Letter
Medicine, General & Internal
Aparna Sharma, Ranjit K. Sahoo, Atul Batra, Archie Bleyer, Toni K. Choueiri, Thomas Powles
Summary: Adding adjuvant pembrolizumab after nephrectomy can significantly improve disease-free survival in patients with renal-cell carcinoma, but there are concerns regarding the arbitrary duration of 12 months of adjuvant treatment. Many patients discontinued treatment due to adverse events.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Urology & Nephrology
Yong Zhang, Tingkun Wu, Jingjing Xie, Liqun Yan, Xiuli Guo, Weijia Xu, Liping Wang
Summary: Radical nephrectomy remains the standard treatment for renal cell carcinoma, but the increased risk of chronic kidney disease in patients with concomitant metabolic syndrome (MetS) should be considered. Monitoring renal function after surgery is crucial, especially for patients with MetS.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2021)
Article
Urology & Nephrology
Pooja Ghatalia, Elizabeth A. Handorf, Daniel M. Geynisman, Mengying Deng, Matthew R. Zibelman, Philip Abbosh, Fern Anari, Richard E. Greenberg, Rosalia Viterbo, David Chen, Marc C. Smaldone, Alexander Kutikov, Robert G. Uzzo
Summary: CN plays an oncologic role in selected mRCC patients, and both upfront and deferred CN provide similar survival benefits in patients receiving CN and systemic therapy.
JOURNAL OF UROLOGY
(2022)
Article
Genetics & Heredity
Enyang Zhao, Xuedong Li, Bosen You, Jinpeng Wang, Wenbin Hou, Qiong Wu
Summary: The study aims to identify kidney renal clear cell carcinoma using miRNAs as biomarkers. By employing a feature selection strategy and Gaussian mixture model, five miRNAs were identified as a signature for diagnosis.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Andrew W. Silagy, Ritesh R. Kotecha, Stanley Weng, Arturo Holmes, Nirmish Singla, Roy Mano, Kyrollis Attalla, Kate L. Weiss, Renzo G. DiNatale, Sujata Patil, Jonathan A. Coleman, Robert J. Motzer, Paul Russo, Martin H. Voss, A. Ari Hakimi
Summary: The systemic responses to cytoreductive nephrectomy in the management of metastatic renal cell carcinoma are variable. Patients undergoing surgery had fewer modifiable IMDC risk factors, fewer metastases, and higher proportions of clear cell histology. An increase in IMDC risk factors at 6 weeks and 6 months post-surgery was associated with adverse overall survival.
Article
Urology & Nephrology
Alberto Olivero, Luca Basso, Emanuele Barabino, Paolo Milintenda, Nicolo Testino, Francesco Chierigo, Paolo Dell'oglio, Carlo E. Neumaier, Nazareno Suardi, Carlo Terrone
Summary: In patients undergoing RN, preoperative visceral adipose tissue ratio significantly predicts AKI incidence and is significantly predictive of 12-month CKD stage worsening.
MINERVA UROLOGY AND NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jianrong Bai, Axiu Zheng, Yanping Ha, Xiaoqing Xu, Yaping Yu, Yanda Lu, Shaojiang Zheng, Zhihua Shen, Botao Luo, Wei Jie
Summary: LAMC1 expression is associated with prognosis in kidney cancer, high expression indicates poor prognosis in KIRP and better prognosis in KIRC. LAMC1 expression is correlated with immune cell infiltration and signaling pathways.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Xu Hu, Yaohui Wang, Yanxiang Shao, Kang Wu, Yaxiong Tang, Shangqing Ren, Xiang Li
Summary: This study compared the outcomes of radical nephrectomy (RN) versus partial nephrectomy (PN) in patients with non-clear cell renal cell carcinoma (nccRCC). The results showed that PN was associated with better overall survival (OS) and cancer-specific survival (CSS) compared to RN. For patients with T1 nccRCC, PN may be the preferred option.
