Article
Oncology
Debansu Sarkar, Pritesh Jain, Piyush Gupta, Dilip Kumar Pal
Summary: The study evaluated the detection rate of prostate cancer using digital rectal examination (DRE) and serum prostate-specific antigen (PSA) levels followed by standard 12-core transrectal ultrasound (TRUS)-guided prostate biopsy. Suspicious DRE findings were significantly associated with the detection of prostate cancer across all PSA levels. Patients with PSA levels below 4 could still have prostate malignancy, and these cases can be detected by DRE screening.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Article
Andrology
Yidie Ying, Wei He, Qiao Xiong, Ziwei Wang, Maoyu Wang, Qing Chen, Meimian Hua, Shuxiong Zeng, Chuanliang Xu
Summary: Digital rectal examination (DRE) can be used as an adjunctive method in the detection of prostate cancer (PCa), helping physicians determine the necessity of biopsy and provide preliminary information about tumor location and invasiveness.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2023)
Article
Oncology
Danielle S. Bitterman, Ming-Hui Chen, Jing Wu, Andrew A. Renshaw, Marian Loffredo, Philip W. Kantoff, Eric J. Small, Anthony V. D'Amico
Summary: This study found that low testosterone level at PSA failure in high-risk patients with PC treated with RT is associated with increased PCSM and ACM risk, and that higher PSAn is also associated with worse PCSM and ACM risk, especially in men with normal testosterone levels at PSA failure.
Article
Urology & Nephrology
Joel Andersson, Thorgerdur Palsdottir, Anna Lantz, Markus Aly, Henrik Gronberg, Lars Egevad, Martin Eklund, Tobias Nordstrom
Summary: The study found that for men with PSA >= 3 ng/ml, a suspicious DRE indicates a more than threefold higher risk of significant prostate cancer. DRE as a variable adds significant precision to the Stockholm3 prediction model.
EUROPEAN UROLOGY OPEN SCIENCE
(2022)
Article
Biochemical Research Methods
Yuefan Wang, Tung-Shing Mamie Lih, Naseruddin Hoeti, Lori J. Sokoll, Gregory Chesnut, Gyorgy Petrovics, Indu Kohaar, Hui Zhang
Summary: The glycoprotein profiles differ between pre- and post-DRE urine specimens. Previously identified AG-PCa-associated glycoproteins were observed in pre-DRE urine specimens, and three new potential AG-PCa-associated glycoproteins were identified. These findings can be further validated in a large cohort of pre-DRE urine specimens for detecting clinically significant PCa.
Article
Public, Environmental & Occupational Health
Chengcheng Wei, Yumao Chen, Yu Yang, Dong Ni, Yu Huang, Miao Wang, Xiong Yang, Zhaohui Chen
Summary: This study revealed the association between VOCs and prostate-specific antigen (PSA), indicating the potential impact of long-term environmental exposure on the prostate.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Oncology
Juan Morote, Natalia Picola, Nahuel Paesano, Anna Celma, Jesus Munoz-Rodriguez, Ignacio Asiain, Xavier Ruiz-Plazas, Marta Munoz-Rivreo, Gemma Garcia de Manuel, Pol Servian, Jose M. Abascal
Summary: The European Association of Urology recommends the use of risk-organized models to decrease unnecessary prostate biopsies and prebiopsy MRI in men with suspected prostate cancer. Low evidence suggests that men with PSA >10 ng/ml and an abnormal DRE do not benefit from prebiopsy MRI and targeted biopsies. A study analyzed a subset of men meeting these criteria and found that performing only random biopsies would result in a small percentage of clinically significant prostate cancer going undetected.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Chemistry, Analytical
Yanbo Wang, Mingyang Wang, Haipeng Yu, Ge Wang, Pengxin Ma, Shuang Pang, Yiming Jiao, Aihua Liu
Summary: PSA is an important index for prostate cancer diagnosis and treatment. In this study, a biopanning method for PSA was established using a pIII phage display library. Two phage monoclonal antibodies specific to PSA were obtained, and an ELISA system was constructed for detecting tPSA with high accuracy.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biochemistry & Molecular Biology
Youngjun Boo, Jae Hoon Chung, Minyong Kang, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Wan Song
Summary: As the incidence of prostate cancer has increased, there is controversy surrounding the use of prostate-specific antigen (PSA) for screening due to its low specificity. In this study, we compared the diagnostic performance of prostate health index (PHI) density (PHID) with PSA, PSA density (PSAD), and PHI as a triaging test for the detection of prostate cancer and clinically significant prostate cancer (csPCa). The results showed that PHID had the highest area under the curve (AUC) for both prostate cancer and csPCa detection, followed by PHI, PSAD, and PSA. Using PHID as a triaging test could significantly reduce unnecessary biopsies for prostate cancer. The findings suggest that PHID can be utilized in a clinical setting to assess the risk of prostate cancer and csPCa.
