Article
Oncology
Maja Niksic, Daniel Redondo-Sanchez, Yoe-Ling Chang, Miguel Rodriguez-Barranco, Jose Exposito-Hernandez, Rafael Marcos-Gragera, Ester Oliva-Poch, Joaquim Bosch-Barrera, Maria-Jose Sanchez, Miguel Angel Luque-Fernandez
Summary: This study in Spain aimed to investigate the prevalence and patterns of comorbidity and multimorbidity among lung cancer patients, as well as their association with short-term mortality risk. The presence of comorbid diseases, rather than the number of comorbidities, was found to be significantly associated with an increased risk of short-term lung cancer mortality. Developing targeted preventive interventions and personalized clinical guidelines may be necessary to address the needs of lung cancer patients with comorbidities in Spain.
Article
Clinical Neurology
Marius Klovgaard, Thomas Hadberg Lynge, Ioannis Tsiropoulos, Peter Vilhelm Uldall, Jytte Banner, Bo Gregers Winkel, Philippe Ryvlin, Jacob Tfelt-Hansen, Anne Sabers
Summary: This study, conducted in Denmark, investigates epilepsy-related mortality and overall mortality in individuals with epilepsy. The results indicate that premature death in individuals with epilepsy is primarily related to epilepsy itself, and many of these deaths could be prevented through seizure control.
Article
Public, Environmental & Occupational Health
Pia Kjaer Kristensen, Thomas Johannesson Hjelholt, Morten Madsen, Alma B. Pedersen
Summary: This study investigated the comorbidity status of hip fracture patients in Denmark and its impact on prognosis. Over 50% of the patients had moderate to severe comorbidity. Different comorbidity indices produced different results, but showed comparable associations with mortality. These results are important for clinicians to improve prevention and treatment, and for researchers to determine the appropriate comorbidity measure to use.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Urology & Nephrology
Michael K. Sullivan, Bhautesh Dinesh Jani, Jennifer S. Lees, Claire E. Welsh, Alex McConnachie, Bethany Stanley, Paul Welsh, Barbara Nicholl, Donald M. Lyall, Juan-Jesus Carrero, Dorothea Nitsch, Naveed Sattar, Frances S. Mair, Patrick B. Mark
Summary: The study found that multimorbidity, especially cardiometabolic multimorbidity, is a risk factor for major adverse kidney events. Future research should focus on high-risk groups based on the number and type of long-term conditions they have.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Rachel Bedenis Forster, Camilla Kjellstadli, Tor Age Myklebust, Grace Egeland, Gerhard Sulo, Tone Bjorge, Kaare Harald Bonaa, Petur Benedikt Juliusson, Rune Kvale
Summary: This study examined the use of invasive treatment and mortality after acute myocardial infarction (AMI) in prostate cancer (PCa) patients. The results showed that except for patients with metastatic PCa experiencing an ST-segment elevation AMI, the rates of invasive treatment and 30-day mortality were similar between PCa patients and the general AMI population.
Article
Urology & Nephrology
Felix Couture, Sarah Hadj-Mimoune, Stephane Michael, Teodora Boblea Podasca, Maxime Noel-Lamy, Patrick O. Richard
Summary: This study aimed to evaluate the impact of the 2019 Bosniak classification on the diagnosis of Bosniak IIF renal cysts and determine their clinical outcomes. The study found that over 20% of cases had an initial overdiagnosis issue in the diagnosis of Bosniak IIF cysts. Upgrading and malignancy rates among Bosniak IIF cysts were markedly lower than previously reported, and no malignant progression was observed after 36 months.
JOURNAL OF UROLOGY
(2023)
Article
Oncology
Sonia Simonetti, Michele Iuliani, Marco Stellato, Silvia Cavaliere, Bruno Vincenzi, Giuseppe Tonini, Daniele Santini, Francesco Pantano
Summary: This study identified RANKL as a potential biomarker associated with treatment response and survival in patients with mRCC treated with nivolumab, through large-scale plasma proteomic profiling.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Line Flytkjaer Virgilsen, Alina Zalounina Falborg, Peter Vedsted, Anders Prior, Anette Fischer Pedersen, Henry Jensen
Summary: Unplanned presentation of cancer is more frequent in patients with psychiatric disorders compared to those without. Understanding the risk factors for unplanned presentation can aid in targeting interventions for early cancer diagnosis in patients with psychiatric disorders.