Review
Oncology
Yuqing Wu, Saisai Chen, Minhao Zhang, Kuangzheng Liu, Jibo Jing, Kehao Pan, Lihua Zhang, Bin Xu, Xiaoming Lu, Ming Chen
Summary: This study aimed to comprehensively characterize Xp11.2 tRCC patients and identify risk factors associated with overall survival (OS) and progression-free survival (PFS). T stage at presentation was found to be significantly associated with both PFS and OS, while age, T stage, and metastasis status were also identified as predictors of OS. Patients with higher T stage, older age, or metastases were shown to have poorer outcomes.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Wenhao Lin, Zhenggang Yang, Ling Yan, Jun Dai, Chen Fang, Yining Hao, Danfeng Xu, Jin Zhang, Juping Zhao
Summary: This study compared radical nephrectomy (RN) with partial nephrectomy (PN) in patients with cystic renal cell carcinoma (cRCC) using data from the SEER database and a Chinese retrospective cohort. The results showed that, after propensity score-matching (PSM), RN was associated with worse overall survival and cancer-specific survival compared to PN in cRCC patients.
SCIENTIFIC REPORTS
(2023)
Article
Urology & Nephrology
Barak Rosenzweig, Pedro Recabal, Caroline Gluck, Jonathan A. Coleman, Katalin Susztak, A. Ari Hakimi, Edgar A. Jaimes, Robert H. Weiss
Summary: Nephrectomy type, gender, blood lipids, and metabolites from benign kidney parenchyma at nephrectomy were found to be significantly associated with long-term kidney function. Some of these metabolites overlapped with previously reported processes related to chronic kidney disease.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Surgery
Zhenhua Liu, Zhenyu Yang, Jibin Li, Zefu Liu, Nan Ma, Peng Chen, Xing Bi, Zhiyong Li, Pei Dong, Hui Han, Xiaobo He, Xiaopeng Mao, Shengjie Guo
Summary: This retrospective study analyzed data of pT3aN0M0 renal cell carcinoma patients and found that PN may have a survival benefit compared to RN, especially in cases with tumor size 0-4 cm. Survival outcomes were similar between PN and RN in cases with tumor size 4-7 cm. These findings suggest that PN could be a viable alternative choice for T3aN0M0 RCC, particularly in smaller tumors.
ASIAN JOURNAL OF SURGERY
(2023)
Review
Oncology
Hana Studentova, Martina Spisarova, Andrea Kopova, Anezka Zemankova, Bohuslav Melichar, Vladimir Student
Summary: Cytoreductive nephrectomy has long been considered the standard of care for patients with metastatic renal cell carcinoma. However, with the rapid changes in systemic therapy, the importance of this procedure has been widely discussed and disputed. Currently, there is a lack of prospective data on cytoreductive nephrectomy in the immunotherapy era, and retrospective studies with small patient numbers are the main source of evidence. Nevertheless, an individualized approach can help identify patients who may benefit from surgery combined with systemic treatment.
Article
Oncology
Sung Han Kim, Min Gee Choi, Ji Hye Shin, Young-Ae Kim, Jinsoo Chung
Summary: The study retrospectively analyzed therapeutic strategies and risk factors for overall survival in recurrent localized renal cell carcinoma patients after curative nephrectomy. It found that the surgery-treated group had the best overall survival among different therapeutic strategies, and emphasized the importance of the time from nephrectomy to secondary treatment as a significant prognostic factor.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Liliana Eleonora Semenescu, Ligia Gabriela Tataranu, Anica Dricu, Gheorghe Vasile Ciubotaru, Mugurel Petrinel Radoi, Silvia Mara Baez Rodriguez, Amira Kamel
Summary: Despite the era of targeted therapies, neurosurgery still plays an important role in the treatment of brain metastases from renal cell carcinoma (BM RCC). This study found that nephrectomy, systemic therapy, and a single brain metastasis were associated with improved survival rates. Additionally, higher levels of hemoglobin were correlated with an increased number of brain metastases.
