Article
Engineering, Biomedical
Sourav Chandra, Nina L. Suresh, Babak Afsharipour, William Zev Rymer, Ales Holobar
Summary: In this study, the effect of botulinum toxin (BT) injection on the motor units (MUs) in spastic muscles was investigated. It was found that two weeks after the injection, there was a significant increase in MU action potential (MUAP) amplitudes and a decrease in MU territory areas (MUTAs). These findings provide valuable insights into the changes in MU characteristics induced by BT and have the potential to improve the treatment of spasticity.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Chemistry, Organic
Curt Wentrup, M. Saeed Mirzaei, David Kvaskoff, Avat Arman Taherpour
Summary: This article discusses the experimental research and theoretical calculations of Dimroth rearrangement, determining the preferred pathways and mechanisms for rearrangement in different heterocyclic compounds, providing important data support for further studies.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Clinical Neurology
Qian Ma, Hao Ran, Changyi Ou, Xiaoxi Liu, Yaru Lu, Huan Huang, Wenhao Yang, Lu Yu, Pei Chen, Xin Huang, Li Qiu, Zhongqiang Lin, Zhidong Huang, Weibin Liu
Summary: Based on clinical data and literature review, it was found that under proper management, patients with myasthenia gravis (MG) can safely and successfully use botulinum toxin (BTX) for comorbidities.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Article
Dermatology
Didem Mullaaziz, Asli Kaptanoglu
Summary: Headache can occur after botulinum toxin injections for cosmetic purposes, but usually resolves spontaneously within the first 3 days without the need for painkillers. Patients with hypertension and patients treated for bunny lines are more likely to develop headache complaints after the procedure.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Oneda Leka, Yufan Wu, Xiaodan Li, Richard A. Kammerer
Summary: Botulinum neurotoxins (BoNTs) are widely used therapeutic proteins, with different subtypes showing distinct catalytic properties and substrate specificities. Among them, BoNT/A3 has a shorter duration of action compared to other BoNT/A subtypes, potentially due to its lower stability. Understanding these differences could be valuable in developing next-generation therapeutic toxins.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Food Science & Technology
Masahiro Nagahama, Keiko Kobayashi, Sadayuki Ochi, Masaya Takehara
Summary: Clostridium botulinum C2 toxin requires lysosomal enzyme cathepsin B (CTSB) for effective cellular entry, with cysteine protease and aspartyl protease having different effects on cell rounding and extracellular ASMase activity induced by C2 toxin.
Review
Food Science & Technology
Matteo Val, Robert Delcanho, Marco Ferrari, Luca Guarda Nardini, Daniele Manfredini
Summary: This paper provides a systematic review of the clinical use of botulinum toxin (BTX) for orofacial neuropathic pain disorders. The review of 6 randomized clinical trials suggests that BTX injections can effectively reduce pain levels and improve the quality of life for patients. However, further improvement in study protocols is needed to guide clinical application.
Article
Food Science & Technology
Jinfang Jia, Maria Braune-Yan, Stefanie Lietz, Mary Wahba, Arto T. Pulliainen, Holger Barth, Katharina Ernst
Summary: Bordetella pertussis toxin (PT) and Clostridium botulinum C2 toxin are ADP-ribosylating toxins that require cellular chaperones Hsp90 and Hsp70, cyclophilins, and FK506-binding proteins for translocation. Inhibition of chaperone activities can protect cells from PT and C2 intoxication. Domperidone, a dopamine receptor antagonist, was found to inhibit Hsp70 activity and protect cells from intoxication. Domperidone inhibits enzyme subunit translocation and reduces toxin uptake, making it a potential therapeutic agent for diseases caused by bacterial toxins that require Hsp70.
Article
Food Science & Technology
Nicola Tambasco, Marta Filidei, Pasquale Nigro, Lucilla Parnetti, Simone Simoni
Summary: Botulinum Toxin (BoNT) is the preferred treatment for Hemifacial spasm (HFS) due to its high efficacy and safety profile. However, there are challenges in comparing results due to differences in dosage, injected muscles, treatment intervals, and rating scales among different studies. Further research is needed to investigate factors that influence treatment outcomes, including optimal timing, injection techniques, dosage, and formulation selection criteria.
Article
Clinical Neurology
David E. Horvat, Justin M. Shields, William W. C. Young, Philip G. Eye
Summary: This study aimed to describe the safety and efficacy of onabotulinum toxin A and incobotulinum toxin A for adolescent chronic migraine headache. The results showed that adolescents experienced an average decrease of 13.1 headache days per month and 69% of them had a 50% reduction in headache days by the time of first follow-up. Overall, these treatment methods demonstrated better efficacy in adolescent chronic migraine patients, with only a few patients experiencing some side effects.
PEDIATRIC NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Tae-Hyeon Cho, Ju-Eun Hong, Hun-Mu Yang
Summary: In this study, the dominant fibers within each compartment of the subscapularis muscle were determined using immunohistochemistry with fresh cadavers. The results showed distinct fascia demarcating the superior and inferior compartments of the muscle. The innervation of the muscle by the upper and lower subscapular nerves was also observed, and the densities of type I and type II fibers were found to differ between the compartments.