Article
Urology & Nephrology
Taewon Hwang, Hyungseok Oh, Jung Ah Lee, Eo Jin Kim
Summary: This study aimed to construct and evaluate a 5-year risk prediction model for prostate cancer (PCa) using PSA levels and individual risk factors. The model included various factors such as age, smoking status, alcohol consumption, family history of PCa, dyslipidemia, cholesterol levels, and PSA level. The model showed good discrimination ability and calibration.
Article
Public, Environmental & Occupational Health
Kailiang Xu, Youji Yan, Cong Cheng, Shiqin Li, Yixiang Liao, Jinmin Zeng, Zhongjun Chen, Jiajie Zhou
Summary: According to the secondary data analysis of the National Health and Nutrition Examination Survey (NHANES) (2003-2010), serum albumin is not associated with prostate-specific antigen (PSA) levels in populations without prostate cancer. However, a non-linear relationship was found between serum albumin and PSA, with a negative association when serum albumin levels exceed 41 g.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Chemistry, Analytical
Zhaokui Zeng, Jingjing Tian, Zixuan Ren, Ying Yang, Qian Gong, Ruowei Sun, Xun Zhang, Wenfang Liu, Chuanpin Chen
Summary: This study presents an integrated microfluidic chip for immunodetection of PSA. The chip utilizes the three-dimensional structure of quartz capillaries to achieve high-throughput parallel detection. It combines the advantages of microfluidic droplet technology, resulting in a highly sensitive PSA detection capability.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Nutrition & Dietetics
Chengcheng Wei, Liang Tian, Bo Jia, Miao Wang, Ming Xiong, Bo Hu, Changqi Deng, Yaxin Hou, Teng Hou, Xiong Yang, Zhaohui Chen
Summary: This study investigates the correlation between serum triglycerides and prostate-specific antigen (PSA) levels using the U.S. National Health and Nutrition Examination Survey (NHANES) database. The results show an independent and negative correlation between serum triglycerides and PSA levels among American males. This correlation may contribute to difficulties in detecting asymptomatic prostate cancer and diagnosing it at advanced stages due to detection bias.
Article
Oncology
Takashi Soyano, Atsunori Yorozu, Nana Natsume, Takashi Hanada, Yutaka Shiraishi, Kazuhito Toya, Shiro Saito
Summary: The study aimed to identify the time to achieve a PSA nadir of <= 0.2 ng/mL and related factors in Japanese prostate cancer patients undergoing I-125 brachytherapy. The median time to achieve the PSA nadir was 44.0 months, with some patients requiring a longer period.
