Article
Veterinary Sciences
Ana Mafalda Rasteiro, Eva Sa e Lemos, Paula A. Oliveira, Rui M. Gil da Costa
Summary: Bladder cancer in veterinary medicine, particularly in companion animals, is still poorly understood but recent advances in identifying tumor markers and introducing targeted therapies have shown promise. This review focuses on small animal oncology and provides an update on the field, drawing comparisons with bladder cancer in humans and experimental models of the disease.
VETERINARY SCIENCES
(2022)
Article
Medicine, General & Internal
Goknur Kalkan, Hilal Ahsen, Bulent Yalcin
Summary: Cutaneous metastases of bladder urothelial carcinoma are rare and can mimic other dermatological disorders. Timely diagnosis is crucial, and immunohistochemical staining can aid in determining the primary origin of the tumor.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2022)
Article
Pharmacology & Pharmacy
Jisoo Song, Jiyeon Ham, Taeyeon Hong, Gwonhwa Song, Whasun Lim
Summary: Fraxetin extracted from Fraxinus rhynchophylla shows anticancer effects in hepatocellular carcinoma (HCC) cells by inhibiting cell proliferation, inducing apoptosis, and disrupting cellular environments. It has the potential to be a therapeutic agent against HCC progression.
Review
Biochemistry & Molecular Biology
Mariam Ahmed Galal, Samhar Samer Alouch, Buthainah Saad Alsultan, Huda Dahman, Nouf Abdullah Alyabis, Sarah Ammar Alammar, Ahmad Aljada
Summary: This comprehensive review thoroughly explores the intricate involvement of insulin receptor isoforms and insulin-like growth factor receptors in the insulin and insulin-like growth factor signaling pathway, emphasizing their crucial roles in cancer development and resistance to anti-cancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Min-Yung Kuo, Wei-Ting Yang, Yann-Jen Ho, Ge-Man Chang, Hsiung-Hao Chang, Chao-Yu Hsu, Chia-Che Chang, Yi-Hsin Chen
Summary: Bladder cancer is a common malignancy worldwide. STAT3 is a transcription factor commonly hyperactivated in cancers, including bladder cancer. HME, a compound derived from a medicinal mushroom, was found to be cytotoxic to bladder cancer cells by blocking STAT3 activation and suppressing the downstream survivin signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Zhihua Liu, Lina Xu, Youcheng Lin, Huaishan Hong, Yongbao Wei, Liefu Ye, Xiang Wu
Summary: This study identified hub genes correlated with the prognosis of bladder transitional cell carcinoma (BTCC) through analyzing gene expression data, with three genes specifically linked to patient prognosis. These findings offer potential biomarkers for BTCC prognosis and establish a theoretical basis for future research on prognostic factors.
FRONTIERS IN GENETICS
(2021)
Article
Chemistry, Multidisciplinary
Momoko Akiyama, Ryosuke Ueki, Masataka Yanagawa, Mitsuhiro Abe, Michio Hiroshima, Yasushi Sako, Shinsuke Sando
Summary: In this study, a synthetic receptor agonist was designed using a DNA aptamer as a building block to fine-tune agonism. The developed synthetic partial agonist can regulate therapeutically relevant cellular activities by eliciting finely-tuned receptor signaling.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Urology & Nephrology
Kathrin Bausch, Florian S. Halbeisen, Soheila Aghlmandi, Sarah U. Sutter, Hannah Ewald, Christian Appenzeller-Herzog, Jan A. Roth, Andreas F. Widmer, Hans H. Seifert
Summary: The study aimed to review the effect of antimicrobial prophylaxis on postoperative urinary tract infections following transurethral resection of bladder tumors. Results showed that there was no significant effect of antimicrobial prophylaxis on urinary tract infections, with pooled odds ratio of 1.55. Additionally, risk factors for urinary tract infections after the surgery were identified, which may inform international guidelines.