SCIENTIFIC REPORTS
(2023)
Article
Otorhinolaryngology
Maria Raffaella Marchese, Francesco Bussu, Stefano Settimi, Emanuele Scarano, Giovanni Almadori, Jacopo Galli
Summary: This study investigated the prevalence and severity of typical and atypical symptoms of Frey syndrome, as well as the effects of BoNT-A therapy. The results showed that before therapy, patients commonly experienced gustatory sweating, paresthesia, gustatory flushing, pain, and gustatory itch. However, after BoNT-A injection, these symptoms improved significantly.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Food Science & Technology
Yan Tereshko, Enrico Belgrado, Christian Lettieri, Gian Luigi Gigli, Mariarosaria Valente
Summary: This study described the treatment effect of botulinum toxin type A in patients with auriculotemporal neuralgia. Both the Penn facial pain scale and NRS scores significantly improved at one month after treatment, with no adverse effects reported.
Article
Multidisciplinary Sciences
Junsoo Park, Maxwell Dylla, Yi Xia, Max Wood, G. Jeffrey Snyder, Anubhav Jain
Summary: Band convergence is a strategy to enhance a material's thermoelectric performance, but the benefit can be negated by interband scattering depending on the manner in which bands converge.
NATURE COMMUNICATIONS
(2021)
Article
Food Science & Technology
Mariam Hull, Mered Pames, Joseph Jankovic
Summary: Opisthotonus is a condition characterized by abnormal trunk extension and arching due to excessive contractions of the paraspinal muscles. It is most commonly seen in children with dystonia secondary to hypoxic injury or other acquired and genetic causes. Treatment options include oral medications, muscle injections, and deep brain stimulation, although management in the pediatric population has not been systematically reviewed.
Correction
Urology & Nephrology
Christopher R. Chapple, Emma Mironska, Adrian Wagg, Ian Milsom, David Castro Diaz, Heinz Koelbl, Dmitry Pushkar, Andrea Tubaro, Dirk De Ridder, Emmanuel Chartier-Kastler, Lawrence D. Phillips
EUROPEAN UROLOGY FOCUS
(2022)
Article
Urology & Nephrology
Sarah Shafaat, Naside Mangir, Christopher Chapple, Sheila MacNeil, Vanessa Hearnden
Summary: In this study, we have successfully developed an estradiol-responsive tissue-engineered vaginal model that closely mimics the structural and physiological properties of the native sheep vaginal tissue.
NEUROUROLOGY AND URODYNAMICS
(2022)
Article
Urology & Nephrology
Jan Willem Olivier van Till, Eri Arita, Kentaro Kuroishi, Richard Croy, Matthias Oelke, Gommert A. Koeveringe, Christopher R. Chapple, Osamu Yamaguchi, Paul Abrams
Summary: This study aimed to evaluate the safety and efficacy of ASP8302, a novel positive allosteric modulator for the muscarinic M3 receptor (M3-PAM), in patients with underactive bladder (UAB). Results showed improvement of symptoms and functional parameters in male patients, but no significant efficacy in the primary endpoint was observed.
NEUROUROLOGY AND URODYNAMICS
(2022)
Review
Urology & Nephrology
Karl H. Pang, Nadir I. Osman, Christopher R. Chapple, Ian Eardley
Summary: Anterior urethroplasty may affect erectile and ejaculatory function, and appropriate counseling should be provided to patients. Due to variations in questionnaires and cutoff scores, the impact of different urethroplasty techniques on sexual function is heterogeneous, with limited data from randomized controlled trials. Establishing consistency in questionnaires and cutoff scores is necessary for consistent reporting. Future research should aim to explore the best approaches for minimizing sexual dysfunction.
