their role in UTI treatment.
LANCET INFECTIOUS DISEASES
(2021)
Article
Oncology
Courtney D. DiNardo, Andre C. Schuh, Eytan M. Stein, Pau Montesinos, Andrew H. Wei, Stephane de Botton, Amer M. Zeidan, Amir T. Fathi, Hagop M. Kantarjian, John M. Bennett, Mark G. Frattini, Patricia Martin-Regueira, Frederik Lersch, Jing Gong, Maroof Hasan, Paresh Vyas, Hartmut Doehner
Summary: The study evaluated the safety and activity of enasidenib plus azacitidine in patients with newly diagnosed, mutant-IDH2 acute myeloid leukaemia, showing that the combination therapy significantly improved overall response rates compared to azacitidine monotherapy, which may lead to improved outcomes for these patients.
Article
Hematology
PanJing Wang, Rongfu Zhou, Feng Xue, Hu Zhou, Jie Bai, Xianghua Wang, Yueshen Ma, Zhen Song, Yunfei Chen, Xiaofan Liu, Rongfeng Fu, Ting Sun, Mankai Ju, Xinyue Dai, Huan Dong, Renchi Yang, Wei Liu, Lei Zhang
Summary: This study compared the efficacy of two immunosuppression therapies for acquired hemophilia A through a multicenter randomized controlled trial. The results showed that the single-dose rituximab combination regimen was noninferior to the cyclophosphamide combination regimen in terms of complete remission rate. Additionally, no significant difference in the incidence of treatment-related adverse events was found between the two regimens. Based on these findings, the single-dose rituximab combination regimen may be recommended as a first-line therapy for acquired hemophilia A, especially in China where there is a young age trend among patients.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Hematology
Thomas Pabst, Cristina Papayannidis, Fatih Demirkan, Vadim Doronin, Laura M. Fogliatto, Christina Guttke, Emmanuel Gyan, Nada Hamad, Pilar Herrera, Anna Hultberg, Julie Jacobs, Amy J. Johnson, Angelique Langlois, Xuewen Ma, Giovanni Martinelli, Montserrat Arnan, Rouven Mueller, Kerri Nottage, Yishai Ofran, Muhit Ozcan, Olga Samoilova, Jaszianne A. Tolbert, Geralyn C. Trudel, Liang Xiu, Norbert Vey, Andrew Wei
Summary: This study aimed to determine the optimal dose of cusatuzumab in combination with azacitidine for the treatment of acute myeloid leukaemia. The results showed that cusatuzumab 20 mg/kg plus azacitidine was the optimal dose for further studies.
LANCET HAEMATOLOGY
(2023)
Review
Medicine, General & Internal
Adel Alrabadi, Mohannad Abuhamad, Hammam Mansi, Sohaib Alhamss, Nadwa Bustami, Saddam Al Demour, Mousa A. Al-Abbadi
Summary: This case report highlights a rare complication of bladder perforation following intravesical doxorubicin instillation after bladder tumor resection. Conservative management was unsuccessful, leading to the need for open surgical repair. It emphasizes the importance of a high index of suspicion, timely management, and consideration of more invasive treatments when necessary to preserve bladder function.
CLINICAL MEDICINE INSIGHTS-CASE REPORTS
(2021)
Review
Urology & Nephrology
Reza Sari Motlagh, Keiichiro Mori, Ekaterina Laukhtina, Abdulmajeed Aydh, Satoshi Katayama, Nico C. Grossmann, Hadi Mostafai, Benjamin Pradere, Fahad Quhal, Victor M. Schuettfort, Mohammad Reza Roshandel, Pierre I. Karakiewicz, Jeremy Teoh, Shahrokh F. Shariat, Harun Fajkovic
Summary: The study found that blue-light cystoscopy during TURBT with concomitant SIIC can improve recurrence outcomes in patients with non-muscle-invasive bladder cancer. The use of photodynamic diagnosis (PDD) can reduce the 12-month recurrence rate, and SIIC further decreases the risk.
Article
Oncology
Ryan L. Steinberg, Vignesh T. Packiam, Lewis J. Thomas, Nathan Brooks, Andrew Vitale, Sarah L. Mott, Trafford Crump, Jonathan Wang, William C. DeWolf, Donald L. Lamm, Max Kates, M. Eric Hyndman, Ashish M. Kamat, Trinity J. Bivalacqua, Kenneth G. Nepple, Michael A. O'Donnell
Summary: Repeat BCG induction is still an option for some select non-muscle invasive bladder cancer (NMIBC) patients who fail initial therapy. Alternative salvage intravesical regimens such as Gemcitabine and Docetaxel (Gem/Doce) have been investigated. The study aimed to compare the efficacy of BCG plus interferon a-2b (BCG/IFN) and Gem/Doce in patients with recurrent NMIBC after a single prior BCG course, showing similar oncologic outcomes for both treatment options.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Hematology
Tapan M. Kadia, Patrick K. Reville, Gautam Borthakur, Musa Yilmaz, Steven Kornblau, Yesid Alvarado, Courtney D. Dinardo, Naval Daver, Nitin Jain, Naveen Pemmaraju, Nicholas Short, Sa A. Wang, Rebecca S. S. Tidwell, Rabiul Islam, Marina Konopleva, Guillermo Garcia-Manero, Farhad Ravandi, Hagop M. Kantarjian
Summary: The addition of venetoclax to intensive chemotherapy in patients with newly diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome was found to be safe and effective, leading to high rates of durable MRD-negative remissions and favorable event-free survival and overall survival outcomes.
LANCET HAEMATOLOGY
(2021)
Article
Medicine, General & Internal
Ulf Petrausch, Martin Spahn, Martina Schneider, Stefanie Hayoz, Cyrill A. Rentsch, Sacha Rothschild, Aurelius Omlin, Richard Cathomas
Summary: This study investigates the use of BCG and PD-1/PD-L1 inhibitors in combination with cisplatin-based chemotherapy for muscle invasive bladder cancer. It is an open-label single-arm phase II trial for resectable MIBC patients. The aim is to achieve higher intravesical responses and better disease control through a new immuno-immuno-chemotherapy induction therapy.
Article
Surgery
L. N. Spaans, M. G. W. Dijkgraaf, P. Meijer, J. Mourisse, R. A. Bouwman, A. F. T. M. Verhagen, F. J. C. van den Broek
Summary: This multi-center randomized study aims to compare the efficacy of continuous paravertebral block (PVB), single-shot intercostal nerve block (ICNB), and thoracic epidural analgesia (TEA) in pain management and recovery quality in patients undergoing video-assisted thoracoscopic surgery (VATS) for lung resection. The results of this trial will have an impact on international guidelines for perioperative care after VATS and may help determine the most cost-effective pain management strategy.
Article
Health Care Sciences & Services
Kevin Gallagher, Nikita Bhatt, Keiran Clement, Eleanor Zimmermann, Sinan Khadhouri, Steven MacLennan, Meghana Kulkarni, Fortis Gaba, Thineskrishna Anbarasan, Aqua Asif, Alexander Light, Alexander Ng, Vinson Chan, Arjun Nathan, David Cooper, Lorna Aucott, Gautier Marcq, Jeremy Yuen -Chun Teoh, Patrick Hensley, Eilidh Duncan, Beatriz Goulao, Tim O'Brien, Matthew Nielsen, Paramananthan Mariappan, Veeru Kasivisvanathan
Summary: This study aims to improve the quality of bladder cancer surgery and reduce cancer recurrence rates through a web-based feedback intervention. The study is funded and is projected to complete data collection in June 2023.
JMIR RESEARCH PROTOCOLS
(2023)