Article
Oncology
Kamaleddin Hassanzadeh, Hoora Hassanzadeh, Hanieh Salehi-Pourmehr
Summary: The study found that 36% of patients had similar pathology after surgery compared to before (Gleason score 3 + 3 = 6), while 64% had inconsistent pathology. Low prostate volume was associated with higher Gleason scores after surgery, and there was a significant relationship between PSA density above 15% and higher Gleason scores after surgery.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Roshan A. Karunamuni, Minh-Phuong Huynh-Le, Chun C. Fan, Wesley Thompson, Asona Lui, Maria Elena Martinez, Brent S. Rose, Brandon Mahal, Rosalind A. Eeles, Zsofia Kote-Jarai, Kenneth Muir, Artitaya Lophatananon, Catherine M. Tangen, Phyllis J. Goodman, Ian M. Thompson, William J. Blot, Wei Zheng, Adam S. Kibel, Bettina F. Drake, Olivier Cussenot, Geraldine Cancel-Tassin, Florence Menegaux, Therese Truong, Jong Y. Park, Hui-Yi Lin, Jack A. Taylor, Jeannette T. Bensen, James L. Mohler, Elizabeth T. H. Fontham, Luc Multigner, Pascal Blanchet, Laurent Brureau, Marc Romana, Robin J. Leach, Esther M. John, Jay H. Fowke, William S. Bush, Melinda C. Aldrich, Dana C. Crawford, Jennifer Cullen, Gyorgy Petrovics, Marie-Elise Parent, Jennifer J. Hu, Maureen Sanderson, Ian G. Mills, Ole A. Andreassen, Anders M. Dale, Tyler M. Seibert
Summary: This study used principal component analysis to uncover subpopulations of men with African ancestry for whom the utility of PHS46+African may differ. The results revealed that PHS46+African may be up to 7 times more beneficial to some African men than others. Further research is needed to improve the clinical utility of polygenic risk scores for men of African ancestry.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Oncology
Chethan Ramamurthy, Eric W. Stutz, Martin Goros, Jonathan Gelfond, Teresa L. Johnson-Pais, Ian M. Thompson, Robin J. Leach, Michael A. Liss
Summary: We investigated germline genetic mutations for prostate cancer in Hispanic men and found a significant rate of mutations in hereditary cancer genes among those with a personal or family history of prostate cancer.
CLINICAL GENITOURINARY CANCER
(2022)
Article
Oncology
Cindy H. Chau, Cathee Till, Douglas K. Price, Phyllis J. Goodman, Marian L. Neuhouser, Michael N. Pollak, Ian M. Thompson, William D. Figg
Summary: The molecular mechanisms linking obesity to prostate cancer involve steroid hormone and insulin/insulin-like growth factor 1 (IGF1) pathways. This study investigated the associations between circulating serum markers (e.g. androgens and IGFs/IGFBPs) and body mass index (BMI), as well as their role in modifying the association between obesity and prostate cancer risk. The results showed that there were significant associations between BMI and serum steroids and IGFs/IGFBPs, and the IGF1 axis played a significant role in the association between obesity and low- and high-grade prostate cancer.