Article
Surgery
Altug Tuncel, Johan Langenhuijsen, Anil Erkan, Taras Mikhaylikov, Murat Arslan, Yilmaz Aslan, Dilek Berker, Yasar Ozgok, Eduard Gallyamov, Ali Serdar Gozen
Summary: In this study, the outcomes of the lateral transperitoneal and posterior retroperitoneal approaches in synchronous bilateral laparoscopic adrenalectomy were compared. The posterior retroperitoneal group had shorter operating time and less blood loss, with similar rates of complications compared to the transperitoneal group. Majority of the cases involved adrenal hyperplasia associated with Cushing's disease.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Orthopedics
Ibrahim Alper Yavuz, Can Aykanat, Cagdas Senel, Fatih Inci, Erman Ceyhan, Yilmaz Aslan, Altug Tuncel, Ahmet Ozgur Yildirim
Summary: The study found that the posterior surgical approach is more advantageous than anterior approaches in preserving the sexual functions of male patients in acetabular fracture surgery. However, the surgical approach did not affect the sexual functions of female patients.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2022)
Article
Urology & Nephrology
Ahmet Asfuroglu, Melih Balci, Yilmaz Aslan, Cagdas Senel, Ozer Guzel, Muhammed Fevzi Kilinckaya, Turan Turhan, Altug Tuncel
Summary: The study aimed to investigate the relationship between benign prostatic hyperplasia and inflammation by measuring urinary C-reactive protein levels before and after alpha-blocker treatment. The results showed that alpha-blocker treatment significantly reduced urine C-reactive protein levels, with a more prominent decrease in severely symptomatic patients.
UROLOGIA INTERNATIONALIS
(2022)
Article
Urology & Nephrology
Cagdas Senel, Ibrahim Can Aykanat, Ahmet Asfuroglu, Tanju Keten, Melih Balci, Yilmaz Aslan, Altug Tuncel
Summary: This study aimed to investigate the role of inflammatory markers in predicting the spontaneous passage of ureteral stones. Retrospectively reviewing 279 patients, it was found that inflammatory markers could not determine the likelihood of spontaneous stone passage, while stone size, location, and presence of hydronephrosis were more significant predictors.
Article
Andrology
Yalcin Kizilkan, Unsal Eroglu, Samet Senel, Mehmet Yildizhan, Melih Balci, Ibrahim Can Aykanat, Binhan Kagan Aktas, Suleyman Bulut, Ozer Guzel, Cevdet Serkan Gokkaya, Yilmaz Aslan, Cuneyt Ozden, Altug Tuncel
Summary: The study evaluated the rate and predictive factors of incidental prostate cancer in patients undergoing open prostatectomy with a pre-diagnosis of benign prostatic hyperplasia. The incidence of incidental prostate cancer was higher in elderly patients, and digital rectal examination and the presence of metabolic syndrome were found to be effective predictors of incidental prostate cancer.
Article
Andrology
Mehmet Yildizhan, Melih Balci, Unsal Eroglu, Erem Asil, Seref Coser, Ali Yasin Ozercan, Burak Koseoglu, Ozer Guzel, Ahmet Asfuroglu, Altug Tuncel
Summary: The study found that PBCG-RC outperformed PCPT-RC 2.0 and ERSPC-RH in predicting benign pathology outcomes at biopsy, and also had a better performance in predicting high-risk disease.
Article
Andrology
Ibrahim C. Aykanat, Sadettin Er, Cagdas Senel, Bulent Comcali, Yilmaz Aslan, Melih Balci, Bulent C. Yuksel, Altug Tuncel
Summary: The study aimed to compare sexual function and pain during sexual activity in men who underwent open or laparoscopic total extraperitoneal hernia repair techniques. Both techniques showed improvement in sexual function and pain during sexual activity, with better results seen in the laparoscopy group.
Article
Urology & Nephrology
Unsal Eroglu, Melih Balci, Seref Coser, Serdar Basboga, Ali Yasin Ozercan, Yalcin Kizilkan, Ozer Guzel, Yilmaz Aslan, Altug Tuncel
Summary: This study aimed to evaluate the changes in anxiety levels among HCWs during the COVID-19 pandemic and the impact on their sexual functions. The results showed a significant increase in anxiety levels among both male and female HCWs during the pandemic, which had a negative effect on their sexual functions.