CANCER EPIDEMIOLOGY
(2022)
Article
Oncology
Toni K. Choueiri, Harriet Kluger, Saby George, Scott S. Tykodi, Timothy M. Kuzel, Ruth Perets, Suresh Nair, Giuseppe Procopio, Michael A. Carducci, Vincent Castonguay, Edmund Folefac, Chung-Han Lee, Sebastien J. Hotte, Wilson H. Miller, Shruti Shally Saggi, Chung-Wei Lee, Heshani Desilva, Prabhu Bhagavatheeswaran, Robert J. Motzer, Bernard Escudier
Summary: This study evaluates the efficacy and safety of nivolumab plus ipilimumab therapy in patients with advanced renal cell carcinoma who progressed on or after first-line immuno-oncology (IO) therapy. The results show that nivolumab plus ipilimumab treatment may provide durable clinical benefits for patients previously treated with IO therapy, with manageable safety.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Jiehui Zhong, Zezhen Liu, Chao Cai, Xiaolu Duan, Tuo Deng, Guohua Zeng
Summary: This study revealed the correlation between m(6)A modification and the tumor immune landscape in ccRCC patients. The m6Ascore was established to quantify the m(6)A modification pattern and was confirmed to be an independent prognostic factor for ccRCC. The findings provide a new approach for immunotherapeutic strategies in ccRCC patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Urology & Nephrology
Nihal E. Mohamed, Emma K. T. Benn, Varuna Astha, Kennedy E. Okhawere, Talia G. Korn, William Nkemdirim, Ami Rambhia, Olajumoke A. Ige, Hassan Funchess, Meredith Mihalopoulos, Kirolos N. Meilika, Natasha Kyprianou, Ketan K. Badani
Summary: This study evaluated the mortality risk of CKD patients infected with COVID-19 and found that CKD was a significant independent predictor of mortality, along with older age, male gender, and hypertension. The mortality rate for COVID-19 was significantly higher in CKD patients.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
James Lucocq, Sanjay Pillai, Richard Oparka, Ghulam Nabi
Summary: This study confirmed a good degree of agreement between radiologists in classifying complex renal masses using the Bosniak classification, with low progression rates of Bosniak IIF cysts but high malignancy rates of surgically resected cysts. Benign cysts were frequently resected, and the majority of histopathologically confirmed cancers in complex renal cysts were of low grade and stage.
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Patrick Bidulka, Soren Viborg Vestergaard, Admire Hlupeni, Anders Kjaersgaard, Angel Y. S. Wong, Sinead M. Langan, Sigrun Alba Johannesdottir Schmidt, Susan Lyon, Christian Fynbo Christiansen, Dorothea Nitsch
Summary: Partner bereavement is associated with an increased rate of cardiovascular disease and acute kidney injury hospitalization, as well as death in individuals with reduced kidney function. Providing additional supportive care may help prevent serious adverse events in this high-risk population.
Article
Public, Environmental & Occupational Health
Sisse Helle Njor, Bo oborg, Mette Tranberg, Matejka Rebolj
Summary: Women in Denmark are invited to participate in breast, cervical, and colorectal cancer screening in their fifties and sixties. However, despite high participation rates, only a small proportion of women undergo screening for all three cancers, with many remaining unscreened for certain cancers. The heterogeneity of cancer-specific patterns suggests a need for a reevaluation of current screening practices.
PREVENTIVE MEDICINE
(2023)
Article
Oncology
Cimarron E. Sharon, Michael Wang, Gabriella N. Tortorello, Nikhita J. Perry, Kevin L. Ma, Julia C. Tchou, Oluwadamilola M. Fayanju, Najjia N. Mahmoud, John T. Miura, Giorgos C. Karakousis
Summary: Patients with multiple comorbidities are more likely to be diagnosed with early-stage colon cancer but late-stage breast cancer. This finding may reflect differences in practice patterns for routine screening in these patients. Providers should continue guideline directed screenings to detect cancers at an earlier stage and optimize outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Andrology
Katrine H. Lund, Anne Sofie D. Laursen, Therese K. Gronborg, Gunnar Toft, Bjarke H. Jacobsen, Tanran R. Wang, Amelia K. Wesselink, Elizabeth E. Hatch, Greg J. Sommer, Michael L. Eisenberg, Kenneth J. Rothman, Henrik T. Sorensen, Lauren A. Wise, Ellen M. Mikkelsen
Summary: This study aimed to examine the association between perceived stress and semen quality. The analysis of data from 644 men revealed that perceived stress was not materially associated with semen volume, sperm concentration, or total sperm count.