ENDOCRINE-RELATED CANCER
(2022)
Article
Urology & Nephrology
Burcu F. Darst, Raymond Hughley, Aaron Pfennig, Ujani Hazra, Caoqi Fan, Peggy Wan, Xin Sheng, Lucy Xia, Caroline Andrews, Fei Chen, Sonja Berndt, Zsofia Kote-Jarai, Koveela Govindasami, Jeannette T. Bensen, Sue A. Ingles, Benjamin A. Rybicki, Barbara Nemesure, Esther M. John, Jay H. Fowke, Chad D. Huff, Sara S. Strom, William B. Isaacs, Jong Y. Park, Wei Zheng, Elaine A. Ostrander, Patrick C. Walsh, John Carpten, Thomas A. Sellers, Kosj Yamoah, Adam B. Murphy, Maureen Sanderson, Dana C. Crawford, Susan M. Gapstur, William S. Bush, Melinda C. Aldrich, Olivier Cussenot, Gyorgy Petrovics, Jennifer Cullen, Christine Neslund-Dudas, Rick A. Kittles, Jianfeng Xu, Mariana C. Stern, Anand P. Chokkalingam, Luc Multigner, Marie-Elise Parent, Florence Menegaux, Geraldine Cancel-Tassin, Adam S. Kibel, Eric A. Klein, Phyllis J. Goodman, Janet L. Stanford, Bettina F. Drake, Jennifer J. Hu, Peter E. Clark, Pascal Blanchet, Graham Casey, Anselm J. M. Hennis, Alexander Lubwama, Ian M. Thompson, Robin J. Leach, Susan M. Gundell, Loreall Pooler, James L. Mohler, Elizabeth T. H. Fontham, Gary J. Smith, Jack A. Taylor, Laurent Brureau, William J. Blot, Richard Biritwum, Evelyn Tay, Ann Truelove, Shelley Niwa, Yao Tettey, Rohit Varma, Roberta McKean-Cowdin, Mina Torres, Mohamed Jalloh, Serigne Magueye Gueye, Lamine Niang, Olufemi Ogunbiyi, Michael Oladimeji Idowu, Olufemi Popoola, Akindele O. Adebiyi, Oseremen Aisuodionoe-Shadrach, Maxwell Nwegbu, Ben Adusei, Sunny Mante, Afua Darkwa-Abrahams, Edward D. Yeboah, James E. Mensah, Andrew Anthony Adjei, Halimatou Diop, Michael B. Cook, Stephen J. Chanock, Stephen Watya, Rosalind A. Eeles, Charleston W. K. Chiang, Joseph Lachance, Timothy R. Rebbeck, David Conti, Christopher A. Haiman
Summary: A specific germline deletion variant in HOXB13 (X285K) was found to be associated with an increased risk of prostate cancer in men of West African ancestry. This variant was more strongly associated with aggressive and advanced disease. Understanding who carries this variant can inform prostate cancer screening in men of West African ancestry.
Article
Pathology
Samuel Ruder, Yan Gao, Yi Ding, Ping Bu, Brian Miles, Thomas Wheeler, Jesse K. McKenney, Heidi Auman, Ladan Fazli, Jeff Simko, Antonio Hurtado-Coll, Dean A. A. Troyer, Peter R. R. Carroll, Martin Gleave, Elizabeth Platz, Bruce Trock, Misop Han, Mohammad Sayeeduddin, Lawrence D. D. True, David Rowley, Daniel W. W. Lin, Peter S. S. Nelson, Ian M. M. Thompson, Ziding Feng, Wei Wei, James D. D. Brooks, Michael Ittmann, MinJae Lee, Gustavo Ayala, Angelo De Marzo
Summary: This study develops a new tissue-based biomarker qRS, which predicts outcomes in localized prostate cancer by measuring the host response to tumor. It is validated in multiple cohorts and shows independent predictive value.
Article
Pathology
Emily Chan, Jesse K. McKenney, Sarah Hawley, Dillon Corrigan, Heidi Auman, Lisa F. Newcomb, Hilary D. Boyer, Peter R. Carroll, Matthew R. Cooperberg, Eric Klein, Ladan Fazli, Martin E. Gleave, Antonio Hurtado-Coll, Jeffry P. Simko, Peter S. Nelson, Ian M. Thompson, Maria S. Tretiakova, Dean Troyer, Lawrence D. True, Funda Vakar-Lopez, Daniel W. Lin, James D. Brooks, Ziding Feng, Jane K. Nguyen
Summary: The study aimed to determine a quantitative cut-off for distinguishing large and small cribriform glands in prostate cancer. The findings suggest that a size greater than 0.25 mm is associated with more aggressive disease and the potential for metastatic disease, independent of Gleason pattern 5 adenocarcinoma.