JOURNAL OF SEXUAL MEDICINE
(2022)
Article
Andrology
Altug Tuncel, Can Aykanat, Serkan Akdemir, Taylan Oksay, Murat Arslan, Serdar Basboga, Yilmaz Aslan, Melih Balci, Ozer Guzel
Summary: This study compared the efficacy and morbidity of holmium laser enucleation of the prostate and bipolar transurethral enucleation of the prostate in patients with benign prostatic hyperplasia. The results showed that both techniques were effective in reducing length of hospital stay and improving voiding parameters, but the laser technique had better outcomes in terms of prostate tissue enucleation and maximum urine flow rate.
Article
Urology & Nephrology
Can Aykanat, Melih Balci, Cagdas Senel, Ali Yasin Ozercan, Seref Coser, Yilmaz Aslan, Ozer Guzel, Ahmet Asfuroglu, Erdem Karabulut, Altug Tuncel
Summary: There were no significant differences between the two groups in terms of patient and stone characteristics, operative time, postoperative stone-free rate, and postoperative infection development parameters. The use of a 12F/14F UAS in patients who are not previously stented increases the risk of high-grade ureteral injuries, but does not affect ureteral stricture formation.
JOURNAL OF ENDOUROLOGY
(2022)
Article
Urology & Nephrology
Tanju Keten, Ali Yasin Ozercan, Unsal Eroglu, Serdar Basboga, Koray Tatlici, Cagdas Senel, Ozer Guzel, Altug Tuncel
Summary: This study aimed to investigate the predictive value of Hemoglobin, Albumin, Lymphocyte and Platelet (HALP) score in Fournier's gangrene (FG) patients and compare it with other scoring systems. The results showed that HALP score was not a successful predictor for survival in FG, while FGSI and ACCI were successful outcome predictors in FG.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Cagdas Senel, Ahmet Asfuroglu, Ibrahim Can Aykanat, Ali Yasin Ozercan, Burak Koseoglu, Melih Balci, Yilmaz Aslan, Altug Tuncel
Summary: The aim of this study was to evaluate the clinical characteristics and renal functions in patients with acute renal infarction. The results showed that flank/abdominal pain and increased serum lactate dehydrogenase level should be taken into consideration in diagnosing acute renal infarction. Additionally, there is a risk of developing chronic kidney disease in patients with acute renal infarction.
EUROPEAN JOURNAL OF THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Cagdas Senel, Ahmet Asfuroglu, Ibrahim Can Aykanat, Melih Balci, Yilmaz Aslan, Altug Tuncel
Summary: This study found that the pre-instillation urinary pH value is associated with the efficacy of postoperative single instillation of mitomycin-C. Higher urinary pH values are associated with better recurrence-free survival rates.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2022)
Article
Urology & Nephrology
Ozer Guzel, Arzu Kosem, Yilmaz Aslan, Ahmet Asfuroglu, Melih Balci, Cagdas Senel, Altug Tuncel
Summary: This study investigated the diagnosis of prostate cancer and explored new biomarkers. The results showed that Pentraxin-3 and Fetuin-A were significantly different in the diagnosis of prostate cancer, suggesting their potential usefulness in diagnosis.
Article
Urology & Nephrology
Mehmet Giray Sonmez, Selcuk Guven, Altug Tuncel, Ibrahim Karabulut, Ozcan Kilic, Ilker Seckiner, Tzevat Tefik, Gokhan Atis, Giray Ergin, Volkan Tugcu, Bulent Erkurt, Ahmet Muslumanoglu, Kemal Sarica
Summary: In this study, the use of holmium:yttrium aluminum garnet laser during retrograde intrarenal surgery for kidney stones was evaluated. The relationship between laser-related parameters and procedure-related perioperative parameters was also investigated. The results showed significant variability in laser-setting parameters based on stone size and HU values. Increased laser-setting parameters were associated with longer anesthesia time, surgery time, and hospitalization period, as well as an increased risk of local trauma.
TURKISH JOURNAL OF UROLOGY
(2022)