Article
Cardiac & Cardiovascular Systems
Martin Bodtker Mortensen, Omar Dzaye, Hans Erik Botker, Jesper Moller Jensen, Michael Maeng, Jacob Fog Bentzon, Helle Kanstrup, Henrik Toft Sorensen, Jonathon Leipsic, Ron Blankstein, Khurram Nasir, Michael J. Blaha, Bjarne Linde Norgaard
Summary: Low-density lipoprotein cholesterol (LDL-C) is associated with atherosclerotic cardiovascular disease (ASCVD), but its association with ASCVD risk is modified by the presence of coronary artery calcification (CAC). This study found that LDL-C is only associated with ASCVD events in patients with CAC, and not in those without CAC. This information is valuable for individualized risk assessment among middle-aged people with or without coronary atherosclerosis.
Article
Public, Environmental & Occupational Health
Soren Viborg Vestergaard, Henrik Birn, Simon Kok Jensen, Henrik Toft Sorensen, Dorothea Nitsch, Christian Fynbo Christiansen
Summary: This study aimed to investigate the incidence, histopathology, and mortality of adult nephrotic syndrome over a 24-year period. The study found a slight increase in the incidence of adult nephrotic syndrome and a significant decrease in mortality. These findings may reflect changes in epidemiology or awareness and coding of nephrotic syndrome.
Article
Psychiatry
Meghan L. Smith, Vijaya Seegulam, Peter Szentkuti, Erzsebet Horvath-Puho, Sandro Galea, Timothy L. Lash, Anthony J. Rosellini, Paula P. Schnurr, Henrik Toft Sorensen, Jaimie L. Gradus
Summary: This study examined the differences in posttraumatic psychopathology between immigrants and native-born persons in Denmark. The findings suggest that immigrants are at a higher risk of developing posttraumatic stress disorder (PTSD) following non-interpersonal trauma, possibly due to adverse experiences during migration.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Education & Educational Research
Kala M. Mehta, Karin Lottrup Petersen, Steve Goodman, Henrik Toft Sorensen, Martin Bogsted, Jeppe Dorup Olesen, Sylvia Burks, Richard E. Shaw, Jens Dahlgaard Hove, Jakob Ousager, Carlos Milla, Vibeke Andersen, Niels Ejskjaer, Vibeke Brix-Christensen, Shomit Ghose, Andreas Kjaer, Peter V. Chin-Hong
Summary: The Danish-American Research Exchange (DARE) program provides Danish medical students with the opportunity to collaborate and conduct biomedical research with US medical institutions. This program enhances students' research skills and interdisciplinary thinking, and encourages exploration of low-cost healthcare interventions. Analysis of the research outcomes and intentions of DARE alumni suggests that this medical student-initiated research model has positive effects on promoting binational collaboration in medicine.
BMC MEDICAL EDUCATION
(2023)
Article
Gastroenterology & Hepatology
Frederikke Schonfeldt Troelsen, Henrik Toft Sorensen, Lars Pedersen, Lone Dragnes Brix, Louise Bang Grode, Evelien Dekker, Rune Erichsen
Summary: This study investigated the plausible explanations for post-colonoscopy colorectal cancer (PCCRC) in a Danish Region using the World Endoscopy Organization algorithm, finding that most PCCRCs originate from possible missed lesions and incompletely resected lesions. These findings underscore the importance of quality assurance of colonoscopy procedures and polypectomy techniques.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ola Olen, Karin E. Smedby, Rune Erichsen, Lars Pedersen, Jonas Halfvarson, Asa Hallqvist-Everhov, Johan SWIBREG Study Grp, Johan Askling, Anders Ekbom, Michael C. Sachs, Henrik Toft Sorensen, Jonas F. Ludvigsson
Summary: Earlier studies on lymphoma risk in patients with inflammatory bowel disease (IBD) have provided varying estimates, but have been limited by detection biases, misclassification, and small sample sizes. Our binational cohort study found that the risk of lymphoma has increased in Crohn's disease (CD) patients over the past 20 years, but not in ulcerative colitis (UC) patients. The increase in risk was mainly driven by T-cell lymphomas and aggressive B-cell lymphomas.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