JOURNAL OF UROLOGY
(2021)
Article
Engineering, Biomedical
Rocco Latorre, Paulina D. Ramirez-Garcia, Alan Hegron, James L. Grace, Jeffri S. Retamal, Priyank Shenoy, Mai Tran, Luigi Aurelio, Bernard Flynn, Daniel P. Poole, Rafael Klein-Cloud, Dane D. Jensen, Thomas P. Davis, Brian L. Schmidt, John F. Quinn, Michael R. Whittaker, Nicholas A. Veldhuis, Nigel W. Bunnett
Summary: Stable star polymer nanostars that release antagonists continuously for 24 hours provide effective and long-lasting relief from chronic pain by disrupting endosomal signaling.
Article
Chemistry, Multidisciplinary
Hui Chen, Wanyu Xu, Hui Shi, Yan Qiao, Xiaoxiao He, Jing Zheng, Shaohong Zhou, Xiaohai Yang, Kemin Wang, Jianbo Liu
Summary: In this study, an artificial transmembrane signal transduction system using DNA-based artificial membrane receptors is described. Through low pH-mediated formation of the i-motif and dimerization of the receptors, fluorescence resonance energy transfer and G-quadruplex/hemin-mediated fluorescence amplification are activated within giant unilamellar vesicles. The study also establishes an intercellular signal communication model using coacervate microdroplets, which activate the dimerization of artificial receptors and subsequent fluorescence production or polymerization in giant unilamellar vesicles.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Medicine, General & Internal
Rahul Gupta, Suhail M. Khan, Manik Mahajan, Poonam Sharma, Arti Mahajan
Summary: This study aims to evaluate the clinico-pathological profile of bladder cancer in female patients managed at a single center in North India. The study found that female bladder cancer was most prevalent in patients in their sixties, with the majority of patients having high-grade but non-muscle-invasive disease. Among all the risk factors, exposure to traditional home cooking stoves was the main risk factor for female bladder cancer.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Kari Hemminki, Asta Foersti, Akseli Hemminki, Borje Ljungberg, Otto Hemminki
Summary: This study analyzed the survival rates of urothelial cancer (UC) in Finland and Sweden over a 50-year period. The results showed that the 1-year survival rates increased until the early 1990s, but subsequent gains were small. Age-specific differences in survival rates narrowed for men in 1-year survival but remained wide in 5-year survival. For women, the age differences were larger. The study's limitations mainly include the lack of information on treatment and stage.
Review
Cell Biology
Theadora Tolkin, E. Jane Albert Hubbard
Summary: Reproduction in the nematode C. elegans declines with age, due in part to the depletion of the germline stem and progenitor cell pool. Understanding these mechanisms has broad implications for aging stem cells, germline stem cells, and reproductive aging as many aspects of stem cell biology and aging are conserved across animals.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Mehdi Kardoust Parizi, Vitaly Margulis, Yair Lotan, Abdulmajeed Aydh, Shahrokh F. Shariat
Summary: Identifying risk factors for upper urinary tract recurrence (UUTR) in patients treated with radical cystectomy (RC) for urothelial bladder carcinoma (UBC). Surgical margin, preoperative hydronephrosis, ureteral margin, and pT stage were identified as risk factors for UUTR.
CLINICAL GENITOURINARY CANCER
(2023)
Article
Urology & Nephrology
Giorgio Bozzini, Christian Gastaldi, Umberto Besana, Alberto Calori, Stefano Casellato, Paolo Parma, Antonio Pastore, Alberto Macchi, Alberto Breda, Ali Gozen, Andreas Skolarikos, Thomas Herrmann, Cesare Scoffone, Ahmed Eissa, Maria C. Sighinolfi, Bernardo Rocco, Carlo Buizza, Evangclos Liatsikos
Summary: This study evaluated the safety and efficacy of Thulium laser in the ureteroscopic ablation of UTUC. The results showed that Thulium laser ablation is safe and feasible in treating low-grade UTUC.
MINERVA UROLOGY AND NEPHROLOGY
(2021)