Article
Oncology
Dharam Kaushik, Pankil K. Shah, Neelam Mukherjee, Niannian Ji, Furkan Dursun, Addanki P. Kumar, Ian M. Thompson, Ahmed M. Mansour, Richapriya Jha, Xiaoyu Yang, Hanzhang Wang, Nydia Darby, J. Ricardo Rivero, Robert S. Svatek, Michael A. Liss
Summary: Yoga can improve the quality of life (QoL), promote immune response, and attenuate inflammation in men with prostate cancer. Yoga has positive effects on QoL and immune cell status, deserving further investigation.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Environmental Studies
Matthias Neumair, Nicole Estrella, Annette Menzel, Donna P. Ankerst
Summary: This study investigated the impact of temperature and weather changes on fatal accidents in mountainous regions of Austria, finding significant associations between daily weather indices and fatal-accident risk.
WEATHER CLIMATE AND SOCIETY
(2022)
Article
Oncology
Zhihong Gong, Mary E. Platek, Cathee Till, Phyllis J. Goodman, Catherine M. Tangen, Elizabeth A. Platz, Marian L. Neuhouser, Ian M. Thompson, Regina M. Santella, Christine B. Ambrosone
Summary: The study of gene polymorphisms related to oxidative stress and DNA repair provides new insights into the genetic basis of prostate cancer. Researchers found associations between certain gene polymorphisms and prostate cancer risk, particularly in the group treated with finasteride. The associations may be influenced by intraprostatic sex hormone levels and antioxidant status.
FRONTIERS IN ONCOLOGY
(2022)
Article
Urology & Nephrology
Marlon Perera, Lewis Smith, Ian Thompson, Geoff Breemer, Nathan Papa, Manish I. Patel, Peter Swindle, Elliot Smith
Summary: Machine learning models can enhance the diagnostic utility of PSA kinetics in the diagnosis of prostate cancer, demonstrating significant improvements in accuracy compared to traditional approaches.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Cardiac & Cardiovascular Systems
Shalender Bhasin, A. Michael Lincoff, Shehzad Basaria, Douglas C. Bauer, William E. Boden, Glenn R. Cunningham, Deborah Davey, Elena Dubcenco, Sandra Fukumoto, Michelle Garcia, Christopher B. Granger, Vidyasagar Kalahasti, Mohit Khera, Michael G. Miller, Lisa M. Mitchell, Michael P. O'Leary, Karol M. Pencina, Peter J. Snyder, Ian M. Jr Jr Thompson, Thomas G. Travison, Kathy Wolski, Steven E. Nissen
Summary: The TRAVERSE study aims to evaluate the cardiovascular safety and long-term efficacy of testosterone treatment in middle-aged and older men with hypogonadism or increased risk of cardiovascular disease.
AMERICAN HEART JOURNAL
(2022)
Article
Oncology
Neeraj Agarwal, Catherine M. Tangen, Maha H. A. Hussain, Shilpa Gupta, Melissa Plets, Primo N. Lara, Andrea L. Harzstark, Przemyslaw W. Twardowski, Channing J. Paller, Dylan Zylla, Matthew R. Zibelman, Ellis Levine, Bruce J. Roth, Amir Goldkorn, Daniel A. Vaena, Manish Kohli, Tony Crispino, Nicholas J. Vogelzang, Ian M. Jr Jr Thompson, David Quinn
Summary: The addition of orteronel to androgen deprivation therapy (ADT) led to significant improvement in progression-free survival (PFS) and PSA response at 7 months in patients with newly diagnosed metastatic hormone-sensitive prostate cancer, but did not show statistically significant improvement in overall survival (OS).
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Mathematical & Computational Biology
Ruth M. Pfeiffer, Yiyao Chen, Mitchell H. Gail, Donna P. Ankerst
Summary: Validating risk prediction models in independent data is more reliable than internal assessment through cross-validation. However, differences in the training and validation data can affect the performance of a risk model. This paper introduces the concepts of similarity and relatedness between the data sets, and defines reproducibility and transportability. The study examines the impact of different distributions of model predictors and variations in outcome verification on model performance.