N. R. Gadgaard, C. Varnum, R. G. H. H. Nelissen, C. Vandenbroucke-Grauls, H. T. Sorensen, A. B. Pedersen
Summary: The impact of comorbidity on infection risk among hip fracture patients is not clear, but a high incidence of infection was found. Comorbidity was identified as an important risk factor for infection up to 1 year after surgery. The results indicate a need for increased investment and support for patients with high comorbidity in pre- and postoperative programs.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Morten Schmidt, Lars Arendt-Nielsen, Ellen-Margrethe Hauge, Henrik Toft Sorensen, Lars Pedersen
Summary: This study investigated the dose dependency of diclofenac's cardiovascular risks by using Danish health registries and a target trial emulation design. The results showed that both high-dose and low-dose diclofenac users had a similar increased risk of cardiovascular events compared to non-users. This finding challenges the assumption that low-dose diclofenac is risk-neutral.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Psychology, Clinical
Gabriella Broms, Sonia Hernandez-Diaz, Krista F. Huybrechts, Brian T. Bateman, Eskild Bendix Kristiansen, Kristjana Einarsdottir, Anders Engeland, Kari Furu, Mika Gissler, Par Karlsson, Kari Klungsoyr, Anna-Maria Lahesmaa-Korpinen, Helen Mogun, Mette Norgaard, Johan Reutfors, Henrik Toft Sorensen, Helga Zoega, Helle Kieler
Summary: This study examined the safety of atomoxetine, an alternative treatment for attention-deficit/hyperactivity disorder (ADHD), during pregnancy. The results showed that there was no increased risk of major congenital malformations overall, as well as no statistically significant increased risk of cardiac and limb malformations.
JOURNAL OF CLINICAL PSYCHIATRY
(2023)
Article
Hematology
Maria A. de Winter, Alicia Uijl, Harry R. Buller, Marc Carrier, Alexander T. Cohen, John-Bjarne Hansen, Karin H. A. H. Kaasjager, Ajay K. Kakkar, Saskia Middeldorp, Gary E. Raskob, Henrik Toft Sorensen, Philip S. Wells, Mathilde Nijkeuter, Jannick A. N. Dorresteijn
Summary: By categorizing VTE patients without cancer, 5 distinct clinical subtypes were identified, which were associated with anticoagulant treatment and clinical outcomes. This suggests that the heterogeneity of VTE cases extends beyond the distinction between provoked and unprovoked VTE.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Correction
Public, Environmental & Occupational Health
Dagrun Slettebo Daltveit, Kari Klungsoyr, Anders Engeland, Anders Ekbom, Mika Gissler, Ingrid Glimelius, Tom Grotmol, Laura Madanat-Harjuoja, Anne Gulbech Ording, Henrik Toft Sorensen, Rebecca Troisi, Tone Bjorge
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Pediatrics
Sidse Hoyer, Uffe Heide-Jorgensen, Simon Kok Jensen, Mette Norgaard, Cara Slagle, Stuart Goldstein, Christian Fynbo Christiansen
Summary: This study aimed to examine the annual rate of acute kidney injury (AKI) and associated changes in patient characteristics among Danish children. The study found that the rate of AKI among Danish children remained stable from 2007 to 2021, with little variation in patient characteristics over time.
PEDIATRIC NEPHROLOGY
(2023)
Article
Oncology
Jazmine Abril, Britton Trabert, Rebecca Troisi, Tom Grotmol, Anders Ekbom, Anders Engeland, Mika Gissler, Ingrid Glimelius, Laura Madanat-Harjuoja, Anne Gulbech Ording, Henrik Toft Sorensen, Steinar Tretli, Tone Bjorge
Summary: This study examines the risk factors for uterine sarcoma and compares them with MMMTs and type I endometrial carcinomas. The results show that risk factors vary substantially between uterine sarcoma and MMMTs.
CANCER CAUSES & CONTROL
(2023)
Article
Oncology
Philip Vestergaard Munch, Mette Norgaard, Uffe Heide-Jorgensen, Simon Kok Jensen, Henrik Birn, Christian Fynbo Christiansen
Summary: This study found that the use of proton pump inhibitors (PPIs) is associated with an increased risk of acute kidney injury (AKI) in cancer patients receiving immune checkpoint inhibitors (ICIs). However, this association becomes less significant when accounting for confounding factors.
INTERNATIONAL JOURNAL OF CANCER
(2023)