EUROPEAN UROLOGY FOCUS
(2022)
Review
Urology & Nephrology
Christopher R. Chapple, Nadir Osman
Summary: It is not possible to diagnose the cause of voiding difficulty based on medical history alone. Different urinary problems may have overlapping symptoms. To differentiate between underactive bladder and bladder outlet obstruction as the underlying cause of lower urinary tract symptoms, invasive urodynamic study of the bladder is often required.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Engineering, Biomedical
Fangzhou Cheng, Paul N. Watton, Giulia Pederzani, Masahiro Kurobe, Ei-ichiro Takaoka, Chris Chapple, Lori Birder, Naoki Yoshimura, Anne M. Robertson
Summary: We present a constrained mixture-micturition-growth (CMMG) model for simulating bladder mechanics, voiding function, and tissue adaptations. This model provides a mechanistic approach for investigating the bladder's structure-function relationship and its adaption in pathological conditions. It has the potential to be used as a tool for developing new treatments for bladder diseases.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Urology & Nephrology
Oluwaseun Akinjise-Ferdinand, Rachel Hubbard, Nadir Osman, Christopher R. Chapple
Summary: This study describes two cases of previous injections of Bulkamid referred for management of a presumed periurethral diverticulum based on MRI findings. We found that a limited noncontrast CT pelvis followed by a VCMG and repeat CT pelvis effectively differentiated between Bulkamid and these presumed periurethral diverticulae.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Obstetrics & Gynecology
Elizabeth R. R. Mueller, Jeffrey P. P. Weiss, J. L. H. Ruud Bosch, Bilal Chughtai, Matt T. T. Rosenberg, Elizabeth D. D. Bacci, Jason C. C. Simeone, Fredrik L. L. Andersson, Kristian Juul, Karin S. S. Coyne, Christopher R. R. Chapple
Summary: This study used data from a large US population-based, cross-sectional, epidemiological study to evaluate the symptoms and bother experienced by women with nocturnal polyuria (NP). The results showed that NP is prevalent in women with significant bother and is often associated with other urinary symptoms. Therefore, multifactorial causes and potential treatments of NP should be considered, particularly at a later age.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Review
Urology & Nephrology
Thomas F. Monaghan, Jeffrey P. Weiss, Alan J. Wein, Syed N. Rahman, Jason M. Lazar, Donald L. Bliwise, Karel Everaert, Gary E. Lemack, Jean-Nicolas Cornu, Marcus J. Drake, Christopher R. Chapple, Hashim Hashim, Jerry G. Blaivas, Roger R. Dmochowski
Summary: This article introduces a novel system, Sleep CALM, for organizing the complex differential diagnosis for nocturia, which includes sleep disorders, comorbidities, patient actions/lifestyle factors, lower urinary tract dysfunction, and medications. Nocturia and sleep disorders are closely intertwined and should not be used as grounds for exclusion from nocturia treatment, but rather leveraged to broaden therapeutic options. Nocturia may be a potential harbinger of serious medical conditions beyond the genitourinary tract, and urologists should have a low threshold for referral to improve health status.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Urology & Nephrology
Christopher R. R. Chapple, Matt T. T. Rosenberg, Elizabeth R. R. Mueller, Bilal Chughtai, Jeffrey P. P. Weiss, Kristian Juul, Anne B. B. Brooks, Elizabeth D. D. Bacci, Fredrik L. L. Andersson, Karin S. S. Coyne, J. L. H. Ruud Bosch
Summary: This large-scale epidemiologic study aimed to explore the impact of nocturnal polyuria (NP) on health-related quality of life (HRQoL). The study found that patients with frequent nocturia had greater burden on daily life, lower urinary tract symptoms bother, prostate symptoms (men only), work productivity, physical and mental health, depression, fatigue, and daytime sleepiness compared to those without nocturia. NP associated with other urologic or comorbid conditions had greater patient burden than idiopathic NP, especially for women.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Cell & Tissue Engineering
Sarah Shafaat, Sabiniano Roman Regueros, Christopher Chapple, Sheila MacNeil, Vanessa Hearnden
Summary: Childbirth can lead to common pelvic floor problems in postmenopausal women, necessitating reconstructive surgery. In this study, a tissue-engineered vaginal wound model was developed to investigate wound healing and the role of estradiol in pelvic tissue repair. The results showed that estradiol significantly improved wound healing and epithelial maturation, as well as promoted collagen reorganization and downregulated α-SMA expression. This model provides a valuable tool for studying vaginal wound healing and developing therapies for improved tissue healing after reconstructive pelvic floor surgery.
JOURNAL OF TISSUE ENGINEERING
(2023)
Review
Urology & Nephrology
Kunlin Yang, Karl H. Pang, Shubo Fan, Xinfei Li, Nadir I. Osman, Christopher R. Chapple, Liqun Zhou, Xuesong Li
Summary: Robotic ureteral reconstruction (RUR) has a success rate of over 90% in treating ureteral diseases and is associated with lower estimated blood loss and shorter length of stay compared to the open and laparoscopic approaches. However, more studies and evidence are needed to determine the superiority of RUR.
Article
Urology & Nephrology
Christopher Chapple, Paul Abrams, Thomas Lam, Altaf Mangera, Mohammed Belal, Carmel Curtis, Jacqueline Emkes, Sarah Hillery, Karen Irwin, Karen Logan, Polly Weston, Ann Yates
Summary: This article provides a multidisciplinary consensus view on clean intermittent self-catheterisation (CISC) as a method for emptying the bladder. It emphasizes the importance of considering each patient individually and the term Bladder Voiding Efficiency (BVE). It also discusses the potential benefits of CISC for patients with neurological disorders.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Urology & Nephrology
Roger Dmochowski, Christopher Chapple, Jennifer Gruenenfelder, Jun Yu, Anand Patel, Mariana Nelson, Eric Rovner
Summary: This study aimed to evaluate the safety of onabotulinumtoxinA treatment for adults with overactive bladder (OAB) and urinary incontinence (UI) and its effect on clean intermittent catheterization (CIC) initiation. The results showed that the incidence of CIC was low overall and less frequent for women. It was rare with PVRmax <= 200 ml and did not appear to correlate with baseline PVR.
EUROPEAN UROLOGY OPEN SCIENCE
(2023)
Meeting Abstract
Pharmacology & Pharmacy
V. Nitti, D. A. Ginsberg, A. Kohan, K. McCammond, B. Jenkins, I. Yushmanova, A. Boroujerdi, C. Chapple