STATISTICS IN MEDICINE
(2022)
Article
Oncology
Harshit Garg, Karen M. Wheeler, Furkan Dursun, Robert E. Cooper, Deepak K. Pruthi, Dharam Kaushik, Ian M. Thompson, Robert S. Svatek, Michael A. Liss
Summary: Using multi-institutional database analysis, it was found that patients who were prescribed finasteride had higher overall survival in bladder cancer. Finasteride use appeared to be an independent predictor for overall survival in overall cohort of bladder cancer as well as non-muscle invasive bladder cancer cohort.
CLINICAL GENITOURINARY CANCER
(2023)
Article
Urology & Nephrology
Fei Chen, Ravi K. Madduri, Alex A. Rodriguez, Burcu F. Darst, Alisha Chou, Xin Sheng, Anqi Wang, Jiayi Shen, Edward J. Saunders, Suhn K. Rhie, Jeannette T. f Bensen, Sue A. Ingles, Rick A. Kittles, Sara S. Strom, Benjamin A. Rybicki, Barbara Nemesure, William B. Isaacs, Janet L. Stanford, Wei Zheng, Maureen Sanderson, Esther M. John, Jong Y. Park, Jianfeng Xu, Ying Wang, Sonja I. Berndt, Chad D. Huff, Edward D. Yeboah, Yao Tettey, Joseph Lachance, Wei Tang, Christopher T. Rentsch, Kelly Cho, Benjamin H. Mcmahon, Richard B. Biritwum, Andrew A. Adjei, Evelyn Tay, Ann Truelove, Shelley Niwa, Thomas A. Sellers, Kosj Yamoah, Adam B. Murphy, Dana C. Crawford, Alpa V. Patel, William S. Bush, Melinda C. Aldrich, Olivier Cussenot, Gyorgy Petrovics, Jennifer Cullen, Christine M. Neslund-Dudas, Mariana C. Stern, Zsofia Kote-Jarai, Koveela Govindasami, Michael B. Cook, Anand P. Chokkalingam, Ann W. Hsing, Phyllis J. Goodman, Thomas J. Hoffmann, Bettina F. Drake, Jennifer J. Hu, Jacob M. Keaton, Jacklyn N. Hellwege, Peter E. Clark, Mohamed Jalloh, Serigne M. Gueye, Lamine Niang, Olufemi Ogunbiyi, Michael O. Idowu, Olufemi Popoola, Akindele O. Adebiyi, Oseremen I. Aisuodionoe-Shadrach, Hafees O. Ajibola, Mustapha A. Jamda, Olabode P. Oluwole, Maxwell Nwegbu, Ben Adusei, Sunny Mante, Afua Darkwa-Abrahams, James E. Mensah, Halimatou Diop, Stephen K. Van Den Eeden, Pascal Blanchet, Jay H. Fowke, Graham Casey, Anselm J. Hennis, Alexander Lubwama, Ian M. Thompson, Robin Leach, Douglas F. Easton, Michael H. Preuss, Ruth J. Loos, Susan M. Gundell, Peggy Wan, James L. Mohler, Elizabeth T. Fontham, Gary J. Smith, Jack A. Taylor, Shiv Srivastava, Rosaline A. Eeles, John D. Carpten, Adam S. Kibel, Luc Multigner, Marie-Elise Parent, Florence Menegaux, Geraldine Cancel-Tassin, Eric A. Klein, Caroline Andrews, Timothy R. Rebbeck, Laurent Brureau, Stefan Ambs, Todd L. Edwards, Stephen Watya, Stephen J. Chanock, John S. Witte, William J. Blot, J. Michael Gaziano, Amy C. Justice, David Conti, Christopher A. Haiman
Summary: In this study, a large-scale genetic analysis was conducted in men of African ancestry, leading to the discovery of nine novel risk variants for prostate cancer (PCa). Furthermore, a multiancestry polygenic risk score was developed to effectively stratify PCa risk and differentiate the risk of aggressive and nonaggressive disease.